Identification of a core set of 58 gene transcripts with broad and specific expression in the microvasculature.

PubWeight™: 1.53‹?› | Rank: Top 4%

🔗 View Article (PMID 18483404)

Published in Arterioscler Thromb Vasc Biol on May 15, 2008

Authors

Elisabet Wallgard1, Erik Larsson, Liqun He, Mats Hellström, Annika Armulik, Maya H Nisancioglu, Guillem Genove, Per Lindahl, Christer Betsholtz

Author Affiliations

1: Department of Medical Biochemistry and Biophysics, KarolinskaInstitutet, Scheeles väg 2, A3, floor 4, SE-171 77, Stockholm, Sweden.

Articles citing this

Pericytes regulate the blood-brain barrier. Nature (2010) 6.62

The Concise Guide to PHARMACOLOGY 2013/14: transporters. Br J Pharmacol (2013) 2.07

A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. PLoS Genet (2012) 1.52

NHERF-2 maintains endothelial homeostasis. Blood (2012) 1.47

A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis. Cancer Cell (2013) 1.15

Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1. Genome Med (2009) 1.15

Correlating global gene regulation to angiogenesis in the developing chick extra-embryonic vascular system. PLoS One (2009) 1.05

CDH5 is specifically activated in glioblastoma stemlike cells and contributes to vasculogenic mimicry induced by hypoxia. Neuro Oncol (2013) 0.94

Orphan G protein-coupled receptor GPR116 regulates pulmonary surfactant pool size. Am J Respir Cell Mol Biol (2013) 0.94

Global analysis of the haematopoietic and endothelial transcriptome during zebrafish development. Mech Dev (2012) 0.94

Combination of reverse and chemical genetic screens reveals angiogenesis inhibitors and targets. Chem Biol (2009) 0.92

Endothelial-like properties of claudin-low breast cancer cells promote tumor vascular permeability and metastasis. Clin Exp Metastasis (2013) 0.91

ELTD1, a potential new biomarker for gliomas. Neurosurgery (2013) 0.91

The vasculome of the mouse brain. PLoS One (2012) 0.89

Glucose intolerance and impaired insulin secretion in pancreas-specific signal transducer and activator of transcription-3 knockout mice are associated with microvascular alterations in the pancreas. Endocrinology (2010) 0.88

Exocyst complex component 3-like 2 (EXOC3L2) associates with the exocyst complex and mediates directional migration of endothelial cells. J Biol Chem (2011) 0.88

Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116. Cell Rep (2013) 0.86

Adrenomedullin gene dosage correlates with tumor and lymph node lymphangiogenesis. FASEB J (2012) 0.86

Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells. PLoS One (2012) 0.85

Gene signature distinguishes patients with chronic ulcerative colitis harboring remote neoplastic lesions. Inflamm Bowel Dis (2013) 0.84

Rap1 signaling in endothelial barrier control. Cell Adh Migr (2014) 0.84

Identification of a novel flow-mediated gene expression signature in patients with bicuspid aortic valve. J Mol Med (Berl) (2012) 0.83

A new procedure for determining the genetic basis of a physiological process in a non-model species, illustrated by cold induced angiogenesis in the carp. BMC Genomics (2009) 0.82

Exercise-induced differential changes in gene expression among arterioles of skeletal muscles of obese rats. J Appl Physiol (1985) (2015) 0.82

Coexpression analysis of large cancer datasets provides insight into the cellular phenotypes of the tumour microenvironment. BMC Genomics (2013) 0.81

Identification of candidate genes linking systemic inflammation to atherosclerosis; results of a human in vivo LPS infusion study. BMC Med Genomics (2011) 0.81

Temporal genome expression profile analysis during t-cell-mediated colitis: identification of novel targets and pathways. Inflamm Bowel Dis (2011) 0.81

Hypertension and genetic variation in endothelial-specific genes. PLoS One (2013) 0.80

Gpr116 Receptor Regulates Distinctive Functions in Pneumocytes and Vascular Endothelium. PLoS One (2015) 0.79

Functional identification of SLC43A3 as an equilibrative nucleobase transporter involved in purine salvage in mammals. Sci Rep (2015) 0.77

Vascular dysfunction and increased metastasis of B16F10 melanomas in Shb deficient mice as compared with their wild type counterparts. BMC Cancer (2015) 0.76

EXOC3L2 rs597668 variant contributes to Alzheimer's disease susceptibility in Asian population. Oncotarget (2017) 0.75

Epidermal growth factor, latrophilin, and seven transmembrane domain-containing protein 1 marker, a novel angiogenesis marker. Onco Targets Ther (2015) 0.75

A 19-Gene expression signature as a predictor of survival in colorectal cancer. BMC Med Genomics (2016) 0.75

Developmental vascular remodeling defects and postnatal kidney failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4). PLoS One (2017) 0.75

Articles by these authors

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov (2012) 26.98

Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal (2013) 19.54

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol (2003) 12.96

Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature (2007) 9.09

Role of platelet-derived growth factors in physiology and medicine. Genes Dev (2008) 8.89

Endothelial/pericyte interactions. Circ Res (2005) 8.24

Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol (2003) 7.42

Pericytes regulate the blood-brain barrier. Nature (2010) 6.62

Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. Dev Cell (2011) 6.12

Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. Genes Dev (2002) 5.15

Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature (2008) 5.15

A new method for large scale isolation of kidney glomeruli from mice. Am J Pathol (2002) 4.63

Endothelial-pericyte interactions in angiogenesis. Cell Tissue Res (2003) 4.39

HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF. Cancer Cell (2011) 3.89

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature (2012) 3.80

Endothelial-mural cell signaling in vascular development and angiogenesis. Arterioscler Thromb Vasc Biol (2009) 3.78

Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke. Nat Med (2008) 3.64

Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall. Genes Dev (2003) 3.48

Vascular endothelial growth factor B controls endothelial fatty acid uptake. Nature (2010) 3.40

Target mRNA abundance dilutes microRNA and siRNA activity. Mol Syst Biol (2010) 3.37

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med (2013) 3.35

Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors. J Clin Invest (2003) 3.31

Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy. EMBO J (2002) 2.73

BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. Proc Natl Acad Sci U S A (2002) 2.62

Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice. Nat Genet (2013) 2.62

Pericytes limit tumor cell metastasis. J Clin Invest (2006) 2.55

Follicular dendritic cells emerge from ubiquitous perivascular precursors. Cell (2012) 2.50

RNA targets of wild-type and mutant FET family proteins. Nat Struct Mol Biol (2011) 2.46

Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities. Development (2004) 2.44

Pericytes and vascular stability. Exp Cell Res (2005) 2.39

Pericytes and the pathogenesis of diabetic retinopathy. Diabetes (2002) 2.31

Cytokine detection by antibody-based proximity ligation. Proc Natl Acad Sci U S A (2004) 2.29

Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling. Dev Biol (2003) 2.24

Antioxidants accelerate lung cancer progression in mice. Sci Transl Med (2014) 2.23

The landscape of viral expression and host gene fusion and adaptation in human cancer. Nat Commun (2013) 2.17

miRcode: a map of putative microRNA target sites in the long non-coding transcriptome. Bioinformatics (2012) 2.13

Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system. Dev Dyn (2004) 2.11

Utilization of small pediatric donors including infants for pancreas and kidney transplantation: exemplification of the surgical technique and the surveillance. Ann Surg (2014) 2.01

Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics. Cell (2006) 1.92

Analysis of mural cell recruitment to tumor vessels. Circulation (2002) 1.90

A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling. Nat Genet (2004) 1.87

Pericyte-specific expression of Rgs5: implications for PDGF and EDG receptor signaling during vascular maturation. FASEB J (2003) 1.76

Integrated analyses of microRNAs demonstrate their widespread influence on gene expression in high-grade serous ovarian carcinoma. PLoS One (2012) 1.76

Systemic and targeted delivery of semaphorin 3A inhibits tumor angiogenesis and progression in mouse tumor models. Arterioscler Thromb Vasc Biol (2011) 1.75

Transcription profiling of platelet-derived growth factor-B-deficient mouse embryos identifies RGS5 as a novel marker for pericytes and vascular smooth muscle cells. Am J Pathol (2003) 1.74

Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate. Cancer Res (2004) 1.72

Large-scale identification of genes implicated in kidney glomerulus development and function. EMBO J (2006) 1.69

Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development. Genes Dev (2007) 1.68

The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2. Dev Cell (2012) 1.66

Paracrine signaling by platelet-derived growth factor-CC promotes tumor growth by recruitment of cancer-associated fibroblasts. Cancer Res (2009) 1.65

Developmental origin of smooth muscle cells in the descending aorta in mice. Development (2008) 1.59

Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis. Genes Dev (2005) 1.56

Heterogeneity prevails: the state of clinical trial data management in Europe - results of a survey of ECRIN centres. Trials (2010) 1.53

Dietary nitrate attenuates oxidative stress, prevents cardiac and renal injuries, and reduces blood pressure in salt-induced hypertension. Cardiovasc Res (2010) 1.53

Microarray analysis of blood microvessels from PDGF-B and PDGF-Rbeta mutant mice identifies novel markers for brain pericytes. FASEB J (2006) 1.52

Retracted The SNARE protein SNAP23 and the SNARE-interacting protein Munc18c in human skeletal muscle are implicated in insulin resistance/type 2 diabetes. Diabetes (2010) 1.51

Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis. FASEB J (2009) 1.44

mRNA expression profiling of laser microbeam microdissected cells from slender embryonic structures. Am J Pathol (2002) 1.37

Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik. J Am Soc Nephrol (2007) 1.33

How do endothelial cells orientate? EXS (2005) 1.32

Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines. Proc Natl Acad Sci U S A (2011) 1.30

A reverse genetic screen in the zebrafish identifies crb2b as a regulator of the glomerular filtration barrier. Dev Biol (2009) 1.26

CXCL16 recruits bone marrow-derived fibroblast precursors in renal fibrosis. J Am Soc Nephrol (2011) 1.24

PDGF-A/PDGF alpha-receptor signaling is required for lung growth and the formation of alveoli but not for early lung branching morphogenesis. Dev Dyn (2002) 1.21

Determination of N- and C-terminal borders of the transmembrane domain of integrin subunits. J Biol Chem (2004) 1.21

Glcci1 deficiency leads to proteinuria. J Am Soc Nephrol (2011) 1.19

Temporal trends of molecular markers associated with artemether-lumefantrine tolerance/resistance in Bagamoyo district, Tanzania. Malar J (2013) 1.17

Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization. J Pathol (2012) 1.16

Blockade of platelet-derived growth factor or its receptors transiently delays but does not prevent fibrous cap formation in ApoE null mice. Am J Pathol (2002) 1.15

Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1. Genome Med (2009) 1.15

Zebrafish: a model system for the study of vertebrate renal development, function, and pathophysiology. Curr Opin Nephrol Hypertens (2011) 1.14

Generation and characterization of rgs5 mutant mice. Mol Cell Biol (2008) 1.13

Under stress, the absence of intermediate filaments from Müller cells in the retina has structural and functional consequences. J Cell Sci (2004) 1.12

Expression analysis of PDGF-C in adult and developing mouse tissues. Mech Dev (2002) 1.10

A two-way communication between microglial cells and angiogenic sprouts regulates angiogenesis in aortic ring cultures. PLoS One (2011) 1.09

Adiponectin promotes monocyte-to-fibroblast transition in renal fibrosis. J Am Soc Nephrol (2013) 1.09

The absence of pericytes does not increase the sensitivity of tumor vasculature to vascular endothelial growth factor-A blockade. Cancer Res (2010) 1.08

Absence of SV40 antibodies or DNA fragments in prediagnostic mesothelioma serum samples. Int J Cancer (2007) 1.07