Published in Am J Pathol on April 06, 2009
Crosstalk of reactive oxygen species and NF-κB signaling. Cell Res (2010) 3.71
Mitochondrial glutathione, a key survival antioxidant. Antioxid Redox Signal (2009) 2.28
Interleukin-33 is hepatoprotective during liver ischemia/reperfusion in mice. Hepatology (2012) 1.21
Ischemia/Reperfusion injury in liver surgery and transplantation: pathophysiology. HPB Surg (2012) 1.12
Redox control of liver function in health and disease. Antioxid Redox Signal (2010) 1.12
Apoptosis and necrosis in the liver. Compr Physiol (2013) 1.05
Growth arrest-specific protein 6 is hepatoprotective against murine ischemia/reperfusion injury. Hepatology (2010) 1.05
Hepatocytes produce TNF-α following hypoxia-reoxygenation and liver ischemia-reperfusion in a NADPH oxidase- and c-Src-dependent manner. Am J Physiol Gastrointest Liver Physiol (2013) 0.91
RORγt+IL-17+ neutrophils play a critical role in hepatic ischemia-reperfusion injury. J Mol Cell Biol (2013) 0.89
Hydroxysafflor yellow A attenuates ischemia/reperfusion-induced liver injury by suppressing macrophage activation. Int J Clin Exp Pathol (2014) 0.86
SPA0355 attenuates ischemia/reperfusion-induced liver injury in mice. Exp Mol Med (2014) 0.84
Mangafodipir protects against hepatic ischemia-reperfusion injury in mice. PLoS One (2011) 0.83
Concise review: immunologic lessons from solid organ transplantation for stem cell-based therapies. Stem Cells Transl Med (2013) 0.83
Chinese Herbal Preparation Xuebijing Potently Inhibits Inflammasome Activation in Hepatocytes and Ameliorates Mouse Liver Ischemia-Reperfusion Injury. PLoS One (2015) 0.81
Ethanol extract from portulaca oleracea L. attenuated acetaminophen-induced mice liver injury. Am J Transl Res (2015) 0.81
Ethanol extract of Portulaca Oleracea L. reduced the carbon tetrachloride induced liver injury in mice involving enhancement of NF-κB activity. Am J Transl Res (2014) 0.81
Retracted Effect of preischemic treatment with fenofibrate, a peroxisome proliferator-activated receptor-α ligand, on hepatic ischemia-reperfusion injury in rats. J Mol Histol (2011) 0.80
Regulation of molecular pathways in ischemia-reperfusion injury after liver transplantation. Transplantation (2013) 0.80
Comparative effects of triflusal, S-adenosylmethionine, and dextromethorphan over intestinal ischemia/reperfusion injury. ScientificWorldJournal (2011) 0.77
Innate Immune Regulations and Liver Ischemia-Reperfusion Injury. Transplantation (2016) 0.75
Mesenchymal Stromal Cell-Derived Factors Promote Tissue Repair in a Small-for-Size Ischemic Liver Model but Do Not Protect against Early Effects of Ischemia and Reperfusion Injury. J Immunol Res (2015) 0.75
Gadolinium chloride suppresses acute rejection and induces tolerance following rat liver transplantation by inhibiting Kupffer-cell activation. Exp Ther Med (2014) 0.75
Apocynin reduced doxycycline-induced acute liver injury in ovariectomized mice. Toxicol Rep (2016) 0.75
Shared principles in NF-kappaB signaling. Cell (2008) 20.96
Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med (2007) 6.52
Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis. Cell Metab (2006) 3.95
HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling. J Exp Med (2007) 3.72
Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Am J Physiol Gastrointest Liver Physiol (2006) 3.16
Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha. Cell (1996) 3.00
Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci U S A (2001) 2.93
Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells. J Immunol (2005) 2.78
Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. J Clin Invest (2005) 2.20
Interactions of NF-kappaB with chromatin: the art of being at the right place at the right time. Nat Immunol (2005) 2.18
Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase. J Biol Chem (2003) 2.05
Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues. Cancer Res (1994) 2.02
Overexpression of MnSOD protects against myocardial ischemia/reperfusion injury in transgenic mice. J Mol Cell Cardiol (1998) 1.72
Hepatocyte-specific IKK gamma/NEMO expression determines the degree of liver injury. Gastroenterology (2007) 1.57
Hepatic mitochondrial glutathione: transport and role in disease and toxicity. Toxicol Appl Pharmacol (2005) 1.54
Dual role of mitochondrial reactive oxygen species in hypoxia signaling: activation of nuclear factor-{kappa}B via c-SRC and oxidant-dependent cell death. Cancer Res (2007) 1.53
Functions of glutathione and glutathione disulfide in immunology and immunopathology. FASEB J (1994) 1.44
Manganese porphyrin reduces renal injury and mitochondrial damage during ischemia/reperfusion. Free Radic Biol Med (2007) 1.38
Tyrosine phosphorylation of I kappa B alpha activates NF kappa B through a redox-regulated and c-Src-dependent mechanism following hypoxia/reoxygenation. J Biol Chem (2002) 1.38
Dual role of tumor necrosis factor-alpha in hepatic ischemia-reperfusion injury: studies in tumor necrosis factor-alpha gene knockout mice. Hepatology (2004) 1.35
Feeding S-adenosyl-L-methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes. Hepatology (1995) 1.35
Mitochondria-targeted cytoprotective peptides for ischemia-reperfusion injury. Antioxid Redox Signal (2008) 1.34
Role of the intronic enhancer in tumor necrosis factor-mediated induction of manganous superoxide dismutase. J Biol Chem (2003) 1.31
Functional and morphological characterization of cultures of Kupffer cells and liver endothelial cells prepared by means of density separation in Percoll, and selective substrate adherence. Cell Tissue Res (1985) 1.31
Hepatocyte NF-kappaB activation is hepatoprotective during ischemia-reperfusion injury and is augmented by ischemic hypothermia. Am J Physiol Gastrointest Liver Physiol (2006) 1.28
Intracellular survival pathways in the liver. Liver Int (2006) 1.26
Absence of toll-like receptor 4 (TLR4) signaling in the donor organ reduces ischemia and reperfusion injury in a murine liver transplantation model. Liver Transpl (2007) 1.22
Metabolic regulatory properties of S-adenosylmethionine and S-adenosylhomocysteine. Clin Chem Lab Med (2007) 1.21
Role of NF-kappaB on liver cold ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol (2002) 1.19
Critical role of acidic sphingomyelinase in murine hepatic ischemia-reperfusion injury. Hepatology (2006) 1.19
Evidence for the pivotal role of endogenous toll-like receptor 4 ligands in liver ischemia and reperfusion injury. Transplantation (2008) 1.17
Mitochondrial reactive oxygen species and c-Src play a critical role in hypoxic response in vascular smooth muscle cells. Cardiovasc Res (2005) 1.15
IkappaBalpha and IkappaBbeta possess injury context-specific functions that uniquely influence hepatic NF-kappaB induction and inflammation. J Clin Invest (2004) 1.13
Sub-lethal oxidative stress triggers the protective effects of ischemic preconditioning in the mouse liver. J Hepatol (2003) 1.13
Melatonin and N-acetylcysteine have beneficial effects during hepatic ischemia and reperfusion. Life Sci (2003) 1.13
Glutathione protects the rat liver against reperfusion injury after prolonged warm ischemia. Ann Surg (2004) 1.08
Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis. J Clin Invest (2004) 0.98
Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms. J Biol Chem (2007) 0.97
Nuclear factor {kappa}B inactivation in the rat liver ameliorates short term total warm ischaemia/reperfusion injury. Gut (2005) 0.96
Ischemic preconditioning prevents free radical production and mitochondrial depolarization in small-for-size rat liver grafts. Transplantation (2008) 0.95
S-adenosylmethionine protects post-ischemic mitochondrial injury in rat liver. J Hepatol (2001) 0.89
Reperfusion injury of the liver: role of mitochondria and protection by glutathione ester. J Surg Res (1999) 0.89
Role of reactive metabolites of oxygen and nitrogen in partial liver transplantation: lessons learned from reduced-size liver ischaemia and reperfusion injury. Clin Exp Pharmacol Physiol (2007) 0.88
Differential expression of S-adenosylmethionine synthetase isozymes in different cell types of rat liver. Hepatology (1997) 0.85
Decreased hepatic ischemia-reperfusion injury by manganese-porphyrin complexes. Free Radic Res (2007) 0.85
Preconditioning with death ligands FasL and TNF-alpha protects the cirrhotic mouse liver against ischaemic injury. Gut (2007) 0.83
Ebselen, a novel anti-oxidant compound, protects the rat liver from ischemia-reperfusion injury. Transpl Int (1997) 0.78
Antioxidants and gadolinium chloride attenuate hepatic parenchymal and endothelial cell injury induced by low flow ischemia and reperfusion in perfused rat livers. Free Radic Res (2000) 0.77
Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis. Cell Metab (2006) 3.95
Mitochondrial glutathione, a key survival antioxidant. Antioxid Redox Signal (2009) 2.28
Rapid determination of scopolamine in evidence of recreational and predatory use. Sci Justice (2013) 2.01
Critical role of tumor necrosis factor receptor 1, but not 2, in hepatic stellate cell proliferation, extracellular matrix remodeling, and liver fibrogenesis. Hepatology (2011) 1.73
Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion. Hepatology (2003) 1.72
Ghrelin attenuates hepatocellular injury and liver fibrogenesis in rodents and influences fibrosis progression in humans. Hepatology (2010) 1.61
ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading. J Hepatol (2013) 1.61
Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH. J Hepatol (2009) 1.60
Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice. J Clin Invest (2003) 1.58
Dual role of mitochondrial reactive oxygen species in hypoxia signaling: activation of nuclear factor-{kappa}B via c-SRC and oxidant-dependent cell death. Cancer Res (2007) 1.53
Targeting cholesterol at different levels in the mevalonate pathway protects fatty liver against ischemia-reperfusion injury. J Hepatol (2010) 1.51
Caveolin-1 deficiency causes cholesterol-dependent mitochondrial dysfunction and apoptotic susceptibility. Curr Biol (2011) 1.31
Mitochondrial cholesterol loading exacerbates amyloid beta peptide-induced inflammation and neurotoxicity. J Neurosci (2009) 1.27
Trafficking of ganglioside GD3 to mitochondria by tumor necrosis factor-alpha. J Biol Chem (2002) 1.24
Acidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesis. Am J Pathol (2010) 1.24
Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential. Hepatology (2009) 1.23
Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione. J Biol Chem (2010) 1.22
Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma. Cancer Res (2008) 1.21
Critical role of acidic sphingomyelinase in murine hepatic ischemia-reperfusion injury. Hepatology (2006) 1.19
Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress. Gastroenterology (2003) 1.14
Sphingolipid signalling and liver diseases. Liver Int (2007) 1.13
Redox control of liver function in health and disease. Antioxid Redox Signal (2010) 1.12
Mitochondrial glutathione: features, regulation and role in disease. Biochim Biophys Acta (2012) 1.11
Critical role of mitochondrial glutathione in the survival of hepatocytes during hypoxia. J Biol Chem (2004) 1.10
Cathepsin B overexpression due to acid sphingomyelinase ablation promotes liver fibrosis in Niemann-Pick disease. J Biol Chem (2011) 1.07
Cholesterol impairs the adenine nucleotide translocator-mediated mitochondrial permeability transition through altered membrane fluidity. J Biol Chem (2003) 1.07
Statins and protein prenylation in cancer cell biology and therapy. Anticancer Agents Med Chem (2012) 1.05
Growth arrest-specific protein 6 is hepatoprotective against murine ischemia/reperfusion injury. Hepatology (2010) 1.05
Mechanism of mitochondrial glutathione-dependent hepatocellular susceptibility to TNF despite NF-kappaB activation. Gastroenterology (2008) 1.04
Prevalence and mechanisms of hyperhomocysteinemia in chronic alcoholics. Alcohol Clin Exp Res (2005) 1.04
Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis. J Clin Invest (2004) 0.98
Cholesterol and peroxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell death. Biochim Biophys Acta (2010) 0.95
Ganglioside GD3 sensitizes human hepatoma cells to cancer therapy. J Biol Chem (2002) 0.93
S-Adenosyl-L-methionine and mitochondrial reduced glutathione depletion in alcoholic liver disease. Alcohol (2002) 0.91
Redox regulation of hepatocyte apoptosis. J Gastroenterol Hepatol (2007) 0.90
Ceramide, tumor necrosis factor and alcohol-induced liver disease. Alcohol Clin Exp Res (2005) 0.90
Alcohol, signaling, and ECM turnover. Alcohol Clin Exp Res (2009) 0.89
Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury. Gastroenterology (2007) 0.89
Stromal interaction molecule 2 (STIM2) is frequently overexpressed in colorectal tumors and confers a tumor cell growth suppressor phenotype. Mol Carcinog (2011) 0.88
Mitochondrial cholesterol: a connection between caveolin, metabolism, and disease. Traffic (2011) 0.87
Neutral sphingomyelinase-induced ceramide triggers germinal vesicle breakdown and oxidant-dependent apoptosis in Xenopus laevis oocytes. J Lipid Res (2007) 0.87
Probiotic sonicates selectively induce mucosal immune cells apoptosis through ceramide generation via neutral sphingomyelinase. PLoS One (2011) 0.86
Mitochondrial S-adenosyl-L-methionine transport is insensitive to alcohol-mediated changes in membrane dynamics. Alcohol Clin Exp Res (2009) 0.86
Traceability markers to the botanical origin in olive oils. J Agric Food Chem (2010) 0.85
Systemic effects of cigarette smoke exposure in the guinea pig. Respir Med (2005) 0.85
Mitochondria, cholesterol and amyloid beta peptide: a dangerous trio in Alzheimer disease. J Bioenerg Biomembr (2009) 0.85
Mitochondrial permeability transition induced by reactive oxygen species is independent of cholesterol-regulated membrane fluidity. FEBS Lett (2004) 0.84
GD3 synthase overexpression sensitizes hepatocarcinoma cells to hypoxia and reduces tumor growth by suppressing the cSrc/NF-kappaB survival pathway. PLoS One (2009) 0.83
Determination of nitrocellulose by capillary electrophoresis with laser-induced fluorescence detection. Anal Chim Acta (2012) 0.82
Impaired liver regeneration in Ldlr-/- mice is associated with an altered hepatic profile of cytokines, growth factors, and lipids. J Hepatol (2013) 0.82
Divergent role of ceramide generated by exogenous sphingomyelinases on NF-kappa B activation and apoptosis in human colon HT-29 cells. FEBS Lett (2002) 0.81