Published in Zebrafish on March 01, 2009
The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis. PLoS Biol (2010) 1.81
Epithelial cell proliferation in the developing zebrafish intestine is regulated by the Wnt pathway and microbial signaling via Myd88. Proc Natl Acad Sci U S A (2010) 1.47
Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish. Dis Model Mech (2013) 0.83
Wnt signaling meets internal dissent. Genes Dev (2011) 0.81
Profiling spermatogenic failure in adult testes bearing Sox9-deficient Sertoli cells identifies genes involved in feminization, inflammation and stress. Reprod Biol Endocrinol (2010) 0.78
Fibroblast growth factor receptor 2c signaling is required for intestinal cell differentiation in zebrafish. PLoS One (2013) 0.75
TCF/Lef regulates the Gsx ParaHox gene in central nervous system development in chordates. BMC Evol Biol (2016) 0.75
Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature (2007) 29.32
Wnt signalling in stem cells and cancer. Nature (2005) 19.26
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature (2009) 19.18
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell (2002) 13.92
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell (2010) 12.23
Crypt stem cells as the cells-of-origin of intestinal cancer. Nature (2008) 11.66
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature (2005) 11.49
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature (2010) 10.60
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol (2002) 8.60
Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell (2002) 8.08
Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta (2003) 7.85
Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nat Biotechnol (2011) 7.84
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell (2005) 7.64
Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat Genet (2008) 7.55
Coexistence of quiescent and active adult stem cells in mammals. Science (2010) 7.54
Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu Rev Physiol (2009) 7.29
Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell (2010) 7.25
Transcription factor achaete scute-like 2 controls intestinal stem cell fate. Cell (2009) 7.08
FoxM1 is required for execution of the mitotic programme and chromosome stability. Nat Cell Biol (2005) 7.02
Notch1 functions as a tumor suppressor in mouse skin. Nat Genet (2003) 6.76
Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science (2012) 6.55
Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. Gastroenterology (2011) 6.36
Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev (2003) 6.27
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature (2011) 6.09
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev (2004) 5.66
Self-renewal and cancer of the gut: two sides of a coin. Science (2005) 5.44
Myc deletion rescues Apc deficiency in the small intestine. Nature (2007) 5.42
Mining the Wnt pathway for cancer therapeutics. Nat Rev Drug Discov (2006) 5.29
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature (2013) 4.94
The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. Cell Stem Cell (2011) 4.79
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell (2012) 4.58
Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. EMBO Rep (2003) 4.52
The Intestinal Wnt/TCF Signature. Gastroenterology (2006) 4.48
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science (2010) 4.45
Wnt signaling controls the phosphorylation status of beta-catenin. J Biol Chem (2002) 4.40
De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine. Science (2004) 4.39
Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nat Cell Biol (2005) 4.34
Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes Dev (2005) 4.27
The intestinal stem cell. Genes Dev (2008) 4.21
SOX9 is required for the differentiation of paneth cells in the intestinal epithelium. Gastroenterology (2007) 4.17
Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine. Gastroenterology (2009) 4.16
Expression pattern of Wnt signaling components in the adult intestine. Gastroenterology (2005) 4.09
Signaling pathways in intestinal development and cancer. Annu Rev Cell Dev Biol (2004) 4.00
Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell (2013) 3.97
Transcriptome profile of human colorectal adenomas. Mol Cancer Res (2007) 3.82
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. EMBO J (2012) 3.70
Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue. Cell Stem Cell (2010) 3.65
Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications. Science (2013) 3.43
OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells. Gastroenterology (2009) 3.39
Strategies for homeostatic stem cell self-renewal in adult tissues. Cell (2011) 3.33
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage. Nat Cell Biol (2012) 3.30
SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. J Cell Biol (2004) 3.24
Isolation and in vitro expansion of human colonic stem cells. Nat Med (2011) 3.20
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell (2011) 3.19
HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat Neurosci (2009) 3.18
Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell. Nat Med (2012) 3.17
Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene. PLoS Med (2007) 3.17
Human embryonic stem cell-derived cardiomyocytes survive and mature in the mouse heart and transiently improve function after myocardial infarction. Stem Cell Res (2007) 3.04
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2. EMBO Rep (2008) 3.03
Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex. Cell (2012) 3.03
Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells. Mol Cell Biol (2008) 3.02
The Wnt/beta-catenin pathway regulates cardiac valve formation. Nature (2003) 2.89
EphB receptor activity suppresses colorectal cancer progression. Nature (2005) 2.84
Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Mol Cell Biol (2006) 2.83
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. Nature (2012) 2.76
Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines. Breast Cancer Res Treat (2009) 2.76
Single-molecule transcript counting of stem-cell markers in the mouse intestine. Nat Cell Biol (2011) 2.72
Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells. Gastroenterology (2012) 2.57
Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells. Gastroenterology (2010) 2.55
beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds. Proc Natl Acad Sci U S A (2002) 2.55
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature (2012) 2.53
Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nat Cell Biol (2012) 2.51
Illegitimate WNT signaling promotes proliferation of multiple myeloma cells. Proc Natl Acad Sci U S A (2004) 2.46
Wnt signaling, lgr5, and stem cells in the intestine and skin. Am J Pathol (2009) 2.45
Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell (2012) 2.45
Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex. Dev Cell (2009) 2.40
Crypt base columnar stem cells in small intestines of mice are radioresistant. Gastroenterology (2012) 2.31
SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. J Clin Invest (2009) 2.28
Survivin and molecular pathogenesis of colorectal cancer. Lancet (2003) 2.25
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis. EMBO J (2013) 2.24
Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. J Cell Biol (2011) 2.21
Tissue-resident adult stem cell populations of rapidly self-renewing organs. Cell Stem Cell (2010) 2.15
Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl. Mol Cell (2010) 2.13
Zebrafish mutants in the von Hippel-Lindau tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia. Blood (2009) 2.11
Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Cell (2013) 2.10
Wnt control of stem cells and differentiation in the intestinal epithelium. Exp Cell Res (2005) 2.08
Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes. EMBO J (2011) 2.08
The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium. Gastroenterology (2009) 2.01
T-cell factors: turn-ons and turn-offs. EMBO J (2002) 2.00
Controlled gene expression in primary Lgr5 organoid cultures. Nat Methods (2011) 1.98
TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling. Biol Chem (2002) 1.95
Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development (2007) 1.94
TCF transcription factors, mediators of Wnt-signaling in development and cancer. Dev Biol (2002) 1.93