Abnormal DNA methylation in CD4+ T cells from patients with systemic lupus erythematosus, systemic sclerosis, and dermatomyositis.

PubWeight™: 1.17‹?› | Rank: Top 10%

🔗 View Article (PMID 19444718)

Published in Scand J Rheumatol on January 01, 2009

Authors

W Lei1, Y Luo, W Lei, Y Luo, K Yan, S Zhao, Y Li, X Qiu, Y Zhou, H Long, M Zhao, Y Liang, Y Su, Q Lu

Author Affiliations

1: Department of Dermatology, Epigenetic Research Centre, Second Xiangya Hospital, Central South University, Changsha, China.

Articles citing this

Pathogenesis of human systemic lupus erythematosus: recent advances. Trends Mol Med (2010) 2.35

Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition. Cell Res (2013) 2.07

DNA methylation and gene expression changes in monozygotic twins discordant for psoriasis: identification of epigenetically dysregulated genes. PLoS Genet (2012) 1.35

Unraveling the genetic component of systemic sclerosis. Hum Genet (2012) 1.25

Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases. Trends Mol Med (2011) 1.25

cAMP-responsive element modulator (CREM)α protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus. J Biol Chem (2011) 1.07

Association of anti-RNA polymerase III autoantibodies and cancer in scleroderma. Arthritis Res Ther (2014) 1.04

Pathogenesis of type 1 diabetes: lessons from natural history studies of high-risk individuals. Ann N Y Acad Sci (2013) 1.02

Epigenetics and autoimmune diseases. Autoimmune Dis (2012) 0.97

Hypomethylation of IL10 and IL13 promoters in CD4+ T cells of patients with systemic lupus erythematosus. J Biomed Biotechnol (2010) 0.96

Types of DNA methylation status of the interspersed repetitive sequences for LINE-1, Alu, HERV-E and HERV-K in the neutrophils from systemic lupus erythematosus patients and healthy controls. J Hum Genet (2014) 0.95

Selected Aspects in the Pathogenesis of Autoimmune Diseases. Mediators Inflamm (2015) 0.95

Mbd2 promotes foxp3 demethylation and T-regulatory-cell function. Mol Cell Biol (2013) 0.92

Foxp3+ T-regulatory cells require DNA methyltransferase 1 expression to prevent development of lethal autoimmunity. Blood (2013) 0.92

DNA methylation patterns in naïve CD4+ T cells identify epigenetic susceptibility loci for malar rash and discoid rash in systemic lupus erythematosus. Lupus Sci Med (2015) 0.91

X chromosome gene methylation in peripheral lymphocytes from monozygotic twins discordant for scleroderma. Clin Exp Immunol (2012) 0.87

Autoimmune disease in the epigenetic era: how has epigenetics changed our understanding of disease and how can we expect the field to evolve? Expert Rev Clin Immunol (2015) 0.84

Epigenetic alterations and microRNA misexpression in cancer and autoimmune diseases: a critical review. Clin Rev Allergy Immunol (2014) 0.84

Effects of ultraviolet B exposure on DNA methylation in patients with systemic lupus erythematosus. Exp Ther Med (2013) 0.84

Perspectives on epigenetic-based immune intervention for rheumatic diseases. Arthritis Res Ther (2013) 0.83

The role of epigenetic mechanisms and processes in autoimmune disorders. Biologics (2012) 0.82

Plasma DNA aberrations in systemic lupus erythematosus revealed by genomic and methylomic sequencing. Proc Natl Acad Sci U S A (2014) 0.81

Emerging role of epigenetics in systemic sclerosis pathogenesis. Genes Immun (2014) 0.81

Hypomethylation and overexpression of ITGAL (CD11a) in CD4(+) T cells in systemic sclerosis. Clin Epigenetics (2014) 0.81

Environmental risk factors of systemic sclerosis. Semin Immunopathol (2015) 0.80

The real culprit in systemic lupus erythematosus: abnormal epigenetic regulation. Int J Mol Sci (2015) 0.80

Emerging Molecular and Biological Functions of MBD2, a Reader of DNA Methylation. Front Genet (2016) 0.80

Associations between the expression of epigenetically regulated genes and the expression of DNMTs and MBDs in systemic lupus erythematosus. PLoS One (2012) 0.79

Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation. JCI Insight (2016) 0.77

MBD4 gene is associated with rheumatoid arthritis in Chinese patients in Taiwan. Rheumatol Int (2010) 0.76

DNA methylation similarities in genes of black South Africans with systemic lupus erythematosus and systemic sclerosis. J Biomed Sci (2015) 0.75

TIGIT signaling pathway negatively regulates CD4(+) T cell responses in systemic lupus erythematosus. Immunology (2017) 0.75

Epigenetics in systemic lupus erythematosus. Biomed Rep (2015) 0.75

Genomics of lymphoid malignancies reveal major activation pathways in lymphocytes. J Autoimmun (2013) 0.75

DUSP23 is over-expressed and linked to the expression of DNMTs in CD4(+) T cells from systemic lupus erythematosus patients. Clin Exp Immunol (2016) 0.75

Unfolding the pathogenesis of scleroderma through genomics and epigenomics. J Autoimmun (2017) 0.75

Epigenetic involvement in etiopathogenesis and implications in treatment of systemic lupus erythematous. Inflamm Res (2017) 0.75

Epigenetics in SLE. Curr Rheumatol Rep (2017) 0.75

New insights into the epigenetics of inflammatory rheumatic diseases. Nat Rev Rheumatol (2017) 0.75

Down-regulation of MBD4 contributes to hypomethylation and overexpression of CD70 in CD4(+) T cells in systemic lupus erythematosus. Clin Epigenetics (2017) 0.75

Articles by these authors

The sequence of the human genome. Science (2001) 101.55

The genome sequence of Drosophila melanogaster. Science (2000) 74.32

Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry (1994) 48.75

A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature (2000) 47.15

A whole-genome assembly of Drosophila. Science (2000) 38.48

Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest (2001) 23.21

SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields. J Struct Biol (1996) 22.89

A protein interaction map of Drosophila melanogaster. Science (2003) 20.06

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature (1995) 13.80

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science (1999) 13.19

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell (2000) 11.90

Integration of cytogenetic landmarks into the draft sequence of the human genome. Nature (2001) 10.96

A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat Genet (1997) 10.93

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell (1992) 9.19

Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis. Osteoarthritis Cartilage (2004) 8.50

A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell (1994) 8.44

Neurogenesis in the adult is involved in the formation of trace memories. Nature (2001) 8.13

The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell (1999) 7.99

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature (2000) 7.46

LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature (2001) 7.44

Changes in forest biomass carbon storage in China between 1949 and 1998. Science (2001) 7.39

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science (1997) 7.31

Rapid method for measurement of bronchial responsiveness. Thorax (1983) 7.06

The genome of the natural genetic engineer Agrobacterium tumefaciens C58. Science (2001) 6.90

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem (1999) 6.88

The ClpXP and ClpAP proteases degrade proteins with carboxy-terminal peptide tails added by the SsrA-tagging system. Genes Dev (1998) 6.73

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature (1995) 6.62

Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke (2001) 6.61

RSC, an essential, abundant chromatin-remodeling complex. Cell (1996) 6.17

Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. Science (1997) 6.00

BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science (1999) 5.99

The evolution of H5N1 influenza viruses in ducks in southern China. Proc Natl Acad Sci U S A (2004) 5.87

A simple method for clinical assay of superoxide dismutase. Clin Chem (1988) 5.66

Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs. Mol Cell (1998) 5.60

Stimulation of bone formation in vitro and in rodents by statins. Science (1999) 5.55

Energetic optimization of ion conduction rate by the K+ selectivity filter. Nature (2001) 5.45

Traditional Framingham risk factors fail to fully account for accelerated atherosclerosis in systemic lupus erythematosus. Arthritis Rheum (2001) 5.36

Genetic diversity and disease control in rice. Nature (2000) 5.34

Macrophage tropism determinants of human immunodeficiency virus type 1 in vivo. J Virol (1992) 5.19

Spin-torque switching with the giant spin Hall effect of tantalum. Science (2012) 5.18

Extensive variation of human immunodeficiency virus type-1 in vivo. Nature (1988) 5.02

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature (2000) 4.68

Somatic mutations of the mitochondrial genome in human colorectal tumours. Nat Genet (1998) 4.67

Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke (2001) 4.64

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc Natl Acad Sci U S A (1995) 4.54

Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. Mol Cell (1999) 4.49

Femtosecond electronic response of atoms to ultra-intense X-rays. Nature (2010) 4.46

MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. Oncogene (2008) 4.43

A comparison of the Celera and Ensembl predicted gene sets reveals little overlap in novel genes. Cell (2001) 4.36

Past-year use of outpatient services for psychiatric problems in the National Comorbidity Survey. Am J Psychiatry (1999) 4.31

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev (1994) 4.30

The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and F. J Virol (1998) 4.26

Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J Biol Chem (2000) 4.24

Characterization of infectious molecular clones of simian immunodeficiency virus (SIVmac) and human immunodeficiency virus type 2: persistent infection of rhesus monkeys with molecularly cloned SIVmac. J Virol (1988) 4.24

Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors. Cancer Res (1999) 4.20

Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation. Curr Biol (2001) 4.16

A model for the mechanism of human topoisomerase I. Science (1998) 4.10

A viral phospholipase A2 is required for parvovirus infectivity. Dev Cell (2001) 3.97

Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues. J Exp Med (2001) 3.96

A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma. Nature (1994) 3.87

Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. EMBO J (1993) 3.85

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J Biol Chem (1998) 3.83

Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. Dev Biol (2001) 3.82

A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme. Mol Cell (1999) 3.80

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. J Clin Invest (2001) 3.79

Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa. Nat Genet (2000) 3.72

The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rate in hematologic malignancy patients: outcome of a pilot clinical study. Leukemia (2008) 3.69

Distinct physiological states of Plasmodium falciparum in malaria-infected patients. Nature (2007) 3.69

Auxin-induced expression of the soybean GH3 promoter in transgenic tobacco plants. Plant Mol Biol (1991) 3.67

Methylotrophic bacteria: biochemical diversity and genetics. Science (1983) 3.65

Green fluorescent protein as a noninvasive intracellular pH indicator. Biophys J (1998) 3.61

Significance of premature stop codons in env of simian immunodeficiency virus. J Virol (1989) 3.60

Tumor necrosis factor-alpha synergizes with IFN-gamma in mediating killing of Leishmania major through the induction of nitric oxide. J Immunol (1990) 3.56

A model of protein synthesis based on cryo-electron microscopy of the E. coli ribosome. Nature (1995) 3.56

U(L)31 and U(L)34 proteins of herpes simplex virus type 1 form a complex that accumulates at the nuclear rim and is required for envelopment of nucleocapsids. J Virol (2001) 3.56

The significance of skeletal-related events for the health-related quality of life of patients with metastatic prostate cancer. Ann Oncol (2005) 3.56

The isolation of antibiotic-resistant salmonella from retail ground meats. N Engl J Med (2001) 3.55

Is routine indwelling catheterisation of the bladder for caesarean section necessary? A systematic review. BJOG (2010) 3.54

A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy. Nat Genet (2001) 3.52

Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Am J Hum Genet (2001) 3.51

Regulation of human placental development by oxygen tension. Science (1997) 3.49

Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease. Nature (1994) 3.46

Laboratory tests as predictors of disease exacerbations in systemic lupus erythematosus. Why some tests fail. Arthritis Rheum (1996) 3.40

Correction of deafness in shaker-2 mice by an unconventional myosin in a BAC transgene. Science (1998) 3.39

Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis. Cell (2000) 3.39

A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter. Mol Cell Biol (1993) 3.38

Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A. J Biol Chem (2001) 3.38

Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machinery. EMBO J (1999) 3.35

A search for proteins that interact genetically with histone H3 and H4 amino termini uncovers novel regulators of the Swe1 kinase in Saccharomyces cerevisiae. Genes Dev (1996) 3.35

The CC chemokine thymus-derived chemotactic agent 4 (TCA-4, secondary lymphoid tissue chemokine, 6Ckine, exodus-2) triggers lymphocyte function-associated antigen 1-mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules. J Exp Med (2000) 3.32

Changes to AIDS dementia complex in the era of highly active antiretroviral therapy. AIDS (1999) 3.28

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway. Oncogene (1999) 3.23

Generating yeast transcriptional activators containing no yeast protein sequences. Nature (1991) 3.21

Determinants of genital human papillomavirus detection in a US population. J Infect Dis (2001) 3.21

A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity. Pharm Res (1999) 3.19

Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis. Cell Prolif (2012) 3.18

Prevalence, correlates, and course of minor depression and major depression in the National Comorbidity Survey. J Affect Disord (1997) 3.18

Precise and ultrafast molecular sieving through graphene oxide membranes. Science (2014) 3.13

Gr-1+ myeloid cells derived from tumor-bearing mice inhibit primary T cell activation induced through CD3/CD28 costimulation. J Immunol (2000) 3.07