Published in Cell on August 06, 1999
The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors. Br J Pharmacol (2013) 5.74
Sleep state switching. Neuron (2010) 4.94
Identification of SLEEPLESS, a sleep-promoting factor. Science (2008) 4.56
History of the development of sleep medicine in the United States. J Clin Sleep Med (2005) 4.22
Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Am J Hum Genet (2001) 3.51
Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nat Genet (2009) 3.33
Control of sleep and wakefulness. Physiol Rev (2012) 3.06
Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior. Proc Natl Acad Sci U S A (2005) 3.05
Circadian topology of metabolism. Nature (2012) 2.63
Circadian rhythms, sleep, and metabolism. J Clin Invest (2011) 2.60
Orexin/hypocretin and histamine: distinct roles in the control of wakefulness demonstrated using knock-out mouse models. J Neurosci (2009) 2.35
Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants. PLoS Biol (2007) 2.34
Concomitant loss of dynorphin, NARP, and orexin in narcolepsy. Neurology (2005) 2.33
The orexin system regulates alcohol-seeking in rats. Br J Pharmacol (2006) 2.30
An essential role for orexins in emergence from general anesthesia. Proc Natl Acad Sci U S A (2008) 2.27
Genetics of sleep and sleep disorders. Cell (2011) 2.26
Monitoring neural activity with bioluminescence during natural behavior. Nat Neurosci (2010) 2.24
Canine genomics and genetics: running with the pack. PLoS Genet (2005) 2.23
Arousal effect of orexin A depends on activation of the histaminergic system. Proc Natl Acad Sci U S A (2001) 2.20
Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle. Proc Natl Acad Sci U S A (2009) 2.20
Identification of neuropeptide-like protein gene families in Caenorhabditiselegans and other species. Proc Natl Acad Sci U S A (2001) 2.19
Population structure and inbreeding from pedigree analysis of purebred dogs. Genetics (2008) 2.14
Role of lateral hypothalamic orexin neurons in reward processing and addiction. Neuropharmacology (2008) 2.06
Genome-wide association of sleep and circadian phenotypes. BMC Med Genet (2007) 2.05
Control of hypothalamic orexin neurons by acid and CO2. Proc Natl Acad Sci U S A (2007) 1.99
Chromosome-specific single-locus FISH probes allow anchorage of an 1800-marker integrated radiation-hybrid/linkage map of the domestic dog genome to all chromosomes. Genome Res (2001) 1.88
A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep. BMC Neurosci (2003) 1.88
The genetic and molecular regulation of sleep: from fruit flies to humans. Nat Rev Neurosci (2009) 1.82
Lateral hypothalamic orexin/hypocretin neurons: A role in reward-seeking and addiction. Brain Res (2009) 1.79
Lateral hypothalamic orexin neurons are critically involved in learning to associate an environment with morphine reward. Behav Brain Res (2007) 1.73
CSF hypocretin-1 levels in narcolepsy, Kleine-Levin syndrome, and other hypersomnias and neurological conditions. J Neurol Neurosurg Psychiatry (2003) 1.69
Neuropeptide transmission in brain circuits. Neuron (2012) 1.69
Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking. Eur J Neurosci (2009) 1.67
Circadian rhythm disturbances in depression. Hum Psychopharmacol (2008) 1.66
Clinical and therapeutic aspects of childhood narcolepsy-cataplexy: a retrospective study of 51 children. Sleep (2010) 1.64
Animal evolution during domestication: the domesticated fox as a model. Bioessays (2009) 1.64
Neuromodulation of brain states. Neuron (2012) 1.64
Conservation of sleep: insights from non-mammalian model systems. Trends Neurosci (2008) 1.62
An integrated 4249 marker FISH/RH map of the canine genome. BMC Genomics (2004) 1.61
Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice. Proc Natl Acad Sci U S A (2004) 1.61
Retrotransposon insertion in SILV is responsible for merle patterning of the domestic dog. Proc Natl Acad Sci U S A (2006) 1.61
Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice. J Neurosci (2011) 1.58
Sleep homeostasis modulates hypocretin-mediated sleep-to-wake transitions. J Neurosci (2009) 1.58
Short interspersed elements (SINEs) are a major source of canine genomic diversity. Genome Res (2005) 1.57
Noradrenergic transmission in the extended amygdala: role in increased drug-seeking and relapse during protracted drug abstinence. Brain Struct Funct (2008) 1.54
Orexin receptors: pharmacology and therapeutic opportunities. Annu Rev Pharmacol Toxicol (2011) 1.53
Methylphenidate actively induces emergence from general anesthesia. Anesthesiology (2011) 1.51
Man's best friend becomes biology's best in show: genome analyses in the domestic dog. Annu Rev Genet (2010) 1.51
Role of orexin/hypocretin in reward-seeking and addiction: implications for obesity. Physiol Behav (2010) 1.50
Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are associated with recent onset of cataplexy. Sleep (2010) 1.47
Leading the way: canine models of genomics and disease. Dis Model Mech (2010) 1.47
Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons. J Clin Invest (2007) 1.45
Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture. Proc Natl Acad Sci U S A (2009) 1.44
The hypocretins/orexins: integrators of multiple physiological functions. Br J Pharmacol (2014) 1.42
Mechanism for Hypocretin-mediated sleep-to-wake transitions. Proc Natl Acad Sci U S A (2012) 1.41
Control and function of the homeostatic sleep response by adenosine A1 receptors. J Neurosci (2009) 1.40
Effects of saporin-induced lesions of three arousal populations on daily levels of sleep and wake. J Neurosci (2007) 1.40
Circadian system, sleep and endocrinology. Mol Cell Endocrinol (2011) 1.38
Pharmacological and Genetic Modulation of REV-ERB Activity and Expression Affects Orexigenic Gene Expression. PLoS One (2016) 1.38
Melanin concentrating hormone depresses synaptic activity of glutamate and GABA neurons from rat lateral hypothalamus. J Physiol (2001) 1.38
Complex movement disorders at disease onset in childhood narcolepsy with cataplexy. Brain (2011) 1.35
The hypocretins as sensors for metabolism and arousal. J Physiol (2008) 1.35
Circadian and homeostatic regulation of structural synaptic plasticity in hypocretin neurons. Neuron (2010) 1.33
Genetic contributions to behavioural diversity at the gene-environment interface. Nat Rev Genet (2011) 1.32
Neuroimaging insights into the pathophysiology of sleep disorders. Sleep (2008) 1.31
Sleep/wake fragmentation disrupts metabolism in a mouse model of narcolepsy. J Physiol (2007) 1.30
Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy. Proc Natl Acad Sci U S A (2004) 1.29
Canine population structure: assessment and impact of intra-breed stratification on SNP-based association studies. PLoS One (2007) 1.29
Sleep-waking discharge patterns of neurons recorded in the rat perifornical lateral hypothalamic area. J Physiol (2002) 1.29
Orexin/hypocretin is necessary for context-driven cocaine-seeking. Neuropharmacology (2009) 1.29
Selective enhancement of synaptic inhibition by hypocretin (orexin) in rat vagal motor neurons: implications for autonomic regulation. J Neurosci (2003) 1.28
Hypocretin (orexin) enhances neuron activity and cell synchrony in developing mouse GFP-expressing locus coeruleus. J Physiol (2002) 1.28
Narcolepsy: immunological aspects. Sleep Med Rev (2008) 1.28
Genetic analysis of sleep. Genes Dev (2010) 1.26
Multiple roles for orexin/hypocretin in addiction. Prog Brain Res (2012) 1.26
Clinical and neurobiological aspects of narcolepsy. Sleep Med (2007) 1.26
The role of hypocretin in driving arousal and goal-oriented behaviors. Brain Res (2009) 1.25
An approximately 140-kb deletion associated with feline spinal muscular atrophy implies an essential LIX1 function for motor neuron survival. Genome Res (2006) 1.25
Centrally administered orexin A increases motivation for sweet pellets in rats. Psychopharmacology (Berl) (2005) 1.23
Innervation of orexin/hypocretin neurons by GABAergic, glutamatergic or cholinergic basal forebrain terminals evidenced by immunostaining for presynaptic vesicular transporter and postsynaptic scaffolding proteins. J Comp Neurol (2006) 1.23
Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep. J Neurosci (2011) 1.23
Adenosine inhibits activity of hypocretin/orexin neurons by the A1 receptor in the lateral hypothalamus: a possible sleep-promoting effect. J Neurophysiol (2006) 1.22
The diurnal rhythm of hypocretin in young and old F344 rats. Sleep (2004) 1.22
Metabolism-independent sugar sensing in central orexin neurons. Diabetes (2008) 1.21
Orexin signaling via the orexin 1 receptor mediates operant responding for food reinforcement. Biol Psychiatry (2010) 1.21
Activity of dorsal raphe cells across the sleep-waking cycle and during cataplexy in narcoleptic dogs. J Physiol (2004) 1.19
Addiction and arousal: the hypocretin connection. Physiol Behav (2007) 1.19
Adaptive sugar sensors in hypothalamic feeding circuits. Proc Natl Acad Sci U S A (2008) 1.18
GABAergic neurons intermingled with orexin and MCH neurons in the lateral hypothalamus discharge maximally during sleep. Eur J Neurosci (2010) 1.17
Developmental divergence of sleep-wake patterns in orexin knockout and wild-type mice. Eur J Neurosci (2007) 1.17
Decreased CSF histamine in narcolepsy with and without low CSF hypocretin-1 in comparison to healthy controls. Sleep (2009) 1.16
The cerebrospinal fluid: regulator of neurogenesis, behavior, and beyond. Cell Mol Life Sci (2012) 1.16
Translational profiling of hypocretin neurons identifies candidate molecules for sleep regulation. Genes Dev (2013) 1.15
Sleep neurobiology from a clinical perspective. Sleep (2011) 1.14
Regulation of synaptic efficacy in hypocretin/orexin-containing neurons by melanin concentrating hormone in the lateral hypothalamus. J Neurosci (2008) 1.14
New developments in sleep research: molecular genetics, gene expression, and systems neurobiology. J Neurosci (2008) 1.14
Discovery and development of orexin receptor antagonists as therapeutics for insomnia. Br J Pharmacol (2014) 1.14
A septal-hypothalamic pathway drives orexin neurons, which is necessary for conditioned cocaine preference. J Neurosci (2012) 1.13
Role of orexin/hypocretin in dependence and addiction. Brain Res (2009) 1.12
Eating disorder and metabolism in narcoleptic patients. Sleep (2007) 1.11
The sequence of the human genome. Science (2001) 101.55
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science (2009) 13.45
A physical map of the human genome. Nature (2001) 12.39
Ligation-independent cloning of PCR products (LIC-PCR). Nucleic Acids Res (1990) 12.16
The functioning and well-being of depressed patients. Results from the Medical Outcomes Study. JAMA (1989) 12.07
Integration of cytogenetic landmarks into the draft sequence of the human genome. Nature (2001) 10.96
Hypocretin (orexin) deficiency in human narcolepsy. Lancet (2000) 7.92
A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med (2000) 7.05
Variations in resource utilization among medical specialties and systems of care. Results from the medical outcomes study. JAMA (1992) 6.88
Reverse transcriptase template switching: a SMART approach for full-length cDNA library construction. Biotechniques (2001) 5.92
Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev (1995) 5.53
Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev (1995) 5.51
A new bacteriophage P1-derived vector for the propagation of large human DNA fragments. Nat Genet (1994) 5.34
Patient and visit characteristics related to physicians' participatory decision-making style. Results from the Medical Outcomes Study. Med Care (1995) 5.17
Bacterial artificial chromosome libraries for mouse sequencing and functional analysis. Genome Res (2000) 5.13
The validity and relative precision of MOS short- and long-form health status scales and Dartmouth COOP charts. Results from the Medical Outcomes Study. Med Care (1992) 4.58
Activation of BPV-1 replication in vitro by the transcription factor E2. Nature (1991) 4.51
Dysferlin, a novel skeletal muscle gene, is mutated in Miyoshi myopathy and limb girdle muscular dystrophy. Nat Genet (1998) 4.38
Activation of Arp2/3 complex-mediated actin polymerization by cortactin. Nat Cell Biol (2001) 4.38
Genetic definition and sequence analysis of Arabidopsis centromeres. Science (1999) 4.20
Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility. J Cell Biol (1999) 4.20
A model for the mechanism of human topoisomerase I. Science (1998) 4.10
Health-related quality of life in patients served by the Department of Veterans Affairs: results from the Veterans Health Study. Arch Intern Med (1998) 4.07
Stable propagation of cosmid sized human DNA inserts in an F factor based vector. Nucleic Acids Res (1992) 3.97
Functioning and well-being outcomes of patients with depression compared with chronic general medical illnesses. Arch Gen Psychiatry (1995) 3.92
A bacterial artificial chromosome library for sequencing the complete human genome. Genome Res (2001) 3.81
GeneSplicer: a new computational method for splice site prediction. Nucleic Acids Res (2001) 3.71
An improved approach for construction of bacterial artificial chromosome libraries. Genomics (1998) 3.65
Inappropriate medication prescribing in skilled-nursing facilities. Ann Intern Med (1992) 3.63
A BAC-based physical map of the major autosomes of Drosophila melanogaster. Science (2000) 3.51
Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Am J Hum Genet (2001) 3.51
Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl Acad Sci U S A (1995) 3.47
Sequential assembly of myosin II, an IQGAP-like protein, and filamentous actin to a ring structure involved in budding yeast cytokinesis. J Cell Biol (1998) 3.44
Kleine-Levin syndrome: a systematic review of 186 cases in the literature. Brain (2005) 3.37
Differences in the mix of patients among medical specialties and systems of care. Results from the medical outcomes study. JAMA (1992) 3.32
Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. Blood (1996) 3.14
Familial patterns of narcolepsy. Lancet (1989) 3.07
Diuretic therapy for hypertension and the risk of primary cardiac arrest. N Engl J Med (1994) 3.04
Dopaminergic role in stimulant-induced wakefulness. J Neurosci (2001) 2.91
The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse. EMBO J (1996) 2.83
Detection of depressive disorder for patients receiving prepaid or fee-for-service care. Results from the Medical Outcomes Study. JAMA (1989) 2.79
Positional cloning of the mouse saccharin preference (Sac) locus. Chem Senses (2001) 2.75
The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches. Curr Biol (1997) 2.71
Activation of the yeast Arp2/3 complex by Bee1p, a WASP-family protein. Curr Biol (1999) 2.64
Complete genome sequence of the shrimp white spot bacilliform virus. J Virol (2001) 2.58
Structure of Arp2/3 complex in its activated state and in actin filament branch junctions. Science (2001) 2.58
In vivo analysis of plant promoters and transcription factors by agroinfiltration of tobacco leaves. Plant J (2000) 2.57
Low cerebrospinal fluid hypocretin (Orexin) and altered energy homeostasis in human narcolepsy. Ann Neurol (2001) 2.47
Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta. EMBO J (2000) 2.41
Simultaneous recovery of RNA and DNA from soils and sediments. Appl Environ Microbiol (2001) 2.38
Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia (2011) 2.37
Cytokinesis in eukaryotes: a mechanistic comparison. Curr Opin Cell Biol (1999) 2.36
Health status in VA patients: results from the Veterans Health Study. Am J Med Qual (1999) 2.35
Concomitant loss of dynorphin, NARP, and orexin in narcolepsy. Neurology (2005) 2.33
Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. J Biol Chem (1993) 2.30
Parasitisms of catfish and other farm-raised food fish. J Am Vet Med Assoc (1995) 2.29
Genetic dissection of the budding yeast Arp2/3 complex: a comparison of the in vivo and structural roles of individual subunits. Proc Natl Acad Sci U S A (1999) 2.29
A CLOCK polymorphism associated with human diurnal preference. Sleep (1998) 2.24
A comparative linkage map of oilseed rape and its use for QTL analysis of seed oil and erucic acid content. Theor Appl Genet (2006) 2.21
The retinoblastoma gene product regulates Sp1-mediated transcription. Mol Cell Biol (1992) 2.21
A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis. Genes Immun (2002) 2.21
A modular, positive selection bacterial artificial chromosome vector with multiple cloning sites. Genomics (1999) 2.17
Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases. J Biol Chem (1998) 2.17
Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Nature (2000) 2.17
The MHC haplotype project: a resource for HLA-linked association studies. Tissue Antigens (2002) 2.16
Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities. Eur J Neurosci (2001) 2.15
Direct involvement of yeast type I myosins in Cdc42-dependent actin polymerization. J Cell Biol (2000) 2.15
Dual function of Cyk2, a cdc15/PSTPIP family protein, in regulating actomyosin ring dynamics and septin distribution. J Cell Biol (1998) 2.14
DQ (rather than DR) gene marks susceptibility to narcolepsy. Lancet (1992) 2.08
Association between apolipoprotein E epsilon4 and sleep-disordered breathing in adults. JAMA (2001) 2.05
Phylogenetic relationships between toxic and non-toxic strains of the genus Microcystis based on 16S to 23S internal transcribed spacer sequence. FEMS Microbiol Lett (1999) 2.04
Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation. Nat Med (1998) 2.04
Latent variable models for longitudinal data with multiple continuous outcomes. Biometrics (2000) 2.02
Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor. Science (2000) 2.01
Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5. Proc Natl Acad Sci U S A (1995) 1.97
Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless. Development (2001) 1.96
Mutation rate varies among alleles at a microsatellite locus: phylogenetic evidence. Proc Natl Acad Sci U S A (1996) 1.96
Prospective comparison treatment of 595-nm pulsed-dye lasers for virgin port-wine stain. Br J Dermatol (2015) 1.96
BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations. J Cell Biol (2001) 1.96
Prevalence of Staphylococcus aureus carrying Panton-Valentine leukocidin genes among isolates from hospitalised patients in China. Clin Microbiol Infect (2008) 1.95
Independent evolution of the prochlorophyte and green plant chlorophyll a/b light-harvesting proteins. Proc Natl Acad Sci U S A (1996) 1.93
The course of depression in adult outpatients. Results from the Medical Outcomes Study. Arch Gen Psychiatry (1992) 1.91
The importance of radiating leg pain in assessing health outcomes among patients with low back pain. Results from the Veterans Health Study. Spine (Phila Pa 1976) (1998) 1.89
Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Nature (2000) 1.85
Divergent response to LPS and bacteria in CD14-deficient murine macrophages. J Immunol (2000) 1.84
Differential effects of BMI on diabetes risk among black and white Americans. Diabetes Care (1998) 1.84