Published in J Comp Neurol on July 01, 2009
Long distance directional growth of dopaminergic axons along pathways of netrin-1 and GDNF. Exp Neurol (2013) 1.40
Cell Therapy From Bench to Bedside Translation in CNS Neurorestoratology Era. Cell Med (2010) 0.96
Vesicular expression and release of ATP from dopaminergic neurons of the mouse retina and midbrain. Front Cell Neurosci (2015) 0.91
Cell intrinsic and extrinsic factors contribute to enhance neural circuit reconstruction following transplantation in Parkinsonian mice. J Physiol (2012) 0.89
Cellular repair in the parkinsonian nonhuman primate brain. Rejuvenation Res (2010) 0.83
Functional multipotency of stem cells: a conceptual review of neurotrophic factor-based evidence and its role in translational research. Curr Neuropharmacol (2011) 0.82
Characterization of the stability and bio-functionality of tethered proteins on bioengineered scaffolds: implications for stem cell biology and tissue repair. J Biol Chem (2014) 0.80
Comparison of fetal mesencephalic grafts, AAV-delivered GDNF, and both combined in an MPTP-induced nonhuman primate Parkinson's model. Mol Ther (2013) 0.79
Enhancement of polysialic acid expression improves function of embryonic stem-derived dopamine neuron grafts in Parkinsonian mice. Stem Cells Transl Med (2013) 0.79
Human neural stem cells survive long term in the midbrain of dopamine-depleted monkeys after GDNF overexpression and project neurites toward an appropriate target. Stem Cells Transl Med (2014) 0.77
Development of a stereotaxic device for low impact implantation of neural constructs or pieces of neural tissues into the mammalian brain. Biomed Res Int (2014) 0.75
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nat Med (2008) 6.90
Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat Med (2008) 6.86
GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science (1993) 6.73
Cross-packaging of a single adeno-associated virus (AAV) type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity. J Virol (2002) 5.82
Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial. Lancet Neurol (2008) 4.16
Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science (2000) 3.89
Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years. Nat Med (2008) 2.80
Simultaneous intrastriatal and intranigral fetal dopaminergic grafts in patients with Parkinson disease: a pilot study. Report of three cases. J Neurosurg (2002) 2.45
Dopaminergic neurons protected from degeneration by GDNF gene therapy. Science (1997) 2.40
Functional recovery in parkinsonian monkeys treated with GDNF. Nature (1996) 2.35
Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells. Proc Natl Acad Sci U S A (2007) 2.19
Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease. Hum Gene Ther (2000) 1.81
Six-month continuous intraputamenal infusion toxicity study of recombinant methionyl human glial cell line-derived neurotrophic factor (r-metHuGDNF) in rhesus monkeys. Toxicol Pathol (2007) 1.52
Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys. Ann Neurol (2006) 1.46
Dyskinesia after fetal cell transplantation for parkinsonism: a PET study. Ann Neurol (2002) 1.39
Subdivisions of the dopamine-containing A8-A9-A10 complex identified by their differential mesostriatal innervation of striosomes and extrastriosomal matrix. Neuroscience (1987) 1.27
Cellular replacement therapy for Parkinson's disease--where we are today? Neuroscientist (2002) 1.25
Glial cell line-derived neurotrophic factor is expressed in the developing but not adult striatum and stimulates developing dopamine neurons in vivo. Exp Neurol (1993) 1.19
Ontogeny and distribution of glial cell line-derived neurotrophic factor (GDNF) mRNA in rat. Brain Res Dev Brain Res (1995) 1.07
Striatal expression of GDNF and differential vulnerability of midbrain dopaminergic cells. Eur J Neurosci (2005) 0.99
Fifty years of dopamine research. Trends Neurosci (2007) 0.97
Development of a maturing T-cell-mediated immune response in patients with idiopathic Parkinson's disease receiving r-metHuGDNF via continuous intraputaminal infusion. J Clin Immunol (2007) 0.96
Lentivector-mediated delivery of GDNF protects complex motor functions relevant to human Parkinsonism in a rat lesion model. Eur J Neurosci (2005) 0.95
Reformation of the nigrostriatal pathway by fetal dopaminergic micrografts into the substantia nigra is critically dependent on the age of the host. Exp Neurol (1999) 0.90
AAV2-mediated gene transfer of GDNF to the striatum of MPTP monkeys enhances the survival and outgrowth of co-implanted fetal dopamine neurons. Exp Neurol (2008) 0.88
Efferent synaptic connections of dopaminergic neurons grafted into the caudate nucleus of experimentally induced parkinsonian monkeys are different from those of control animals. Exp Brain Res (1998) 0.86
Intranigral ventral mesencephalic grafts and nigrostriatal injections of glial cell line-derived neurotrophic factor restore dopamine release in the striatum of 6-hydroxydopamine-lesioned rats. Exp Brain Res (1998) 0.85
Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP-treated monkeys: feasibility relevant to multiple-target grafting as a therapy for Parkinson's disease. J Comp Neurol (2002) 0.84
Embryonic substantia nigra grafts show directional outgrowth to cografted striatal grafts and potential for pathway reconstruction in nonhuman primate. Cell Transplant (2008) 0.83
Reconstruction of the nigrostriatal pathway by simultaneous intrastriatal and intranigral dopaminergic transplants. J Neurosci (1996) 0.82
Reconstruction of the striato-nigro-striatal circuitry by simultaneous double dopaminergic grafts: a tracer study using fluorogold and horseradish peroxidase. Brain Res (1997) 0.81
Evidence that histochemically distinct zones of the primate substantia nigra pars compacta are related to patterned distributions of nigrostriatal projection neurons and striatonigral fibers. Exp Brain Res (1989) 0.80
Simultaneous intrastriatal and intranigral grafting (double grafts) in the rat model of Parkinson's disease. Brain Res Brain Res Rev (2000) 0.80
The substantia nigra and its relations with the striatum in the monkey. Prog Brain Res (1991) 0.79
Bridge grafts of fibroblast growth factor-4-secreting schwannoma cells promote functional axonal regeneration in the nigrostriatal pathway of the adult rat. Neuroscience (1996) 0.78
Functional and anatomical reconstruction of the 6-hydroxydopamine lesioned nigrostriatal system of the adult rat. Neuroscience (1996) 0.78
Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions. J Virol (1998) 8.45
Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield. Gene Ther (1999) 7.96
Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus. J Virol (1998) 7.76
Site-specific integration by adeno-associated virus. Proc Natl Acad Sci U S A (1990) 7.06
Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector. J Virol (1996) 6.43
Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors. J Virol (1996) 6.22
Cloning of adeno-associated virus into pBR322: rescue of intact virus from the recombinant plasmid in human cells. Proc Natl Acad Sci U S A (1982) 5.73
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain. Nat Genet (1994) 5.49
Rescue of adeno-associated virus from recombinant plasmids: gene correction within the terminal repeats of AAV. Cell (1983) 5.27
AlphaVbeta5 integrin: a co-receptor for adeno-associated virus type 2 infection. Nat Med (1999) 5.26
Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: an anterograde tract-tracing study with Phaseolus vulgaris leucoagglutinin. J Comp Neurol (1989) 4.96
Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo. Gene Ther (2003) 4.92
A recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replication. J Virol (1987) 4.57
Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis. Gene Ther (2001) 4.35
Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science (2000) 3.89
Infectious entry pathway of adeno-associated virus and adeno-associated virus vectors. J Virol (2000) 3.84
The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia. Neuropsychopharmacology (1999) 3.78
Several log increase in therapeutic transgene delivery by distinct adeno-associated viral serotype vectors. Mol Ther (2000) 3.32
In vitro resolution of covalently joined AAV chromosome ends. Cell (1990) 3.24
Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector. Brain Res (1996) 3.03
alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease. Proc Natl Acad Sci U S A (2002) 2.81
Features of the adeno-associated virus origin involved in substrate recognition by the viral Rep protein. J Virol (1993) 2.69
Unilateral transplantation of human fetal mesencephalic tissue into the caudate nucleus of patients with Parkinson's disease. N Engl J Med (1992) 2.39
Cellular recombination pathways and viral terminal repeat hairpin structures are sufficient for adeno-associated virus integration in vivo and in vitro. J Virol (1997) 2.32
Role for highly regulated rep gene expression in adeno-associated virus vector production. J Virol (1997) 2.19
Evidence that angiotensin enhances transmitter release during sympathetic nerve stimulation. Br J Pharmacol (1971) 2.17
Identification of a repeated sequence element required for efficient encapsidation of the adenovirus type 5 chromosome. J Virol (1987) 2.09
Selective and rapid uptake of adeno-associated virus type 2 in brain. Hum Gene Ther (1998) 2.06
Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity. J Pharmacol Exp Ther (1973) 2.05
Controlled release of dopamine from a polymeric brain implant: in vivo characterization. Ann Neurol (1989) 2.01
Enduring cognitive deficits and cortical dopamine dysfunction in monkeys after long-term administration of phencyclidine. Science (1997) 2.01
Colocalization of adeno-associated virus Rep and capsid proteins in the nuclei of infected cells. J Virol (1992) 1.86
Regulated high level expression of a human gamma-globin gene introduced into erythroid cells by an adeno-associated virus vector. Proc Natl Acad Sci U S A (1992) 1.82
Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease. Hum Gene Ther (2000) 1.81
Insertional mutagenesis of AAV2 capsid and the production of recombinant virus. Virology (1999) 1.76
Recombinant adeno-associated virus-mediated gene transfer into hematopoietic progenitor cells. Blood (1994) 1.75
Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations. Brain Res (1997) 1.75
Immune responses to AAV in a phase I study for Canavan disease. J Gene Med (2006) 1.74
Gene transfer by adeno-associated virus vectors into the central nervous system. Exp Neurol (1997) 1.73
A combination of BDNF and NT-3 promotes supraspinal axonal regeneration into Schwann cell grafts in adult rat thoracic spinal cord. Exp Neurol (1995) 1.70
The role of Kupffer cell oxidant production in early ethanol-induced liver disease. Free Radic Biol Med (2001) 1.69
Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys. Proc Natl Acad Sci U S A (1996) 1.66
Deprenyl in Parkinson's disease. Lancet (1977) 1.66
Sustained and complete phenotype correction of hemophilia B mice following intramuscular injection of AAV1 serotype vectors. Mol Ther (2001) 1.65
Dopamine synaptic complex with pyramidal neurons in primate cerebral cortex. Proc Natl Acad Sci U S A (1989) 1.64
Acceleration of noradrenaline biosynthesis in the guinea-pig vas deferens by potassium. Br J Pharmacol (1970) 1.64
Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease. J Neurosci (1995) 1.61
Comparison of effects of L-dopa, amphetamine and apomorphine on firing rate of rat dopaminergic neurones. Nat New Biol (1973) 1.61
Rapid purification of covalently closed circular DNAs of bacterial plasmids and animal tumor viruses. Anal Biochem (1980) 1.60
A novel 165-base-pair terminal repeat sequence is the sole cis requirement for the adeno-associated virus life cycle. J Virol (1997) 1.57
Lentiviral gene transfer to the nonhuman primate brain. Exp Neurol (1999) 1.56
Selective reduction of tryptophan hydroxylase activity in rat forebrain after midbrain raphe lesions. Brain Res (1971) 1.54
Direct intramuscular injection with recombinant AAV vectors results in sustained expression in a dog model of hemophilia. Gene Ther (1998) 1.52
Targeted adeno-associated virus vector transduction of nonpermissive cells mediated by a bispecific F(ab'gamma)2 antibody. Nat Biotechnol (1999) 1.51
Comparison of Coxiella burnetii shedding in milk of dairy bovine, caprine, and ovine herds. J Dairy Sci (2007) 1.51
Insulin-like growth factor-I is necessary for neural stem cell proliferation and demonstrates distinct actions of epidermal growth factor and fibroblast growth factor-2. J Neurosci (2001) 1.48
Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy. Proc Natl Acad Sci U S A (2001) 1.47
Robust spinal motor neuron transduction following intrathecal delivery of AAV9 in pigs. Gene Ther (2011) 1.47
AAV vectors: is clinical success on the horizon? Gene Ther (2000) 1.47
The determinants of stress-induced activation of the prefrontal cortical dopamine system. Prog Brain Res (1990) 1.45
Choline: selective accumulation by central cholinergic neurons. J Neurochem (1973) 1.45
Adeno-associated virus vectors for gene therapy: more pros than cons? Mol Med Today (2000) 1.45
Dopamine synthesis, uptake, metabolism, and receptors: relevance to gene therapy of Parkinson's disease. Exp Neurol (1997) 1.43
Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension. Nat Biotechnol (2000) 1.42
A gene therapy approach to regulated delivery of erythropoietin as a function of oxygen tension. Hum Gene Ther (1997) 1.42
Anti-HPA-4b (anti-Yuk(a)) neonatal alloimmune thrombocytopenia: first report in a Caucasian family. Transfus Med (1992) 1.42
Susceptibility to a parkinsonian toxin varies during primate development. Exp Neurol (2012) 1.41
Tumor necrosis factor alpha is toxic to embryonic mesencephalic dopamine neurons. Exp Neurol (2001) 1.40
Fetal neural graft survival. Lancet (1990) 1.40
Genes for IFN-beta-2 (IL-6), tumor necrosis factor, and IL-1 are expressed at high levels in the organs of normal individuals. J Immunol (1988) 1.39
Comment on Roth appliance. Am J Orthod Dentofacial Orthop (1993) 1.39
Treatment of diseases of the central nervous system using encapsulated cells. Adv Tech Stand Neurosurg (1999) 1.39
Phenotypic correction of Fanconi anemia in human hematopoietic cells with a recombinant adeno-associated virus vector. J Clin Invest (1994) 1.39
Syngeneic Schwann cells derived from adult nerves seeded in semipermeable guidance channels enhance peripheral nerve regeneration. J Neurosci (1992) 1.38
Spontaneous blink rates correlate with dopamine levels in the caudate nucleus of MPTP-treated monkeys. Exp Neurol (1999) 1.38
Fetal tissue grafting into the central nervous system: yesterday, today, and tomorrow. Neurosurgery (1993) 1.38
Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates. Gene Ther (2006) 1.38
Role of the amygdala in the coordination of behavioral, neuroendocrine, and prefrontal cortical monoamine responses to psychological stress in the rat. J Neurosci (1996) 1.38
Roles of adeno-associated virus Rep protein and human chromosome 19 in site-specific recombination. J Virol (2000) 1.37
Interferon messenger RNA is produced constitutively in the organs of normal individuals. Proc Natl Acad Sci U S A (1987) 1.36
Deprenyl is metabolized to methamphetamine and amphetamine in man. Br J Clin Pharmacol (1978) 1.35
Tissue reaction to intraperitoneal polymer implants: species difference and effects of corticoid and doxorubicin. J Biomed Mater Res (1989) 1.32
Novel transcriptional regulatory signals in the adeno-associated virus terminal repeat A/D junction element. J Virol (2000) 1.32
Isolation of multipotent neural precursors residing in the cortex of the adult human brain. Exp Neurol (2001) 1.32
Variations in noradrenaline output with respect to stimulus frequency, train length and origin of the transmitter. Br J Pharmacol (1972) 1.32
Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6. Gene Ther (2009) 1.31
Regrowth of axons into the distal spinal cord through a Schwann-cell-seeded mini-channel implanted into hemisected adult rat spinal cord. Eur J Neurosci (1999) 1.30
Estrogen is essential for maintaining nigrostriatal dopamine neurons in primates: implications for Parkinson's disease and memory. J Neurosci (2000) 1.30
Lentiviral vectors as a gene delivery system in the mouse midbrain: cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF. Exp Neurol (2000) 1.29
Deprenyl administration in man: a selective monoamine oxidase B inhibitor without the 'cheese effect'. Psychopharmacology (Berl) (1978) 1.29
High affinity binding of 125I-Labeled mouse interferon to a specific cell surface receptor. II. Analysis of binding properties. Virology (1981) 1.29
Recombinant adeno-associated virus (rAAV)-mediated expression of a human gamma-globin gene in human progenitor-derived erythroid cells. Proc Natl Acad Sci U S A (1994) 1.28
Pharmacology of mesocortical dopamine neurons. Pharmacol Rev (1983) 1.27