Published in Dev Biol on April 08, 2009
Signals and switches in Mammalian neural crest cell differentiation. Cold Spring Harb Perspect Biol (2013) 1.17
Deletion of exon 20 of the Familial Dysautonomia gene Ikbkap in mice causes developmental delay, cardiovascular defects, and early embryonic lethality. PLoS One (2011) 0.95
Trigenic neural crest-restricted Smad7 over-expression results in congenital craniofacial and cardiovascular defects. Dev Biol (2010) 0.87
In Vivo Confocal Microscopy of Corneal Nerves in Health and Disease. Ocul Surf (2016) 0.82
Dendrite complexity of sympathetic neurons is controlled during postnatal development by BMP signaling. J Neurosci (2013) 0.79
TGFβ superfamily signaling in the neural crest lineage. Cell Adh Migr (2011) 0.78
Ontogeny of cardiac sympathetic innervation and its implications for cardiac disease. Pediatr Cardiol (2012) 0.75
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell (2010) 8.70
Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci U S A (2006) 8.01
Recent progress in the biology and physiology of sirtuins. Nature (2009) 7.73
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc Natl Acad Sci U S A (2008) 6.53
SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell (2010) 5.40
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell (2008) 5.11
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab (2005) 4.79
Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol Cell Biol (2004) 4.45
Silencing of unsynapsed meiotic chromosomes in the mouse. Nat Genet (2004) 4.25
Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis. Mol Cell (2008) 3.32
Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Cell (2005) 3.26
Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling. Proc Natl Acad Sci U S A (2008) 2.98
Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab (2010) 2.89
Instructive role of Wnt/beta-catenin in sensory fate specification in neural crest stem cells. Science (2004) 2.82
Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform. Genes Dev (2003) 2.78
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. Cancer Cell (2011) 2.73
BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation. Curr Biol (2004) 2.67
Generation of Smad4/Dpc4 conditional knockout mice. Genesis (2002) 2.52
A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Mol Cell (2009) 2.41
Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas. Cancer Cell (2007) 2.36
Neural crest-derived cells with stem cell features can be traced back to multiple lineages in the adult skin. J Cell Biol (2006) 2.32
RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis. Nat Genet (2007) 2.22
Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice. Science (2003) 2.16
SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression. Int J Biol Sci (2008) 2.12
Human CD271-positive melanoma stem cells associated with metastasis establish tumor heterogeneity and long-term growth. Cancer Res (2011) 2.08
Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. J Clin Invest (2006) 2.03
The XIST noncoding RNA functions independently of BRCA1 in X inactivation. Cell (2007) 2.00
SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell (2013) 1.99
Lineage-specific requirements of beta-catenin in neural crest development. J Cell Biol (2002) 1.87
SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice. J Biol Chem (2010) 1.86
Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells. J Neurosci (2008) 1.81
Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. J Clin Invest (2011) 1.80
Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155. Nat Med (2011) 1.79
Muscarinic induction of hippocampal gamma oscillations requires coupling of the M1 receptor to two mixed cation currents. Neuron (2002) 1.71
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. Nat Med (2012) 1.69
Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion. Cell Stem Cell (2008) 1.67
A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint. Proc Natl Acad Sci U S A (2004) 1.63
Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice. Circulation (2011) 1.57
Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation. Development (2006) 1.56
The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock. Dev Cell (2007) 1.54
A Ser252Trp [corrected] substitution in mouse fibroblast growth factor receptor 2 (Fgfr2) results in craniosynostosis. Bone (2003) 1.50
Inactivation of TGFbeta signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome. Genes Dev (2005) 1.50
Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. Proc Natl Acad Sci U S A (2010) 1.49
Impaired meiotic DNA-damage repair and lack of crossing-over during spermatogenesis in BRCA1 full-length isoform deficient mice. Development (2003) 1.49
Identification of an integrated SV40 T/t-antigen cancer signature in aggressive human breast, prostate, and lung carcinomas with poor prognosis. Cancer Res (2007) 1.49
Depletion of ceramides with very long chain fatty acids causes defective skin permeability barrier function, and neonatal lethality in ELOVL4 deficient mice. Int J Biol Sci (2007) 1.49
Sox10 promotes the formation and maintenance of giant congenital naevi and melanoma. Nat Cell Biol (2012) 1.48
Sox10 haploinsufficiency affects maintenance of progenitor cells in a mouse model of Hirschsprung disease. Hum Mol Genet (2002) 1.45
Neural crest stem cell maintenance by combinatorial Wnt and BMP signaling. J Cell Biol (2005) 1.44
Squamous cell carcinoma and mammary abscess formation through squamous metaplasia in Smad4/Dpc4 conditional knockout mice. Development (2003) 1.43
Development of the Schwann cell lineage: from the neural crest to the myelinated nerve. Glia (2008) 1.42
Wnt signaling and the regulation of stem cell function. Curr Opin Cell Biol (2004) 1.42
Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference. Nucleic Acids Res (2005) 1.41
SRp20 is a proto-oncogene critical for cell proliferation and tumor induction and maintenance. Int J Biol Sci (2010) 1.40
Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D, and their receptor VEGFR-3, during different stages of cervical carcinogenesis. J Pathol (2003) 1.39
ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency. EMBO J (2006) 1.38
SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse. Blood (2010) 1.36
Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice. J Clin Invest (2007) 1.36
FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate. Development (2009) 1.35
Efficient isolation and gene expression profiling of small numbers of neural crest stem cells and developing Schwann cells. J Neurosci (2004) 1.33
Establishment and controlled differentiation of neural crest stem cell lines using conditional transgenesis. Differentiation (2007) 1.30
Roles of FGF receptors in mammalian development and congenital diseases. Birth Defects Res C Embryo Today (2003) 1.30
Neural crest progenitors and stem cells: from early development to adulthood. Dev Biol (2012) 1.29
Cranial neural crest cells regulate head muscle patterning and differentiation during vertebrate embryogenesis. Development (2007) 1.27
Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3. EMBO J (2011) 1.27
The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation. Dev Biol (2009) 1.25
Fibroblast growth factor receptor-1 is required for long-term potentiation, memory consolidation, and neurogenesis. Biol Psychiatry (2007) 1.25
Smad4 is critical for self-renewal of hematopoietic stem cells. J Exp Med (2007) 1.25
Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1. Cell Stem Cell (2009) 1.25
The hypoxia-inducible microRNA cluster miR-199a∼214 targets myocardial PPARδ and impairs mitochondrial fatty acid oxidation. Cell Metab (2013) 1.24
Early onset of craniosynostosis in an Apert mouse model reveals critical features of this pathology. Dev Biol (2009) 1.24
Temporal control of neural crest lineage generation by Wnt/β-catenin signaling. Development (2012) 1.22
SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis. Cancer Res (2012) 1.22
Wnt/BMP signal integration regulates the balance between proliferation and differentiation of neuroepithelial cells in the dorsal spinal cord. Dev Biol (2006) 1.21
A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus. J Clin Invest (2009) 1.20
Promotion of mammary cancer development by tamoxifen in a mouse model of Brca1-mutation-related breast cancer. Oncogene (2005) 1.19
Frequent met oncogene amplification in a Brca1/Trp53 mouse model of mammary tumorigenesis. Cancer Res (2006) 1.19
Versican V0 and V1 guide migratory neural crest cells. J Biol Chem (2006) 1.19
Murine Wee1 plays a critical role in cell cycle regulation and pre-implantation stages of embryonic development. Int J Biol Sci (2006) 1.18
Probing transcription-specific outputs of β-catenin in vivo. Genes Dev (2011) 1.18
Generation of Fgfr1 conditional knockout mice. Genesis (2002) 1.18
Priming of CD8+ T cell responses by pathogens typically depends on CD70-mediated interactions with dendritic cells. Eur J Immunol (2007) 1.17
The balance of WNT and FGF signaling influences mesenchymal stem cell fate during skeletal development. Sci Signal (2010) 1.16
Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition. Int J Biol Sci (2010) 1.16
Functional sphere profiling reveals the complexity of neuroblastoma tumor-initiating cell model. Neoplasia (2011) 1.15
ATM and p21 cooperate to suppress aneuploidy and subsequent tumor development. Cancer Res (2005) 1.14
A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors. J Neurosci (2010) 1.14
Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3. PLoS One (2012) 1.13
The protooncogene Ski controls Schwann cell proliferation and myelination. Neuron (2004) 1.13
Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice. J Biol Chem (2012) 1.13
Neuronal Nogo-A regulates neurite fasciculation, branching and extension in the developing nervous system. Development (2010) 1.13
BRCA1 is an essential regulator of heart function and survival following myocardial infarction. Nat Commun (2011) 1.11
Membrane-bound neuregulin1 type III actively promotes Schwann cell differentiation of multipotent Progenitor cells. Dev Biol (2002) 1.10
Activin regulates luteinizing hormone beta-subunit gene expression through Smad-binding and homeobox elements. Mol Endocrinol (2005) 1.08
Functions of the type 1 BMP receptor Acvr1 (Alk2) in lens development: cell proliferation, terminal differentiation, and survival. Invest Ophthalmol Vis Sci (2008) 1.08
Tumor formation in mice with conditional inactivation of Brca1 in epithelial tissues. Oncogene (2003) 1.07
PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers? Int J Med Sci (2006) 1.07
SIRT3 deacetylates ATP synthase F1 complex proteins in response to nutrient- and exercise-induced stress. Antioxid Redox Signal (2014) 1.06