PubRank

Claus-Michael Lehr

Author PubWeight™ 92.39‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Lectin-mediated drug targeting: history and applications. Adv Drug Deliv Rev 2004 1.59
2 Nanoparticles--an efficient carrier for drug delivery into the hair follicles. Eur J Pharm Biopharm 2006 1.56
3 Differentiation of human alveolar epithelial cells in primary culture: morphological characterization and synthesis of caveolin-1 and surfactant protein-C. Cell Tissue Res 2002 1.33
4 Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin E TPGS: influence on ATPase activity and membrane fluidity. Mol Pharm 2007 1.28
5 Chitosan-coated PLGA nanoparticles for DNA/RNA delivery: effect of the formulation parameters on complexation and transfection of antisense oligonucleotides. Nanomedicine 2007 1.21
6 Towards an in vitro model of cystic fibrosis small airway epithelium: characterisation of the human bronchial epithelial cell line CFBE41o-. Cell Tissue Res 2005 1.15
7 Influence of vitamin E TPGS poly(ethylene glycol) chain length on apical efflux transporters in Caco-2 cell monolayers. J Control Release 2006 1.13
8 Vitamin E TPGS P-glycoprotein inhibition mechanism: influence on conformational flexibility, intracellular ATP levels, and role of time and site of access. Mol Pharm 2010 1.13
9 The interplay of lung surfactant proteins and lipids assimilates the macrophage clearance of nanoparticles. PLoS One 2012 1.11
10 Interaction of metal oxide nanoparticles with lung surfactant protein A. Eur J Pharm Biopharm 2010 1.04
11 Relevance of the colloidal stability of chitosan/PLGA nanoparticles on their cytotoxicity profile. Int J Pharm 2009 1.04
12 Selective follicular targeting by modification of the particle sizes. J Control Release 2010 1.03
13 Optical tweezers reveal relationship between microstructure and nanoparticle penetration of pulmonary mucus. Proc Natl Acad Sci U S A 2012 1.03
14 Uptake of nanoparticles by alveolar macrophages is triggered by surfactant protein A. Nanomedicine 2011 1.02
15 In vitro assessment of transferrin-conjugated liposomes as drug delivery systems for inhalation therapy of lung cancer. Eur J Pharm Sci 2006 0.98
16 Differential cell reaction upon Toll-like receptor 4 and 9 activation in human alveolar and lung interstitial macrophages. Respir Res 2010 0.97
17 P-glycoprotein (MDR1) functional activity in human alveolar epithelial cell monolayers. Cell Tissue Res 2006 0.97
18 Human skin penetration of flufenamic acid: in vivo/in vitro correlation (deeper skin layers) for skin samples from the same subject. J Invest Dermatol 2002 0.97
19 Depletion of alveolar macrophages by clodronate-liposomes aggravates ischemia-reperfusion injury of the lung. J Heart Lung Transplant 2005 0.96
20 Nano- and microscaled particles for drug targeting to inflamed intestinal mucosa: a first in vivo study in human patients. J Control Release 2012 0.96
21 A three-dimensional coculture of enterocytes, monocytes and dendritic cells to model inflamed intestinal mucosa in vitro. Mol Pharm 2010 0.95
22 Nano- and microparticulate drug carriers for targeting of the inflamed intestinal mucosa. J Control Release 2012 0.94
23 Nanoparticle geometry and surface orientation influence mode of cellular uptake. ACS Nano 2013 0.93
24 Coupling of biotin-(poly(ethylene glycol))amine to poly(D,L-lactide-co-glycolide) nanoparticles for versatile surface modification. Bioconjug Chem 2007 0.93
25 Large porous particle impingement on lung epithelial cell monolayers--toward improved particle characterization in the lung. Pharm Res 2003 0.92
26 Permeability of the reconstructed human epidermis model Episkin in comparison to various human skin preparations. Eur J Pharm Biopharm 2006 0.92
27 Mucus as a barrier to lipophilic drugs. Int J Pharm 2013 0.92
28 Soluplus® as an effective absorption enhancer of poorly soluble drugs in vitro and in vivo. Eur J Pharm Sci 2011 0.90
29 An in vitro triple cell co-culture model with primary cells mimicking the human alveolar epithelial barrier. Eur J Pharm Biopharm 2010 0.89
30 Cellular responses after exposure of lung cell cultures to secondary organic aerosol particles. Environ Sci Technol 2010 0.89
31 Pulmonary surfactant is indispensable in order to simulate the in vivo situation. Part Fibre Toxicol 2013 0.88
32 Propidium iodide labeling of nanoparticles as a novel tool for the quantification of cellular binding and uptake. Nanomedicine 2011 0.88
33 Conformational change of membrane proteins leads to shape changes of red blood cells. Bioelectrochemistry 2006 0.87
34 Assessing transferrin modification of liposomes by atomic force microscopy and transmission electron microscopy. Eur J Pharm Biopharm 2005 0.87
35 Porcine alveolar epithelial cells in primary culture: morphological, bioelectrical and immunocytochemical characterization. Pharm Res 2006 0.87
36 In vitro toxicological screening of nanoparticles on primary human endothelial cells and the role of flow in modulating cell response. Nanotoxicology 2013 0.87
37 Influence of apical fluid volume on the development of functional intercellular junctions in the human epithelial cell line 16HBE14o-: implications for the use of this cell line as an in vitro model for bronchial drug absorption studies. Cell Tissue Res 2002 0.87
38 Hyaluronic acid-modified DOTAP/DOPE liposomes for the targeted delivery of anti-telomerase siRNA to CD44-expressing lung cancer cells. Oligonucleotides 2009 0.86
39 Multiphoton microscopy for the investigation of dermal penetration of nanoparticle-borne drugs. J Invest Dermatol 2006 0.86
40 A new Pharmaceutical Aerosol Deposition Device on Cell Cultures (PADDOCC) to evaluate pulmonary drug absorption for metered dose dry powder formulations. Eur J Pharm Biopharm 2010 0.86
41 Multilayer coating of gold nanoparticles with drug-polymer coadsorbates. Langmuir 2010 0.86
42 Effect of cationic lipid and matrix lipid composition on solid lipid nanoparticle-mediated gene transfer. Eur J Pharm Biopharm 2004 0.86
43 Transfection with different colloidal systems: comparison of solid lipid nanoparticles and liposomes. J Control Release 2004 0.86
44 Influence of particle size and material properties on mucociliary clearance from the airways. J Aerosol Med Pulm Drug Deliv 2010 0.86
45 Nanoparticle mediated delivery of 2'-O-methyl-RNA leads to efficient telomerase inhibition and telomere shortening in human lung cancer cells. Lung Cancer 2009 0.86
46 A comparative evaluation of corneal epithelial cell cultures for assessing ocular permeability. Altern Lab Anim 2008 0.85
47 Atomic force microscopy and analytical ultracentrifugation for probing nanomaterial protein interactions. ACS Nano 2012 0.85
48 PEG-functionalized microparticles selectively target inflamed mucosa in inflammatory bowel disease. Eur J Pharm Biopharm 2013 0.85
49 Expression of ABC-transporters in human corneal tissue and the transformed cell line, HCE-T. J Ocul Pharmacol Ther 2007 0.85
50 Salbutamol is actively absorbed across human bronchial epithelial cell layers. Pulm Pharmacol Ther 2005 0.85
51 Non-invasive delivery of nanoparticles to hair follicles: a perspective for transcutaneous immunization. Vaccine 2013 0.85
52 In-silico model of skin penetration based on experimentally determined input parameters. Part I: experimental determination of partition and diffusion coefficients. Eur J Pharm Biopharm 2007 0.85
53 Nanoparticles for transcutaneous vaccination. Microb Biotechnol 2011 0.84
54 Estimation of paracellular conductance of primary rat alveolar epithelial cell monolayers. J Appl Physiol (1985) 2004 0.84
55 The use of reconstructed human epidermis for skin absorption testing: Results of the validation study. Altern Lab Anim 2008 0.84
56 Delivery of ethinylestradiol from film forming polymeric solutions across human epidermis in vitro and in vivo in pigs. J Control Release 2006 0.84
57 Cellular delivery of polynucleotides by cationic cyclodextrin polyrotaxanes. J Control Release 2012 0.84
58 Mucociliary clearance of micro- and nanoparticles is independent of size, shape and charge--an ex vivo and in silico approach. J Control Release 2011 0.83
59 A novel cell compatible impingement system to study in vitro drug absorption from dry powder aerosol formulations. Eur J Pharm Biopharm 2008 0.83
60 Comparison of bovine udder skin with human and porcine skin in percutaneous permeation experiments. Altern Lab Anim 2006 0.83
61 Permeability assessment for solid oral drug formulations based on Caco-2 monolayer in combination with a flow through dissolution cell. Eur J Pharm Biopharm 2006 0.83
62 Computational modeling of the sugar-lectin interaction. Adv Drug Deliv Rev 2004 0.82
63 Isolation and culture of human alveolar epithelial cells. Methods Mol Med 2005 0.82
64 Effect of PEGylation on the stability of liposomes during nebulisation and in lung surfactant. J Nanosci Nanotechnol 2006 0.82
65 Assessment of transport rates of proteins and peptides across primary human alveolar epithelial cell monolayers. Eur J Pharm Sci 2006 0.82
66 Screening of budesonide nanoformulations for treatment of inflammatory bowel disease in an inflamed 3D cell-culture model. ALTEX 2012 0.81
67 In-silico model of skin penetration based on experimentally determined input parameters. Part II: mathematical modelling of in-vitro diffusion experiments. Identification of critical input parameters. Eur J Pharm Biopharm 2007 0.81
68 16HBE14o- human bronchial epithelial cell layers express P-glycoprotein, lung resistance-related protein, and caveolin-1. Pharm Res 2003 0.81
69 TEWL measurements as a routine method for evaluating the integrity of epidermis sheets in static Franz type diffusion cells in vitro. Limitations shown by transport data testing. Eur J Pharm Biopharm 2005 0.81
70 In vitro and in vivo performance of biocompatible negatively-charged salbutamol-loaded nanoparticles. J Control Release 2009 0.80
71 Development and characterization of film forming polymeric solutions for skin drug delivery. Eur J Pharm Biopharm 2006 0.80
72 Monolayers of porcine alveolar epithelial cells in primary culture as an in vitro model for drug absorption studies. Eur J Pharm Biopharm 2006 0.80
73 The buccal mucosa as a route for TiO2 nanoparticle uptake. Nanotoxicology 2014 0.80
74 The cell line NCl-H441 is a useful in vitro model for transport studies of human distal lung epithelial barrier. Mol Pharm 2014 0.80
75 Optimization of the TRAP assay to evaluate specificity of telomerase inhibitors. Lab Invest 2005 0.80
76 Developments in the area of bioadhesive drug delivery systems. Expert Opin Biol Ther 2002 0.79
77 Inhalative nanomedicine--opportunities and challenges. Inhal Toxicol 2009 0.79
78 Preparation and characterization of chitosan and trimethyl-chitosan-modified poly-(epsilon-caprolactone) nanoparticles as DNA carriers. AAPS PharmSciTech 2005 0.79
79 Assessment of mucoadhesion by a resonant mirror biosensor. Int J Pharm 2006 0.79
80 Transfollicular delivery takes root: the future for vaccine design? Expert Rev Vaccines 2014 0.78
81 Permutation Test (PT) and Tolerated Difference Test (TDT): two new, robust and powerful nonparametric tests for statistical comparison of dissolution profiles. Int J Pharm 2012 0.78
82 A hydrophobic starch polymer for nanoparticle-mediated delivery of docetaxel. Macromol Biosci 2011 0.78
83 Online monitoring of transepithelial electrical resistance (TEER) in an apparatus for combined dissolution and permeation testing. Int J Pharm 2010 0.78
84 Improved photostability and reduced skin permeation of tretinoin: development of a semisolid nanomedicine. Eur J Pharm Biopharm 2011 0.78
85 Lectin-sugar interaction. Calculated versus experimental binding energies. Eur J Biochem 2002 0.78
86 Biopharmaceutical in vitro characterization of CPZEN-45, a drug candidate for inhalation therapy of tuberculosis. Ther Deliv 2013 0.77
87 Pulmonary drug delivery: medicines for inhalation. Handb Exp Pharmacol 2010 0.77
88 Enhanced cellular delivery of idarubicin by surface modification of propyl starch nanoparticles employing pteroic acid conjugated polyvinyl alcohol. Int J Pharm 2011 0.77
89 Modeling the human skin barrier--towards a better understanding of dermal absorption. Adv Drug Deliv Rev 2012 0.77
90 Isolation, cultivation, and application of human alveolar epithelial cells. Methods Mol Biol 2012 0.77
91 Size-Limited Penetration of Nanoparticles into Porcine Respiratory Mucus after Aerosol Deposition. Biomacromolecules 2016 0.77
92 In vitro systems for studying epithelial transport of macromolecules. Methods Mol Biol 2009 0.77
93 Transfection system of amino-functionalized calcium phosphate nanoparticles: in vitro efficacy, biodegradability, and immunogenicity study. ACS Appl Mater Interfaces 2015 0.77
94 The role of corneocytes in skin transport revised--a combined computational and experimental approach. Pharm Res 2009 0.77
95 In vitro cell response to a polymer surface micropatterned by laser interference lithography. Biomacromolecules 2005 0.77
96 Design of starch-graft-PEI polymers: an effective and biodegradable gene delivery platform. Biomacromolecules 2014 0.77
97 Correlation between stratum corneum/water-partition coefficient and amounts of flufenamic acid penetrated into the stratum corneum. J Pharm Sci 2002 0.76
98 Tissue slice model of human lung cancer to investigate telomerase inhibition by nanoparticle delivery of antisense 2'-O-methyl-RNA. Int J Pharm 2011 0.76
99 Reconstructed human epidermis for skin absorption testing: results of the German prevalidation study. Altern Lab Anim 2006 0.76
100 Pulmonary cell culture models to study the safety and efficacy of innovative aerosol medicines. Expert Opin Drug Deliv 2008 0.76
101 Human vascular endothelial cells in primary cell culture for the evaluation of nanoparticle bioadhesion. J Nanosci Nanotechnol 2006 0.76
102 Particle based vaccine formulations for transcutaneous immunization. Hum Vaccin Immunother 2013 0.76
103 Drug transport across pulmonary epithelial cell monolayers: effects of particle size, apical liquid volume, and deposition technique. J Aerosol Med Pulm Drug Deliv 2010 0.76
104 A dynamic ratio of the alpha+ and alpha- isoforms of the tight junction protein ZO-1 is characteristic of Caco-2 cells and correlates with their degree of differentiation. Cell Biol Int 2010 0.76
105 A Design of Experiment Study of Nanoprecipitation and Nano Spray Drying as Processes to Prepare PLGA Nano- and Microparticles with Defined Sizes and Size Distributions. Pharm Res 2015 0.76
106 Biological barriers and nanomedicine--timely challenges in advanced drug delivery research. Eur J Pharm Biopharm 2009 0.75
107 Chemical coupling of a monoclonal antisurfactant protein-B antibody to human urokinase for targeting surfactant-incorporating alveolar fibrin. Bioconjug Chem 2002 0.75
108 Efficient telomerase inhibition in human non-small cell lung cancer cells by liposomal delivery of 2'-O-methyl-RNA. J Pharm Sci 2009 0.75
109 Biological barriers--a need for novel tools in nanotoxicology and nanomedicine. Preface. Eur J Pharm Biopharm 2011 0.75
110 Focused Ultrasound as a Scalable and Contact-Free Method to Manufacture Protein-Loaded PLGA Nanoparticles. Pharm Res 2015 0.75
111 Non-invasive determination of cellular oxygen consumption as novel cytotoxicity assay for nanomaterials. Nanotoxicology 2012 0.75
112 Template-assisted polyelectrolyte encapsulation of nanoparticles into dispersible, hierarchically nanostructured microfibers. Adv Mater 2011 0.75
113 Tissue distribution of moxaverine-hydrochloride in the rabbit eye and plasma. J Ocul Pharmacol Ther 2005 0.75
114 Wistar rat skin as surrogate for human skin in nortriptyline hydrochloride patch studies. Int J Pharm 2009 0.75
115 Characterization and evaluation of β-glucan formulations as injectable implants for protein and peptide delivery. Drug Dev Ind Pharm 2012 0.75
116 Automated measurement of permeation and dissolution of propranolol HCl tablets using sequential injection analysis. Anal Chim Acta 2006 0.75
117 Differentiation potential of human pancreatic stem cells for epithelial- and endothelial-like cell types. Ann Anat 2008 0.75
118 Dissolution testing of powders for inhalation: influence of particle deposition and modeling of dissolution profiles. Pharm Res 2014 0.75
119 The Pharmaceutical Aerosol Deposition Device on Cell Cultures (PADDOCC) in vitro system: design and experimental protocol. Altern Lab Anim 2010 0.75
120 Semi-automated nanoprecipitation-system--an option for operator independent, scalable and size adjustable nanoparticle synthesis. Pharm Res 2014 0.75
121 Nanoencapsulation in lipid-core nanocapsules controls mometasone furoate skin permeability rate and its penetration to the deeper skin layers. Skin Pharmacol Physiol 2014 0.75
122 The physicochemical parameters of marker compounds and vehicles for use in in vitro percutaneous absorption studies. Altern Lab Anim 2008 0.75
123 Crossing biological barriers for advanced drug delivery. Eur J Pharm Biopharm 2013 0.75
124 Nanoparticles made of fluorescence-labelled Poly(L-lactide-co-glycolide): preparation, stability, and biocompatibility. J Nanosci Nanotechnol 2006 0.75
125 Influence of the application area on finite dose permeation in relation to drug type applied. Exp Dermatol 2012 0.75
126 Chemical crosslinking of urokinase to pulmonary surfactant protein B for targeting alveolar fibrin. Thromb Haemost 2003 0.75
127 Laser interference lithography as a new and efficient technique for micropatterning of biopolymer surface. Biomaterials 2005 0.75
128 Improved input parameters for diffusion models of skin absorption. Adv Drug Deliv Rev 2012 0.75
129 Laser ablation patterning by interference induces directional cell growth. IEEE Trans Nanobioscience 2003 0.75