Published in Blood on September 21, 2006
A shear gradient-dependent platelet aggregation mechanism drives thrombus formation. Nat Med (2009) 3.57
Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network. Blood (2013) 2.05
Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model. J Clin Invest (2007) 1.76
High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction. Blood (2010) 1.75
Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes. J Clin Invest (2008) 1.33
Regulating thrombus growth and stability to achieve an optimal response to injury. J Thromb Haemost (2011) 1.20
APT102, a novel adpase, cooperates with aspirin to disrupt bone metastasis in mice. J Cell Biochem (2008) 1.18
Fluid Mechanics of Blood Clot Formation. Annu Rev Fluid Mech (2015) 1.13
Fibrin networks regulate protein transport during thrombus development. PLoS Comput Biol (2013) 1.04
Shaping the platelet response to vascular injury. Curr Opin Hematol (2014) 1.03
Platelet secretion: From haemostasis to wound healing and beyond. Blood Rev (2014) 1.03
Platelet adhesion: a game of catch and release. J Clin Invest (2008) 1.00
Neutrophil granulocyte-dependent proteolysis enhances platelet adhesion to the arterial wall under high-shear flow. J Thromb Haemost (2010) 0.92
What is vinculin needed for in platelets? J Thromb Haemost (2010) 0.90
Serotonin stimulates platelet receptor shedding by tumor necrosis factor-alpha-converting enzyme (ADAM17). J Thromb Haemost (2009) 0.89
Current concepts of platelet activation: possibilities for therapeutic modulation of heterotypic vs. homotypic aggregation. Br J Clin Pharmacol (2011) 0.86
Platelets lacking PIP5KIγ have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion. Blood (2013) 0.86
Mechanobiology of platelets: techniques to study the role of fluid flow and platelet retraction forces at the micro- and nano-scale. Int J Mol Sci (2011) 0.83
Computational fluid dynamics modeling of symptomatic intracranial atherosclerosis may predict risk of stroke recurrence. PLoS One (2014) 0.82
Rapamycin promoted thrombosis and platelet adhesion to endothelial cells by inducing membrane remodeling. BMC Cell Biol (2014) 0.82
Identification of different proaggregatory abilities of activated platelet subpopulations. Biophys J (2012) 0.80
Collagen can selectively trigger a platelet secretory phenotype via glycoprotein VI. PLoS One (2014) 0.80
Microfluidics for simultaneous quantification of platelet adhesion and blood viscosity. Sci Rep (2016) 0.78
Threshold of microvascular occlusion: injury size defines the thrombosis scenario. Biophys J (2015) 0.77
Elevating local concentrations of GPIIb-IIIa antagonists counteracts platelet thrombus stability. J Thromb Thrombolysis (2013) 0.76
Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in mice. J Biol Chem (2014) 0.76
Activation and shedding of platelet glycoprotein IIb/IIIa under non-physiological shear stress. Mol Cell Biochem (2015) 0.76
In the shadow of the thrombus. Nat Med (2009) 0.76
Repetitive Hypershear Activates and Sensitizes Platelets in a Dose-Dependent Manner. Artif Organs (2015) 0.76
Regulation of Platelet Activation and Coagulation and Its Role in Vascular Injury and Arterial Thrombosis. Interv Cardiol Clin (2017) 0.75
Establishment of a sticky, large, oval-shaped thrombocyte cell line from tree frog as an ancestor of mammalian megakaryocytes. Springerplus (2015) 0.75
Historical perspective on ADP-induced platelet activation. Purinergic Signal (2011) 0.75
Polyphosphate co-localizes with factor XII on platelet-bound fibrin and augments its plasminogen activator activity. Blood (2016) 0.75
Effect of diabetic duration on hemorheological properties and platelet aggregation in streptozotocin-induced diabetic rats. Sci Rep (2016) 0.75
A Novel Model of Intravital Platelet Imaging Using CD41-ZsGreen1 Transgenic Rats. PLoS One (2016) 0.75
Effects of different shear rates on the attachment and detachment of platelet thrombi. Mol Med Rep (2016) 0.75
A physical description of the adhesion and aggregation of platelets. R Soc Open Sci (2017) 0.75
PI 3-kinase p110beta: a new target for antithrombotic therapy. Nat Med (2005) 3.96
A shear gradient-dependent platelet aggregation mechanism drives thrombus formation. Nat Med (2009) 3.57
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood (2005) 2.35
Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth. Blood (2008) 1.82
High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction. Blood (2010) 1.75
Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochem J (2007) 1.74
Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function. Blood (2009) 1.74
Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function. Blood (2012) 1.67
Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets. Blood (2011) 1.56
Towards effective and safe thrombolysis and thromboprophylaxis: preclinical testing of a novel antibody-targeted recombinant plasminogen activator directed against activated platelets. Circ Res (2014) 1.54
Shear-dependent tether formation during platelet translocation on von Willebrand factor. Blood (2002) 1.42
Intercellular calcium communication regulates platelet aggregation and thrombus growth. J Cell Biol (2003) 1.42
Reconstituted high-density lipoprotein attenuates platelet function in individuals with type 2 diabetes mellitus by promoting cholesterol efflux. Circulation (2009) 1.40
Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRgamma deficiency. Blood (2006) 1.37
The role of platelets in atherothrombosis. Hematology Am Soc Hematol Educ Program (2011) 1.34
Interaction between platelet glycoprotein Ibalpha and filamin-1 is essential for glycoprotein Ib/IX receptor anchorage at high shear. J Biol Chem (2001) 1.30
Targeting the PI3K p110alpha isoform inhibits medulloblastoma proliferation, chemoresistance, and migration. Clin Cancer Res (2008) 1.30
SHIP1 and Lyn Kinase Negatively Regulate Integrin alpha IIb beta 3 signaling in platelets. J Biol Chem (2004) 1.25
Signaling role for phospholipase C gamma 2 in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcR gamma chain and Fc gamma RIIA. J Biol Chem (2003) 1.24
Distinct glycoprotein Ib/V/IX and integrin alpha IIbbeta 3-dependent calcium signals cooperatively regulate platelet adhesion under flow. J Biol Chem (2001) 1.23
An experimental model to study the in vivo survival of von Willebrand factor. Basic aspects and application to the R1205H mutation. J Biol Chem (2003) 1.21
Continuous signaling via PI3K isoforms beta and gamma is required for platelet ADP receptor function in dynamic thrombus stabilization. Blood (2006) 1.21
A microfluidics device to monitor platelet aggregation dynamics in response to strain rate micro-gradients in flowing blood. Lab Chip (2009) 1.16
Mapping the collagen-binding site in the von Willebrand factor-A3 domain. J Biol Chem (2003) 1.16
Novel role of platelets in mediating inflammatory responses and ventricular rupture or remodeling following myocardial infarction. Arterioscler Thromb Vasc Biol (2011) 1.15
Integrin alpha IIb beta 3-dependent calcium signals regulate platelet-fibrinogen interactions under flow. Involvement of phospholipase C gamma 2. J Biol Chem (2003) 1.13
Role of phosphoinositide 3-kinase beta in glycoprotein VI-mediated Akt activation in platelets. J Biol Chem (2009) 1.11
Erythrocyte hemolysis and hemoglobin oxidation promote ferric chloride-induced vascular injury. J Biol Chem (2009) 1.10
Essential role for phosphoinositide 3-kinase in shear-dependent signaling between platelet glycoprotein Ib/V/IX and integrin alpha(IIb)beta(3). Blood (2002) 1.09
Pathophysiological levels of soluble P-selectin mediate adhesion of leukocytes to the endothelium through Mac-1 activation. Circ Res (2008) 1.08
Platelet factor XIII and calpain negatively regulate integrin alphaIIbbeta3 adhesive function and thrombus growth. J Biol Chem (2004) 1.04
Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin alpha IIb beta 3 adhesive function in platelets. J Biol Chem (2007) 1.04
A mechanistic model for paradoxical platelet activation by ligand-mimetic alphaIIb beta3 (GPIIb/IIIa) antagonists. Arterioscler Thromb Vasc Biol (2006) 1.04
LDL-receptor-related protein regulates beta2-integrin-mediated leukocyte adhesion. Blood (2004) 1.04
The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi. Blood (2013) 1.03
Leucine-rich repeats 2-4 (Leu60-Glu128) of platelet glycoprotein Ibalpha regulate shear-dependent cell adhesion to von Willebrand factor. J Biol Chem (2006) 1.03
RhoA sustains integrin alpha IIbbeta 3 adhesion contacts under high shear. J Biol Chem (2002) 1.01
Shear induces a unique series of morphological changes in translocating platelets: effects of morphology on translocation dynamics. Arterioscler Thromb Vasc Biol (2005) 1.01
The impact of blood rheology on the molecular and cellular events underlying arterial thrombosis. J Mol Med (Berl) (2006) 1.01
New insights into the haemostatic function of platelets. Br J Haematol (2009) 1.01
Identification of a novel 14-3-3zeta binding site within the cytoplasmic tail of platelet glycoprotein Ibalpha. Blood (2004) 0.99
Class I phosphoinositide 3-kinases. Int J Biochem Cell Biol (2003) 0.99
Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells. Nat Commun (2011) 0.99
Identification of a unique filamin A binding region within the cytoplasmic domain of glycoprotein Ibalpha. Biochem J (2005) 0.98
Novel role for insulin as an autocrine growth factor for malignant brain tumour cells. Biochem J (2007) 0.97
A sensitized RNA interference screen identifies a novel role for the PI3K p110γ isoform in medulloblastoma cell proliferation and chemoresistance. Mol Cancer Res (2011) 0.96
Bcl-xL-inhibitory BH3 mimetics (ABT-737 or ABT-263) and the modulation of cytosolic calcium flux and platelet function. Blood (2012) 0.95
PI3-kinase p110α mediates β1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading. Cell Signal (2010) 0.94
A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis. Blood (2006) 0.94
Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocket. Biochem J (2008) 0.94
Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces. J Biol Chem (2009) 0.92
Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation. J Biol Chem (2009) 0.92
Evidence of platelet activation at medically used hypothermia and mechanistic data indicating ADP as a key mediator and therapeutic target. Arterioscler Thromb Vasc Biol (2011) 0.92
Insulin-like growth factor-1 regulates platelet activation through PI3-Kalpha isoform. Blood (2007) 0.90
Conversion of platelets from a proaggregatory to a proinflammatory adhesive phenotype: role of PAF in spatially regulating neutrophil adhesion and spreading. Blood (2007) 0.89
Role of the intracellular domains of GPIb in controlling the adhesive properties of the platelet GPIb/V/IX complex. Blood (2003) 0.89
Importance of temporal flow gradients and integrin alphaIIbbeta3 mechanotransduction for shear activation of platelets. J Biol Chem (2005) 0.89
Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene. Genesis (2010) 0.88
Techniques to examine platelet adhesive interactions under flow. Methods Mol Biol (2004) 0.88
Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110alpha inhibitors. Bioorg Med Chem (2007) 0.87
Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels. Blood (2012) 0.87
Bidirectional integrin alphaIIbbeta3 signalling regulating platelet adhesion under flow: contribution of protein kinase C. Biochem J (2003) 0.86
Platelet recruitment to the inflamed glomerulus occurs via an alphaIIbbeta3/GPVI-dependent pathway. Am J Pathol (2010) 0.86
An investigation on platelet transport during thrombus formation at micro-scale stenosis. PLoS One (2013) 0.86
Nonlinear Dynamic Modelling of Platelet Aggregation via Microfluidic Devices. IEEE Trans Biomed Eng (2015) 0.81
The clot thickens--oxidized lipids and thrombosis. Nat Med (2007) 0.81
The contribution of thrombin-induced platelet activation to thrombus growth is diminished under pathological blood shear conditions. Thromb Haemost (2011) 0.80
Structural and hydrodynamic simulation of an acute stenosis-dependent thrombosis model in mice. J Biomech (2011) 0.77
Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in mice. J Biol Chem (2014) 0.76
Are Erk, Btk, and PECAM-1 major players in GPIb signaling? The challenge of unraveling signaling events downstream of platelet GPIb. Blood (2007) 0.76
The catalytic class I(A) PI3K isoforms play divergent roles in breast cancer cell migration. Cell Signal (2010) 0.76
Is thrombin the problem or (dis)solution? Blood (2009) 0.76
SR-BI and fatty platelets. Blood (2010) 0.75