Published in Cancer Sci on March 15, 2009
Metronomic chemotherapy: new rationale for new directions. Nat Rev Clin Oncol (2010) 3.02
Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network. Proc Natl Acad Sci U S A (2009) 2.82
Posttranscriptional regulation of cancer traits by HuR. Wiley Interdiscip Rev RNA (2010) 2.59
microRNA expression patterns reveal differential expression of target genes with age. PLoS One (2010) 1.92
miR-22 represses cancer progression by inducing cellular senescence. J Cell Biol (2011) 1.78
Nuclear functions of the HMG proteins. Biochim Biophys Acta (2009) 1.63
Apoptosis and beyond: cytometry in studies of programmed cell death. Methods Cell Biol (2011) 1.61
Targeting of integrin beta1 and kinesin 2alpha by microRNA 183. J Biol Chem (2009) 1.28
A senescence-like cell-cycle arrest occurs during megakaryocytic maturation: implications for physiological and pathological megakaryocytic proliferation. PLoS Biol (2010) 1.14
New biomarkers probing depth of cell senescence assessed by laser scanning cytometry. Cytometry A (2010) 1.07
CHK2 kinase in the DNA damage response and beyond. J Mol Cell Biol (2014) 1.05
Suppression of tumor and metastasis progression through the scaffolding functions of SSeCKS/Gravin/AKAP12. Cancer Metastasis Rev (2012) 0.99
Growth inhibition by miR-519 via multiple p21-inducing pathways. Mol Cell Biol (2012) 0.95
Apoptosis and autophagy have opposite roles on imatinib-induced K562 leukemia cell senescence. Cell Death Dis (2012) 0.93
DNA Methylation Changes during In Vitro Propagation of Human Mesenchymal Stem Cells: Implications for Their Genomic Stability? Stem Cells Int (2013) 0.90
Real-time in vivo imaging of p16gene expression: a new approach to study senescence stress signaling in living animals. Cell Div (2010) 0.89
Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells. Oncotarget (2011) 0.88
Molecular mechanisms underlying hepatocellular carcinoma. Viruses (2009) 0.87
A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3. Cell Cycle (2013) 0.85
Differences in the expression of five senescence markers in oral cancer, oral leukoplakia and control samples in humans. Oncol Lett (2012) 0.84
Inhibition of Breast Tumor Cell Growth by Ectopic Expression of p16/INK4A Via Combined Effects of Cell Cycle Arrest, Senescence and Apoptotic Induction, and Angiogenesis Inhibition. J Cancer (2012) 0.83
Absence of cytoglobin promotes multiple organ abnormalities in aged mice. Sci Rep (2016) 0.82
Mechanisms underlying the anti-aging and anti-tumor effects of lithocholic bile acid. Int J Mol Sci (2014) 0.82
Gene expression profiling of replicative and induced senescence. Cell Cycle (2014) 0.82
Differences in the nemosis response of normal and cancer-associated fibroblasts from patients with oral squamous cell carcinoma. PLoS One (2009) 0.81
Inactivation of heat shock factor Hsf4 induces cellular senescence and suppresses tumorigenesis in vivo. Mol Cancer Res (2012) 0.80
Fast-proliferating adipose tissue mesenchymal-stromal-like cells for therapy. Stem Cells Dev (2014) 0.79
The Intricate Interplay between Mechanisms Underlying Aging and Cancer. Aging Dis (2014) 0.79
Heparan sulfation is essential for the prevention of cellular senescence. Cell Death Differ (2015) 0.78
Persistent amplification of DNA damage signal involved in replicative senescence of normal human diploid fibroblasts. Oxid Med Cell Longev (2012) 0.77
Immortalization of Primary Keratinocytes and Its Application to Skin Research. Biomol Ther (Seoul) (2015) 0.75
Novel interactions of the von Hippel-Lindau (pVHL) tumor suppressor with the CDKN1 family of cell cycle inhibitors. Sci Rep (2017) 0.75
The Immortal Senescence. Methods Mol Biol (2017) 0.75
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature (2013) 7.51
Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. Nat Cell Biol (2006) 3.63
Genome sequence of Babesia bovis and comparative analysis of apicomplexan hemoprotozoa. PLoS Pathog (2007) 3.27
Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation. Cell (2009) 2.99
Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes. Science (2005) 2.71
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Res (2013) 1.92
The intricacies of p21 phosphorylation: protein/protein interactions, subcellular localization and stability. Cell Cycle (2006) 1.91
The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression. J Med Invest (2004) 1.72
Real-time in vivo imaging of p16Ink4a reveals cross talk with p53. J Cell Biol (2009) 1.66
Protein myristoylation in health and disease. J Chem Biol (2009) 1.57
A case of Mikulicz's disease complicated by malignant lymphoma: a postmortem histopathological finding. Intern Med (2012) 1.56
Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts. Mol Cell Biol (2002) 1.36
Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53. J Cell Biol (2005) 1.35
Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6. EMBO J (2005) 1.29
A role for p53 in maintaining and establishing the quiescence growth arrest in human cells. J Biol Chem (2002) 1.27
DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells. Mol Cell (2011) 1.21
H2O2 induces a transient multi-phase cell cycle arrest in mouse fibroblasts through modulating cyclin D and p21Cip1 expression. J Biol Chem (2002) 1.21
Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5. J Cell Biol (2003) 1.16
Activation of cyclin D1-kinase in murine fibroblasts lacking both p21(Cip1) and p27(Kip1). Oncogene (2002) 1.15
Visualizing the dynamics of p21(Waf1/Cip1) cyclin-dependent kinase inhibitor expression in living animals. Proc Natl Acad Sci U S A (2007) 1.14
Using chemical genetics and ATP analogues to dissect protein kinase function. ACS Chem Biol (2007) 1.06
Phosphorylation of the cyclin-dependent kinase inhibitor p21Cip1 on serine 130 is essential for viral cyclin-mediated bypass of a p21Cip1-imposed G1 arrest. Mol Cell Biol (2006) 1.05
Roles and mechanisms of cellular senescence in regulation of tissue homeostasis. Cancer Sci (2013) 1.02
Protein kinase A determines timing of early differentiation through epigenetic regulation with G9a. Cell Stem Cell (2012) 1.02
Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo. Cancer Res (2010) 1.02
Cell cycle-dependent regulation of the forkhead transcription factor FOXK2 by CDK·cyclin complexes. J Biol Chem (2010) 1.01
Synthesis and reactivity of novel gamma-phosphate modified ATP analogues. Bioorg Med Chem Lett (2009) 0.97
FUS/TLS is a novel mediator of androgen-dependent cell-cycle progression and prostate cancer growth. Cancer Res (2010) 0.96
Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence. Exp Cell Res (2002) 0.95
Kinetic template-guided tethering of fragments. ChemMedChem (2012) 0.93
Hepatocyte growth factor induces redistribution of p21(CIP1) and p27(KIP1) through ERK-dependent p16(INK4a) up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells. J Biol Chem (2005) 0.93
A quantitative comparison of wild-type and gatekeeper mutant cdk2 for chemical genetic studies with ATP analogues. Chembiochem (2009) 0.92
Cellular senescence: a double-edged sword in the fight against cancer. Exp Dermatol (2012) 0.91
Real-time in vivo imaging of p16gene expression: a new approach to study senescence stress signaling in living animals. Cell Div (2010) 0.89
Irreversibility of cellular senescence: dual roles of p16INK4a/Rb-pathway in cell cycle control. Cell Div (2007) 0.86
p27Kip1 and p130 cooperate to regulate hematopoietic cell proliferation in vivo. Mol Cell Biol (2006) 0.85
In vivo imaging models of bone and brain metastases and pleural carcinomatosis with a novel human EML4-ALK lung cancer cell line. Cancer Sci (2015) 0.84
Differential regulation of the cyclin-dependent kinase inhibitors p21(Cip1) and p27(Kip1) by phosphorylation directed by the cyclin encoded by Murine Herpesvirus 68. Exp Cell Res (2007) 0.83
Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence. Cell Cycle (2015) 0.83
A cancer-derived mutation in the PSTAIRE helix of cyclin-dependent kinase 2 alters the stability of cyclin binding. Biochim Biophys Acta (2010) 0.82
Development of mice without Cip/Kip CDK inhibitors. Biochem Biophys Res Commun (2012) 0.81
High-throughput analysis of meiotic crossover frequency and interference via flow cytometry of fluorescent pollen in Arabidopsis thaliana. Nat Protoc (2013) 0.81
Clickable 5'-γ-ferrocenyl adenosine triphosphate bioconjugates in kinase-catalyzed phosphorylations. Chemistry (2015) 0.81
The expression of p16INK4a tumor suppressor is upregulated by human cytomegalovirus infection and required for optimal viral replication. Virology (2006) 0.81
In vitro DNA scission activity of heterometallocenes. Dalton Trans (2007) 0.81
Jab1 co-activation of c-Jun is abrogated by the serine 10-phosphorylated form of p27Kip1. J Biol Chem (2002) 0.80
Identification of cyclin A2 as the downstream effector of the nuclear phosphatidylinositol 4,5-bisphosphate signaling network. J Biol Chem (2007) 0.80
Obesity and cancer: a gut microbial connection. Cancer Res (2014) 0.80
Normal proliferation and tumorigenesis but impaired pancreatic function in mice lacking the cell cycle regulator sei1. PLoS One (2010) 0.79
A tri-copper(II) complex displaying DNA-cleaving properties and antiproliferative activity against cancer cells. Chemistry (2012) 0.78
The chemoselective one-step alkylation and isolation of thiophosphorylated cdk2 substrates in the presence of native cysteine. Chembiochem (2011) 0.78
E2FBP1 antagonizes the p16(INK4A)-Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic leukemia protein stability. Int J Oral Sci (2011) 0.78
Clinical decision making based on histopathologic grading and margin status of dysplastic nevi. Arch Dermatol (2012) 0.77
[Tumor suppression by cellular senescence: molecular link between aging and cancer]. Tanpakushitsu Kakusan Koso (2006) 0.76
Syntheses of polypyridyl metal complexes and studies of their interaction with quadruplex DNA. Dalton Trans (2015) 0.76
Dose-dependent changes in cyclin D1 in response to 4-nitroquinoline 1-oxide-induced DNA damage. Arch Biochem Biophys (2010) 0.76
Aziridinium ion ring formation from nitrogen mustards: mechanistic insights from ab initio dynamics. J Phys Chem A (2010) 0.76
Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases. Bioorg Med Chem (2012) 0.75
Inhibition of mitogen-activated protein kinase (MAPK) and cyclin-dependent kinase 2 (Cdk2) by platinum(II) phenanthroline complexes. J Chem Biol (2011) 0.75
A platinum complex that binds non-covalently to DNA and induces cell death via a different mechanism than cisplatin. Metallomics (2013) 0.75
Bullous amyloidosis presenting as naproxen-induced photosensitivity. Int J Dermatol (2007) 0.75
Synthesis and O-phosphorylation of 3,3,4,4-tetrafluoroaryl-C-nucleoside analogues. Org Biomol Chem (2010) 0.75
[Obesity and liver cancer: the roles of gut microbiota and cellular senescence]. Seikagaku (2015) 0.75
[Role of non-coding RNAs in genome network]. Tanpakushitsu Kakusan Koso (2004) 0.75
Exploring the roles of protein kinases using chemical genetics. Future Med Chem (2009) 0.75
Pityriasis rubra pilaris sensitive to narrow band-ultraviolet B light therapy. J Drugs Dermatol (2009) 0.75
Synthesis, structure and assessment of the cytotoxic properties of 2,5-dimethylazaferrocenyl phosphonates. Dalton Trans (2005) 0.75
Cyclin D1 and cyclin D3 show divergent responses to distinct mitogenic stimulation. J Cell Physiol (2010) 0.75