Published in Proc Natl Acad Sci U S A on March 01, 2010
RAS oncogenes: weaving a tumorigenic web. Nat Rev Cancer (2011) 6.45
A comprehensive survey of Ras mutations in cancer. Cancer Res (2012) 3.67
Accessing protein conformational ensembles using room-temperature X-ray crystallography. Proc Natl Acad Sci U S A (2011) 2.92
Analysis of binding site hot spots on the surface of Ras GTPase. J Mol Biol (2011) 1.22
Novel allosteric sites on Ras for lead generation. PLoS One (2011) 1.20
Conformational selection in G-proteins: lessons from Ras and Rho. Biophys J (2010) 1.20
Conformational states of human rat sarcoma (Ras) protein complexed with its natural ligand GTP and their role for effector interaction and GTP hydrolysis. J Biol Chem (2010) 1.12
The distinct conformational dynamics of K-Ras and H-Ras A59G. PLoS Comput Biol (2010) 1.06
The structural basis for cancer treatment decisions. Oncotarget (2014) 1.05
Regulation of RAS oncogenicity by acetylation. Proc Natl Acad Sci U S A (2012) 1.02
The GTPase activity of murine guanylate-binding protein 2 (mGBP2) controls the intracellular localization and recruitment to the parasitophorous vacuole of Toxoplasma gondii. J Biol Chem (2012) 0.98
Allosteric modulation of Ras-GTP is linked to signal transduction through RAF kinase. J Biol Chem (2010) 0.98
Crystal structure of the Gtr1p(GTP)-Gtr2p(GDP) protein complex reveals large structural rearrangements triggered by GTP-to-GDP conversion. J Biol Chem (2012) 0.97
Rare codons capacitate Kras-driven de novo tumorigenesis. J Clin Invest (2014) 0.95
Site-specific processing of Ras and Rap1 Switch I by a MARTX toxin effector domain. Nat Commun (2015) 0.93
Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding. FASEB J (2015) 0.90
The role of conserved waters in conformational transitions of Q61H K-ras. PLoS Comput Biol (2012) 0.90
Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design. Nat Rev Drug Discov (2016) 0.88
Lessons from computer simulations of Ras proteins in solution and in membrane. Biochim Biophys Acta (2013) 0.87
Oncogenic K-Ras Binds to an Anionic Membrane in Two Distinct Orientations: A Molecular Dynamics Analysis. Biophys J (2016) 0.86
Identification of potential small molecule binding pockets on Rho family GTPases. PLoS One (2012) 0.82
Similar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistance. Oncotarget (2015) 0.82
Binding hotspots on K-ras: consensus ligand binding sites and other reactive regions from probe-based molecular dynamics analysis. Proteins (2015) 0.82
Mapping the Conformation Space of Wildtype and Mutant H-Ras with a Memetic, Cellular, and Multiscale Evolutionary Algorithm. PLoS Comput Biol (2015) 0.81
Evolution of the genetic code by incorporation of amino acids that improved or changed protein function. J Mol Evol (2013) 0.81
Neutron Crystal Structure of RAS GTPase Puts in Question the Protonation State of the GTP γ-Phosphate. J Biol Chem (2015) 0.80
Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view. Chem Soc Rev (2016) 0.80
Combining NMR and molecular dynamics studies for insights into the allostery of small GTPase-protein interactions. Methods Mol Biol (2012) 0.80
Ras effector mutant expression suggest a negative regulator inhibits lung tumor formation. PLoS One (2014) 0.80
Overview of simulation studies on the enzymatic activity and conformational dynamics of the GTPase Ras. Mol Simul (2014) 0.79
Ser or Leu: structural snapshots of mistranslation in Candida albicans. Front Mol Biosci (2014) 0.78
Enhanced interrogation: emerging strategies for cell signaling inhibition. Nat Struct Mol Biol (2010) 0.78
Prediction of allosteric sites and mediating interactions through bond-to-bond propensities. Nat Commun (2016) 0.78
Molecular Mechanism for Conformational Dynamics of Ras·GTP Elucidated from In-Situ Structural Transition in Crystal. Sci Rep (2016) 0.77
Enrichment of druggable conformations from apo protein structures using cosolvent-accelerated molecular dynamics. Biology (Basel) (2015) 0.77
Searching for the Chokehold of NRAS Mutant Melanoma. J Invest Dermatol (2016) 0.77
Mechanism of the exchange reaction in HRAS from multiscale modeling. PLoS One (2014) 0.76
Intrinsic K-Ras dynamics: A novel molecular dynamics data analysis method shows causality between residue pair motions. Sci Rep (2016) 0.76
Decoding RAS isoform and codon-specific signalling. Biochem Soc Trans (2014) 0.76
Distinct dynamics and interaction patterns in H- and K-Ras oncogenic P-loop mutants. Proteins (2017) 0.76
The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects. J Biol Chem (2017) 0.75
Structural dataset for the fast-exchanging KRAS G13D. Data Brief (2015) 0.75
Allosteric control of antibody-prion recognition through oxidation of a disulfide bond between the CH and CL chains. Protein Eng Des Sel (2016) 0.75
Ras: structural details to guide direct targeting. Aging (Albany NY) (2015) 0.75
Targeting mutant NRAS signaling pathways in melanoma. Pharmacol Res (2016) 0.75
Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance. Nat Commun (2017) 0.75
The Architecture of the Rag GTPase Signaling Network. Biomolecules (2017) 0.75
Deconstruction of the Ras switching cycle through saturation mutagenesis. Elife (2017) 0.75
The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science (1997) 9.21
Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis. EMBO J (1990) 6.51
Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins. Science (1990) 5.76
Cloning of bovine GAP and its interaction with oncogenic ras p21. Nature (1988) 5.56
Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro. Nature (1993) 4.61
The structural basis of the activation of Ras by Sos. Nature (1998) 4.50
Solution structure and dynamics of ras p21.GDP determined by heteronuclear three- and four-dimensional NMR spectroscopy. Biochemistry (1994) 3.72
Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma. Cell (2000) 3.68
The ras protein family: evolutionary tree and role of conserved amino acids. Biochemistry (1991) 3.38
Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules. Cell (1990) 2.77
Dynamics of the Ras/ERK MAPK cascade as monitored by fluorescent probes. J Biol Chem (2006) 2.73
Ras/Rap effector specificity determined by charge reversal. Nat Struct Biol (1996) 2.52
Renewing the conspiracy theory debate: does Raf function alone to mediate Ras oncogenesis? Trends Cell Biol (2004) 2.32
Integration of calcium and Ras signalling. Nat Rev Mol Cell Biol (2002) 2.23
Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor. J Biol Chem (1996) 2.14
Dynamic properties of the Ras switch I region and its importance for binding to effectors. Proc Natl Acad Sci U S A (2001) 1.99
Structure and dynamics of the full-length lipid-modified H-Ras protein in a 1,2-dimyristoylglycero-3-phosphocholine bilayer. J Med Chem (2007) 1.84
The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins. Structure (1999) 1.80
Ras conformational switching: simulating nucleotide-dependent conformational transitions with accelerated molecular dynamics. PLoS Comput Biol (2009) 1.67
Crystal structures at 2.2 A resolution of the catalytic domains of normal ras protein and an oncogenic mutant complexed with GDP. J Mol Biol (1991) 1.59
CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway. Curr Biol (2001) 1.50
Role of glutamine-61 in the hydrolysis of GTP by p21H-ras: an experimental and theoretical study. Biochemistry (1994) 1.50
C-terminal truncation of p21H preserves crucial kinetic and structural properties. J Biol Chem (1989) 1.41
Regulatory mechanisms and function of ERK MAP kinases. J Biochem (2004) 1.34
How Ras-related proteins talk to their effectors. Trends Biochem Sci (1996) 1.33
Structural determinants of Ras-Raf interaction analyzed in live cells. Mol Biol Cell (2002) 1.31
Transformation efficiency of RasQ61 mutants linked to structural features of the switch regions in the presence of Raf. Structure (2007) 1.26
NMR characterization of full-length farnesylated and non-farnesylated H-Ras and its implications for Raf activation. J Mol Biol (2004) 1.25
Kinetic analysis of the hydrolysis of GTP by p21N-ras. The basal GTPase mechanism. J Biol Chem (1988) 1.23
The role of scaffold proteins in MEK/ERK signalling. Biochem Soc Trans (2006) 1.22
Structural differences between a ras oncogene protein and the normal protein. Nature (1989) 1.20
Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras. Biochemistry (1993) 1.17
Global conformational dynamics in ras. Biochemistry (2008) 1.16
Vibrational structure of GDP and GTP bound to RAS: an isotope-edited FTIR study. Biochemistry (2001) 1.09
Substrate assisted catalysis -- application to G proteins. Trends Biochem Sci (2001) 1.01
Quantitative analysis of mutually competitive binding of human Raf-1 and yeast adenylyl cyclase to Ras proteins. J Biol Chem (1994) 0.98
Organic solvents order the dynamic switch II in Ras crystals. Structure (2003) 0.95
Different structural requirements within the switch II region of the Ras protein for interactions with specific downstream targets. Oncogene (1995) 0.95
Transition state structures and the roles of catalytic residues in GAP-facilitated GTPase of Ras as elucidated by (18)O kinetic isotope effects. Biochemistry (2009) 0.94
Three-dimensional structure of p21 in the active conformation and analysis of an oncogenic mutant. Environ Health Perspect (1991) 0.87
T-type calcium channel trigger p21ras signaling pathway to ERK in Cav3.1-expressed HEK293 cells. Brain Res (2005) 0.80
A comprehensive survey of Ras mutations in cancer. Cancer Res (2012) 3.67
Fragment-based identification of druggable 'hot spots' of proteins using Fourier domain correlation techniques. Bioinformatics (2009) 3.00
Inhibitory signalling to the Arp2/3 complex steers cell migration. Nature (2013) 2.06
A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis. Biochem J (2009) 1.33
Transformation efficiency of RasQ61 mutants linked to structural features of the switch regions in the presence of Raf. Structure (2007) 1.26
Analysis of binding site hot spots on the surface of Ras GTPase. J Mol Biol (2011) 1.22
Role of loop bundle hydrogen bonds in the maturation and activity of (Pro)caspase-3. Biochemistry (2006) 1.12
Structural mechanism of oxidative regulation of the phosphatase Cdc25B via an intramolecular disulfide bond. Biochemistry (2005) 1.03
Crystal structures of Ral-GppNHp and Ral-GDP reveal two binding sites that are also present in Ras and Rap. Structure (2004) 0.99
Allosteric modulation of Ras-GTP is linked to signal transduction through RAF kinase. J Biol Chem (2010) 0.98
Organic solvents order the dynamic switch II in Ras crystals. Structure (2003) 0.95
Mutations in GYPB exon 5 drive the S-s-U+(var) phenotype in persons of African descent: implications for transfusion. Transfusion (2003) 0.94
Multiple solvent crystal structures of ribonuclease A: an assessment of the method. Proteins (2009) 0.91
'Pathway drug cocktail': targeting Ras signaling based on structural pathways. Trends Mol Med (2013) 0.89
Allosteric modulation of caspase 3 through mutagenesis. Biosci Rep (2012) 0.84
Rapid folding and unfolding of Apaf-1 CARD. J Mol Biol (2007) 0.83
Shift in the equilibrium between on and off states of the allosteric switch in Ras-GppNHp affected by small molecules and bulk solvent composition. Biochemistry (2012) 0.82
STAR: a novel high-prevalence antigen in the Scianna blood group system. Transfusion (2005) 0.82
Thermodynamic, enzymatic and structural effects of removing a salt bridge at the base of loop 4 in (pro)caspase-3. Arch Biochem Biophys (2011) 0.80
Comparative analysis of the 15.5kD box C/D snoRNP core protein in the primitive eukaryote Giardia lamblia reveals unique structural and functional features. Biochemistry (2011) 0.77
Structurally conserved Nop56/58 N-terminal domain facilitates archaeal box C/D ribonucleoprotein-guided methyltransferase activity. J Biol Chem (2012) 0.75
Commentary: Biochemistry and molecular biology educators launch national network. Biochem Mol Biol Educ (2010) 0.75