Published in Chem Biol on April 24, 2009
Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis. Development (2010) 1.64
Molecular basis for endothelial lumen formation and tubulogenesis during vasculogenesis and angiogenic sprouting. Int Rev Cell Mol Biol (2011) 1.36
Generation of Rab-based transgenic lines for in vivo studies of endosome biology in zebrafish. Dev Dyn (2011) 1.13
Development and validation of an automated high-throughput system for zebrafish in vivo screenings. PLoS One (2012) 1.01
Phenotype-based high-content chemical library screening identifies statins as inhibitors of in vivo lymphangiogenesis. Proc Natl Acad Sci U S A (2012) 0.99
Global analysis of the haematopoietic and endothelial transcriptome during zebrafish development. Mech Dev (2012) 0.94
A chemical screen to identify novel inhibitors of fin regeneration in zebrafish. Zebrafish (2010) 0.86
PD 404,182 is a virocidal small molecule that disrupts hepatitis C virus and human immunodeficiency virus. Antimicrob Agents Chemother (2011) 0.85
Single-cell analysis of endothelial morphogenesis in vivo. Development (2015) 0.83
A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide. J Pharmacol Exp Ther (2013) 0.81
Phenotype-based Discovery of 2-[(E)-2-(Quinolin-2-yl)vinyl]phenol as a Novel Regulator of Ocular Angiogenesis. J Biol Chem (2016) 0.78
Interactions between α-tocopherol, polyunsaturated fatty acids, and lipoxygenases during embryogenesis. Free Radic Biol Med (2013) 0.78
Zebrafish xenotransplantation as a tool for in vivo cancer study. Fam Cancer (2015) 0.76
Zebrafish Rab5 proteins and a role for Rab5ab in nodal signalling. Dev Biol (2014) 0.75
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature (1995) 15.15
Effective targeted gene 'knockdown' in zebrafish. Nat Genet (2000) 14.40
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov (2004) 9.96
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell (2005) 9.18
VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer (2008) 7.86
Molecular regulation of angiogenesis and lymphangiogenesis. Nat Rev Mol Cell Biol (2007) 7.75
Statistical tests for differential expression in cDNA microarray experiments. Genome Biol (2003) 7.65
Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell (1998) 7.25
High-fidelity mRNA amplification for gene profiling. Nat Biotechnol (2000) 6.97
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature (2006) 6.56
Protein phosphatase 1--targeted in many directions. J Cell Sci (2002) 5.59
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res (2004) 5.45
SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res (1999) 4.23
Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci U S A (2000) 4.08
Endothelial-mural cell signaling in vascular development and angiogenesis. Arterioscler Thromb Vasc Biol (2009) 3.78
Construction and characterization of a normalized cDNA library. Proc Natl Acad Sci U S A (1994) 3.73
PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell (1996) 3.60
Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor: systematic review and meta-analysis. Am J Kidney Dis (2007) 3.47
Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol (2004) 3.39
Integration of endothelial cells in multicellular spheroids prevents apoptosis and induces differentiation. J Cell Biol (1998) 2.89
Medical uses of mylabris in ancient China and recent studies. J Ethnopharmacol (1989) 2.87
Tensional forces in fibrillar extracellular matrices control directional capillary sprouting. J Cell Sci (1999) 2.71
The clinical toxicity profile of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) targeting angiogenesis inhibitors; a review. Eur J Cancer (2006) 2.33
Anti-vascular endothelial growth factor therapy for ocular neovascular disease. Curr Opin Ophthalmol (2007) 2.08
Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish. Cancer Res (2007) 1.88
Dissection of angiogenic signaling in zebrafish using a chemical genetic approach. Cancer Cell (2002) 1.86
Morphants: a new systematic vertebrate functional genomics approach. Yeast (2000) 1.60
Identification of a core set of 58 gene transcripts with broad and specific expression in the microvasculature. Arterioscler Thromb Vasc Biol (2008) 1.53
Microarray analysis of blood microvessels from PDGF-B and PDGF-Rbeta mutant mice identifies novel markers for brain pericytes. FASEB J (2006) 1.52
Protein phosphatase 4--from obscurity to vital functions. FEBS Lett (2005) 1.41
Cyclooxygenase-2 and 5-lipoxygenase converging functions on cell proliferation and tumor angiogenesis: implications for cancer therapy. FASEB J (2003) 1.41
Duplicate VegfA genes and orthologues of the KDR receptor tyrosine kinase family mediate vascular development in the zebrafish. Blood (2007) 1.39
mRNA expression profiling of laser microbeam microdissected cells from slender embryonic structures. Am J Pathol (2002) 1.37
Expression of VE-cadherin in zebrafish embryos: a new tool to evaluate vascular development. Dev Dyn (2004) 1.34
Protein phosphatase 2A and its [3H]cantharidin/[3H]endothall thioanhydride binding site. Inhibitor specificity of cantharidin and ATP analogues. Biochem Pharmacol (1993) 1.11
Zebrafish neuropilins are differentially expressed and interact with vascular endothelial growth factor during embryonic vascular development. Dev Dyn (2004) 1.04
Protein phosphatase-2A regulates endothelial cell motility and both the phosphorylation and the stability of focal adhesion complexes. Int J Cancer (2002) 1.01
Phosphorylation of TIMAP by glycogen synthase kinase-3beta activates its associated protein phosphatase 1. J Biol Chem (2007) 0.95
Smad7 and protein phosphatase 1alpha are critical determinants in the duration of TGF-beta/ALK1 signaling in endothelial cells. BMC Cell Biol (2006) 0.92
Visualization and experimental analysis of blood vessel formation using transgenic zebrafish. Birth Defects Res C Embryo Today (2007) 0.90
Cantharidin effects on protein phosphatases and the phosphorylation state of phosphoproteins in mice. Toxicol Appl Pharmacol (1995) 0.89
Endothall thioanhydride inhibits protein phosphatases-1 and -2A in vivo. Am J Physiol (1995) 0.87
Involvement of NO/cGMP signaling in the apoptotic and anti-angiogenic effects of beta-lapachone on endothelial cells in vitro. J Cell Physiol (2007) 0.84
Involvement of protein phosphatase-1 in cytoskeletal organization of cultured endothelial cells. J Cell Biochem (1995) 0.83
Cantharidin enhances norepinephrine-induced vasoconstriction in an endothelium-dependent fashion. J Pharmacol Exp Ther (2000) 0.80
Extracellular ATP induces assembly and activation of the myosin light chain phosphatase complex in endothelial cells. Cardiovasc Res (2007) 0.79
The protein phosphatase inhibitor cantharidin alters vascular endothelial cell permeability. J Pharmacol Exp Ther (1999) 0.78
Forward in reverse: how reverse genetics complements chemical genetics. Pharmacogenomics (2005) 0.77
Discovery of new small molecules and targets towards angiogenesis via chemical genomics approach. Curr Drug Targets (2006) 0.76
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature (2007) 9.09
In vivo genome editing using a high-efficiency TALEN system. Nature (2012) 7.11
p53 activation by knockdown technologies. PLoS Genet (2007) 6.85
Pericytes regulate the blood-brain barrier. Nature (2010) 6.62
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature (2008) 5.15
A new method for large scale isolation of kidney glomeruli from mice. Am J Pathol (2002) 4.63
CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature. Proc Natl Acad Sci U S A (2007) 3.85
Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen. J Exp Med (2003) 3.64
Gene transfer into genomes of human cells by the sleeping beauty transposon system. Mol Ther (2003) 3.34
Accuracy and clinical implications of seven 25-hydroxyvitamin D methods compared with liquid chromatography-tandem mass spectrometry as a reference. Ann Clin Biochem (2008) 3.14
Harnessing a high cargo-capacity transposon for genetic applications in vertebrates. PLoS Genet (2006) 2.99
Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy. EMBO J (2002) 2.73
A primer for morpholino use in zebrafish. Zebrafish (2009) 2.60
Redirecting specificity of T-cell populations for CD19 using the Sleeping Beauty system. Cancer Res (2008) 2.57
Structure-function analysis of the inverted terminal repeats of the sleeping beauty transposon. J Mol Biol (2002) 2.30
Efficient nonmeiotic allele introgression in livestock using custom endonucleases. Proc Natl Acad Sci U S A (2013) 2.22
The landscape of viral expression and host gene fusion and adaptation in human cancer. Nat Commun (2013) 2.17
Gel-forming mucins appeared early in metazoan evolution. Proc Natl Acad Sci U S A (2007) 2.16
SRPDB: Signal Recognition Particle Database. Nucleic Acids Res (2003) 2.16
Mammalian germ-line transgenesis by transposition. Proc Natl Acad Sci U S A (2002) 2.13
Efficient gene delivery and gene expression in zebrafish using the Sleeping Beauty transposon. Dev Biol (2003) 2.01
The tmRDB and SRPDB resources. Nucleic Acids Res (2006) 2.01
RNA as a source of transposase for Sleeping Beauty-mediated gene insertion and expression in somatic cells and tissues. Mol Ther (2005) 1.98
Spheroid-based engineering of a human vasculature in mice. Nat Methods (2008) 1.90
Target-site preferences of Sleeping Beauty transposons. J Mol Biol (2004) 1.83
Neuropilin-1 and neuropilin-2 enhance VEGF121 stimulated signal transduction by the VEGFR-2 receptor. FASEB J (2006) 1.75
Angiogenetic signaling through hypoxia: HMGB1: an angiogenetic switch molecule. Am J Pathol (2005) 1.75
Transcription profiling of platelet-derived growth factor-B-deficient mouse embryos identifies RGS5 as a novel marker for pericytes and vascular smooth muscle cells. Am J Pathol (2003) 1.74
Extracellular matrix-bound angiopoietin-like 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton. Circ Res (2006) 1.73
Preferential delivery of the Sleeping Beauty transposon system to livers of mice by hydrodynamic injection. Nat Protoc (2007) 1.73
RNAcentral: A vision for an international database of RNA sequences. RNA (2011) 1.73
Prediction of signal recognition particle RNA genes. Nucleic Acids Res (2002) 1.72
Vascular endothelial growth factor (VEGF-A) expression in human mesenchymal stem cells: autocrine and paracrine role on osteoblastic and endothelial differentiation. J Cell Biochem (2005) 1.72
Large-scale identification of genes implicated in kidney glomerulus development and function. EMBO J (2006) 1.69
The recombinant C-terminus of the human MUC2 mucin forms dimers in Chinese-hamster ovary cells and heterodimers with full-length MUC2 in LS 174T cells. Biochem J (2003) 1.67
The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2. Dev Cell (2012) 1.66
Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis. Development (2010) 1.64
Genome-wide reverse genetics framework to identify novel functions of the vertebrate secretome. PLoS One (2006) 1.60
Duration of expression and activity of Sleeping Beauty transposase in mouse liver following hydrodynamic DNA delivery. Mol Ther (2010) 1.57
Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2. J Cell Biol (2005) 1.57
Identification and analysis of ribonuclease P and MRP RNA in a broad range of eukaryotes. Nucleic Acids Res (2005) 1.56
Spheroid-based human endothelial cell microvessel formation in vivo. Nat Protoc (2009) 1.55
Heterogeneity prevails: the state of clinical trial data management in Europe - results of a survey of ECRIN centres. Trials (2010) 1.53
Identification of a core set of 58 gene transcripts with broad and specific expression in the microvasculature. Arterioscler Thromb Vasc Biol (2008) 1.53
Microarray analysis of blood microvessels from PDGF-B and PDGF-Rbeta mutant mice identifies novel markers for brain pericytes. FASEB J (2006) 1.52
Revealing the role of phospholipase Cβ3 in the regulation of VEGF-induced vascular permeability. Blood (2012) 1.51
De novo induction of genetically engineered brain tumors in mice using plasmid DNA. Cancer Res (2009) 1.49
Structure-based prediction of insertion-site preferences of transposons into chromosomes. Nucleic Acids Res (2006) 1.48
Characterization of the Zoarces viviparus liver transcriptome using massively parallel pyrosequencing. BMC Genomics (2009) 1.48
BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis. Circ Res (2008) 1.48
Nicotine response genetics in the zebrafish. Proc Natl Acad Sci U S A (2009) 1.45
Translating Sleeping Beauty transposition into cellular therapies: victories and challenges. Bioessays (2010) 1.42
mRNA expression profiling of laser microbeam microdissected cells from slender embryonic structures. Am J Pathol (2002) 1.37
Precision editing of large animal genomes. Adv Genet (2012) 1.34
Expression of VE-cadherin in zebrafish embryos: a new tool to evaluate vascular development. Dev Dyn (2004) 1.34
Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik. J Am Soc Nephrol (2007) 1.33
Prolonged expression of a lysosomal enzyme in mouse liver after Sleeping Beauty transposon-mediated gene delivery: implications for non-viral gene therapy of mucopolysaccharidoses. J Gene Med (2007) 1.33
A family of putative transcription termination factors shared amongst metazoans and plants. Curr Genet (2005) 1.33
Gene insertion and long-term expression in lung mediated by the Sleeping Beauty transposon system. Mol Ther (2003) 1.31
Excision of Sleeping Beauty transposons: parameters and applications to gene therapy. J Gene Med (2004) 1.30
Infusing CD19-directed T cells to augment disease control in patients undergoing autologous hematopoietic stem-cell transplantation for advanced B-lymphoid malignancies. Hum Gene Ther (2012) 1.29
Mojo Hand, a TALEN design tool for genome editing applications. BMC Bioinformatics (2013) 1.29
Kinship in the SRP RNA family. RNA Biol (2009) 1.28
Evolution of the iron-responsive element. RNA (2007) 1.27
A reverse genetic screen in the zebrafish identifies crb2b as a regulator of the glomerular filtration barrier. Dev Biol (2009) 1.26
SCORE imaging: specimen in a corrected optical rotational enclosure. Zebrafish (2010) 1.26
CXCL16 recruits bone marrow-derived fibroblast precursors in renal fibrosis. J Am Soc Nephrol (2011) 1.24
Systemic correction of storage disease in MPS I NOD/SCID mice using the sleeping beauty transposon system. Mol Ther (2009) 1.24
A nomenclature for all signal recognition particle RNAs. RNA (2005) 1.20
Early evolution of histone mRNA 3' end processing. RNA (2007) 1.20
The Sleeping Beauty transposon system: a non-viral vector for gene therapy. Hum Mol Genet (2011) 1.18
Inventory and analysis of the protein subunits of the ribonucleases P and MRP provides further evidence of homology between the yeast and human enzymes. Nucleic Acids Res (2006) 1.17
Bioinformatic identification of polymerizing and transmembrane mucins in the puffer fish Fugu rubripes. Glycobiology (2004) 1.17
DDE transposases: Structural similarity and diversity. Adv Drug Deliv Rev (2010) 1.16
The CRISPR system--keeping zebrafish gene targeting fresh. Zebrafish (2013) 1.13
Targeting DNA With Fingers and TALENs. Mol Ther Nucleic Acids (2012) 1.12
Morpholino phosphorodiamidate oligonucleotides in zebrafish: a recipe for functional genomics? Brief Funct Genomic Proteomic (2002) 1.10