Published in Science on January 29, 2010
Adult neurogenesis in the mammalian brain: significant answers and significant questions. Neuron (2011) 8.06
A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature (2011) 5.45
Intestinal label-retaining cells are secretory precursors expressing Lgr5. Nature (2013) 4.83
Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration. Cell Stem Cell (2012) 4.67
Interconversion between intestinal stem cell populations in distinct niches. Science (2011) 4.23
Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampus. Cell Stem Cell (2011) 4.08
Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. Proc Natl Acad Sci U S A (2010) 3.94
The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations. Proc Natl Acad Sci U S A (2011) 3.80
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. EMBO J (2012) 3.70
Eyes wide open: a critical review of sphere-formation as an assay for stem cells. Cell Stem Cell (2011) 3.55
The cell-cycle state of stem cells determines cell fate propensity. Cell (2013) 3.50
In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics. Cell (2011) 3.47
Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells. Cell (2012) 3.26
Molecular regulation of stem cell quiescence. Nat Rev Mol Cell Biol (2013) 3.07
Arteriolar niches maintain haematopoietic stem cell quiescence. Nature (2013) 3.07
mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert). Nature (2014) 2.85
Single-molecule transcript counting of stem-cell markers in the mouse intestine. Nat Cell Biol (2011) 2.72
Development and applications of single-cell transcriptome analysis. Nat Methods (2011) 2.62
Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nat Cell Biol (2012) 2.51
Spatial organization within a niche as a determinant of stem-cell fate. Nature (2013) 2.49
FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man. Dev Cell (2012) 2.43
Maintenance of muscle stem-cell quiescence by microRNA-489. Nature (2012) 2.39
Understanding cancer stem cell heterogeneity and plasticity. Cell Res (2012) 2.39
Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche. Cell (2012) 2.36
Interaction between differentiating cell- and niche-derived signals in hematopoietic progenitor maintenance. Cell (2011) 2.31
Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma. Cancer Cell (2014) 2.30
Prospective identification and purification of quiescent adult neural stem cells from their in vivo niche. Neuron (2014) 2.25
Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Cell (2013) 2.10
Self-organizing and stochastic behaviors during the regeneration of hair stem cells. Science (2011) 1.96
Manifestations and mechanisms of stem cell aging. J Cell Biol (2011) 1.93
A family business: stem cell progeny join the niche to regulate homeostasis. Nat Rev Mol Cell Biol (2012) 1.91
The germline stem cell niche unit in mammalian testes. Physiol Rev (2012) 1.86
Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells? Int J Cancer (2011) 1.79
Cigarette smoking and lung cancer--relative risk estimates for the major histological types from a pooled analysis of case-control studies. Int J Cancer (2011) 1.74
Drug discovery approaches to target Wnt signaling in cancer stem cells. Oncotarget (2010) 1.71
The proper criteria for identification and sorting of very small embryonic-like stem cells, and some nomenclature issues. Stem Cells Dev (2014) 1.70
Detection, characterization, and spontaneous differentiation in vitro of very small embryonic-like putative stem cells in adult mammalian ovary. Stem Cells Dev (2011) 1.69
Activation of two distinct Sox9-EGFP-expressing intestinal stem cell populations during crypt regeneration after irradiation. Am J Physiol Gastrointest Liver Physiol (2012) 1.67
Maintaining tissue homeostasis: dynamic control of somatic stem cell activity. Cell Stem Cell (2011) 1.65
Isolation and characterization of intestinal stem cells based on surface marker combinations and colony-formation assay. Gastroenterology (2013) 1.64
Nice neighborhood: emerging concepts of the stem cell niche. Cell (2014) 1.63
Intestinal subepithelial myofibroblasts support in vitro and in vivo growth of human small intestinal epithelium. PLoS One (2011) 1.63
Sorting mouse jejunal epithelial cells with CD24 yields a population with characteristics of intestinal stem cells. Am J Physiol Gastrointest Liver Physiol (2010) 1.60
Paneth cells in intestinal homeostasis and tissue injury. PLoS One (2012) 1.57
Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors. Dev Cell (2012) 1.57
Tracking adult stem cells. EMBO Rep (2011) 1.56
The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism. Cell Stem Cell (2015) 1.56
A comprehensive model of the spatio-temporal stem cell and tissue organisation in the intestinal crypt. PLoS Comput Biol (2011) 1.55
Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later. Cell Stem Cell (2015) 1.54
Unravelling stem cell dynamics by lineage tracing. Nat Rev Mol Cell Biol (2013) 1.53
Asymmetric cancer cell division regulated by AKT. Proc Natl Acad Sci U S A (2011) 1.52
Transit-amplifying cells orchestrate stem cell activity and tissue regeneration. Cell (2014) 1.50
Stem cells, progenitors & regenerative medicine: A retrospection. Indian J Med Res (2015) 1.48
The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate. PLoS Genet (2011) 1.48
Prostate Sphere-forming Stem Cells Are Derived from the P63-expressing Basal Compartment. J Biol Chem (2015) 1.47
Extracellular matrix: a dynamic microenvironment for stem cell niche. Biochim Biophys Acta (2014) 1.45
An artificial niche preserves the quiescence of muscle stem cells and enhances their therapeutic efficacy. Nat Biotechnol (2016) 1.44
Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice. J Clin Invest (2016) 1.43
Targeting metabolic remodeling in glioblastoma multiforme. Oncotarget (2010) 1.42
Vertebrate intestinal endoderm development. Dev Dyn (2011) 1.41
Intestinal stem cells and epithelial-mesenchymal interactions in the crypt and stem cell niche. Transl Res (2010) 1.40
Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT. Cell (2016) 1.36
The retinoblastoma tumor suppressor and stem cell biology. Genes Dev (2012) 1.34
TCF/Lef1 activity controls establishment of diverse stem and progenitor cell compartments in mouse epidermis. EMBO J (2011) 1.34
Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21. Mol Cancer Res (2011) 1.34
Regenerative medicine as applied to solid organ transplantation: current status and future challenges. Transpl Int (2010) 1.33
Functional analysis of two distinct bronchiolar progenitors during lung injury and repair. Am J Respir Cell Mol Biol (2010) 1.33
An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration. Nature (2012) 1.32
Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells. J Clin Invest (2011) 1.29
Post-embryonic nerve-associated precursors to adult pigment cells: genetic requirements and dynamics of morphogenesis and differentiation. PLoS Genet (2011) 1.28
A unifying hypothesis on mammalian neural stem cell properties in the adult hippocampus. Curr Opin Neurobiol (2012) 1.27
Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis. Proc Natl Acad Sci U S A (2010) 1.26
Empowering adult stem cells for myocardial regeneration. Circ Res (2011) 1.25
Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice. PLoS One (2011) 1.24
Epigenomic enhancer annotation reveals a key role for NFIX in neural stem cell quiescence. Genes Dev (2013) 1.23
Distinct levels of Sox9 expression mark colon epithelial stem cells that form colonoids in culture. Am J Physiol Gastrointest Liver Physiol (2011) 1.23
Parathyroid hormone induces differentiation of mesenchymal stromal/stem cells by enhancing bone morphogenetic protein signaling. J Bone Miner Res (2012) 1.22
Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice. J Clin Invest (2011) 1.20
Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium. Development (2013) 1.19
The Dynamic Duo: Niche/Stem Cell Interdependency. Stem Cell Reports (2015) 1.19
Adipogenic potential of adipose stem cell subpopulations. Plast Reconstr Surg (2011) 1.19
Symmetric vs. asymmetric stem cell divisions: an adaptation against cancer? PLoS One (2013) 1.18
Independent stem cell lineages regulate adipose organogenesis and adipose homeostasis. Cell Rep (2014) 1.18
Life history trade-offs in cancer evolution. Nat Rev Cancer (2013) 1.16
c-Kit-positive cardiac stem cells nested in hypoxic niches are activated by stem cell factor reversing the aging myopathy. Circ Res (2013) 1.15
Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury. Development (2011) 1.15
SINCERA: A Pipeline for Single-Cell RNA-Seq Profiling Analysis. PLoS Comput Biol (2015) 1.14
Tuberous sclerosis complex and Myc coordinate the growth and division of Drosophila intestinal stem cells. J Cell Biol (2011) 1.13
Krt19(+)/Lgr5(-) Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine. Cell Stem Cell (2015) 1.13
Adipose tissue plasticity from WAT to BAT and in between. Biochim Biophys Acta (2013) 1.12
Prospective identification and isolation of enteric nervous system progenitors using Sox2. Stem Cells (2011) 1.11
Very small embryonic-like stem cells (VSELs) represent a real challenge in stem cell biology: recent pros and cons in the midst of a lively debate. Leukemia (2013) 1.10
Identification of stem cells that maintain and regenerate lingual keratinized epithelial cells. Nat Cell Biol (2013) 1.10
Stem cell dynamics in the hair follicle niche. Semin Cell Dev Biol (2013) 1.08
Germline replications and somatic mutation accumulation are independent of vegetative life span in Arabidopsis. Proc Natl Acad Sci U S A (2016) 1.08
Niche contributions to oncogenesis: emerging concepts and implications for the hematopoietic system. Haematologica (2011) 1.08
Very small embryonic-like stem cells: implications in reproductive biology. Biomed Res Int (2013) 1.07
JAM-A regulates epithelial proliferation through Akt/β-catenin signalling. EMBO Rep (2011) 1.07
p63 regulates olfactory stem cell self-renewal and differentiation. Neuron (2011) 1.06
Single-cell analysis of proxy reporter allele-marked epithelial cells establishes intestinal stem cell hierarchy. Stem Cell Reports (2014) 1.06
Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature (2007) 29.32
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell (2005) 24.00
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature (2009) 19.18
Identification of the haematopoietic stem cell niche and control of the niche size. Nature (2003) 18.17
Defining the epithelial stem cell niche in skin. Science (2003) 14.93
Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell (2004) 12.67
Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell (1990) 12.13
Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell (2008) 11.53
Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity (2006) 11.28
Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell (2004) 10.79
Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet (2008) 10.22
Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types. Am J Anat (1974) 8.05
Stem cells find their niche. Nature (2001) 7.98
Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat Genet (2008) 7.55
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nat Genet (2004) 7.37
Stem cells: units of development, units of regeneration, and units in evolution. Cell (2000) 7.36
Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche. Nature (2008) 6.61
In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells. Proc Natl Acad Sci U S A (1999) 5.65
Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol (2007) 5.48
A two-step mechanism for stem cell activation during hair regeneration. Cell Stem Cell (2009) 5.40
Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells. Nat Med (2006) 5.33
Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU. Nature (2007) 4.62
Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells. Nat Biotechnol (2008) 4.41
On the control of germ cell development in Caenorhabditis elegans. Dev Biol (1981) 4.28
Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes Dev (2005) 4.27
The intestinal stem cell. Genes Dev (2008) 4.21
Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells. Blood (2005) 4.17
Detection of functional haematopoietic stem cell niche using real-time imaging. Nature (2008) 4.06
The tortoise and the hair: slow-cycling cells in the stem cell race. Cell (2009) 3.90
Current view: intestinal stem cells and signaling. Gastroenterology (2008) 3.46
The intestinal epithelial stem cell: the mucosal governor. Int J Exp Pathol (1997) 3.32
Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors. Proc Natl Acad Sci U S A (2007) 3.20
Stem cells: a new lease on life. Cell (2000) 2.83
Individual stem cells with highly variable proliferation and self-renewal properties comprise the human hematopoietic stem cell compartment. Nat Immunol (2006) 2.60
Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones. Blood (2009) 2.58
Distinct self-renewal and differentiation phases in the niche of infrequently dividing hair follicle stem cells. Cell Stem Cell (2009) 2.45
Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling. Development (2006) 2.28
Cellular analyses of the mitotic region in the Caenorhabditis elegans adult germ line. Mol Biol Cell (2006) 2.23
Quantitative proliferation dynamics and random chromosome segregation of hair follicle stem cells. EMBO J (2008) 2.14
Bone morphogenetic protein signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion. Stem Cells (2006) 2.09
N-cadherin expression level distinguishes reserved versus primed states of hematopoietic stem cells. Cell Stem Cell (2008) 1.98
Notch signaling controls germline stem cell niche formation in the Drosophila ovary. Development (2007) 1.93
Designer skin: lineage commitment in postnatal epidermis. Trends Cell Biol (2002) 1.59
Tracking down the stem cells of the intestine: strategies to identify adult stem cells. Gastroenterology (2007) 1.55
Response of small intestinal epithelial cells to acute disruption of cell division through CDC25 deletion. Proc Natl Acad Sci U S A (2009) 1.37
Evidence for the maintenance of hematopoiesis in a large animal by the sequential activation of stem-cell clones. Proc Natl Acad Sci U S A (1990) 1.30
Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells. Growth Factors (2005) 1.18
Soluble frizzled-related protein 1 is estrogen inducible in bone marrow stromal cells and suppresses the earliest events in lymphopoiesis. J Immunol (2008) 1.11
Subcellular distribution of Wnt-1 at adherens junctions and actin-rich densities in endothelial cells. Exp Cell Res (2003) 0.87
Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature (2007) 29.32
Wnt signalling in stem cells and cancer. Nature (2005) 19.26
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature (2009) 19.18
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell (2002) 13.92
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell (2010) 12.23
Crypt stem cells as the cells-of-origin of intestinal cancer. Nature (2008) 11.66
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature (2005) 11.49
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature (2010) 10.60
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol (2002) 8.60
Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell (2002) 8.08
Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta (2003) 7.85
Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nat Biotechnol (2011) 7.84
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell (2005) 7.64
Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat Genet (2008) 7.55
Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu Rev Physiol (2009) 7.29
Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell (2010) 7.25
Transcription factor achaete scute-like 2 controls intestinal stem cell fate. Cell (2009) 7.08
FoxM1 is required for execution of the mitotic programme and chromosome stability. Nat Cell Biol (2005) 7.02
Notch1 functions as a tumor suppressor in mouse skin. Nat Genet (2003) 6.76
Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science (2012) 6.55
Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. Gastroenterology (2011) 6.36
Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev (2003) 6.27
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature (2011) 6.09
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev (2004) 5.66
Self-renewal and cancer of the gut: two sides of a coin. Science (2005) 5.44
Myc deletion rescues Apc deficiency in the small intestine. Nature (2007) 5.42
Mining the Wnt pathway for cancer therapeutics. Nat Rev Drug Discov (2006) 5.29
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature (2013) 4.94
The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. Cell Stem Cell (2011) 4.79
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell (2012) 4.58
Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. EMBO Rep (2003) 4.52
The Intestinal Wnt/TCF Signature. Gastroenterology (2006) 4.48
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science (2010) 4.45
Wnt signaling controls the phosphorylation status of beta-catenin. J Biol Chem (2002) 4.40
De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine. Science (2004) 4.39
Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nat Cell Biol (2005) 4.34
Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes Dev (2005) 4.27
The intestinal stem cell. Genes Dev (2008) 4.21
SOX9 is required for the differentiation of paneth cells in the intestinal epithelium. Gastroenterology (2007) 4.17
Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine. Gastroenterology (2009) 4.16
Expression pattern of Wnt signaling components in the adult intestine. Gastroenterology (2005) 4.09
Signaling pathways in intestinal development and cancer. Annu Rev Cell Dev Biol (2004) 4.00
Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell (2013) 3.97
Transcriptome profile of human colorectal adenomas. Mol Cancer Res (2007) 3.82
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. EMBO J (2012) 3.70
Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue. Cell Stem Cell (2010) 3.65
Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications. Science (2013) 3.43
OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells. Gastroenterology (2009) 3.39
Strategies for homeostatic stem cell self-renewal in adult tissues. Cell (2011) 3.33
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage. Nat Cell Biol (2012) 3.30
SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. J Cell Biol (2004) 3.24
Isolation and in vitro expansion of human colonic stem cells. Nat Med (2011) 3.20
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell (2011) 3.19
HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat Neurosci (2009) 3.18
Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell. Nat Med (2012) 3.17
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2. EMBO Rep (2008) 3.03
Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex. Cell (2012) 3.03
Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells. Mol Cell Biol (2008) 3.02
The Wnt/beta-catenin pathway regulates cardiac valve formation. Nature (2003) 2.89
EphB receptor activity suppresses colorectal cancer progression. Nature (2005) 2.84
Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Mol Cell Biol (2006) 2.83
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. Nature (2012) 2.76
Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines. Breast Cancer Res Treat (2009) 2.76
Single-molecule transcript counting of stem-cell markers in the mouse intestine. Nat Cell Biol (2011) 2.72
Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells. Gastroenterology (2012) 2.57
Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells. Gastroenterology (2010) 2.55
beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds. Proc Natl Acad Sci U S A (2002) 2.55
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature (2012) 2.53
Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nat Cell Biol (2012) 2.51
Illegitimate WNT signaling promotes proliferation of multiple myeloma cells. Proc Natl Acad Sci U S A (2004) 2.46
Wnt signaling, lgr5, and stem cells in the intestine and skin. Am J Pathol (2009) 2.45
Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell (2012) 2.45
Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex. Dev Cell (2009) 2.40
Crypt base columnar stem cells in small intestines of mice are radioresistant. Gastroenterology (2012) 2.31
SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. J Clin Invest (2009) 2.28
Survivin and molecular pathogenesis of colorectal cancer. Lancet (2003) 2.25
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis. EMBO J (2013) 2.24
Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. J Cell Biol (2011) 2.21
Tissue-resident adult stem cell populations of rapidly self-renewing organs. Cell Stem Cell (2010) 2.15
Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl. Mol Cell (2010) 2.13
Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Cell (2013) 2.10
Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes. EMBO J (2011) 2.08
Wnt control of stem cells and differentiation in the intestinal epithelium. Exp Cell Res (2005) 2.08
The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium. Gastroenterology (2009) 2.01
T-cell factors: turn-ons and turn-offs. EMBO J (2002) 2.00
Controlled gene expression in primary Lgr5 organoid cultures. Nat Methods (2011) 1.98
TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling. Biol Chem (2002) 1.95
Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development (2007) 1.94
TCF transcription factors, mediators of Wnt-signaling in development and cancer. Dev Biol (2002) 1.93
LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism. Physiol Rev (2009) 1.93
You Wnt some, you lose some: oncogenes in the Wnt signaling pathway. Curr Opin Genet Dev (2003) 1.93
APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Dev Biol (2008) 1.90
Wnt signaling mediates regional specification in the vertebrate face. Development (2007) 1.89
Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors. Nat Commun (2010) 1.89
Identifying the stem cell of the intestinal crypt: strategies and pitfalls. Cell Stem Cell (2012) 1.88
A functional CFTR assay using primary cystic fibrosis intestinal organoids. Nat Med (2013) 1.87
Live and let die in the intestinal epithelium. Curr Opin Cell Biol (2003) 1.85
The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis. PLoS Biol (2010) 1.81
WNT signaling in the normal intestine and colorectal cancer. Front Biosci (2007) 1.79
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Dev Cell (2010) 1.79