Published in In Vivo on May 05, 2009
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High-throughput screening identifies two classes of antibiotics as radioprotectors: tetracyclines and fluoroquinolones. Clin Cancer Res (2009) 1.02
Bactericidal/permeability-increasing protein (rBPI21) and fluoroquinolone mitigate radiation-induced bone marrow aplasia and death. Sci Transl Med (2011) 0.98
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Synthetic protection short interfering RNA screen reveals glyburide as a novel radioprotector. Radiat Res (2009) 0.87
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Conditional radioresistance of Tet-inducible manganese superoxide dismutase bone marrow stromal cell lines. Radiat Res (2013) 0.85
Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. Sci Rep (2015) 0.85
Evaluating Radioprotective Effect of Hesperidin on Acute Radiation Damage in the Lung Tissue of Rats. J Biomed Phys Eng (2016) 0.82
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Radioprotective properties of tocopherol succinate against ionizing radiation in mice. J Radiat Res (2012) 0.80
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Protective effects of polysaccharides from Sipunculus nudus on Beagle dogs exposed to γ-radiation. PLoS One (2014) 0.78
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Protective effects of sodium selenite supplementation against irradiation-induced damage in non-cancerous human esophageal cells. Oncol Lett (2016) 0.75
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An amino acid-based oral rehydration solution (AA-ORS) enhanced intestinal epithelial proliferation in mice exposed to radiation. Sci Rep (2016) 0.75
Protective effect of an antithyroid compound against γ-radiation-induced damage in human colon cancer cells. Radiat Environ Biophys (2014) 0.75
ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer (2003) 16.06
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Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev (2001) 12.46
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science (2005) 11.31
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Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer (2004) 7.91
Gastric cancer originating from bone marrow-derived cells. Science (2004) 6.04
An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models. Science (2008) 4.89
Macrophage diversity in renal injury and repair. J Clin Invest (2008) 4.41
HST2 mediates SIR2-independent life-span extension by calorie restriction. Science (2005) 4.12
Delayed ageing through damage protection by the Arf/p53 pathway. Nature (2007) 3.87
Sirtuins: critical regulators at the crossroads between cancer and aging. Oncogene (2007) 3.85
Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. Cell (2002) 3.71
Exploring the role of cancer stem cells in radioresistance. Nat Rev Cancer (2008) 3.56
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PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome. Cell Stem Cell (2008) 2.68
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Interference with transforming growth factor-beta/ Smad3 signaling results in accelerated healing of wounds in previously irradiated skin. Am J Pathol (2003) 1.64
Targeting multiple arms of the apoptotic regulatory machinery. Cancer Res (2007) 1.59
Manganese superoxide dismutase (SOD2) inhibits radiation-induced apoptosis by stabilization of the mitochondrial membrane. Radiat Res (2002) 1.46
Targeted induction of apoptosis in cancer management: the emerging role of tumor necrosis factor-related apoptosis-inducing ligand receptor activating agents. J Clin Oncol (2005) 1.44
The human Bloom syndrome gene suppresses the DNA replication and repair defects of yeast dna2 mutants. Proc Natl Acad Sci U S A (2003) 1.42
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A mitochondria-targeted nitroxide/hemigramicidin S conjugate protects mouse embryonic cells against gamma irradiation. Int J Radiat Oncol Biol Phys (2008) 1.39
Deficiency of microvascular thrombomodulin and up-regulation of protease-activated receptor-1 in irradiated rat intestine: possible link between endothelial dysfunction and chronic radiation fibrosis. Am J Pathol (2002) 1.39
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Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection. Free Radic Biol Med (2007) 1.37
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Suppression of the malignant phenotype of human glioma cells by overexpression of manganese superoxide dismutase. Oncogene (1997) 1.25
Manganese-containing superoxide dismutase overexpression causes phenotypic reversion in SV40-transformed human lung fibroblasts. Cancer Res (1996) 1.24
Modulation of radiation-induced tumour necrosis factor alpha (TNF-alpha) expression in the lung tissue by pentoxifylline. Radiother Oncol (2002) 1.24
Normal cellular radiosensitivity in an adult Fanconi anaemia patient with marked clinical radiosensitivity. Radiother Oncol (2001) 1.24
Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice. Blood (2006) 1.23
Bone marrow sinusoidal endothelial cells undergo nonapoptotic cell death and are replaced by proliferating sinusoidal cells in situ to maintain the vascular niche following lethal irradiation. Exp Hematol (2008) 1.22
Werner and Bloom helicases are involved in DNA repair in a complementary fashion. Oncogene (2002) 1.22
Apoptotic interactions of cytochrome c: redox flirting with anionic phospholipids within and outside of mitochondria. Biochim Biophys Acta (2006) 1.15
Ascorbate as a "redox sensor" and protector against irradiation-induced oxidative stress in 32D CL 3 hematopoietic cells and subclones overexpressing human manganese superoxide dismutase. Int J Radiat Oncol Biol Phys (2004) 1.13
Differing roles of mitochondrial nitric oxide synthase in cardiomyocytes and urothelial cells. Am J Physiol Heart Circ Physiol (2004) 1.13
Radioprotective gene therapy. Curr Gene Ther (2003) 1.12
Deterministic rather than stochastic factors explain most of the variation in the expression of skin telangiectasia after radiotherapy. Int J Radiat Oncol Biol Phys (2002) 1.10
Proapoptotic activity of new glutathione S-transferase inhibitors. Cancer Res (2005) 1.10
Treatment of radiation nephropathy with ACE inhibitors and AII type-1 and type-2 receptor antagonists. Curr Pharm Des (2007) 1.10
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The origins and early evolution of DNA mismatch repair genes--multiple horizontal gene transfers and co-evolution. Nucleic Acids Res (2007) 1.10
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Inhalation delivery of manganese superoxide dismutase-plasmid/liposomes protects the murine lung from irradiation damage. Gene Ther (2005) 1.03
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Radioprotection by vitamin E: injectable vitamin E administered alone or with WR-3689 enhances survival of irradiated mice. Int J Radiat Oncol Biol Phys (1992) 1.03
The "pro-apoptotic genies" get out of mitochondria: oxidative lipidomics and redox activity of cytochrome c/cardiolipin complexes. Chem Biol Interact (2006) 1.01
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Intraesophageal MnSOD-plasmid liposome enhances engraftment and self-renewal of bone marrow derived progenitors of esophageal squamous epithelium. Gene Ther (2007) 1.00
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Striking regression of subcutaneous fibrosis induced by high doses of gamma rays using a combination of pentoxifylline and alpha-tocopherol: an experimental study. Int J Radiat Oncol Biol Phys (1999) 0.97
Identification of nitroxide radioprotectors. Radiat Res (1992) 0.97
Dosimetric predictors of radiation-induced lung injury. Int J Radiat Oncol Biol Phys (2002) 0.96
Modulation of radiation-induced life shortening by systemic intravenous MnSOD-plasmid liposome gene therapy. Radiat Res (2008) 0.96
Homologous recombination is the principal pathway for the repair of DNA damage induced by tirapazamine in mammalian cells. Cancer Res (2008) 0.96
Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted antioxidants. Crit Care Med (2007) 0.95
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Activation of the nitric oxide synthase 2 pathway in the response of bone marrow stromal cells to high doses of ionizing radiation. Radiat Res (2000) 0.91
Vascular endothelial cells produce soluble factors that mediate the recovery of human hematopoietic stem cells after radiation injury. Biol Blood Marrow Transplant (2006) 0.90
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Overexpression of the MnSOD transgene product protects cryopreserved bone marrow hematopoietic progenitor cells from ionizing radiation. Radiat Res (2007) 0.86
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Enhancement of radioprotection and anti-tumor immunity by yeast-derived beta-glucan in mice. J Med Food (2005) 0.81