PubRank

Chu-Xia Deng

Author PubWeight™ 195.07‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell 2010 8.70
2 Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci U S A 2006 8.01
3 Recent progress in the biology and physiology of sirtuins. Nature 2009 7.73
4 A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc Natl Acad Sci U S A 2008 6.53
5 SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell 2010 5.40
6 Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell 2008 5.11
7 A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab 2005 4.79
8 Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol Cell Biol 2004 4.45
9 Silencing of unsynapsed meiotic chromosomes in the mouse. Nat Genet 2004 4.25
10 Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis. Mol Cell 2008 3.32
11 Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Cell 2005 3.26
12 Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling. Proc Natl Acad Sci U S A 2008 2.98
13 Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab 2010 2.89
14 Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform. Genes Dev 2003 2.78
15 SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. Cancer Cell 2011 2.73
16 BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation. Curr Biol 2004 2.67
17 Generation of Smad4/Dpc4 conditional knockout mice. Genesis 2002 2.52
18 A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Mol Cell 2009 2.41
19 Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas. Cancer Cell 2007 2.36
20 RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis. Nat Genet 2007 2.22
21 Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice. Science 2003 2.16
22 SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression. Int J Biol Sci 2008 2.12
23 Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. J Clin Invest 2006 2.03
24 The XIST noncoding RNA functions independently of BRCA1 in X inactivation. Cell 2007 2.00
25 SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell 2013 1.99
26 SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice. J Biol Chem 2010 1.86
27 Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. J Clin Invest 2011 1.80
28 Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155. Nat Med 2011 1.79
29 Muscarinic induction of hippocampal gamma oscillations requires coupling of the M1 receptor to two mixed cation currents. Neuron 2002 1.71
30 The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. Nat Med 2012 1.69
31 A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint. Proc Natl Acad Sci U S A 2004 1.63
32 Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation. Development 2006 1.56
33 The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock. Dev Cell 2007 1.54
34 A Ser252Trp [corrected] substitution in mouse fibroblast growth factor receptor 2 (Fgfr2) results in craniosynostosis. Bone 2003 1.50
35 Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. Proc Natl Acad Sci U S A 2010 1.49
36 Identification of an integrated SV40 T/t-antigen cancer signature in aggressive human breast, prostate, and lung carcinomas with poor prognosis. Cancer Res 2007 1.49
37 Impaired meiotic DNA-damage repair and lack of crossing-over during spermatogenesis in BRCA1 full-length isoform deficient mice. Development 2003 1.49
38 Depletion of ceramides with very long chain fatty acids causes defective skin permeability barrier function, and neonatal lethality in ELOVL4 deficient mice. Int J Biol Sci 2007 1.49
39 Squamous cell carcinoma and mammary abscess formation through squamous metaplasia in Smad4/Dpc4 conditional knockout mice. Development 2003 1.43
40 Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer. Oncogene 2002 1.42
41 Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference. Nucleic Acids Res 2005 1.41
42 SRp20 is a proto-oncogene critical for cell proliferation and tumor induction and maintenance. Int J Biol Sci 2010 1.40
43 ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency. EMBO J 2006 1.38
44 SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse. Blood 2010 1.36
45 Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice. J Clin Invest 2007 1.36
46 FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate. Development 2009 1.35
47 Roles of FGF receptors in mammalian development and congenital diseases. Birth Defects Res C Embryo Today 2003 1.30
48 Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3. EMBO J 2011 1.27
49 The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation. Dev Biol 2009 1.25
50 Fibroblast growth factor receptor-1 is required for long-term potentiation, memory consolidation, and neurogenesis. Biol Psychiatry 2007 1.25
51 Smad4 is critical for self-renewal of hematopoietic stem cells. J Exp Med 2007 1.25
52 Early onset of craniosynostosis in an Apert mouse model reveals critical features of this pathology. Dev Biol 2009 1.24
53 SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis. Cancer Res 2012 1.22
54 A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus. J Clin Invest 2009 1.20
55 Frequent met oncogene amplification in a Brca1/Trp53 mouse model of mammary tumorigenesis. Cancer Res 2006 1.19
56 Promotion of mammary cancer development by tamoxifen in a mouse model of Brca1-mutation-related breast cancer. Oncogene 2005 1.19
57 Murine Wee1 plays a critical role in cell cycle regulation and pre-implantation stages of embryonic development. Int J Biol Sci 2006 1.18
58 Generation of Fgfr1 conditional knockout mice. Genesis 2002 1.18
59 The balance of WNT and FGF signaling influences mesenchymal stem cell fate during skeletal development. Sci Signal 2010 1.16
60 Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition. Int J Biol Sci 2010 1.16
61 A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors. J Neurosci 2010 1.14
62 ATM and p21 cooperate to suppress aneuploidy and subsequent tumor development. Cancer Res 2005 1.14
63 Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3. PLoS One 2012 1.13
64 Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice. J Biol Chem 2012 1.13
65 BRCA1 is an essential regulator of heart function and survival following myocardial infarction. Nat Commun 2011 1.11
66 Activin regulates luteinizing hormone beta-subunit gene expression through Smad-binding and homeobox elements. Mol Endocrinol 2005 1.08
67 Functions of the type 1 BMP receptor Acvr1 (Alk2) in lens development: cell proliferation, terminal differentiation, and survival. Invest Ophthalmol Vis Sci 2008 1.08
68 Tumor formation in mice with conditional inactivation of Brca1 in epithelial tissues. Oncogene 2003 1.07
69 PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers? Int J Med Sci 2006 1.07
70 SIRT3 deacetylates ATP synthase F1 complex proteins in response to nutrient- and exercise-induced stress. Antioxid Redox Signal 2014 1.06
71 FGFR1 function at the earliest stages of mouse limb development plays an indispensable role in subsequent autopod morphogenesis. Development 2005 1.05
72 BRCA1 affects global DNA methylation through regulation of DNMT1. Cell Res 2010 1.04
73 Uterus hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1. Mol Cell Biol 2004 1.03
74 Roles of FGF signaling in skeletal development and human genetic diseases. Front Biosci 2005 1.03
75 BRCA1 shifts p53-mediated cellular outcomes towards irreversible growth arrest. Oncogene 2003 1.01
76 The inhibition and treatment of breast cancer with poly (ADP-ribose) polymerase (PARP-1) inhibitors. Int J Biol Sci 2006 1.00
77 Absence of full-length Brca1 sensitizes mice to oxidative stress and carcinogen-induced tumorigenesis in the esophagus and forestomach. Carcinogenesis 2007 1.00
78 Normal lymphocyte development and thymic lymphoma formation in Brca1 exon-11-deficient mice. Oncogene 2003 0.98
79 Identification and characterization of cancer initiating cells from BRCA1 related mammary tumors using markers for normal mammary stem cells. Int J Biol Sci 2008 0.98
80 Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6. J Lipid Res 2013 0.98
81 Cerebellar deficits and hyperactivity in mice lacking Smad4. J Biol Chem 2003 0.97
82 A novel FGFR3-binding peptide inhibits FGFR3 signaling and reverses the lethal phenotype of mice mimicking human thanatophoric dysplasia. Hum Mol Genet 2012 0.95
83 CDDO-imidazolide induces DNA damage, G2/M arrest and apoptosis in BRCA1-mutated breast cancer cells. Cancer Prev Res (Phila) 2011 0.93
84 FoxO3 transcription factor and Sirt6 deacetylase regulate low density lipoprotein (LDL)-cholesterol homeostasis via control of the proprotein convertase subtilisin/kexin type 9 (Pcsk9) gene expression. J Biol Chem 2013 0.93
85 Smad3 in the mammary epithelium has a nonredundant role in the induction of apoptosis, but not in the regulation of proliferation or differentiation by transforming growth factor-beta. Cell Growth Differ 2002 0.93
86 Hyperplasia and spontaneous tumor development in the gynecologic system in mice lacking the BRCA1-Delta11 isoform. Mol Cell Biol 2006 0.93
87 FGF signaling facilitates postinjury recovery of mouse hematopoietic system. Blood 2012 0.92
88 Mouse models of BRCA1 and their application to breast cancer research. Cancer Metastasis Rev 2013 0.91
89 Effect of bilateral oophorectomy on mammary tumor formation in BRCA1 mutant mice. Oncol Rep 2005 0.91
90 A HIF-1 target, ATIA, protects cells from apoptosis by modulating the mitochondrial thioredoxin, TRX2. Mol Cell 2011 0.90
91 SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis. Transl Cancer Res 2012 0.90
92 Nodal/activin signaling promotes male germ cell fate and suppresses female programming in somatic cells. Development 2012 0.89
93 RNAi in mice: a promising approach to decipher gene functions in vivo. Biochimie 2005 0.88
94 Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure. J Biol Chem 2004 0.86
95 RNAi-based conditional gene knockdown in mice using a U6 promoter driven vector. Int J Biol Sci 2007 0.86
96 Aberrant p63 and WT-1 expression in myoepithelial cells of pregnancy-associated breast cancer: implications for tumor aggressiveness and invasiveness. Int J Biol Sci 2009 0.85
97 N-(4-Hydroxyphenyl)retinamide is more potent than other phenylretinamides in inhibiting the growth of BRCA1-mutated breast cancer cells. Carcinogenesis 2005 0.85
98 SIRT1 deacetylates FOXA2 and is critical for Pdx1 transcription and β-cell formation. Int J Biol Sci 2013 0.84
99 Correlated alterations in prostate basal cell layer and basement membrane. Int J Biol Sci 2009 0.84
100 Genetically modified bone morphogenetic protein signalling alters traumatic brain injury-induced gene expression responses in the adult mouse. J Neurosci Res 2006 0.84
101 A PP1-binding motif present in BRCA1 plays a role in its DNA repair function. Int J Biol Sci 2008 0.83
102 Maintenance of a normal thymic microenvironment and T-cell homeostasis require Smad4-mediated signaling in thymic epithelial cells. Blood 2008 0.82
103 Crosstalk between the DNA damage response, histone modifications and neovascularisation. Int J Biochem Cell Biol 2009 0.82
104 Multiple lineage-specific roles of Smad4 during neural crest development. Dev Biol 2009 0.81
105 Impaired skin and mammary gland development and increased gamma-irradiation-induced tumorigenesis in mice carrying a mutation of S1152-ATM phosphorylation site in Brca1. Cancer Res 2009 0.81
106 Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection. Cell Cycle 2015 0.81
107 Anterior visceral endoderm SMAD4 signaling specifies anterior embryonic patterning and head induction in mice. Int J Biol Sci 2010 0.79
108 Mouse models orthologous to FGFR3-related skeletal dysplasias. Pediatr Pathol Mol Med 2003 0.79
109 IGF signaling pathway as a selective target of familial breast cancer therapy. Curr Mol Med 2008 0.79
110 Metastasis-associated protein 1 is an integral component of the circadian molecular machinery. Nat Commun 2013 0.79
111 Soluble form of FGFR2 with S252W partially prevents craniosynostosis of the apert mouse model. Dev Dyn 2013 0.79
112 Dendrite complexity of sympathetic neurons is controlled during postnatal development by BMP signaling. J Neurosci 2013 0.79
113 Smad4 is required predominantly in the developmental processes dependent on the BMP branch of the TGF-β signaling system in the embryonic mouse retina. Invest Ophthalmol Vis Sci 2011 0.78
114 Hepatic sirtuin 1 is dispensable for fibrate-induced peroxisome proliferator-activated receptor-α function in vivo. Am J Physiol Endocrinol Metab 2014 0.78