Published in Circulation on April 13, 2009
SERCA2a gene transfer decreases sarcoplasmic reticulum calcium leak and reduces ventricular arrhythmias in a model of chronic heart failure. Circ Arrhythm Electrophysiol (2011) 1.40
Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons. J Neurosci (2011) 0.95
Subcellular heterogeneity of ryanodine receptor properties in ventricular myocytes with low T-tubule density. PLoS One (2011) 0.93
The role of the renin-angiotensin-aldosterone system in the pathobiology of pulmonary arterial hypertension (2013 Grover Conference series). Pulm Circ (2014) 0.84
Abnormal Ca2+ spark/STOC coupling in cerebral artery smooth muscle cells of obese type 2 diabetic mice. PLoS One (2013) 0.84
Molecular signature of mineralocorticoid receptor signaling in cardiomyocytes: from cultured cells to mouse heart. Endocrinology (2010) 0.84
Aldosterone, mineralocorticoid receptor activation, and cardiovascular remodeling. Circulation (2011) 0.84
Aldosterone-receptor antagonism as a potential therapeutic option for atrial fibrillation. Br J Pharmacol (2010) 0.84
Ryanodol action on calcium sparks in ventricular myocytes. Pflugers Arch (2010) 0.83
Aldosterone and cardiovascular disease: the heart of the matter. Trends Endocrinol Metab (2012) 0.82
RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin mice. PLoS One (2011) 0.80
Deletion of mineralocorticoid receptors in smooth muscle cells blunts renal vascular resistance following acute cyclosporine administration. Kidney Int (2016) 0.80
The other side of cardiac Ca(2+) signaling: transcriptional control. Front Physiol (2012) 0.80
Hypoglycaemia increases aldosterone in a dose-dependent fashion. Diabet Med (2010) 0.78
FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation? Eur J Pharmacol (2013) 0.78
Corticosteroids Are Essential for Maintaining Cardiovascular Function in Male Mice. Endocrinology (2016) 0.77
Transient Receptor Potential Canonical (TRPC)/Orai1-dependent Store-operated Ca2+ Channels: NEW TARGETS OF ALDOSTERONE IN CARDIOMYOCYTES. J Biol Chem (2016) 0.77
Aldosterone promotes cardiac endothelial cell proliferation in vivo. J Am Heart Assoc (2015) 0.76
RU28318, an aldosterone antagonist, in combination with an ACE inhibitor and angiotensin receptor blocker attenuates cardiac dysfunction in diabetes. J Diabetes Res (2013) 0.75
Aldosterone-to-Renin Ratio Is Associated With Reduced 24-Hour Heart Rate Variability and QTc Prolongation in Hypertensive Patients. Medicine (Baltimore) (2016) 0.75
MicroRNA profiling of tacrolimus-stimulated Jurkat human T lympocytes. J Korean Surg Soc (2013) 0.75
Aldosterone Disrupts the Intercellular Flow of Glucose in Cardiac Muscle. Front Endocrinol (Lausanne) (2015) 0.75
PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development. Development (2002) 3.13
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. J Clin Invest (2009) 2.98
Luminal Ca2+ controls termination and refractory behavior of Ca2+-induced Ca2+ release in cardiac myocytes. Circ Res (2002) 2.89
Arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia: insights from a RyR2 R4496C knock-in mouse model. Circ Res (2006) 2.81
Abnormal Ca2+ release, but normal ryanodine receptors, in canine and human heart failure. Circ Res (2002) 2.79
Impact of graft nephrectomy on outcomes of second kidney transplantation. Int J Urol (2014) 2.67
Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties. J Immunol (2003) 2.48
Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes. Circ Res (2003) 2.44
Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation (2010) 2.32
Hyperphosphorylation of the cardiac ryanodine receptor at serine 2808 is not involved in cardiac dysfunction after myocardial infarction. Circ Res (2012) 2.16
Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation. Nature (2013) 2.08
Ryanodine receptor channelopathies. Biochem Biophys Res Commun (2004) 1.99
Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis. Nat Cell Biol (2009) 1.92
Characterization of a novel PKA phosphorylation site, serine-2030, reveals no PKA hyperphosphorylation of the cardiac ryanodine receptor in canine heart failure. Circ Res (2005) 1.86
The cAMP binding protein Epac modulates Ca2+ sparks by a Ca2+/calmodulin kinase signalling pathway in rat cardiac myocytes. J Physiol (2007) 1.85
Alternative splicing of ryanodine receptors modulates cardiomyocyte Ca2+ signaling and susceptibility to apoptosis. Circ Res (2007) 1.83
Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy. Brain (2007) 1.83
Functional heterogeneity of ryanodine receptor mutations associated with sudden cardiac death. Cardiovasc Res (2004) 1.72
Epithelial sodium channel stiffens the vascular endothelium in vitro and in Liddle mice. Hypertension (2013) 1.70
Abnormal plasma microparticles impair vasoconstrictor responses in patients with cirrhosis. Gastroenterology (2012) 1.69
Ca2+-dependent reduction of IK1 in rat ventricular cells: a novel paradigm for arrhythmia in heart failure? Cardiovasc Res (2005) 1.69
Increased Ca2+ sensitivity of the ryanodine receptor mutant RyR2R4496C underlies catecholaminergic polymorphic ventricular tachycardia. Circ Res (2008) 1.67
Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy. Proc Natl Acad Sci U S A (2010) 1.67
Mineralocorticoid receptor activation and blockade: an emerging paradigm in chronic kidney disease. Kidney Int (2011) 1.64
Increased leakage of sarcoplasmic reticulum Ca2+ contributes to abnormal myocyte Ca2+ handling and shortening in sepsis. Crit Care Med (2005) 1.63
Ryanodine receptor type I and nicotinic acid adenine dinucleotide phosphate receptors mediate Ca2+ release from insulin-containing vesicles in living pancreatic beta-cells (MIN6). J Biol Chem (2003) 1.59
Epidermal growth factor receptor mediates the vascular dysfunction but not the remodeling induced by aldosterone/salt. Hypertension (2011) 1.57
Terlipressin, a provasopressin drug exhibits direct vasoconstrictor properties: consequences on heart perfusion and performance. Crit Care Med (2009) 1.57
Ryanodine receptors and ventricular arrhythmias: emerging trends in mutations, mechanisms and therapies. J Mol Cell Cardiol (2006) 1.55
Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity. Circulation (2007) 1.51
Carbon monoxide induces cardiac arrhythmia via induction of the late Na+ current. Am J Respir Crit Care Med (2012) 1.50
Mechanisms of [Ca2+]i transient decrease in cardiomyopathy of db/db type 2 diabetic mice. Diabetes (2006) 1.49
Β-adrenergic blockade combined with subcutaneous B-type natriuretic peptide: a promising approach to reduce ventricular arrhythmia in heart failure? Heart (2014) 1.40
Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability. J Cell Biol (2009) 1.28
Characterization of rat NDRG2 (N-Myc downstream regulated gene 2), a novel early mineralocorticoid-specific induced gene. J Biol Chem (2002) 1.27
Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants. Circ Res (2014) 1.27
Role of phospholipase C-zeta domains in Ca2+-dependent phosphatidylinositol 4,5-bisphosphate hydrolysis and cytoplasmic Ca2+ oscillations. J Biol Chem (2005) 1.26
Arrhythmogenic mutation-linked defects in ryanodine receptor autoregulation reveal a novel mechanism of Ca2+ release channel dysfunction. Circ Res (2005) 1.26
A single olfactory receptor specifically binds a set of odorant molecules. Eur J Neurosci (2002) 1.25
The endothelial mineralocorticoid receptor regulates vasoconstrictor tone and blood pressure. FASEB J (2010) 1.24
Regulation of myocyte contraction via neuronal nitric oxide synthase: role of ryanodine receptor S-nitrosylation. J Physiol (2010) 1.22
Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation. Cardiovasc Res (2010) 1.22
Ca2+ syntillas, miniature Ca2+ release events in terminals of hypothalamic neurons, are increased in frequency by depolarization in the absence of Ca2+ influx. J Neurosci (2004) 1.22
Sodium and potassium balance depends on αENaC expression in connecting tubule. J Am Soc Nephrol (2010) 1.21
Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains. Mol Biol Cell (2004) 1.20
Paradoxical effect of increased diastolic Ca(2+) release and decreased sinoatrial node activity in a mouse model of catecholaminergic polymorphic ventricular tachycardia. Circulation (2012) 1.19
Increased nitration of sarcoplasmic reticulum Ca2+-ATPase in human heart failure. Circulation (2005) 1.19
Aldosterone, mineralocorticoid receptor, and heart failure. Mol Cell Endocrinol (2011) 1.18
Lipopolysaccharide improves cardiomyocyte survival and function after serum deprivation. J Biol Chem (2005) 1.17
Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias. Circulation (2005) 1.15
Ryanodine stores and calcium regulation in the inner segments of salamander rods and cones. J Physiol (2003) 1.15
Physical coupling between ryanodine receptor-calcium release channels. J Mol Biol (2005) 1.14
PLCzeta, a sperm-specific PLC and its potential role in fertilization. Biochem Soc Symp (2007) 1.14
Redox sensitivity of the ryanodine receptor interaction with FK506-binding protein. J Biol Chem (2007) 1.13
Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension. J Clin Invest (2013) 1.13
Cardiomyocyte overexpression of neuronal nitric oxide synthase delays transition toward heart failure in response to pressure overload by preserving calcium cycling. Circulation (2008) 1.12
p38 MAPK regulates IL-1beta induced IL-6 expression through mRNA stability in osteoblasts. Immunol Invest (2004) 1.12
Binding of phosphoinositide-specific phospholipase C-zeta (PLC-zeta) to phospholipid membranes: potential role of an unstructured cluster of basic residues. J Biol Chem (2007) 1.11
The neuroretina is a novel mineralocorticoid target: aldosterone up-regulates ion and water channels in Müller glial cells. FASEB J (2010) 1.11
Sorcin inhibits calcium release and modulates excitation-contraction coupling in the heart. J Biol Chem (2003) 1.09
Ryanodine receptor-mediated arrhythmias and sudden cardiac death. Pharmacol Ther (2009) 1.08
Motor and respiratory heterogeneity in Duchenne patients: implication for clinical trials. Eur J Paediatr Neurol (2011) 1.08
Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its loss accelerates skeletal muscle aging process by altering calcium homeostasis. Aging (Albany NY) (2010) 1.08
Defective glycosylation of calsequestrin in heart failure. Cardiovasc Res (2004) 1.07
Interaction of FKBP12.6 with the cardiac ryanodine receptor C-terminal domain. J Biol Chem (2004) 1.07
Ryanodine receptors. Skelet Muscle (2011) 1.06
Prevention of liver cancer cachexia-induced cardiac wasting and heart failure. Eur Heart J (2013) 1.06
Dried blood spot for hepatitis C virus serology and molecular testing. Hepatology (2010) 1.05
Extrarenal effects of aldosterone. Curr Opin Nephrol Hypertens (2012) 1.04
Conditional FKBP12.6 overexpression in mouse cardiac myocytes prevents triggered ventricular tachycardia through specific alterations in excitation-contraction coupling. Circulation (2008) 1.04
Cross-talk between mineralocorticoid and angiotensin II signaling for cardiac remodeling. Hypertension (2008) 1.04
PLCζ and the initiation of Ca(2+) oscillations in fertilizing mammalian eggs. Cell Calcium (2012) 1.04
Dihydropyridine receptors and type 1 ryanodine receptors constitute the molecular machinery for voltage-induced Ca2+ release in nerve terminals. J Neurosci (2006) 1.02
Role of FKBP12.6 in hypoxia- and norepinephrine-induced Ca2+ release and contraction in pulmonary artery myocytes. Cell Calcium (2004) 1.02
FKBP12.6 overexpression decreases Ca2+ spark amplitude but enhances [Ca2+]i transient in rat cardiac myocytes. Am J Physiol Heart Circ Physiol (2004) 1.01
Effects of amiodarone and dronedarone on voltage-dependent sodium current in human cardiomyocytes. J Cardiovasc Electrophysiol (2003) 1.01
Two-dimensional crystallization of the ryanodine receptor Ca2+ release channel on lipid membranes. J Struct Biol (2005) 1.01
PKA phosphorylation of cardiac ryanodine receptor modulates SR luminal Ca2+ sensitivity. J Mol Cell Cardiol (2012) 1.01
Male infertility-linked point mutation disrupts the Ca2+ oscillation-inducing and PIP(2) hydrolysis activity of sperm PLCζ. Biochem J (2011) 1.01
Use of luciferase chimaera to monitor PLCzeta expression in mouse eggs. Methods Mol Biol (2009) 1.00
Heparin binding EGF is necessary for vasospastic response to endothelin. FASEB J (2006) 1.00
The mitochondrial ryanodine receptor in rat heart: a pharmaco-kinetic profile. Biochim Biophys Acta (2007) 1.00
Starting a new life: sperm PLC-zeta mobilizes the Ca2+ signal that induces egg activation and embryo development: an essential phospholipase C with implications for male infertility. Bioessays (2011) 1.00
Oligomerization of the cardiac ryanodine receptor C-terminal tail. Biochem J (2003) 1.00
Molecular consequences of a frameshifted DLX3 mutant leading to Tricho-Dento-Osseous syndrome. J Biol Chem (2008) 0.99
Aldosterone increases T-type calcium channel expression and in vitro beating frequency in neonatal rat cardiomyocytes. Cardiovasc Res (2005) 0.99
Differential Ca2+ sensitivity of RyR2 mutations reveals distinct mechanisms of channel dysfunction in sudden cardiac death. Biochem Biophys Res Commun (2005) 0.99
A mechanism of ryanodine receptor modulation by FKBP12/12.6, protein kinase A, and K201. Cardiovasc Res (2010) 0.98