Published in Eur J Pharm Sci on December 08, 2011
Artemether-Soluplus Hot-Melt Extrudate Solid Dispersion Systems for Solubility and Dissolution Rate Enhancement with Amorphous State Characteristics. J Pharm (Cairo) (2013) 0.82
In vitro lipolysis data does not adequately predict the in vivo performance of lipid-based drug delivery systems containing fenofibrate. AAPS J (2014) 0.80
Preparation and characterization of celecoxib dispersions in soluplus(®): comparison of spray drying and conventional methods. Iran J Pharm Res (2015) 0.79
Soluplus®/TPGS-based solid dispersions prepared by hot-melt extrusion equipped with twin-screw systems for enhancing oral bioavailability of valsartan. Drug Des Devel Ther (2015) 0.79
Angelica gigas Nakai and Soluplus-Based Solid Formulations Prepared by Hot-Melting Extrusion: Oral Absorption Enhancing and Memory Ameliorating Effects. PLoS One (2015) 0.78
Thermal Processing of PVP- and HPMC-Based Amorphous Solid Dispersions. AAPS PharmSciTech (2015) 0.78
Stabilizing Agents for Drug Nanocrystals: Effect on Bioavailability. Pharmaceutics (2016) 0.75
Soluplus micelles for improving the oral bioavailability of scopoletin and their hypouricemic effect in vivo. Acta Pharmacol Sin (2017) 0.75
Lectin-mediated drug targeting: history and applications. Adv Drug Deliv Rev (2004) 1.59
Nanoparticles--an efficient carrier for drug delivery into the hair follicles. Eur J Pharm Biopharm (2006) 1.56
Differentiation of human alveolar epithelial cells in primary culture: morphological characterization and synthesis of caveolin-1 and surfactant protein-C. Cell Tissue Res (2002) 1.33
Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin E TPGS: influence on ATPase activity and membrane fluidity. Mol Pharm (2007) 1.28
Chitosan-coated PLGA nanoparticles for DNA/RNA delivery: effect of the formulation parameters on complexation and transfection of antisense oligonucleotides. Nanomedicine (2007) 1.21
Towards an in vitro model of cystic fibrosis small airway epithelium: characterisation of the human bronchial epithelial cell line CFBE41o-. Cell Tissue Res (2005) 1.15
Influence of vitamin E TPGS poly(ethylene glycol) chain length on apical efflux transporters in Caco-2 cell monolayers. J Control Release (2006) 1.13
Vitamin E TPGS P-glycoprotein inhibition mechanism: influence on conformational flexibility, intracellular ATP levels, and role of time and site of access. Mol Pharm (2010) 1.13
The interplay of lung surfactant proteins and lipids assimilates the macrophage clearance of nanoparticles. PLoS One (2012) 1.11
Toxico-/biokinetics of nanomaterials. Arch Toxicol (2012) 1.08
Comparing fate and effects of three particles of different surface properties: nano-TiO(2), pigmentary TiO(2) and quartz. Toxicol Lett (2008) 1.07
Interaction of metal oxide nanoparticles with lung surfactant protein A. Eur J Pharm Biopharm (2010) 1.04
Relevance of the colloidal stability of chitosan/PLGA nanoparticles on their cytotoxicity profile. Int J Pharm (2009) 1.04
Optical tweezers reveal relationship between microstructure and nanoparticle penetration of pulmonary mucus. Proc Natl Acad Sci U S A (2012) 1.03
Selective follicular targeting by modification of the particle sizes. J Control Release (2010) 1.03
Uptake of nanoparticles by alveolar macrophages is triggered by surfactant protein A. Nanomedicine (2011) 1.02
In vitro assessment of transferrin-conjugated liposomes as drug delivery systems for inhalation therapy of lung cancer. Eur J Pharm Sci (2006) 0.98
Postoperative morbidity and mortality after induction chemoradiotherapy for locally advanced lung cancer: an analysis of 350 operated patients. Eur J Cardiothorac Surg (2002) 0.98
Differential cell reaction upon Toll-like receptor 4 and 9 activation in human alveolar and lung interstitial macrophages. Respir Res (2010) 0.97
P-glycoprotein (MDR1) functional activity in human alveolar epithelial cell monolayers. Cell Tissue Res (2006) 0.97
Human skin penetration of flufenamic acid: in vivo/in vitro correlation (deeper skin layers) for skin samples from the same subject. J Invest Dermatol (2002) 0.97
Depletion of alveolar macrophages by clodronate-liposomes aggravates ischemia-reperfusion injury of the lung. J Heart Lung Transplant (2005) 0.96
Nano- and microscaled particles for drug targeting to inflamed intestinal mucosa: a first in vivo study in human patients. J Control Release (2012) 0.96
A three-dimensional coculture of enterocytes, monocytes and dendritic cells to model inflamed intestinal mucosa in vitro. Mol Pharm (2010) 0.95
Nano- and microparticulate drug carriers for targeting of the inflamed intestinal mucosa. J Control Release (2012) 0.94
Putting the parts together: combining in vitro methods to test for skin sensitizing potentials. Regul Toxicol Pharmacol (2012) 0.94
Nanoparticle geometry and surface orientation influence mode of cellular uptake. ACS Nano (2013) 0.93
Coupling of biotin-(poly(ethylene glycol))amine to poly(D,L-lactide-co-glycolide) nanoparticles for versatile surface modification. Bioconjug Chem (2007) 0.93
Metabolomics in toxicology and preclinical research. ALTEX (2013) 0.93
Large porous particle impingement on lung epithelial cell monolayers--toward improved particle characterization in the lung. Pharm Res (2003) 0.92
Experimental analysis of tablet properties for discrete element modeling of an active coating process. AAPS PharmSciTech (2013) 0.92
Dissolution rate improvement of poorly water-soluble drugs obtained by adsorbing solutions of drugs in hydrophilic solvents onto high surface area carriers. Eur J Pharm Biopharm (2005) 0.92
Permeability of the reconstructed human epidermis model Episkin in comparison to various human skin preparations. Eur J Pharm Biopharm (2006) 0.92
Mucus as a barrier to lipophilic drugs. Int J Pharm (2013) 0.92
Stability-enhanced hot-melt extruded amorphous solid dispersions via combinations of Soluplus® and HPMCAS-HF. AAPS PharmSciTech (2015) 0.91
Cellular responses after exposure of lung cell cultures to secondary organic aerosol particles. Environ Sci Technol (2010) 0.89
An in vitro triple cell co-culture model with primary cells mimicking the human alveolar epithelial barrier. Eur J Pharm Biopharm (2010) 0.89
Xenobiotic metabolism capacities of human skin in comparison with a 3D epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: activating enzymes (Phase I). Exp Dermatol (2012) 0.88
Propidium iodide labeling of nanoparticles as a novel tool for the quantification of cellular binding and uptake. Nanomedicine (2011) 0.88
Pulmonary surfactant is indispensable in order to simulate the in vivo situation. Part Fibre Toxicol (2013) 0.88
Conformational change of membrane proteins leads to shape changes of red blood cells. Bioelectrochemistry (2006) 0.87
Assessing transferrin modification of liposomes by atomic force microscopy and transmission electron microscopy. Eur J Pharm Biopharm (2005) 0.87
Porcine alveolar epithelial cells in primary culture: morphological, bioelectrical and immunocytochemical characterization. Pharm Res (2006) 0.87
Drug-metabolizing enzymes in the skin of man, rat, and pig. Drug Metab Rev (2007) 0.87
In vitro toxicological screening of nanoparticles on primary human endothelial cells and the role of flow in modulating cell response. Nanotoxicology (2013) 0.87
Influence of apical fluid volume on the development of functional intercellular junctions in the human epithelial cell line 16HBE14o-: implications for the use of this cell line as an in vitro model for bronchial drug absorption studies. Cell Tissue Res (2002) 0.87
Hyaluronic acid-modified DOTAP/DOPE liposomes for the targeted delivery of anti-telomerase siRNA to CD44-expressing lung cancer cells. Oligonucleotides (2009) 0.86
Multiphoton microscopy for the investigation of dermal penetration of nanoparticle-borne drugs. J Invest Dermatol (2006) 0.86
Influence of particle size and material properties on mucociliary clearance from the airways. J Aerosol Med Pulm Drug Deliv (2010) 0.86
Multilayer coating of gold nanoparticles with drug-polymer coadsorbates. Langmuir (2010) 0.86
Transfection with different colloidal systems: comparison of solid lipid nanoparticles and liposomes. J Control Release (2004) 0.86
A new Pharmaceutical Aerosol Deposition Device on Cell Cultures (PADDOCC) to evaluate pulmonary drug absorption for metered dose dry powder formulations. Eur J Pharm Biopharm (2010) 0.86
Effect of cationic lipid and matrix lipid composition on solid lipid nanoparticle-mediated gene transfer. Eur J Pharm Biopharm (2004) 0.86
Nanoparticle mediated delivery of 2'-O-methyl-RNA leads to efficient telomerase inhibition and telomere shortening in human lung cancer cells. Lung Cancer (2009) 0.86
Atomic force microscopy and analytical ultracentrifugation for probing nanomaterial protein interactions. ACS Nano (2012) 0.85
A comparative evaluation of corneal epithelial cell cultures for assessing ocular permeability. Altern Lab Anim (2008) 0.85
PEG-functionalized microparticles selectively target inflamed mucosa in inflammatory bowel disease. Eur J Pharm Biopharm (2013) 0.85
In-silico model of skin penetration based on experimentally determined input parameters. Part I: experimental determination of partition and diffusion coefficients. Eur J Pharm Biopharm (2007) 0.85
Expression of ABC-transporters in human corneal tissue and the transformed cell line, HCE-T. J Ocul Pharmacol Ther (2007) 0.85
Salbutamol is actively absorbed across human bronchial epithelial cell layers. Pulm Pharmacol Ther (2005) 0.85
Non-invasive delivery of nanoparticles to hair follicles: a perspective for transcutaneous immunization. Vaccine (2013) 0.85
Nanoparticles for transcutaneous vaccination. Microb Biotechnol (2011) 0.84
Delivery of ethinylestradiol from film forming polymeric solutions across human epidermis in vitro and in vivo in pigs. J Control Release (2006) 0.84
Estimation of paracellular conductance of primary rat alveolar epithelial cell monolayers. J Appl Physiol (1985) (2004) 0.84
The use of reconstructed human epidermis for skin absorption testing: Results of the validation study. Altern Lab Anim (2008) 0.84
Cellular delivery of polynucleotides by cationic cyclodextrin polyrotaxanes. J Control Release (2012) 0.84
Mucociliary clearance of micro- and nanoparticles is independent of size, shape and charge--an ex vivo and in silico approach. J Control Release (2011) 0.83
The use of inorganic salts to improve the dissolution characteristics of tablets containing Soluplus®-based solid dispersions. Eur J Pharm Sci (2013) 0.83
Permeability assessment for solid oral drug formulations based on Caco-2 monolayer in combination with a flow through dissolution cell. Eur J Pharm Biopharm (2006) 0.83
Comparison of bovine udder skin with human and porcine skin in percutaneous permeation experiments. Altern Lab Anim (2006) 0.83
Autofluorescence imaging videobronchoscopy in the detection of lung cancer: from research tool to everyday procedure. Expert Rev Med Devices (2011) 0.83
A novel cell compatible impingement system to study in vitro drug absorption from dry powder aerosol formulations. Eur J Pharm Biopharm (2008) 0.83
Computational modeling of the sugar-lectin interaction. Adv Drug Deliv Rev (2004) 0.82
Assessment of transport rates of proteins and peptides across primary human alveolar epithelial cell monolayers. Eur J Pharm Sci (2006) 0.82
Isolation and culture of human alveolar epithelial cells. Methods Mol Med (2005) 0.82
Effect of PEGylation on the stability of liposomes during nebulisation and in lung surfactant. J Nanosci Nanotechnol (2006) 0.82
In-silico model of skin penetration based on experimentally determined input parameters. Part II: mathematical modelling of in-vitro diffusion experiments. Identification of critical input parameters. Eur J Pharm Biopharm (2007) 0.81
TEWL measurements as a routine method for evaluating the integrity of epidermis sheets in static Franz type diffusion cells in vitro. Limitations shown by transport data testing. Eur J Pharm Biopharm (2005) 0.81
16HBE14o- human bronchial epithelial cell layers express P-glycoprotein, lung resistance-related protein, and caveolin-1. Pharm Res (2003) 0.81
Screening of budesonide nanoformulations for treatment of inflammatory bowel disease in an inflamed 3D cell-culture model. ALTEX (2012) 0.81
In vitro and in vivo performance of biocompatible negatively-charged salbutamol-loaded nanoparticles. J Control Release (2009) 0.80
Development and characterization of film forming polymeric solutions for skin drug delivery. Eur J Pharm Biopharm (2006) 0.80
Effects of estrogen coadministration on epoxiconazole toxicity in rats. Birth Defects Res B Dev Reprod Toxicol (2013) 0.80
The cell line NCl-H441 is a useful in vitro model for transport studies of human distal lung epithelial barrier. Mol Pharm (2014) 0.80
Optimization of the TRAP assay to evaluate specificity of telomerase inhibitors. Lab Invest (2005) 0.80
Monolayers of porcine alveolar epithelial cells in primary culture as an in vitro model for drug absorption studies. Eur J Pharm Biopharm (2006) 0.80
Intralaboratory validation of four in vitro assays for the prediction of the skin sensitizing potential of chemicals. Toxicol In Vitro (2011) 0.80
The buccal mucosa as a route for TiO2 nanoparticle uptake. Nanotoxicology (2014) 0.80
Assessment of mucoadhesion by a resonant mirror biosensor. Int J Pharm (2006) 0.79
Developments in the area of bioadhesive drug delivery systems. Expert Opin Biol Ther (2002) 0.79
Preparation and characterization of chitosan and trimethyl-chitosan-modified poly-(epsilon-caprolactone) nanoparticles as DNA carriers. AAPS PharmSciTech (2005) 0.79
Inhalative nanomedicine--opportunities and challenges. Inhal Toxicol (2009) 0.79
Extrahepatic metabolism at the body's internal-external interfaces. Drug Metab Rev (2014) 0.79
Transfollicular delivery takes root: the future for vaccine design? Expert Rev Vaccines (2014) 0.78
Lectin-sugar interaction. Calculated versus experimental binding energies. Eur J Biochem (2002) 0.78
Online monitoring of transepithelial electrical resistance (TEER) in an apparatus for combined dissolution and permeation testing. Int J Pharm (2010) 0.78