PubRank

Phang-Lang Chen

Author PubWeight™ 37.26‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Science 2002 6.32
2 Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells. Proc Natl Acad Sci U S A 2005 1.91
3 Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts. Cancer Res 2002 1.60
4 BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks. J Biol Chem 2002 1.50
5 Assembly of functional ALT-associated promyelocytic leukemia bodies requires Nijmegen Breakage Syndrome 1. Cancer Res 2003 1.36
6 NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage. J Biol Chem 2003 1.34
7 Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation. J Biol Chem 2002 1.34
8 Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature. Cancer Cell 2006 1.24
9 Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. Cancer Res 2008 1.23
10 Human mitochondrial SUV3 and polynucleotide phosphorylase form a 330-kDa heteropentamer to cooperatively degrade double-stranded RNA with a 3'-to-5' directionality. J Biol Chem 2009 1.23
11 Never-in-mitosis related kinase 1 functions in DNA damage response and checkpoint control. Cell Cycle 2008 1.18
12 Retracted STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage. J Cell Sci 2005 1.17
13 Deficiency of Retinoblastoma gene in mouse embryonic stem cells leads to genetic instability. Cancer Res 2002 1.12
14 Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells. J Biol Chem 2004 1.11
15 NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response. Cancer Res 2004 1.10
16 Purified human SUV3p exhibits multiple-substrate unwinding activity upon conformational change. Biochemistry 2004 1.01
17 Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR. Cell Cycle 2011 1.01
18 Expression of PCNA-binding domain of CtIP, a motif required for CtIP localization at DNA replication foci, causes DNA damage and activation of DNA damage checkpoint. Cell Cycle 2009 1.00
19 NFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage response. J Biol Chem 2002 1.00
20 A novel role of the chromokinesin Kif4A in DNA damage response. Cell Cycle 2008 0.97
21 Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability. Mol Cancer 2011 0.96
22 A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia. EMBO Mol Med 2013 0.95
23 Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching. J Exp Med 2012 0.95
24 Synthesis and biological evaluation of a series of novel inhibitor of Nek2/Hec1 analogues. J Med Chem 2009 0.95
25 NFBD1/Mdc1 mediates ATR-dependent DNA damage response. Cancer Res 2005 0.91
26 Uncoupling the roles of the SUV3 helicase in maintenance of mitochondrial genome stability and RNA degradation. J Biol Chem 2011 0.83
27 Cell lineage-specific effects associated with multiple deficiencies of tumor susceptibility genes in Msh2(-/-)Rb(+/-) mice. Cancer Res 2002 0.82
28 Structural requirements of chromokinesin Kif4A for its proper function in mitosis. Biochem Biophys Res Commun 2008 0.80
29 Loss of p53-regulatory protein IFI16 induces NBS1 leading to activation of p53-mediated checkpoint by phosphorylation of p53 SER37. Front Biosci 2008 0.78