Published in Blood on April 22, 2009
Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease. J Clin Oncol (2011) 5.14
Arterial thrombosis--insidious, unpredictable and deadly. Nat Med (2011) 1.96
High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction. Blood (2010) 1.75
Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. J Biol Chem (2013) 1.74
The ins and outs of phospholipid asymmetry in the plasma membrane: roles in health and disease. Crit Rev Biochem Mol Biol (2009) 1.71
Necrotic platelets provide a procoagulant surface during thrombosis. Blood (2015) 1.45
Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets. J Exp Med (2011) 1.27
Dynamic transbilayer lipid asymmetry. Cold Spring Harb Perspect Biol (2011) 1.18
The maternal immune response to fetal platelet GPIbα causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies. J Clin Invest (2011) 1.13
Identification of a lipid scrambling domain in ANO6/TMEM16F. Elife (2015) 1.12
Molecular functions of anoctamin 6 (TMEM16F): a chloride channel, cation channel, or phospholipid scramblase? Pflugers Arch (2013) 1.02
Calcium-activated and apoptotic phospholipid scrambling induced by Ano6 can occur independently of Ano6 ion currents. Cell Death Dis (2013) 0.99
Roles of platelet STIM1 and Orai1 in glycoprotein VI- and thrombin-dependent procoagulant activity and thrombus formation. J Biol Chem (2010) 0.97
Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor. Cell Death Dis (2012) 0.94
Platelet mechanosensing of substrate stiffness during clot formation mediates adhesion, spreading, and activation. Proc Natl Acad Sci U S A (2014) 0.93
Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces. J Biol Chem (2009) 0.92
The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation. Am J Physiol Cell Physiol (2013) 0.92
Calpain activator dibucaine induces platelet apoptosis. Int J Mol Sci (2011) 0.91
Aldose reductase-mediated phosphorylation of p53 leads to mitochondrial dysfunction and damage in diabetic platelets. Circulation (2014) 0.90
State of the art in platelet function testing. Transfus Med Hemother (2013) 0.90
Targeting BCL2-Proteins for the Treatment of Solid Tumours. Adv Med (2014) 0.89
Vinblastine rapidly induces NOXA and acutely sensitizes primary chronic lymphocytic leukemia cells to ABT-737. Mol Cancer Ther (2013) 0.89
Bioassay-Guided Isolation and HPLC Determination of Bioactive Compound That Relate to the Antiplatelet Activity (Adhesion, Secretion, and Aggregation) from Solanum lycopersicum. Evid Based Complement Alternat Med (2012) 0.89
Shear enhances thrombopoiesis and formation of microparticles that induce megakaryocytic differentiation of stem cells. Blood (2014) 0.89
Characterization of platelet aminophospholipid externalization reveals fatty acids as molecular determinants that regulate coagulation. Proc Natl Acad Sci U S A (2013) 0.89
Exposure of phosphatidylserine on the cell surface. Cell Death Differ (2016) 0.86
Key role of integrin α(IIb)β (3) signaling to Syk kinase in tissue factor-induced thrombin generation. Cell Mol Life Sci (2012) 0.86
Platelet lipidomics: modern day perspective on lipid discovery and characterization in platelets. Circ Res (2014) 0.86
Protein degradation systems in platelets. Thromb Haemost (2013) 0.83
Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets. Blood (2012) 0.83
Mitochondrially mediated integrin αIIbβ3 protein inactivation limits thrombus growth. J Biol Chem (2013) 0.83
Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism. Blood (2014) 0.82
Mitochondrial calcium and reactive oxygen species regulate agonist-initiated platelet phosphatidylserine exposure. Arterioscler Thromb Vasc Biol (2012) 0.81
Impact of the β-Lactam Resistance Modifier (-)-Epicatechin Gallate on the Non-Random Distribution of Phospholipids across the Cytoplasmic Membrane of Staphylococcus aureus. Int J Mol Sci (2015) 0.81
Platelet senescence and phosphatidylserine exposure. Transfusion (2010) 0.80
Understanding platelet generation from megakaryocytes: implications for in vitro-derived platelets. Blood (2016) 0.79
Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis. Circulation (2014) 0.79
Atherothrombosis: Seeing Red? Circulation (2015) 0.78
BCL-2 is dispensable for thrombopoiesis and platelet survival. Cell Death Dis (2015) 0.77
Sphingosine kinase 1 (Sphk1) negatively regulates platelet activation and thrombus formation. Am J Physiol Cell Physiol (2014) 0.77
Non-apoptotic functions of caspases in myeloid cell differentiation. Cell Death Differ (2017) 0.76
In vitro evaluation of pathogen-inactivated buffy coat-derived platelet concentrates during storage: psoralen-based photochemical treatment step-by-step. Blood Transfus (2014) 0.76
Combined Quantification of the Global Proteome, Phosphoproteome, and Proteolytic Cleavage to Characterize Altered Platelet Functions in the Human Scott Syndrome. Mol Cell Proteomics (2016) 0.76
Epicatechin and catechin modulate endothelial activation induced by platelets of patients with peripheral artery disease. Oxid Med Cell Longev (2014) 0.76
Hemolysate-mediated platelet aggregation: an additional risk mechanism contributing to thrombosis of continuous flow ventricular assist devices. Perfusion (2015) 0.76
A genome-wide linkage scan in German shepherd dogs localizes canine platelet procoagulant deficiency (Scott syndrome) to canine chromosome 27. Gene (2010) 0.76
Platelet Integrin αIIbβ3 Inhibitor Rescues Progression of Apoptosis in Human Platelets. Med Sci Monit (2016) 0.75
Platelet Hyperactivity in TNFSF14/LIGHT Knockout Mouse Model of Impaired Healing. Adv Wound Care (New Rochelle) (2016) 0.75
Pathogenetic determinants in Kawasaki disease: the haematological point of view. J Cell Mol Med (2017) 0.75
Ex vivo apoptotic and autophagic influence of an estradiol analogue on platelets. Exp Hematol Oncol (2016) 0.75
Antiplatelet Agents Inhibit the Generation of Platelet-Derived Microparticles. Front Pharmacol (2016) 0.75
14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function. Nat Commun (2016) 0.75
The Procoagulant Activity of Apoptotic Cells Is Mediated by Interaction with Factor XII. Front Immunol (2017) 0.75
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell (2005) 13.59
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science (2007) 10.60
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell (2006) 10.19
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev (2005) 8.95
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med (2013) 8.89
ER stress triggers apoptosis by activating BH3-only protein Bim. Cell (2007) 7.50
The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene (2003) 7.41
Colonoscopy versus fecal immunochemical testing in colorectal-cancer screening. N Engl J Med (2012) 7.18
Programmed anuclear cell death delimits platelet life span. Cell (2007) 5.98
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. Nature (2011) 5.32
Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease. J Clin Oncol (2011) 5.14
Genome structure of the legume, Lotus japonicus. DNA Res (2008) 4.93
SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol (2003) 4.90
Global regulation of erythroid gene expression by transcription factor GATA-1. Blood (2004) 4.22
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature (2009) 4.12
PI 3-kinase p110beta: a new target for antithrombotic therapy. Nat Med (2005) 3.96
A shear gradient-dependent platelet aggregation mechanism drives thrombus formation. Nat Med (2009) 3.57
The genomic landscape of hypodiploid acute lymphoblastic leukemia. Nat Genet (2013) 3.43
Structural insights into the degradation of Mcl-1 induced by BH3 domains. Proc Natl Acad Sci U S A (2007) 3.41
The academic trajectories of immigrant youths: analysis within and across cohorts. Demography (2003) 3.22
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome. Nature (2002) 3.15
Consolidation therapy with low-dose thalidomide and prednisolone prolongs the survival of multiple myeloma patients undergoing a single autologous stem-cell transplantation procedure. J Clin Oncol (2009) 3.14
The BH3-only protein bid is dispensable for DNA damage- and replicative stress-induced apoptosis or cell-cycle arrest. Cell (2007) 3.13
Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics. PLoS Med (2007) 3.09
The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nat Immunol (2008) 3.07
Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic. Proc Natl Acad Sci U S A (2006) 3.06
XIAP discriminates between type I and type II FAS-induced apoptosis. Nature (2009) 3.00
Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis. Cell (2013) 2.75
Warfarin reversal: consensus guidelines, on behalf of the Australasian Society of Thrombosis and Haemostasis. Med J Aust (2004) 2.74
A cluster of interferon-γ-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii. Immunity (2012) 2.50
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood (2005) 2.35
Complete genomic structure of the bloom-forming toxic cyanobacterium Microcystis aeruginosa NIES-843. DNA Res (2008) 2.31
SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. Immunity (2004) 2.30
The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins. J Cell Biol (2009) 2.27
How the Bcl-2 family of proteins interact to regulate apoptosis. Cell Res (2006) 2.26
Glycosylation restores survival of chilled blood platelets. Science (2003) 2.18
A Si/Glass Bulk-Micromachined Cryogenic Heat Exchanger for High Heat Loads: Fabrication, Test, and Application Results. J Microelectromech Syst (2010) 2.15
NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells. Immunity (2012) 2.14
Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands. J Biol Chem (2004) 2.12
Efficacy of the invasive/non-invasive pattern by magnifying chromoendoscopy to estimate the depth of invasion of early colorectal neoplasms. Am J Gastroenterol (2008) 2.05
A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation. J Cell Biol (2008) 2.04
Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1. Nat Immunol (2007) 1.97
Migration, community context, and child immunization in Ethiopia. Soc Sci Med (2004) 1.97
The potential contribution of mass treatment to the control of Plasmodium falciparum malaria. PLoS One (2011) 1.95
Endoscopic submucosal resection with a ligation device is an effective and safe treatment for carcinoid tumors in the lower rectum. J Gastroenterol Hepatol (2008) 1.93
SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis. J Clin Invest (2006) 1.92
Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance. Proc Natl Acad Sci U S A (2005) 1.91
The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments. Immunity (2012) 1.89
Granulocyte colony-stimulating factor and neutrophils--forgotten mediators of inflammatory disease. Nat Clin Pract Rheumatol (2006) 1.85
A novel endoscopic suturing technique using a specially designed so-called "8-ring" in combination with resolution clips (with videos). Gastrointest Endosc (2007) 1.83
In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas. Proc Natl Acad Sci U S A (2008) 1.83
Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice. Blood (2011) 1.83
Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth. Blood (2008) 1.82
Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling. Proc Natl Acad Sci U S A (2004) 1.81
Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells. Blood (2012) 1.81
miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta. Genes Dev (2010) 1.80
Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome. Blood (2009) 1.79
betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis. Mol Cell (2009) 1.77
High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction. Blood (2010) 1.75
Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochem J (2007) 1.74
Novel mechanisms of apoptosis induced by histone deacetylase inhibitors. Cancer Res (2003) 1.73
CD95, BIM and T cell homeostasis. Nat Rev Immunol (2009) 1.73
Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax. Proc Natl Acad Sci U S A (2008) 1.73
Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice. Blood (2011) 1.69
Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor-induced thrombocytopenia. Blood (2011) 1.69
Mutation discovery in mice by whole exome sequencing. Genome Biol (2011) 1.69
Structure-guided design of a selective BCL-X(L) inhibitor. Nat Chem Biol (2013) 1.68
Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function. Blood (2012) 1.67
Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically. Cancer Cell (2013) 1.67
Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak. J Cell Biol (2007) 1.67
IL-17 promotes p38 MAPK-dependent endothelial activation enhancing neutrophil recruitment to sites of inflammation. J Immunol (2010) 1.65
A type III effector antagonizes death receptor signalling during bacterial gut infection. Nature (2013) 1.65
Identification of a 2-stage platelet aggregation process mediating shear-dependent thrombus formation. Blood (2006) 1.63
Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity. J Cell Biol (2003) 1.60