Hyperphosphorylation of the cardiac ryanodine receptor at serine 2808 is not involved in cardiac dysfunction after myocardial infarction.

PubWeight™: 2.16‹?› | Rank: Top 2%

🔗 View Article (PMC 3322671)

Published in Circ Res on February 02, 2012

Authors

Hongyu Zhang1, Catherine A Makarewich, Hajime Kubo, Wei Wang, Jason M Duran, Ying Li, Remus M Berretta, Walter J Koch, Xiongwen Chen, Erhe Gao, Héctor H Valdivia, Steven R Houser

Author Affiliations

1: Temple University School of Medicine, Philadelphia, PA 19140, USA.

Articles citing this

Role of RyR2 phosphorylation at S2814 during heart failure progression. Circ Res (2012) 1.41

Mechanisms of altered Ca²⁺ handling in heart failure. Circ Res (2013) 1.37

Ryanodine receptor S2808 phosphorylation in heart failure: smoking gun or red herring. Circ Res (2012) 1.31

Dysfunctional ryanodine receptors in the heart: new insights into complex cardiovascular diseases. J Mol Cell Cardiol (2013) 1.08

Role of RyR2 phosphorylation in heart failure and arrhythmias: Controversies around ryanodine receptor phosphorylation in cardiac disease. Circ Res (2014) 1.06

PKA phosphorylation of cardiac ryanodine receptor modulates SR luminal Ca2+ sensitivity. J Mol Cell Cardiol (2012) 1.01

Genetic ablation of ryanodine receptor 2 phosphorylation at Ser-2808 aggravates Ca(2+)-dependent cardiomyopathy by exacerbating diastolic Ca2+ release. J Physiol (2014) 0.99

Alterations in ryanodine receptors and related proteins in heart failure. Biochim Biophys Acta (2013) 0.99

Role of RyR2 phosphorylation in heart failure and arrhythmias: protein kinase A-mediated hyperphosphorylation of the ryanodine receptor at serine 2808 does not alter cardiac contractility or cause heart failure and arrhythmias. Circ Res (2014) 0.93

Transient receptor potential channels contribute to pathological structural and functional remodeling after myocardial infarction. Circ Res (2014) 0.92

Integrins protect cardiomyocytes from ischemia/reperfusion injury. J Clin Invest (2013) 0.90

Ryanodine receptor phosphorylation and heart failure: phasing out S2808 and "criminalizing" S2814. Circ Res (2012) 0.90

CaMKII regulation of cardiac ryanodine receptors and inositol triphosphate receptors. Front Pharmacol (2014) 0.89

Anchoring proteins as regulators of signaling pathways. Circ Res (2012) 0.89

Targeting cardiomyocyte Ca2+ homeostasis in heart failure. Curr Pharm Des (2015) 0.87

Abnormal Ca(2+) cycling in failing ventricular myocytes: role of NOS1-mediated nitroso-redox balance. Antioxid Redox Signal (2014) 0.83

Genetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of protein kinase A signaling. Circ Res (2014) 0.83

Regulation of Ca(2+) transient by PP2A in normal and failing heart. Front Physiol (2015) 0.78

Platelet endothelial cell adhesion molecule-1 mediates endothelial-cardiomyocyte communication and regulates cardiac function. J Am Heart Assoc (2015) 0.77

Imatinib activates pathological hypertrophy by altering myocyte calcium regulation. Clin Transl Sci (2014) 0.77

Chronic heart failure: Ca(2+), catabolism, and catastrophic cell death. Biochim Biophys Acta (2016) 0.77

The ryanodine receptor leak: how a tattered receptor plunges the failing heart into crisis. Heart Fail Rev (2013) 0.76

Counteracting Protein Kinase Activity in the Heart: The Multiple Roles of Protein Phosphatases. Front Pharmacol (2015) 0.75

Comparative effects of urocortins and stresscopin on cardiac myocyte contractility. J Mol Cell Cardiol (2015) 0.75

The effect of PKA-mediated phosphorylation of ryanodine receptor on SR Ca(2+) leak in ventricular myocytes. J Mol Cell Cardiol (2017) 0.75

Ablation of the cardiac ryanodine receptor phospho-site Ser2808 does not alter the adrenergic response or the progression to heart failure in mice. Elimination of the genetic background as critical variable. J Mol Cell Cardiol (2017) 0.75

A compartmentalized mathematical model of the β1-adrenergic signaling system in mouse ventricular myocytes. PLoS One (2014) 0.75

Calcium Signaling and Cardiac Arrhythmias. Circ Res (2017) 0.75

Articles cited by this

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell (2000) 10.25

Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research Group. N Engl J Med (1991) 6.65

FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell (2003) 4.68

Mechanisms and models in heart failure: the biomechanical model and beyond. Circulation (2005) 3.86

The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications. J Am Coll Cardiol (2009) 3.55

Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase. Circ Res (2007) 3.46

Mechanisms of calcium channel modulation by beta-adrenergic agents and dihydropyridine calcium agonists. J Mol Cell Cardiol (1986) 3.31

A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse. Circ Res (2010) 3.00

Cellular basis of abnormal calcium transients of failing human ventricular myocytes. Circ Res (2003) 2.86

Functional adult myocardium in the absence of Na+-Ca2+ exchange: cardiac-specific knockout of NCX1. Circ Res (2004) 2.82

Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proc Natl Acad Sci U S A (2006) 2.81

Abnormal Ca2+ release, but normal ryanodine receptors, in canine and human heart failure. Circ Res (2002) 2.79

Adrenergic regulation of cardiac contractility does not involve phosphorylation of the cardiac ryanodine receptor at serine 2808. Circ Res (2008) 2.73

L-type Ca2+ channel density and regulation are altered in failing human ventricular myocytes and recover after support with mechanical assist devices. Circ Res (2002) 2.62

Intact beta-adrenergic response and unmodified progression toward heart failure in mice with genetic ablation of a major protein kinase A phosphorylation site in the cardiac ryanodine receptor. Circ Res (2007) 2.57

Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks. Circ Res (2010) 2.29

Abnormalities of calcium cycling in the hypertrophied and failing heart. J Mol Cell Cardiol (2000) 2.25

Adverse consequences of high sympathetic nervous activity in the failing human heart. J Am Coll Cardiol (1995) 2.15

Cardiac troponin I phosphorylation increases the rate of cardiac muscle relaxation. Circ Res (1995) 2.09

Protein kinase A phosphorylation of the ryanodine receptor does not affect calcium sparks in mouse ventricular myocytes. Circ Res (2002) 2.06

Modulation of excitation-contraction coupling by isoproterenol in cardiomyocytes with controlled SR Ca2+ load and Ca2+ current trigger. J Physiol (2004) 1.81

Ca2+ sparks in rabbit ventricular myocytes evoked by action potentials: involvement of clusters of L-type Ca2+ channels. Circ Res (2003) 1.79

Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice. J Clin Invest (2010) 1.77

Altered intracellular Ca2+ handling in heart failure. J Clin Invest (2005) 1.70

Heart failure after myocardial infarction: altered excitation-contraction coupling. Circulation (2001) 1.69

Cardiac intracellular calcium release channels: role in heart failure. Circ Res (2000) 1.62

Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice. J Clin Invest (2010) 1.60

Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes. Biochem Biophys Res Commun (2008) 1.57

Regulation of cardiac sarcoplasmic reticulum Ca release by luminal [Ca] and altered gating assessed with a mathematical model. Biophys J (2005) 1.47

Involvement of the cardiac ryanodine receptor/calcium release channel in catecholaminergic polymorphic ventricular tachycardia. J Cell Physiol (2002) 1.43

Intracellular calcium-release channels: regulators of cell life and death. Am J Physiol (1997) 1.35

Relation between reverse sodium-calcium exchange and sarcoplasmic reticulum calcium release in guinea pig ventricular cells. Circ Res (1994) 1.28

Acute myocardial infarction and heart failure: role of apoptosis. Int J Biochem Cell Biol (2006) 1.26

Intracellular calcium homeostasis in cardiac myocytes. Circulation (1993) 1.24

Patients with end-stage congestive heart failure treated with beta-adrenergic receptor antagonists have improved ventricular myocyte calcium regulatory protein abundance. Circulation (2001) 1.20

Ryanodine receptors/calcium release channels in heart failure and sudden cardiac death. J Mol Cell Cardiol (2001) 1.18

Progression of heart failure: is protein kinase a hyperphosphorylation of the ryanodine receptor a contributing factor? Circulation (2002) 1.16

Functional consequence of protein kinase A-dependent phosphorylation of the cardiac ryanodine receptor: sensitization of store overload-induced Ca2+ release. J Biol Chem (2007) 1.15

Modeling the isolated cardiac myocyte. Prog Biophys Mol Biol (2004) 1.08

Transgenic overexpression of the sarcoplasmic reticulum Ca2+ATPase improves reticular Ca2+ handling in normal and diabetic rat hearts. FASEB J (2002) 1.02

Role of the sarcoplasmic reticulum in contraction and relaxation of immature rabbit ventricular myocytes. J Mol Cell Cardiol (1997) 0.99

No Role for the Ryanodine Receptor in Regulating Cardiac Contraction? News Physiol Sci (2000) 0.97

Defective Ca(2+) handling proteins regulation during heart failure. Physiol Res (2010) 0.96

Functional properties of failing human ventricular myocytes. Trends Cardiovasc Med (2000) 0.94

Is ryanodine receptor phosphorylation key to the fight or flight response and heart failure? J Clin Invest (2010) 0.91

The cardiac ryanodine receptor (RyR2) and its role in heart disease. Cardiol Rev (2005) 0.86

Articles by these authors

A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39

Scalable molecular dynamics with NAMD. J Comput Chem (2005) 59.49

The diploid genome sequence of an Asian individual. Nature (2008) 46.29

Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet (2007) 32.41

Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet (2008) 12.51

piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature (2009) 11.27

Sequencing of 50 human exomes reveals adaptation to high altitude. Science (2010) 11.27

Distinct epigenomic landscapes of pluripotent and lineage-committed human cells. Cell Stem Cell (2010) 8.74

The genome of the cucumber, Cucumis sativus L. Nat Genet (2009) 8.19

A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen. Cancer Cell (2004) 8.06

Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease. J Am Soc Nephrol (2006) 8.05

Automatic atom type and bond type perception in molecular mechanical calculations. J Mol Graph Model (2006) 7.93

Genome sequence and analysis of the tuber crop potato. Nature (2011) 7.77

The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity (2008) 7.60

Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nat Biotechnol (2009) 7.59

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell (2012) 7.36

Acute renal failure and sepsis. N Engl J Med (2004) 7.18

The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models. Nat Biotechnol (2010) 7.08

High-performance neuroprosthetic control by an individual with tetraplegia. Lancet (2012) 6.66

Negative Staining and Image Classification - Powerful Tools in Modern Electron Microscopy. Biol Proced Online (2004) 6.14

Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol (2011) 5.98

The dog genome: survey sequencing and comparative analysis. Science (2003) 5.84

Incorporating structure to predict microRNA targets. Proc Natl Acad Sci U S A (2005) 5.68

DNA helicase Srs2 disrupts the Rad51 presynaptic filament. Nature (2003) 5.66

New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58

Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS Med (2008) 5.54

The draft genome of the transgenic tropical fruit tree papaya (Carica papaya Linnaeus). Nature (2008) 5.54

Validation of the ITS2 region as a novel DNA barcode for identifying medicinal plant species. PLoS One (2010) 5.39

Seven-transmembrane-spanning receptors and heart function. Nature (2002) 5.38

Aptamers evolved from live cells as effective molecular probes for cancer study. Proc Natl Acad Sci U S A (2006) 5.35

Predictive value for the Chinese population of the Framingham CHD risk assessment tool compared with the Chinese Multi-Provincial Cohort Study. JAMA (2004) 5.34

The oyster genome reveals stress adaptation and complexity of shell formation. Nature (2012) 5.30

De novo mutations in histone-modifying genes in congenital heart disease. Nature (2013) 5.15

Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals. J Exp Med (2008) 5.14

Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell (2005) 5.10

Mitochondrial gene replacement in primate offspring and embryonic stem cells. Nature (2009) 4.98

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A (2010) 4.95

MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. Cancer Res (2007) 4.95

Sequence and analysis of rice chromosome 4. Nature (2002) 4.39

Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations. Cancer Res (2008) 4.30

Probable limited person-to-person transmission of highly pathogenic avian influenza A (H5N1) virus in China. Lancet (2008) 4.17

EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. Cancer Res (2008) 4.17

A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure. Nat Med (2008) 3.98

Pelvic Organ Support Study (POSST): the distribution, clinical definition, and epidemiologic condition of pelvic organ support defects. Am J Obstet Gynecol (2005) 3.85

Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance. Lancet (2013) 3.83

Epigenomic analysis of multilineage differentiation of human embryonic stem cells. Cell (2013) 3.81

Epidemiological transition of stroke in China: twenty-one-year observational study from the Sino-MONICA-Beijing Project. Stroke (2008) 3.81

Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders. Proc Natl Acad Sci U S A (2010) 3.78

Acute renal failure: definitions, diagnosis, pathogenesis, and therapy. J Clin Invest (2004) 3.75

Discovery and annotation of functional chromatin signatures in the human genome. PLoS Comput Biol (2009) 3.61

Residential proximity to naturally occurring asbestos and mesothelioma risk in California. Am J Respir Crit Care Med (2005) 3.55

Clinical application of massively parallel sequencing-based prenatal noninvasive fetal trisomy test for trisomies 21 and 18 in 11,105 pregnancies with mixed risk factors. Prenat Diagn (2012) 3.54

Surgical treatment of giant coronary artery aneurysm. J Thorac Cardiovasc Surg (2005) 3.53

Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells. J Immunol (2007) 3.47

ChromaSig: a probabilistic approach to finding common chromatin signatures in the human genome. PLoS Comput Biol (2008) 3.46

Genomic analyses identify distinct patterns of selection in domesticated pigs and Tibetan wild boars. Nat Genet (2013) 3.41

A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates. Proc Natl Acad Sci U S A (2009) 3.39

Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. Nature (2012) 3.38

Characteristics associated with differences in survival among black and white women with breast cancer. JAMA (2013) 3.35

Effects of acupuncture on pregnancy rates in women undergoing in vitro fertilization: a systematic review and meta-analysis. Fertil Steril (2012) 3.33

Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist. Science (2006) 3.26

Genetic analysis of complex traits in the emerging Collaborative Cross. Genome Res (2011) 3.25

Effects of a universal classroom behavior management program in first and second grades on young adult behavioral, psychiatric, and social outcomes. Drug Alcohol Depend (2008) 3.22

Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome. Genome Res (2010) 3.17

Transcriptome profiling of human and murine ESCs identifies divergent paths required to maintain the stem cell state. Stem Cells (2005) 3.16

A recalibrated molecular clock and independent origins for the cholera pandemic clones. PLoS One (2008) 3.16

Effectiveness of strengthened stimulation during acupuncture for the treatment of Bell palsy: a randomized controlled trial. CMAJ (2013) 3.15

Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress. Circulation (2002) 3.15

Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure. J Clin Invest (2007) 3.13

The Selaginella genome identifies genetic changes associated with the evolution of vascular plants. Science (2011) 3.10

Methods for testing theory and evaluating impact in randomized field trials: intent-to-treat analyses for integrating the perspectives of person, place, and time. Drug Alcohol Depend (2008) 3.09

Quantum-sized carbon dots for bright and colorful photoluminescence. J Am Chem Soc (2006) 3.08

Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption. Sci Transl Med (2012) 3.08

Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands. Cancer Cell (2011) 3.07

Bone marrow cells adopt the cardiomyogenic fate in vivo. Proc Natl Acad Sci U S A (2007) 3.06

Assessing the performance of the MM/PBSA and MM/GBSA methods. 1. The accuracy of binding free energy calculations based on molecular dynamics simulations. J Chem Inf Model (2010) 3.04

Epidemiology of Alzheimer's disease and other forms of dementia in China, 1990-2010: a systematic review and analysis. Lancet (2013) 3.02

A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse. Circ Res (2010) 3.00

Long non-coding RNA H19 increases bladder cancer metastasis by associating with EZH2 and inhibiting E-cadherin expression. Cancer Lett (2013) 2.99

Use of ITS2 region as the universal DNA barcode for plants and animals. PLoS One (2010) 2.92

Luminal Ca2+ controls termination and refractory behavior of Ca2+-induced Ca2+ release in cardiac myocytes. Circ Res (2002) 2.89

Cellular basis of abnormal calcium transients of failing human ventricular myocytes. Circ Res (2003) 2.86

The polymorphism architecture of mouse genetic resources elucidated using genome-wide resequencing data: implications for QTL discovery and systems genetics. Mamm Genome (2007) 2.82

Sleep restriction for 1 week reduces insulin sensitivity in healthy men. Diabetes (2010) 2.81

Abnormal Ca2+ release, but normal ryanodine receptors, in canine and human heart failure. Circ Res (2002) 2.79

NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants. Nature (2012) 2.76

Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair. Mol Cell Biol (2003) 2.74

Adrenergic regulation of cardiac contractility does not involve phosphorylation of the cardiac ryanodine receptor at serine 2808. Circ Res (2008) 2.73

Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis. Nat Neurosci (2013) 2.71

U-Pb ages from the neoproterozoic Doushantuo Formation, China. Science (2005) 2.71

Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression. Nat Cell Biol (2008) 2.68

Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell (2007) 2.65

Phase II randomized study of vaccine treatment of advanced prostate cancer (E7897): a trial of the Eastern Cooperative Oncology Group. J Clin Oncol (2004) 2.65