Published in PLoS Pathog on May 15, 2009
Leishmaniasis: complexity at the host-pathogen interface. Nat Rev Microbiol (2011) 2.93
Apoptosis mediated leishmanicidal activity of Azadirachta indica bioactive fractions is accompanied by Th1 immunostimulatory potential and therapeutic cure in vivo. Parasit Vectors (2015) 1.41
Dynamic imaging of experimental Leishmania donovani-induced hepatic granulomas detects Kupffer cell-restricted antigen presentation to antigen-specific CD8 T cells. PLoS Pathog (2010) 1.32
Inhibitory receptors on lymphocytes: insights from infections. J Immunol (2012) 1.30
The PD-1/PD-L1 (B7-H1) pathway in chronic infection-induced cytotoxic T lymphocyte exhaustion. J Biomed Biotechnol (2011) 1.22
CD8 cells of patients with diffuse cutaneous leishmaniasis display functional exhaustion: the latter is reversed, in vitro, by TLR2 agonists. PLoS Negl Trop Dis (2010) 1.20
Programmed death 1-mediated T cell exhaustion during visceral leishmaniasis impairs phagocyte function. J Immunol (2013) 1.14
Murine visceral leishmaniasis: IgM and polyclonal B-cell activation lead to disease exacerbation. Eur J Immunol (2010) 1.11
Immunobiology of visceral leishmaniasis. Front Immunol (2012) 1.10
CD8 T cell exhaustion in human visceral leishmaniasis. J Infect Dis (2013) 1.06
Impairment of T cell function in parasitic infections. PLoS Negl Trop Dis (2014) 1.01
T cell exhaustion in protozoan disease. Trends Parasitol (2012) 1.01
Immunotherapy and targeted therapies in treatment of visceral leishmaniasis: current status and future prospects. Front Immunol (2014) 1.00
IL-10-producing Th1 cells and disease progression are regulated by distinct CD11c⁺ cell populations during visceral leishmaniasis. PLoS Pathog (2012) 1.00
Therapeutic vaccination with recombinant adenovirus reduces splenic parasite burden in experimental visceral leishmaniasis. J Infect Dis (2012) 0.98
Hyperlipidemia offers protection against Leishmania donovani infection: role of membrane cholesterol. J Lipid Res (2012) 0.97
Parasite-derived arginase influences secondary anti-Leishmania immunity by regulating programmed cell death-1-mediated CD4+ T cell exhaustion. J Immunol (2013) 0.94
Regulation of immunity during visceral Leishmania infection. Parasit Vectors (2016) 0.92
Live attenuated Leishmania donovani p27 gene knockout parasites are nonpathogenic and elicit long-term protective immunity in BALB/c mice. J Immunol (2013) 0.92
CD8(+) T cells in leishmania infections: friends or foes? Front Immunol (2012) 0.92
Immunoregulation in human American leishmaniasis: balancing pathology and protection. Parasite Immunol (2014) 0.90
Vaccine Development Against Leishmania donovani. Front Immunol (2012) 0.90
Malaria drives T cells to exhaustion. Front Microbiol (2014) 0.90
Role of CD8(+) T cells in protection against Leishmania donovani infection in healed Visceral Leishmaniasis individuals. BMC Infect Dis (2014) 0.88
Immune regulation during chronic visceral leishmaniasis. PLoS Negl Trop Dis (2014) 0.88
Lessons from other diseases: granulomatous inflammation in leishmaniasis. Semin Immunopathol (2015) 0.85
Differential Regulation of the Immune Response in the Spleen and Liver of Mice Infected with Leishmania donovani. J Trop Med (2011) 0.84
Identifying vaccine targets for anti-leishmanial vaccine development. Expert Rev Vaccines (2014) 0.82
IRF-5-Mediated Inflammation Limits CD8+ T Cell Expansion by Inducing HIF-1α and Impairing Dendritic Cell Functions during Leishmania Infection. PLoS Pathog (2015) 0.80
The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis. Front Immunol (2016) 0.79
Dysfunctional adaptive immunity during parasitic infections. Curr Immunol Rev (2013) 0.78
Post-Genomics and Vaccine Improvement for Leishmania. Front Microbiol (2016) 0.78
Dual immune modulatory effect of vitamin A in human visceral leishmaniasis. PLoS One (2014) 0.76
Modulation of Innate Immune Mechanisms to Enhance Leishmania Vaccine-Induced Immunity: Role of Coinhibitory Molecules. Front Immunol (2016) 0.76
Leishmania-encoded orthologs of macrophage migration inhibitory factor regulate host immunity to promote parasite persistence. FASEB J (2016) 0.76
Infection-adapted emergency hematopoiesis promotes visceral leishmaniasis. PLoS Pathog (2017) 0.76
CD4+ Recent Thymic Emigrants Are Recruited into Granulomas during Leishmania donovani Infection but Have Limited Capacity for Cytokine Production. PLoS One (2016) 0.75
The Combined Deficiency of Immunoproteasome Subunits Affects Both the Magnitude and Quality of Pathogen- and Genetic Vaccination-Induced CD8+ T Cell Responses to the Human Protozoan Parasite Trypanosoma cruzi. PLoS Pathog (2016) 0.75
Splenic CD4+ T Cells in Progressive Visceral Leishmaniasis Show a Mixed Effector-Regulatory Phenotype and Impair Macrophage Effector Function through Inhibitory Receptor Expression. PLoS One (2017) 0.75
Structure-guided development of a high-affinity human Programmed Cell Death-1: Implications for tumor immunotherapy. EBioMedicine (2017) 0.75
Leishmanicidal Activity of Piper nigrum Bioactive Fractions is Interceded via Apoptosis In Vitro and Substantiated by Th1 Immunostimulatory Potential In Vivo. Front Microbiol (2015) 0.75
The role of PD-1 in regulation of macrophage apoptosis and its subversion by Leishmania donovani. Clin Transl Immunology (2017) 0.75
HIF-1α is a key regulator in potentiating suppressor activity and limiting the microbicidal capacity of MDSC-like cells during visceral leishmaniasis. PLoS Pathog (2017) 0.75
American tegumentary leishmaniasis: T-cell differentiation profile of cutaneous and mucosal forms-co-infection with Trypanosoma cruzi. Med Microbiol Immunol (2016) 0.75
Restoring function in exhausted CD8 T cells during chronic viral infection. Nature (2005) 28.04
Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med (2002) 23.42
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med (2000) 19.81
Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity (1998) 17.27
Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat Immunol (2003) 15.51
Viral immune evasion due to persistence of activated T cells without effector function. J Exp Med (1998) 14.39
The B7 family revisited. Annu Rev Immunol (2005) 13.51
Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity (2007) 12.98
Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. J Immunol Methods (2003) 11.81
Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity (2007) 10.83
Effector and memory T-cell differentiation: implications for vaccine development. Nat Rev Immunol (2002) 9.45
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nat Immunol (2005) 8.27
Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat Med (2003) 7.35
Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat Rev Immunol (2004) 7.16
Massive expansion of antigen-specific CD8+ T cells during an acute virus infection. Immunity (1998) 6.29
Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. J Immunol (2003) 6.07
Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates. J Exp Med (2008) 5.71
Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8(+) T cell responses. J Exp Med (2007) 5.22
Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. Nature (2006) 5.19
Estimating the precursor frequency of naive antigen-specific CD8 T cells. J Exp Med (2002) 5.16
Programmed contraction of CD8(+) T cells after infection. Nat Immunol (2002) 5.16
Cross-presentation, dendritic cells, tolerance and immunity. Annu Rev Immunol (2001) 5.15
In vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies. Science (2008) 5.09
Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8(+) T cell response to infection. Immunity (2007) 4.92
Shaping and reshaping CD8+ T-cell memory. Nat Rev Immunol (2008) 4.88
Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection. Immunity (2008) 4.25
CD8 T cell dysfunction during chronic viral infection. Curr Opin Immunol (2007) 3.87
Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells. J Exp Med (2007) 3.67
Interleukin 10 production correlates with pathology in human Leishmania donovani infections. J Clin Invest (1993) 3.28
Visualizing priming of virus-specific CD8+ T cells by infected dendritic cells in vivo. Nat Immunol (2002) 3.22
Size estimate of the alpha beta TCR repertoire of naive mouse splenocytes. J Immunol (2000) 3.14
Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy. Blood (2007) 3.00
Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells. Blood (2007) 2.93
In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma. J Clin Invest (1993) 2.84
CD69 is an immunoregulatory molecule induced following activation. Trends Immunol (2005) 2.83
Immune resistance orchestrated by the tumor microenvironment. Immunol Rev (2006) 2.83
Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major. J Exp Med (1997) 2.81
Splenic accumulation of IL-10 mRNA in T cells distinct from CD4+CD25+ (Foxp3) regulatory T cells in human visceral leishmaniasis. J Exp Med (2007) 2.75
Evolution of a complex T cell receptor repertoire during primary and recall bacterial infection. J Exp Med (1998) 2.32
B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression. Blood (2002) 2.17
CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major. J Immunol (2002) 2.16
IL-10 mediates susceptibility to Leishmania donovani infection. Eur J Immunol (2001) 1.99
Role of L3T4+ and LyT-2+ cells in experimental visceral leishmaniasis. J Immunol (1988) 1.87
Interleukin-10 (IL-10) in experimental visceral leishmaniasis and IL-10 receptor blockade as immunotherapy. Infect Immun (2002) 1.85
Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T-cell responses. Nat Med (2003) 1.75
T cell death and memory. Science (2001) 1.74
Immunization with a recombinant stage-regulated surface protein from Leishmania donovani induces protection against visceral leishmaniasis. J Immunol (2000) 1.72
Posttranscriptional regulation of II10 gene expression allows natural killer cells to express immunoregulatory function. Immunity (2008) 1.65
The immunopathology of experimental visceral leishmaniasis. Immunol Rev (2004) 1.64
Uptake of Leishmania major by dendritic cells is mediated by Fcgamma receptors and facilitates acquisition of protective immunity. J Exp Med (2006) 1.59
Quantification of repertoire diversity of influenza-specific epitopes with predominant public or private TCR usage. J Immunol (2006) 1.56
Fibroblasts as host cells in latent leishmaniosis. J Exp Med (2000) 1.54
Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8+ T cell functions during chronic viral infection. Proc Natl Acad Sci U S A (2007) 1.51
Immunological and genetic evidence for a crucial role of IL-10 in cutaneous lesions in humans infected with Leishmania braziliensis. J Immunol (2008) 1.46
Regulation of the expression of nitric oxide synthase and leishmanicidal activity by glycoconjugates of Leishmania lipophosphoglycan in murine macrophages. Proc Natl Acad Sci U S A (1996) 1.46
Intradermal infection model for pathogenesis and vaccine studies of murine visceral leishmaniasis. Infect Immun (2003) 1.38
Tumor-induced immune suppression of in vivo effector T-cell priming is mediated by the B7-H1/PD-1 axis and transforming growth factor beta. Cancer Res (2008) 1.38
Generation, specificity, and function of CD8+ T cells in Trypanosoma cruzi infection. Immunol Rev (2004) 1.36
B7-H1 up-regulation on myeloid dendritic cells significantly suppresses T cell immune function in patients with chronic hepatitis B. J Immunol (2007) 1.35
Blockade of PD-1/B7-H1 interaction restores effector CD8+ T cell responses in a hepatitis C virus core murine model. J Immunol (2008) 1.27
Leishmania antigens are presented to CD8+ T cells by a transporter associated with antigen processing-independent pathway in vitro and in vivo. J Immunol (2006) 1.22
Immunotherapy with OX40L-Fc or anti-CTLA-4 enhances local tissue responses and killing of Leishmania donovani. Eur J Immunol (2004) 1.19
Perforin and gamma interferon are critical CD8+ T-cell-mediated responses in vaccine-induced immunity against Leishmania amazonensis infection. Infect Immun (2003) 1.16
Subversion of host cell signalling by the protozoan parasite Leishmania. Parasitology (2005) 1.10
Delayed expansion and contraction of CD8+ T cell response during infection with virulent Salmonella typhimurium. J Immunol (2006) 1.09
Stable CD8+ T cell memory during persistent Trypanosoma cruzi infection. J Immunol (2008) 1.05
Cutting edge: dysfunctional CD8+ T cells reside in nonlymphoid tissues during chronic Trypanosoma cruzi infection. J Immunol (2003) 1.02
Altered course of visceral leishmaniasis in mice expressing transgenic I-E molecules. Eur J Immunol (1992) 0.99
Leishmania major modulates chemokine and chemokine receptor expression by dendritic cells and affects their migratory capacity. Infect Immun (2005) 0.99
Adoptive immunotherapy against experimental visceral leishmaniasis with CD8+ T cells requires the presence of cognate antigen. Infect Immun (2006) 0.98
Pathogen-imposed skewing of mouse chemokine and cytokine expression at the infected tissue site. J Clin Invest (2008) 0.97
Hybrid cell vaccination resolves Leishmania donovani infection by eliciting a strong CD8+ cytotoxic T-lymphocyte response with concomitant suppression of interleukin-10 (IL-10) but not IL-4 or IL-13. Infect Immun (2007) 0.86
T cells from Leishmania major-susceptible BALB/c mice have a defect in efficiently up-regulating CXCR3 upon activation. J Immunol (2008) 0.84
CD8+ T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes. Nat Med (2007) 2.79
Virulence of malaria is associated with differential expression of Plasmodium falciparum var gene subgroups in a case-control study. J Infect Dis (2006) 1.89
Defective CCR7 expression on dendritic cells contributes to the development of visceral leishmaniasis. Nat Immunol (2002) 1.44
Platelet factor 4 mediates inflammation in experimental cerebral malaria. Cell Host Microbe (2008) 1.34
IL-4 receptor expression on CD8+ T cells is required for the development of protective memory responses against liver stages of malaria parasites. J Exp Med (2005) 1.31
Characterization of conserved properties of hemagglutinin of H5N1 and human influenza viruses: possible consequences for therapy and infection control. BMC Struct Biol (2009) 1.27
Distinct roles for lymphotoxin-alpha and tumor necrosis factor in the control of Leishmania donovani infection. Am J Pathol (2004) 1.17
Key apoptotic pathways for heat-induced programmed germ cell death in the testis. Endocrinology (2003) 1.13
Identification of hemagglutinin structural domain and polymorphisms which may modulate swine H1N1 interactions with human receptor. BMC Struct Biol (2009) 1.09
Discovery of new therapeutic targets by the informational spectrum method. Curr Protein Pept Sci (2008) 1.06
Prevalence of insulin resistance and its association with metabolic syndrome criteria among Bolivian children and adolescents with obesity. BMC Pediatr (2008) 1.00
Mitochondria-dependent pathway is involved in heat-induced male germ cell death: lessons from mutant mice. Biol Reprod (2004) 0.97
Critical role of IRF-5 in the development of T helper 1 responses to Leishmania donovani infection. PLoS Pathog (2011) 0.96
Marginal zone B cells regulate antigen-specific T cell responses during infection. J Immunol (2012) 0.94
A human IL10 BAC transgene reveals tissue-specific control of IL-10 expression and alters disease outcome. Proc Natl Acad Sci U S A (2009) 0.94
CD4+ T cells modulate expansion and survival but not functional properties of effector and memory CD8+ T cells induced by malaria sporozoites. PLoS One (2011) 0.94
Lipoprotein lipase: A bioinformatics criterion for assessment of mutations as a risk factor for cardiovascular disease. Proteins (2008) 0.90
The role of long-range intermolecular interactions in discovery of new drugs. Expert Opin Drug Discov (2011) 0.86
CpG-enhanced CD8+ T-cell responses to peptide immunization are severely inhibited by B cells. Eur J Immunol (2010) 0.86
Differential Regulation of the Immune Response in the Spleen and Liver of Mice Infected with Leishmania donovani. J Trop Med (2011) 0.84
Insulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesis. Endocrinology (2009) 0.82
New in silico and conventional in vitro approaches to advance HIV drug discovery and design. Expert Opin Drug Discov (2012) 0.81
Protective CD8+ T cells induced by malaria sporozoites do not undergo modulation of interleukin-7 receptor expression. Infect Immun (2006) 0.81
Chemical-genetic induction of Malonyl-CoA decarboxylase in skeletal muscle. BMC Biochem (2014) 0.80
Functional role of caspases in heat-induced testicular germ cell apoptosis. Biol Reprod (2004) 0.80
Simple and general criterion for "in silico" screening of candidate HIV drugs. Curr Pharm Biotechnol (2013) 0.80
Genetic alterations in SMAD4 and K-ras in Serbian patients with endometrial carcinoma. Int J Gynecol Cancer (2012) 0.78
Evaluation and clinical application of changes in thyroid hormone and TSH levels in critically ill full-term newborns. J Perinat Med (2010) 0.78
Assessment of hepatitis C virus protein sequences with regard to interferon/ribavirin combination therapy response in patients with HCV genotype 1b. Protein J (2012) 0.76
In silico criterion for prediction of effects of p53 gene missense mutations on p53-Mdm2 feedback loop. Protein Pept Lett (2006) 0.75
The Polymorphism rs3024505 (C/T) Downstream of the IL10 Gene Is Associated with Crohn's Disease in Serbian Patients with Inflammatory Bowel Disease. Tohoku J Exp Med (2016) 0.75
Novel virtual screening protocol based on the combined use of molecular modeling and electron-ion interaction potential techniques to design HIV-1 integrase inhibitors. J Chem Inf Model (2007) 0.75
Natural Products as Promising Therapeutics for Treatment of Influenza Disease. Curr Pharm Des (2015) 0.75