Published in Proc Natl Acad Sci U S A on June 20, 2005
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Pit-1 inhibits BRCA1 and sensitizes human breast tumors to cisplatin and vitamin D treatment. Oncotarget (2015) 0.80
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BRCA1-IRIS inactivation overcomes paclitaxel resistance in triple negative breast cancers. Breast Cancer Res (2015) 0.79
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MicroRNA-206 is differentially expressed in Brca1-deficient mice and regulates epithelial and stromal cell compartments of the mouse mammary gland. Oncogenesis (2016) 0.75
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Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency. Mol Cell Biol (2005) 2.30
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Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis. Cancer Res (2004) 1.67
Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts. Cancer Res (2002) 1.60
BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks. J Biol Chem (2002) 1.50
CtIP activates its own and cyclin D1 promoters via the E2F/RB pathway during G1/S progression. Mol Cell Biol (2006) 1.48
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Breast cancer cells induce cancer-associated fibroblasts to secrete hepatocyte growth factor to enhance breast tumorigenesis. PLoS One (2011) 1.37
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CtIP, a multivalent adaptor connecting transcriptional regulation, checkpoint control and tumor suppression. Cell Cycle (2006) 1.35
Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation. J Biol Chem (2002) 1.34
NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage. J Biol Chem (2003) 1.34
Recruitment of thyroid hormone receptor/retinoblastoma-interacting protein 230 by the aryl hydrocarbon receptor nuclear translocator is required for the transcriptional response to both dioxin and hypoxia. J Biol Chem (2004) 1.26
Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature. Cancer Cell (2006) 1.24
Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. Cancer Res (2008) 1.23
Human mitochondrial SUV3 and polynucleotide phosphorylase form a 330-kDa heteropentamer to cooperatively degrade double-stranded RNA with a 3'-to-5' directionality. J Biol Chem (2009) 1.23
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Hice1, a novel microtubule-associated protein required for maintenance of spindle integrity and chromosomal stability in human cells. Mol Cell Biol (2008) 1.20
Never-in-mitosis related kinase 1 functions in DNA damage response and checkpoint control. Cell Cycle (2008) 1.18
Retracted STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage. J Cell Sci (2005) 1.17
Deficiency of Retinoblastoma gene in mouse embryonic stem cells leads to genetic instability. Cancer Res (2002) 1.12
Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint. Mol Biol Cell (2011) 1.12
Activation of Robo1 signaling of breast cancer cells by Slit2 from stromal fibroblast restrains tumorigenesis via blocking PI3K/Akt/β-catenin pathway. Cancer Res (2012) 1.11
IL-25 causes apoptosis of IL-25R-expressing breast cancer cells without toxicity to nonmalignant cells. Sci Transl Med (2011) 1.11
NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response. Cancer Res (2004) 1.10
Role of SUV3 helicase in maintaining mitochondrial homeostasis in human cells. J Biol Chem (2008) 1.09
UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells. Cancer Res (2014) 1.08
Histone H3 lysine 4 methyltransferases and demethylases in self-renewal and differentiation of stem cells. Cell Biosci (2013) 1.07
M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex. J Biol Chem (2003) 1.07
RINT-1 serves as a tumor suppressor and maintains Golgi dynamics and centrosome integrity for cell survival. Mol Cell Biol (2007) 1.07
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Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease. Mol Cell (2012) 1.06
The DNA double-strand break response pathway: becoming more BRCAish than ever. DNA Repair (Amst) (2004) 1.06
Purified human SUV3p exhibits multiple-substrate unwinding activity upon conformational change. Biochemistry (2004) 1.01
Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR. Cell Cycle (2011) 1.01
Loss of corepressor PER2 under hypoxia up-regulates OCT1-mediated EMT gene expression and enhances tumor malignancy. Proc Natl Acad Sci U S A (2013) 1.00
NFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage response. J Biol Chem (2002) 1.00
Expression of PCNA-binding domain of CtIP, a motif required for CtIP localization at DNA replication foci, causes DNA damage and activation of DNA damage checkpoint. Cell Cycle (2009) 1.00
Degradation of transcription repressor ZBRK1 through the ubiquitin-proteasome pathway relieves repression of Gadd45a upon DNA damage. Mol Cell Biol (2003) 1.00
Retinoblastoma tumor suppressor and genome stability. Adv Cancer Res (2002) 0.99
DNA supercoiling-dependent gene regulation in Chlamydia. J Bacteriol (2008) 0.99
ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer. Cancer Res (2009) 0.99
A novel role of the chromokinesin Kif4A in DNA damage response. Cell Cycle (2008) 0.97
Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability. Mol Cancer (2011) 0.96
Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching. J Exp Med (2012) 0.95
A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia. EMBO Mol Med (2013) 0.95
Synthesis and biological evaluation of a series of novel inhibitor of Nek2/Hec1 analogues. J Med Chem (2009) 0.95
A common DNA-binding site for SZF1 and the BRCA1-associated zinc finger protein, ZBRK1. Cancer Res (2002) 0.92
NFBD1/Mdc1 mediates ATR-dependent DNA damage response. Cancer Res (2005) 0.91
The herpes simplex virus type 1 latency-associated transcript inhibits phenotypic and functional maturation of dendritic cells. Viral Immunol (2012) 0.90
Breast cancer cells induce stromal fibroblasts to secrete ADAMTS1 for cancer invasion through an epigenetic change. PLoS One (2012) 0.89
Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human. EMBO Mol Med (2013) 0.87
Derepression of HMGA2 via removal of ZBRK1/BRCA1/CtIP complex enhances mammary tumorigenesis. J Biol Chem (2009) 0.87
Hec1 contributes to mitotic centrosomal microtubule growth for proper spindle assembly through interaction with Hice1. Mol Biol Cell (2009) 0.87
Aurora-A phosphorylates Augmin complex component Hice1 protein at an N-terminal serine/threonine cluster to modulate its microtubule binding activity during spindle assembly. J Biol Chem (2011) 0.87
Functional dissection of transcription factor ZBRK1 reveals zinc fingers with dual roles in DNA-binding and BRCA1-dependent transcriptional repression. J Biol Chem (2003) 0.87
Breast cancer stem cells and tumor suppressor genes. J Formos Med Assoc (2008) 0.86
Loss of ZBRK1 contributes to the increase of KAP1 and promotes KAP1-mediated metastasis and invasion in cervical cancer. PLoS One (2013) 0.85
Hypersensitivity of Brca1-deficient MEF to the DNA interstrand crosslinking agent mitomycin C is associated with defect in homologous recombination repair and aberrant S-phase arrest. Oncogene (2005) 0.84
A cis-element with mixed G-quadruplex structure of NPGPx promoter is essential for nucleolin-mediated transactivation on non-targeting siRNA stress. Nucleic Acids Res (2012) 0.84
RB·E2F1 complex mediates DNA damage responses through transcriptional regulation of ZBRK1. J Biol Chem (2010) 0.84
Interactions between herpesvirus entry mediator (TNFRSF14) and latency-associated transcript during herpes simplex virus 1 latency. J Virol (2013) 0.83
Uncoupling the roles of the SUV3 helicase in maintenance of mitochondrial genome stability and RNA degradation. J Biol Chem (2011) 0.83
The function of snodprot in the cerato-platanin family from Dactylellina cionopaga in nematophagous fungi. Biosci Biotechnol Biochem (2012) 0.82
Minimal effects of dietary restriction on neuroendocrine carcinogenesis in Rb+/- mice. Carcinogenesis (2003) 0.82
Cell lineage-specific effects associated with multiple deficiencies of tumor susceptibility genes in Msh2(-/-)Rb(+/-) mice. Cancer Res (2002) 0.82
Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). J Med Chem (2014) 0.81
Piloting the NPF data-driven quality improvement initiative. Parkinsonism Relat Disord (2010) 0.80
An anti-B7-H4 antibody-drug conjugate for the treatment of breast cancer. Mol Pharm (2015) 0.80