Published in J Bacteriol on April 17, 2009
Eukaryote-like serine/threonine kinases and phosphatases in bacteria. Microbiol Mol Biol Rev (2011) 1.82
Characterization of a serine/threonine kinase involved in virulence of Staphylococcus aureus. J Bacteriol (2009) 1.36
Exit from dormancy in microbial organisms. Nat Rev Microbiol (2010) 1.35
Regulation of hemolysin expression and virulence of Staphylococcus aureus by a serine/threonine kinase and phosphatase. PLoS One (2010) 1.34
Role of the (p)ppGpp synthase RSH, a RelA/SpoT homolog, in stringent response and virulence of Staphylococcus aureus. Infect Immun (2010) 1.29
Role of PknB kinase in antibiotic resistance and virulence in community-acquired methicillin-resistant Staphylococcus aureus strain USA300. Infect Immun (2010) 1.13
Diamide triggers mainly S Thiolations in the cytoplasmic proteomes of Bacillus subtilis and Staphylococcus aureus. J Bacteriol (2009) 1.12
Whole genome sequencing and complete genetic analysis reveals novel pathways to glycopeptide resistance in Staphylococcus aureus. PLoS One (2011) 1.06
The Streptococcus mutans serine/threonine kinase, PknB, regulates competence development, bacteriocin production, and cell wall metabolism. Infect Immun (2010) 1.05
Phosphorylation of MgrA and its effect on expression of the NorA and NorB efflux pumps of Staphylococcus aureus. J Bacteriol (2010) 1.02
Staphylococcal PknB as the first prokaryotic representative of the proline-directed kinases. PLoS One (2010) 0.97
Ser/Thr phosphorylation as a regulatory mechanism in bacteria. Curr Opin Microbiol (2015) 0.93
The Staphylococcus aureus thiol/oxidative stress global regulator Spx controls trfA, a gene implicated in cell wall antibiotic resistance. Antimicrob Agents Chemother (2013) 0.92
The biofilm inhibitor carolacton disturbs membrane integrity and cell division of Streptococcus mutans through the serine/threonine protein kinase PknB. J Bacteriol (2011) 0.90
A novel mode of regulation of the Staphylococcus aureus catabolite control protein A (CcpA) mediated by Stk1 protein phosphorylation. J Biol Chem (2012) 0.88
Regulation of prokaryotic gene expression by eukaryotic-like enzymes. Curr Opin Microbiol (2012) 0.87
The eukaryotic-type serine/threonine protein kinase Stk is required for biofilm formation and virulence in Staphylococcus epidermidis. PLoS One (2011) 0.86
Implication of the NorB efflux pump in the adaptation of Staphylococcus aureus to growth at acid pH and in resistance to moxifloxacin. Antimicrob Agents Chemother (2011) 0.85
The Staphylococcus aureus autoinducer-2 synthase LuxS is regulated by Ser/Thr phosphorylation. J Bacteriol (2010) 0.83
The Listeria monocytogenes PASTA Kinase PrkA and Its Substrate YvcK Are Required for Cell Wall Homeostasis, Metabolism, and Virulence. PLoS Pathog (2016) 0.81
Contribution of eukaryotic-type serine/threonine kinase to stress response and virulence of Streptococcus suis. PLoS One (2014) 0.81
Eukaryotic-like Ser/Thr protein kinases SpkC/F/K are involved in phosphorylation of GroES in the Cyanobacterium synechocystis. DNA Res (2011) 0.81
The Eukaryotic-Like Ser/Thr Kinase PrkC Regulates the Essential WalRK Two-Component System in Bacillus subtilis. PLoS Genet (2015) 0.80
Pectenotoxin-2 from marine sponges: a potential anti-cancer agent-a review. Mar Drugs (2011) 0.80
Aspects of eukaryotic-like signaling in Gram-positive cocci: a focus on virulence. Future Microbiol (2011) 0.79
Structural analysis of Staphylococcus aureus serine/threonine kinase PknB. PLoS One (2012) 0.79
Costs of life - Dynamics of the protein inventory of Staphylococcus aureus during anaerobiosis. Sci Rep (2016) 0.77
A novel STK1-targeted small-molecule as an "antibiotic resistance breaker" against multidrug-resistant Staphylococcus aureus. Sci Rep (2017) 0.76
Molecular Events for Promotion of Vancomycin Resistance in Vancomycin Intermediate Staphylococcus aureus. Front Microbiol (2016) 0.75
The Eukaryote-Like Serine/Threonine Kinase STK Regulates the Growth and Metabolism of Zoonotic Streptococcus suis. Front Cell Infect Microbiol (2017) 0.75
In Staphylococcus aureus the regulation of pyruvate kinase activity by serine/threonine protein kinase favors biofilm formation. 3 Biotech (2014) 0.75
A screen for kinase inhibitors identifies antimicrobial imidazopyridine aminofurazans as specific inhibitors of the Listeria monocytogenes PASTA kinase PrkA. J Biol Chem (2017) 0.75
Ser/Thr protein kinase PrkC-mediated regulation of GroEL is critical for biofilm formation in Bacillus anthracis. NPJ Biofilms Microbiomes (2017) 0.75
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A (2001) 132.88
A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res (2001) 124.61
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science (1988) 35.59
Two-component signal transduction. Annu Rev Biochem (2000) 19.12
Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell (1995) 9.27
Gene replacement in Staphylococcus carnosus and Staphylococcus xylosus. FEMS Microbiol Lett (1997) 5.02
Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus. Mol Microbiol (2003) 4.77
A eukaryotic-like Ser/Thr kinase signals bacteria to exit dormancy in response to peptidoglycan fragments. Cell (2008) 3.57
A secreted protein kinase of Yersinia pseudotuberculosis is an indispensable virulence determinant. Nature (1993) 3.40
Identification and molecular characterization of a putative regulatory locus that affects autolysis in Staphylococcus aureus. J Bacteriol (1996) 3.27
Isolation and characterization of autolysis-defective mutants of Staphylococcus aureus created by Tn917-lacZ mutagenesis. J Bacteriol (1993) 2.57
The serine/threonine/tyrosine phosphoproteome of the model bacterium Bacillus subtilis. Mol Cell Proteomics (2007) 2.40
The PASTA domain: a beta-lactam-binding domain. Trends Biochem Sci (2002) 2.40
Phosphoproteome analysis of E. coli reveals evolutionary conservation of bacterial Ser/Thr/Tyr phosphorylation. Mol Cell Proteomics (2007) 2.39
Antibiotic resistance as a stress response: complete sequencing of a large number of chromosomal loci in Staphylococcus aureus strain COL that impact on the expression of resistance to methicillin. Microb Drug Resist (1999) 2.35
Identification of LytSR-regulated genes from Staphylococcus aureus. J Bacteriol (1996) 2.18
Activity of the major staphylococcal autolysin Atl. FEMS Microbiol Lett (2006) 2.06
The Mycobacterium tuberculosis protein serine/threonine kinase PknG is linked to cellular glutamate/glutamine levels and is important for growth in vivo. Mol Microbiol (2004) 1.89
A eukaryotic type serine/threonine kinase and phosphatase in Streptococcus agalactiae reversibly phosphorylate an inorganic pyrophosphatase and affect growth, cell segregation, and virulence. J Biol Chem (2003) 1.72
PknB kinase activity is regulated by phosphorylation in two Thr residues and dephosphorylation by PstP, the cognate phospho-Ser/Thr phosphatase, in Mycobacterium tuberculosis. Mol Microbiol (2003) 1.69
Identification of the Bacillus subtilis pur operon repressor. Proc Natl Acad Sci U S A (1995) 1.67
Characterization of a membrane-linked Ser/Thr protein kinase in Bacillus subtilis, implicated in developmental processes. Mol Microbiol (2002) 1.60
Global regulatory impact of ClpP protease of Staphylococcus aureus on regulons involved in virulence, oxidative stress response, autolysis, and DNA repair. J Bacteriol (2006) 1.58
A eukaryotic-type Ser/Thr kinase in Enterococcus faecalis mediates antimicrobial resistance and intestinal persistence. Proc Natl Acad Sci U S A (2007) 1.55
The bactericidal action of penicillin: new clues to an unsolved mystery. Trends Microbiol (2000) 1.49
Identification and biochemical characterization of a eukaryotic-type serine/threonine kinase and its cognate phosphatase in Streptococcus pyogenes: their biological functions and substrate identification. J Mol Biol (2006) 1.41
No longer an exclusive club: eukaryotic signalling domains in bacteria. Trends Cell Biol (2000) 1.39
Regulation of cytotoxin expression by converging eukaryotic-type and two-component signalling mechanisms in Streptococcus agalactiae. Mol Microbiol (2006) 1.39
Characterization of a serine/threonine kinase involved in virulence of Staphylococcus aureus. J Bacteriol (2009) 1.36
Molecular characterization of an atl null mutant of Staphylococcus aureus. Microbiol Immunol (2002) 1.35
Protein serine/threonine kinases in signal transduction for secondary metabolism and morphogenesis in Streptomyces. Appl Microbiol Biotechnol (2002) 1.33
Expression and characterization of the Mycobacterium tuberculosis serine/threonine protein kinase PknB. Infect Immun (1999) 1.32
Eukaryotic-type serine/threonine protein kinase StkP is a global regulator of gene expression in Streptococcus pneumoniae. J Bacteriol (2007) 1.24
Regulation of purine biosynthesis by a eukaryotic-type kinase in Streptococcus agalactiae. Mol Microbiol (2005) 1.22
A novel serine/threonine protein kinase homologue of Pseudomonas aeruginosa is specifically inducible within the host infection site and is required for full virulence in neutropenic mice. J Bacteriol (1998) 1.20
A eukaryotic-type serine/threonine protein kinase is required for biofilm formation, genetic competence, and acid resistance in Streptococcus mutans. J Bacteriol (2006) 1.18
The Ser/Thr/Tyr phosphoproteome of Lactococcus lactis IL1403 reveals multiply phosphorylated proteins. Proteomics (2008) 1.18
Dynamics of protein phosphorylation on Ser/Thr/Tyr in Bacillus subtilis. Proteomics (2007) 1.17
Two purine biosynthetic enzymes that are required for cadmium tolerance in Schizosaccharomyces pombe utilize cysteine sulfinate in vitro. Arch Biochem Biophys (1993) 1.10
Posttranslational modification influences the effects of MgrA on norA expression in Staphylococcus aureus. J Bacteriol (2008) 1.07
Depletion of thiol-containing proteins in response to quinones in Bacillus subtilis. Mol Microbiol (2008) 1.01
An ABC transporter containing a forkhead-associated domain interacts with a serine-threonine protein kinase and is required for growth of Mycobacterium tuberculosis in mice. Infect Immun (2005) 0.98
StoPK-1, a serine/threonine protein kinase from the glycopeptide antibiotic producer Streptomyces toyocaensis NRRL 15009, affects oxidative stress response. Mol Microbiol (2002) 0.95
Activation of 6-phosphofructokinase via phosphorylation by Pkn4, a protein Ser/Thr kinase of Myxococcus xanthus. Mol Microbiol (2002) 0.94
Several enzymes of the central metabolism are phosphorylated in Staphylococcus aureus. FEMS Microbiol Lett (2007) 0.93
Lack of relationship between purine biosynthesis and vancomycin resistance in Staphylococcus aureus: a cautionary tale for microarray interpretation. Antimicrob Agents Chemother (2007) 0.85
Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand. Science (2002) 7.87
Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila. Cell (2005) 3.22
Gangliosides are receptors for murine polyoma virus and SV40. EMBO J (2003) 2.99
In vivo protein crystallization opens new routes in structural biology. Nat Methods (2012) 2.69
Structural basis of GM1 ganglioside recognition by simian virus 40. Proc Natl Acad Sci U S A (2008) 2.37
Repair of global regulators in Staphylococcus aureus 8325 and comparative analysis with other clinical isolates. Infect Immun (2010) 2.33
Cysteine Proteases and Their Inhibitors. Chem Rev (1997) 2.29
Crystal structure of reovirus attachment protein sigma1 reveals evolutionary relationship to adenovirus fiber. EMBO J (2002) 2.06
Emergence of methicillin-resistant Staphylococcus aureus (MRSA) in different animal species. Int J Med Microbiol (2009) 1.69
Does the integrin alphaA domain act as a ligand for its betaA domain? Curr Biol (2002) 1.69
A novel adaptation of the integrin PSI domain revealed from its crystal structure. J Biol Chem (2004) 1.68
Environmental induction of white-opaque switching in Candida albicans. PLoS Pathog (2008) 1.65
The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis. Nat Med (2010) 1.63
Structure-function analysis of the human JC polyomavirus establishes the LSTc pentasaccharide as a functional receptor motif. Cell Host Microbe (2010) 1.60
Structure of the measles virus hemagglutinin bound to the CD46 receptor. Nat Struct Mol Biol (2009) 1.58
Global regulatory impact of ClpP protease of Staphylococcus aureus on regulons involved in virulence, oxidative stress response, autolysis, and DNA repair. J Bacteriol (2006) 1.58
Crystal structure of human junctional adhesion molecule 1: implications for reovirus binding. Proc Natl Acad Sci U S A (2003) 1.57
The influence of agr and sigmaB in growth phase dependent regulation of virulence factors in Staphylococcus aureus. Proteomics (2004) 1.51
Surface display of Gaussia princeps luciferase allows sensitive fungal pathogen detection during cutaneous aspergillosis. Virulence (2012) 1.50
Redox sensing by a Rex-family repressor is involved in the regulation of anaerobic gene expression in Staphylococcus aureus. Mol Microbiol (2010) 1.49
The structure of dimethylallyl tryptophan synthase reveals a common architecture of aromatic prenyltransferases in fungi and bacteria. Proc Natl Acad Sci U S A (2009) 1.48
Cellular invasion by Staphylococcus aureus reveals a functional link between focal adhesion kinase and cortactin in integrin-mediated internalisation. J Cell Sci (2005) 1.46
The stringent response of Staphylococcus aureus and its impact on survival after phagocytosis through the induction of intracellular PSMs expression. PLoS Pathog (2012) 1.46
New insights into the structural basis of integrin activation. Blood (2003) 1.45
Junctional adhesion molecule a serves as a receptor for prototype and field-isolate strains of mammalian reovirus. J Virol (2005) 1.43
Adenovirus type 11 binding alters the conformation of its receptor CD46. Nat Struct Mol Biol (2007) 1.41
Clonal analysis of Staphylococcus epidermidis isolates carrying or lacking biofilm-mediating genes by multilocus sequence typing. J Clin Microbiol (2005) 1.36
Sticky connections: extracellular matrix protein recognition and integrin-mediated cellular invasion by Staphylococcus aureus. Curr Opin Microbiol (2006) 1.32
Role of the (p)ppGpp synthase RSH, a RelA/SpoT homolog, in stringent response and virulence of Staphylococcus aureus. Infect Immun (2010) 1.29
Dynamic interaction of the measles virus hemagglutinin with its receptor signaling lymphocytic activation molecule (SLAM, CD150). J Biol Chem (2008) 1.29
Molecular analysis of the thymidine-auxotrophic small colony variant phenotype of Staphylococcus aureus. Int J Med Microbiol (2007) 1.29
Distinct kinetics for binding of the CD46 and SLAM receptors to overlapping sites in the measles virus hemagglutinin protein. J Biol Chem (2002) 1.28
Identification of CD46 binding sites within the adenovirus serotype 35 fiber knob. J Virol (2007) 1.27
Nitric oxide stress induces different responses but mediates comparable protein thiol protection in Bacillus subtilis and Staphylococcus aureus. J Bacteriol (2008) 1.27
sae is essential for expression of the staphylococcal adhesins Eap and Emp. Microbiology (2005) 1.27
Structure of reovirus sigma1 in complex with its receptor junctional adhesion molecule-A. PLoS Pathog (2008) 1.25
Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1. J Biol Chem (2009) 1.24
Integrin-mediated invasion of Staphylococcus aureus into human cells requires Src family protein-tyrosine kinases. J Biol Chem (2003) 1.23
Viruses and sialic acids: rules of engagement. Curr Opin Struct Biol (2011) 1.21
Structural basis of cell wall cleavage by a staphylococcal autolysin. PLoS Pathog (2010) 1.20
Structure of the extracellular portion of CD46 provides insights into its interactions with complement proteins and pathogens. PLoS Pathog (2010) 1.20
Systems-wide temporal proteomic profiling in glucose-starved Bacillus subtilis. Nat Commun (2010) 1.19
Crystal structure of reovirus attachment protein σ1 in complex with sialylated oligosaccharides. PLoS Pathog (2011) 1.17
Structure-function analysis of reovirus binding to junctional adhesion molecule 1. Implications for the mechanism of reovirus attachment. J Biol Chem (2003) 1.16
Genome-wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol-dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR-family regulator YraB (AdhR). Mol Microbiol (2008) 1.16
The Polyomaviridae: Contributions of virus structure to our understanding of virus receptors and infectious entry. Virology (2009) 1.15
Metaproteomics of a gutless marine worm and its symbiotic microbial community reveal unusual pathways for carbon and energy use. Proc Natl Acad Sci U S A (2012) 1.14
Recombination between ccrC genes in a type V (5C2&5) staphylococcal cassette chromosome mec (SCCmec) of Staphylococcus aureus ST398 leads to conversion from methicillin resistance to methicillin susceptibility in vivo. Antimicrob Agents Chemother (2009) 1.13
Visualization of abscess formation in a murine thigh infection model of Staphylococcus aureus by 19F-magnetic resonance imaging (MRI). PLoS One (2011) 1.12
Diamide triggers mainly S Thiolations in the cytoplasmic proteomes of Bacillus subtilis and Staphylococcus aureus. J Bacteriol (2009) 1.12
Aziridine-2,3-dicarboxylates, peptidomimetic cysteine protease inhibitors with antileishmanial activity. Antimicrob Agents Chemother (2006) 1.11
The crystal structure of human CD21: Implications for Epstein-Barr virus and C3d binding. Proc Natl Acad Sci U S A (2002) 1.11
Advantage of upregulation of succinate dehydrogenase in Staphylococcus aureus biofilms. J Bacteriol (2010) 1.10
An arginine switch in the species B adenovirus knob determines high-affinity engagement of cellular receptor CD46. J Virol (2008) 1.10
Vinylogous chain branching catalysed by a dedicated polyketide synthase module. Nature (2013) 1.09
A chimeric adenovirus vector encoding reovirus attachment protein sigma1 targets cells expressing junctional adhesion molecule 1. Proc Natl Acad Sci U S A (2004) 1.08
A defect in menadione biosynthesis induces global changes in gene expression in Staphylococcus aureus. J Bacteriol (2008) 1.07
Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents. Bioorg Med Chem Lett (2006) 1.07
Trapping and proteomic identification of cellular substrates of the ClpP protease in Staphylococcus aureus. J Proteome Res (2013) 1.06
Cytoplasmic replication of Staphylococcus aureus upon phagosomal escape triggered by phenol-soluble modulin α. Cell Microbiol (2013) 1.06
Lyngbyazothrins A-D, antimicrobial cyclic undecapeptides from the cultured Cyanobacterium lyngbya sp. J Nat Prod (2009) 1.06
Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor. Nat Chem Biol (2011) 1.05
Reovirus binding determinants in junctional adhesion molecule-A. J Biol Chem (2007) 1.05
Characterization of the oxygen-responsive NreABC regulon of Staphylococcus aureus. J Bacteriol (2008) 1.05
RNase Y of Staphylococcus aureus and its role in the activation of virulence genes. Mol Microbiol (2012) 1.05
Structure-function analysis of an enzymatic prenyl transfer reaction identifies a reaction chamber with modifiable specificity. J Am Chem Soc (2010) 1.05
Identification of a general anesthetic binding site in the diacylglycerol-binding domain of protein kinase Cdelta. J Biol Chem (2004) 1.04
Role of the twin-arginine translocation pathway in Staphylococcus. J Bacteriol (2009) 1.04
Global analysis of the Staphylococcus aureus response to mupirocin. Antimicrob Agents Chemother (2011) 1.04
In vitro and in vivo properties of adenovirus vectors with increased affinity to CD46. J Virol (2008) 1.03
Ligand-binding properties and conformational dynamics of autolysin repeat domains in staphylococcal cell wall recognition. J Bacteriol (2012) 1.03
A protocol for the investigation of the intracellular Staphylococcus aureus metabolome. Anal Biochem (2010) 1.03
A structure-guided mutation in the major capsid protein retargets BK polyomavirus. PLoS Pathog (2013) 1.02
Real-time in vivo imaging of invasive- and biomaterial-associated bacterial infections using fluorescently labelled vancomycin. Nat Commun (2013) 1.01
The significance of ionic bonding in sulfur dioxide: bond orders from X-ray diffraction data. Angew Chem Int Ed Engl (2012) 1.01
Depletion of thiol-containing proteins in response to quinones in Bacillus subtilis. Mol Microbiol (2008) 1.01
The stepwise acquisition of fluconazole resistance mutations causes a gradual loss of fitness in Candida albicans. Mol Microbiol (2012) 1.01
Structures of Merkel cell polyomavirus VP1 complexes define a sialic acid binding site required for infection. PLoS Pathog (2012) 1.01
From touchdown to transcription: the reovirus cell entry pathway. Curr Top Microbiol Immunol (2010) 1.01
The alternative sigma factor sigma B of Staphylococcus aureus modulates virulence in experimental central venous catheter-related infections. Microbes Infect (2007) 1.00
A metabolomics and proteomics study of the adaptation of Staphylococcus aureus to glucose starvation. Mol Biosyst (2011) 0.99
The GM2 glycan serves as a functional coreceptor for serotype 1 reovirus. PLoS Pathog (2012) 0.99
A metabolomic view of Staphylococcus aureus and its ser/thr kinase and phosphatase deletion mutants: involvement in cell wall biosynthesis. Chem Biol (2010) 0.99
Antiviral Terpenoid Constituents of Ganoderma pfeifferi. J Nat Prod (2005) 0.99
Immunoglobulin superfamily virus receptors and the evolution of adaptive immunity. PLoS Pathog (2009) 0.98
Pyruvate formate lyase acts as a formate supplier for metabolic processes during anaerobiosis in Staphylococcus aureus. J Bacteriol (2010) 0.98