Published in Cancer Cell on October 18, 2011
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell (2012) 2.78
An evaluation of small-molecule p53 activators as chemoprotectants ameliorating adverse effects of anticancer drugs in normal cells. Cell Cycle (2012) 2.00
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Sorting out functions of sirtuins in cancer. Oncogene (2013) 1.47
Mammalian SIRT2 inhibits keratin 19 expression and is a tumor suppressor in skin. Exp Dermatol (2014) 1.47
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The histone deacetylase SIRT2 stabilizes Myc oncoproteins. Cell Death Differ (2012) 1.16
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HDAC isoenzyme expression is deregulated in chronic lymphocytic leukemia B-cells and has a complex prognostic significance. Epigenetics (2012) 1.10
Regulation of MnSOD enzymatic activity by Sirt3 connects the mitochondrial acetylome signaling networks to aging and carcinogenesis. Antioxid Redox Signal (2013) 1.09
EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore-microtubule interactions in mitosis. Proc Natl Acad Sci U S A (2012) 1.09
An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nat Chem Biol (2012) 1.08
Three-gene immunohistochemical panel adds to clinical staging algorithms to predict prognosis for patients with esophageal adenocarcinoma. J Clin Oncol (2013) 1.06
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Inhibition of the NAD-dependent protein deacetylase SIRT2 induces granulocytic differentiation in human leukemia cells. PLoS One (2013) 0.92
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Sir2a regulates rDNA transcription and multiplication rate in the human malaria parasite Plasmodium falciparum. Nat Commun (2013) 0.89
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Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection. BMC Cancer (2014) 0.88
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Targeting Histone Deacetylases in Diseases: Where Are We? Antioxid Redox Signal (2014) 0.88
The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration. Oncogene (2013) 0.88
Systemic regulation of mammalian ageing and longevity by brain sirtuins. Nat Commun (2014) 0.87
Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2. PLoS Genet (2013) 0.87
Sirtuins, Cell Senescence, and Vascular Aging. Can J Cardiol (2015) 0.87
Histone deacetylases: a saga of perturbed acetylation homeostasis in cancer. J Histochem Cytochem (2013) 0.86
Expression of sirtuin 1 and 2 is associated with poor prognosis in non-small cell lung cancer patients. PLoS One (2015) 0.86
SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1. Hum Mol Genet (2013) 0.85
Metabolism, longevity and epigenetics. Cell Mol Life Sci (2013) 0.85
Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation. J Cell Biol (2013) 0.85
Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming. Dis Model Mech (2014) 0.84
Targeting the anaphase-promoting complex/cyclosome (APC/C)- bromodomain containing 7 (BRD7) pathway for human osteosarcoma. Oncotarget (2014) 0.84
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Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. Nat Commun (2015) 0.83
Sirtuin biology and relevance to diabetes treatment. Diabetes Manag (Lond) (2012) 0.83
Sirt2 deacetylase is a novel AKT binding partner critical for AKT activation by insulin. J Biol Chem (2014) 0.83
SIRT2 interacts with β-catenin to inhibit Wnt signaling output in response to radiation-induced stress. Mol Cancer Res (2014) 0.82
Inhibition of SIRT2 in merlin/NF2-mutant Schwann cells triggers necrosis. Oncotarget (2013) 0.82
Sirtuins in hematological aging and malignancy. Crit Rev Oncog (2013) 0.82
Manganese Superoxide Dismutase Acetylation and Dysregulation, Due to Loss of SIRT3 Activity, Promote a Luminal B-Like Breast Carcinogenic-Permissive Phenotype. Antioxid Redox Signal (2016) 0.82
The controversial world of sirtuins. Drug Discov Today Technol (2014) 0.80
Sub-cellular localization, expression and functions of Sirt6 during the cell cycle in HeLa cells. Nucleus (2012) 0.80
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The Discovery of Novel 10,11-Dihydro-5H-dibenz[b,f]azepine SIRT2 Inhibitors. Medchemcomm (2012) 0.79
Sirtuin deacetylases as therapeutic targets in the nervous system. Neurotherapeutics (2013) 0.79
Regulation of the mitogen-activated protein kinase kinase (MEK)-1 by NAD(+)-dependent deacetylases. Oncogene (2014) 0.79
SIRT2 Expression Is Higher in Uveal Melanoma than In Ocular Melanocytes. Ocul Oncol Pathol (2015) 0.79
SIRT2 Regulates LPS-Induced Renal Tubular CXCL2 and CCL2 Expression. J Am Soc Nephrol (2014) 0.79
Role of sirtuins in stem cell differentiation. Genes Cancer (2013) 0.79
SIRT2 is an unfavorable prognostic biomarker in patients with acute myeloid leukemia. Sci Rep (2016) 0.78
Evaluation of benzoic acid derivatives as sirtuin inhibitors. Bioorg Med Chem Lett (2013) 0.78
Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells. Blood (2015) 0.78
Association between Sirtuin 2 gene rs10410544 polymorphism and depression in Alzheimer's disease in two independent European samples. J Neural Transm (Vienna) (2013) 0.78
Sirtuin 3 inhibits hepatocellular carcinoma growth through the glycogen synthase kinase-3β/BCL2-associated X protein-dependent apoptotic pathway. Oncogene (2015) 0.78
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Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking. Acta Crystallogr F Struct Biol Commun (2015) 0.77
When Anti-Aging Studies Meet Cancer Chemoprevention: Can Anti-Aging Agent Kill Two Birds with One Blow? Curr Pharmacol Rep (2015) 0.77
Group IVA Cytosolic Phospholipase A2 Regulates the G2-to-M Transition by Modulating the Activity of Tumor Suppressor SIRT2. Mol Cell Biol (2015) 0.77
Ubiquitin-Mediated Degradation of Aurora Kinases. Front Oncol (2016) 0.76
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SIRT2 orchestrates the DNA damage response. Cell Cycle (2016) 0.76
SIRT2 controls the pentose phosphate switch. EMBO J (2014) 0.76
SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents. Cancer Res (2016) 0.76
Insight into the Mechanism of Intramolecular Inhibition of the Catalytic Activity of Sirtuin 2 (SIRT2). PLoS One (2015) 0.76
Controlling the response to DNA damage by the APC/C-Cdh1. Cell Mol Life Sci (2015) 0.76
SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth. Cancer Res (2016) 0.76
Unique epigenetic gene profiles define human breast cancers with poor prognosis. Oncotarget (2016) 0.75
Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2. J Clin Invest (2017) 0.75
Sirtuins in metabolism, DNA repair and cancer. J Exp Clin Cancer Res (2016) 0.75
Organotypic culture in three dimensions prevents radiation-induced transformation in human lung epithelial cells. Sci Rep (2016) 0.75
SIRT2 regulates nuclear envelope reassembly via ANKLE2 deacetylation. J Cell Sci (2016) 0.75
Human Sirtuin 2 Localization, Transient Interactions, and Impact on the Proteome Point to Its Role in Intracellular Trafficking. Mol Cell Proteomics (2016) 0.75
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Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Mol Cell (2010) 4.19
EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. Cancer Res (2008) 4.17
SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell (2009) 3.91
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SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization. Cancer Cell (2011) 3.71
AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. Cancer Cell (2003) 3.50
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SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production. Oncogene (2011) 2.35
SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2. Mol Cancer Ther (2010) 2.15
SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression. Int J Biol Sci (2008) 2.12
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E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation. Proc Natl Acad Sci U S A (2009) 1.62
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Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice. J Cell Biol (2009) 1.51
Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis. PLoS One (2007) 1.50
Expression of Aurora A (but not Aurora B) is predictive of survival in breast cancer. Clin Cancer Res (2008) 1.50
Aurora-A kinase is essential for bipolar spindle formation and early development. Mol Cell Biol (2008) 1.44
SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress. Oncogene (2006) 1.37
The function of APC/CCdh1 in cell cycle and beyond. Cell Div (2009) 1.35
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Dynamic association of a tumor amplified kinase, Aurora-A, with the centrosome and mitotic spindle. Cell Motil Cytoskeleton (2003) 1.23
Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53. Biochem Biophys Res Commun (2008) 1.22
High histone deacetylase 7 (HDAC7) expression is significantly associated with adenocarcinomas of the pancreas. Ann Surg Oncol (2008) 1.18
Mammalian sirtuins and energy metabolism. Int J Biol Sci (2011) 1.17
Generation and analysis of Brca1 conditional knockout mice. Methods Mol Biol (2004) 1.16
Identification of a small molecule SIRT2 inhibitor with selective tumor cytotoxicity. Biochem Biophys Res Commun (2009) 1.15
Mouse emi1 has an essential function in mitotic progression during early embryogenesis. Mol Cell Biol (2006) 1.13
Significance of Aurora B overexpression in hepatocellular carcinoma. Aurora B Overexpression in HCC. BMC Cancer (2010) 1.13
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Cellular and molecular mechanisms involved in hepatocellular carcinoma gender disparity. Int J Cancer (2010) 1.11
Frequent overexpression of STK15/Aurora-A/BTAK and chromosomal instability in tumorigenic cell cultures derived from human ovarian cancer. Oncol Res (2005) 1.08
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SIRT2 downregulation confers resistance to microtubule inhibitors by prolonging chronic mitotic arrest. Cell Cycle (2009) 0.97
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Polo-like kinase 1 (Plk1) in non-melanoma skin cancers. Cell Cycle (2009) 0.91
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A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc Natl Acad Sci U S A (2008) 6.53
MicroRNA expression, survival, and response to interferon in liver cancer. N Engl J Med (2009) 6.13
Regulation of Raf-1 by direct feedback phosphorylation. Mol Cell (2005) 5.88
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Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning. Nat Med (2003) 5.45
Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. Am J Epidemiol (2011) 5.41
SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell (2010) 5.40
High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med (2007) 5.18
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell (2008) 5.11
Mutational inactivation of STAG2 causes aneuploidy in human cancer. Science (2011) 5.04
HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells. Nat Immunol (2008) 5.01
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab (2005) 4.79
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Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. Cancer Cell (2006) 4.33
Silencing of unsynapsed meiotic chromosomes in the mouse. Nat Genet (2004) 4.25
Assessing validity of ICD-9-CM and ICD-10 administrative data in recording clinical conditions in a unique dually coded database. Health Serv Res (2008) 4.25
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Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases. Proc Natl Acad Sci U S A (2007) 4.20
Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Mol Cell (2010) 4.19
EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. Cancer Res (2008) 4.17
An accurate mass tag strategy for quantitative and high-throughput proteome measurements. Proteomics (2002) 4.10
Telomerase modulates Wnt signalling by association with target gene chromatin. Nature (2009) 3.96
Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. Hepatology (2009) 3.92
PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. Dev Cell (2006) 3.88
Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood (2008) 3.71
The spindle checkpoint, aneuploidy, and cancer. Oncogene (2004) 3.61
Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophages. J Virol (2006) 3.59
Risk of COPD from exposure to biomass smoke: a metaanalysis. Chest (2010) 3.46
Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation. Mol Cell (2006) 3.38
Characterization of the low molecular weight human serum proteome. Mol Cell Proteomics (2003) 3.34
A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis. Science (2009) 3.34
Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis. Mol Cell (2008) 3.32
Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Cell (2005) 3.26
The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20. Mol Cell (2002) 3.24
Regulation of androgen receptor activity by tyrosine phosphorylation. Cancer Cell (2006) 3.16
The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins. Nat Struct Mol Biol (2007) 3.15
MicroRNA expression in squamous cell carcinoma and adenocarcinoma of the esophagus: associations with survival. Clin Cancer Res (2009) 3.03
Respiratory uncoupling lowers blood pressure through a leptin-dependent mechanism in genetically obese mice. Arterioscler Thromb Vasc Biol (2002) 3.01
Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology. Cancer Metastasis Rev (2004) 3.00
Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling. Proc Natl Acad Sci U S A (2008) 2.98
Docking of axonal mitochondria by syntaphilin controls their mobility and affects short-term facilitation. Cell (2008) 2.93
Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab (2010) 2.89
Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes. Mol Cell (2011) 2.88
Macrophage Wnt7b is critical for kidney repair and regeneration. Proc Natl Acad Sci U S A (2010) 2.87
MSL complex is attracted to genes marked by H3K36 trimethylation using a sequence-independent mechanism. Mol Cell (2007) 2.87
The Mad2 spindle checkpoint protein has two distinct natively folded states. Nat Struct Mol Biol (2004) 2.87
A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Proc Natl Acad Sci U S A (2012) 2.85
Scm3 is essential to recruit the histone h3 variant cse4 to centromeres and to maintain a functional kinetochore. Mol Cell (2007) 2.82
Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform. Genes Dev (2003) 2.78
RSC exploits histone acetylation to abrogate the nucleosomal block to RNA polymerase II elongation. Mol Cell (2006) 2.77
The proteasome regulatory particle alters the SAGA coactivator to enhance its interactions with transcriptional activators. Cell (2005) 2.71
HIV-neutralizing immunoglobulin A and HIV-specific proliferation are independently associated with reduced HIV acquisition in Kenyan sex workers. AIDS (2008) 2.67
BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation. Curr Biol (2004) 2.67
Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint. Mol Cell (2004) 2.66
Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma. Cancer Res (2007) 2.63
Importance of communication between producers and consumers of publicly available experimental data. J Natl Cancer Inst (2005) 2.63
Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases. Proc Natl Acad Sci U S A (2005) 2.60
Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Nature (2006) 2.60
A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients. Cancer Res (2010) 2.59
Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint. EMBO J (2004) 2.57
Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis. Proc Natl Acad Sci U S A (2004) 2.52
Generation of Smad4/Dpc4 conditional knockout mice. Genesis (2002) 2.52
The SELDI-TOF MS approach to proteomics: protein profiling and biomarker identification. Biochem Biophys Res Commun (2002) 2.51
Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice. Science (2013) 2.49