PubRank

Kazuhiro Ito

Author PubWeight™ 93.50‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. J Neurosci 2010 2.22
2 Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. J Exp Med 2004 2.19
3 Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2010 2.06
4 Rhinovirus infection induces degradation of antimicrobial peptides and secondary bacterial infection in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2012 2.06
5 Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy. Am J Respir Crit Care Med 2005 1.93
6 Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms. Am J Physiol Lung Cell Mol Physiol 2004 1.77
7 Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase. Lancet 2004 1.71
8 p38 mitogen-activated protein kinase-γ inhibition by long-acting β2 adrenergic agonists reversed steroid insensitivity in severe asthma. Mol Pharmacol 2011 1.70
9 Nitric oxide synthase isoenzyme expression and activity in peripheral lung tissue of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2009 1.67
10 Epigenetic regulation of airway inflammation. Curr Opin Immunol 2007 1.66
11 Increased p21(CIP1/WAF1) and B cell lymphoma leukemia-x(L) expression and reduced apoptosis in alveolar macrophages from smokers. Am J Respir Crit Care Med 2002 1.65
12 Effects of glucocorticoids on gene transcription. Eur J Pharmacol 2004 1.61
13 Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice. Am J Respir Crit Care Med 2009 1.59
14 Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma. Am J Respir Crit Care Med 2004 1.53
15 A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9. FASEB J 2009 1.47
16 NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription. J Immunol 2006 1.46
17 Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients. J Allergy Clin Immunol 2004 1.38
18 Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3. J Immunol 2007 1.28
19 Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress. Biochem Biophys Res Commun 2011 1.18
20 Histone deacetylation: an important mechanism in inflammatory lung diseases. COPD 2005 1.17
21 Nitrosative stress in the bronchial mucosa of severe chronic obstructive pulmonary disease. J Allergy Clin Immunol 2005 1.17
22 Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2. Biochem Biophys Res Commun 2009 1.17
23 Epigenetics and airways disease. Respir Res 2006 1.16
24 Retracted Kinase inhibitors and airway inflammation. Eur J Pharmacol 2006 1.15
25 Alteration of adenosine receptors in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2005 1.13
26 Cigarette smoke activates human monocytes by an oxidant-AP-1 signaling pathway: implications for steroid resistance. Mol Pharmacol 2005 1.11
27 Defects of protein phosphatase 2A causes corticosteroid insensitivity in severe asthma. PLoS One 2011 1.10
28 Retracted Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients. J Clin Invest 2011 1.10
29 Restoration of corticosteroid sensitivity by p38 mitogen activated protein kinase inhibition in peripheral blood mononuclear cells from severe asthma. PLoS One 2012 1.07
30 The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells. Am J Pathol 2009 1.07
31 MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients. Histopathology 2009 1.06
32 Long-acting fluticasone furoate has a superior pharmacological profile to fluticasone propionate in human respiratory cells. Eur J Pharmacol 2011 1.06
33 Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms. J Biol Chem 2008 1.05
34 A novel macrolide solithromycin exerts superior anti-inflammatory effect via NF-κB inhibition. J Pharmacol Exp Ther 2013 1.04
35 Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic disease. PLoS Med 2009 1.03
36 IL-1 beta and TNF-alpha regulation of the adenosine receptor (A2A) expression: differential requirement for NF-kappa B binding to the proximal promoter. J Immunol 2006 1.03
37 New drugs targeting Th2 lymphocytes in asthma. J Occup Med Toxicol 2008 1.03
38 Peroxynitrite elevation in exhaled breath condensate of COPD and its inhibition by fudosteine. Chest 2009 0.99
39 Steroid resistance in asthma: a major problem requiring novel solutions or a non-issue? Curr Opin Pharmacol 2004 0.98
40 Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer. Thorax 2011 0.96
41 Mitogen-activated protein kinase modulation of nuclear factor-kappaB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages. Am J Respir Cell Mol Biol 2003 0.95
42 Inhibitors of protein kinase C (PKC) prevent activated transcription: role of events downstream of NF-kappaB DNA binding. J Biol Chem 2004 0.94
43 Hypoxia-inducible factor 1alpha induces corticosteroid-insensitive inflammation via reduction of histone deacetylase-2 transcription. J Biol Chem 2009 0.93
44 Redox regulation of histone deacetylases and glucocorticoid-mediated inhibition of the inflammatory response. Antioxid Redox Signal 2005 0.93
45 Frequent hemizygous deletion at 1p36 and hypermethylation downregulate RUNX3 expression in human lung cancer cell lines. Oncol Rep 2005 0.93
46 Molecular mechanisms of respiratory virus-induced asthma and COPD exacerbations and pneumonia. Curr Med Chem 2006 0.93
47 Rhinovirus infection causes steroid resistance in airway epithelium through nuclear factor κB and c-Jun N-terminal kinase activation. J Allergy Clin Immunol 2013 0.92
48 Nortriptyline reverses corticosteroid insensitivity by inhibition of phosphoinositide-3-kinase-δ. J Pharmacol Exp Ther 2011 0.92
49 Oxidative stress and steroid resistance in asthma and COPD: pharmacological manipulation of HDAC-2 as a therapeutic strategy. Expert Opin Ther Targets 2007 0.91
50 Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun 2008 0.91
51 Effect of an inducible nitric oxide synthase inhibitor on differential flow-exhaled nitric oxide in asthmatic patients and healthy volunteers. Chest 2007 0.89
52 Castleman's disease or angiofollicular hyperplasia as a solitary pulmonary nodule: case report. J Bras Pneumol 2007 0.88
53 Glucocorticoid pathways in chronic obstructive pulmonary disease therapy. Proc Am Thorac Soc 2005 0.87
54 Passive smoking impairs histone deacetylase-2 in children with severe asthma. Chest 2014 0.87
55 New insights into the molecular mechanisms of corticosteroids actions. Curr Drug Targets 2006 0.86
56 Sputum plasminogen activator inhibitor-1 elevation by oxidative stress-dependent nuclear factor-κB activation in COPD. Chest 2013 0.86
57 Evaluation of the influence of polymorphic variants CYP1A1 2B, CYP1B1 2, CYP3A4 1B, GSTM1 0, and GSTT1 0 in prostate cancer. Urol Oncol 2010 0.86
58 Accumulation of bisphenol A in hemodialysis patients. Blood Purif 2007 0.85
59 Anti-inflammatory inhibitors of IkappaB kinase in asthma and COPD. Curr Opin Investig Drugs 2004 0.85
60 Quadrilateral space syndrome: a rare complication of thoracic surgery. Ann Thorac Surg 2008 0.85
61 Neutrophil elastase represses IL-8/CXCL8 synthesis in human airway smooth muscle cells through induction of NF-kappa B repressing factor. J Immunol 2009 0.85
62 Analysis of surgeon's line of sight using an optical tracking system with a multifaceted marker device. Int J Comput Assist Radiol Surg 2011 0.85
63 Toll-like receptor 3 stimulation causes corticosteroid-refractory airway neutrophilia and hyperresponsiveness in mice. Chest 2013 0.84
64 Differential patterns of histone acetylation in inflammatory bowel diseases. J Inflamm (Lond) 2011 0.84
65 Effects of aminoguanidine, an inhibitor of inducible nitric oxide synthase, on nitric oxide production and its metabolites in healthy control subjects, healthy smokers, and COPD patients. Chest 2008 0.84
66 Salivary gland tumors: immunohistochemical study of EGF, EGFR, ErbB-2, FAS and Ki-67. Anal Quant Cytol Histol 2009 0.83
67 Increased corticosteroid sensitivity by a long acting β2 agonist formoterol via β2 adrenoceptor independent protein phosphatase 2A activation. Pulm Pharmacol Ther 2012 0.83
68 Differential flow analysis of exhaled nitric oxide in patients with asthma of differing severity. Chest 2007 0.83
69 Activation of NF-kappaB transcription factor in asthma death. Histopathology 2009 0.83
70 Oral administration of a T cell epitope inhibits symptoms and reactions of allergic rhinitis in Japanese cedar pollen allergen-sensitized mice. Eur J Pharmacol 2005 0.82
71 Defect of adaptation to hypoxia in patients with COPD due to reduction of histone deacetylase 7. Chest 2011 0.82
72 Comparison of Symbicort® versus Pulmicort® on steroid pharmacodynamic markers in asthma patients. Respir Med 2011 0.82
73 Autocrine growth by granulocyte colony-stimulating factor in malignant mesothelioma. Ann Thorac Surg 2006 0.81
74 Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils. J Inflamm (Lond) 2010 0.81
75 Triamcinolone acetonide and dexamethasome suppress TNF-alpha-induced histone H4 acetylation on lysine residues 8 and 12 in mononuclear cells. Ann N Y Acad Sci 2002 0.80
76 Can we delay the accelerated lung aging in COPD? Anti-aging molecules and interventions. Curr Drug Targets 2013 0.80
77 5-Azacytidine suppresses RNA polymerase II recruitment to the SLPI gene. Biochem Biophys Res Commun 2005 0.79
78 Aurones serve as probes of beta-amyloid plaques in Alzheimer's disease. Biochem Biophys Res Commun 2007 0.79
79 Novel oxygen storage mechanism based on redox of sulfur in lanthanum oxysulfate/oxysulfide. Chem Commun (Camb) 2004 0.79
80 Transcription factors in asthma and COPD. IDrugs 2004 0.79
81 Targeting Th2 cells in asthmatic airways. Curr Drug Targets Inflamm Allergy 2004 0.78
82 Polymorphisms in the AR and PSA genes as markers of susceptibility and aggressiveness in prostate cancer. Cancer Invest 2010 0.78
83 Anti-TIF1-γ antibody and cancer-associated myositis: A clinicohistopathologic study. Neurology 2016 0.78
84 COPD as a disease of accelerated lung aging(a). Rev Port Pneumol 2015 0.77
85 The influence of severe hypoalbuminemia on the half-life of vancomycin in elderly patients with methicillin-resistant Staphylococcus aureus hospital-acquired pneumonia. Clin Interv Aging 2013 0.76
86 Immunohistochemical study of androgen, estrogen and progesterone receptors in salivary gland tumors. Braz Oral Res 2009 0.76
87 Chronic obstructive pulmonary disease Th1 cells display impaired response to endotoxin. Am J Respir Crit Care Med 2011 0.75
88 Lung metastasis of thymoma manifesting as myasthenia gravis 12 years after thymomectomy: report of a case. Surg Today 2005 0.75
89 [Case report; Chorea as the first manifestation of systemic lupus erythematosus associated with anti-phospholipid syndrome]. Nihon Naika Gakkai Zasshi 2014 0.75
90 [Acute transverse myelitis after allogeneic bone marrow transplantation for acute lymphoblastic leukemia--a case report]. Gan To Kagaku Ryoho 2013 0.75
91 A touch panel surgical navigation system with automatic depth perception. Int J Comput Assist Radiol Surg 2014 0.75
92 [Ubiquitin in Alzheimer's disease]. Tanpakushitsu Kakusan Koso 2006 0.75
93 Percutaneous needle biopsy under CT fluoroscopic guidance for cardiac tumor during continuous intravenous injection of contrast material. J Vasc Interv Radiol 2005 0.75