Published in Br J Pharmacol on May 01, 2009
Recent Findings Concerning PAMAM Dendrimer Conjugates with Cyclodextrins as Carriers of DNA and RNA. Sensors (Basel) (2009) 0.81
Non-viral gene-activated matrices: next generation constructs for bone repair. Organogenesis (2013) 0.79
Cationic liposome-mediated transfection. Nature (1989) 3.46
Therapeutic antibodies: successes, limitations and hopes for the future. Br J Pharmacol (2009) 3.05
Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics. Br J Pharmacol (2009) 2.99
Gene transfer with synthetic cationic amphiphiles: prospects for gene therapy. Bioconjug Chem (1995) 2.46
Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers. Br J Pharmacol (2009) 1.77
Viral vectors: from virology to transgene expression. Br J Pharmacol (2009) 1.19
Physical methods of nucleic acid transfer: general concepts and applications. Br J Pharmacol (2009) 1.09
Nanotechnologies and controlled release systems for the delivery of antisense oligonucleotides and small interfering RNA. Br J Pharmacol (2009) 1.01
A Toll-like receptor recognizes bacterial DNA. Nature (2000) 26.34
Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol (2001) 18.80
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity (1998) 18.12
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity (1999) 17.40
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol (1999) 16.86
Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity (1999) 11.64
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J (1998) 9.36
Toll-like receptors control activation of adaptive immune responses. Nat Immunol (2001) 7.54
Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med (1997) 7.12
Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol (2001) 5.36
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep (2001) 5.32
Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J Biol Chem (1999) 4.38
Endovascular stent-graft placement for the treatment of acute aortic dissection. N Engl J Med (1999) 4.33
Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J Immunol (2000) 4.10
ASK1 is essential for JNK/SAPK activation by TRAF2. Mol Cell (1998) 3.98
IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production. J Immunol (1998) 3.56
Pig cloning by microinjection of fetal fibroblast nuclei. Science (2000) 3.51
Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway. Proc Natl Acad Sci U S A (2001) 3.49
Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation. Mol Biol Cell (1999) 3.27
Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J (1999) 3.19
Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages. J Immunol (2000) 3.10
CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med (2001) 3.05
Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Genes Dev (1999) 2.91
IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases. Int Immunol (1999) 2.84
Caspase-1 activation of IL-1beta and IL-18 are essential for Shigella flexneri-induced inflammation. Immunity (2000) 2.81
STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. Proc Natl Acad Sci U S A (1996) 2.64
TLR6: A novel member of an expanding toll-like receptor family. Gene (1999) 2.55
Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells. FEBS Lett (1996) 2.53
Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation. J Biol Chem (2000) 2.50
Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways. J Immunol (2000) 2.41
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis. J Exp Med (2001) 2.37
Nonmuscle myosin II-B is required for normal development of the mouse heart. Proc Natl Acad Sci U S A (1997) 2.35
Non-A, non-B hepatitis specific antibodies directed at host-derived epitope: implication for an autoimmune process. Lancet (1990) 2.35
Intraductal papillary mucinous tumors of the pancreas comprise 2 clinical subtypes: differences in clinical characteristics and surgical management. Arch Surg (1999) 2.33
The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function. J Exp Med (1999) 2.32
Role for mitochondrial oxidants as regulators of cellular metabolism. Mol Cell Biol (2000) 2.22
Quality of life and disease-related symptoms in previously treated Japanese patients with non-small-cell lung cancer: results of a randomized phase III study (V-15-32) of gefitinib versus docetaxel. Ann Oncol (2009) 2.14
Respiratory syncytial virus infection results in airway hyperresponsiveness and enhanced airway sensitization to allergen. J Clin Invest (1997) 2.10
Activation of hepatic NKT cells and subsequent liver injury following administration of alpha-galactosylceramide. Eur J Immunol (2000) 2.09
HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell. Nature (2001) 2.06
Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation. Genes Cells (2000) 2.05
Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades. Int Immunol (2000) 2.05
Role and regulation of prolyl hydroxylase domain proteins. Cell Death Differ (2008) 2.03
Rubber-degrading enzyme from a bacterial culture. Appl Environ Microbiol (1990) 1.99
Negative regulation of airway responsiveness that is dependent on gammadelta T cells and independent of alphabeta T cells. Nat Med (1999) 1.93
The liver as a crucial organ in the first line of host defense: the roles of Kupffer cells, natural killer (NK) cells and NK1.1 Ag+ T cells in T helper 1 immune responses. Immunol Rev (2000) 1.89
ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. Mol Cell Biol (1998) 1.88
Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice. J Exp Med (1998) 1.88
Passive transfer of immediate hypersensitivity and airway hyperresponsiveness by allergen-specific immunoglobulin (Ig) E and IgG1 in mice. J Clin Invest (1996) 1.86
Microbial degradation of natural rubber vulcanizates. Appl Environ Microbiol (1985) 1.85
Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18-gene-disrupted mice. Infect Immun (1999) 1.85
Differential regulation of Th1 and Th2 functions of NKT cells by CD28 and CD40 costimulatory pathways. J Immunol (2001) 1.85
Generalized resistance to thyroid hormone associated with a mutation in the ligand-binding domain of the human thyroid hormone receptor beta. Proc Natl Acad Sci U S A (1989) 1.85
Requirement of IL-4 and liver NK1+ T cells for concanavalin A-induced hepatic injury in mice. J Immunol (1997) 1.83
Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism. J Immunol (2001) 1.82
Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88. Curr Biol (2000) 1.81
Cytotoxic NK1.1 Ag+ alpha beta T cells with intermediate TCR induced in the liver of mice by IL-12. J Immunol (1995) 1.80
Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis. J Exp Med (2000) 1.77
Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for anti-inflammatory action. J Biol Chem (1999) 1.77
IkappaB kinase alpha is essential for mature B cell development and function. J Exp Med (2001) 1.76
Phase I pharmacokinetic trial of the selective oral epidermal growth factor receptor tyrosine kinase inhibitor gefitinib ('Iressa', ZD1839) in Japanese patients with solid malignant tumors. Ann Oncol (2003) 1.75
The effects of 2-nicotinamidoethyl nitrate on smooth muscle cells of the dog mesenteric artery and trachea. Br J Pharmacol (1983) 1.74
Antiviral response by natural killer cells through TRAIL gene induction by IFN-alpha/beta. Eur J Immunol (2001) 1.72
The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol. Eur J Immunol (2001) 1.71
Non-adrenergic inhibitory nerves and putative transmitters in the smooth muscle of cat trachea. J Physiol (1982) 1.71
A patch-clamp study of the partial agonist actions of tubocurarine on rat myotubes. J Physiol (1984) 1.70
A role for reactive oxygen species in endothelial cell anoikis. Circ Res (1999) 1.69
Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor. J Immunol (1999) 1.69
Caspase-1-independent, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in mice. Immunity (1999) 1.67
What are melanocytes really doing all day long...? Exp Dermatol (2009) 1.65
Development of eosinophilic airway inflammation and airway hyperresponsiveness requires interleukin-5 but not immunoglobulin E or B lymphocytes. Am J Respir Cell Mol Biol (1999) 1.64
STAT6 deficiency in a mouse model of allergen-induced airways inflammation abolishes eosinophilia but induces infiltration of CD8+ T cells. Clin Exp Allergy (1999) 1.64
Endothelial progenitor cells as putative targets for angiostatin. Cancer Res (1999) 1.63
Cutting edge: selective IL-18 requirements for induction of compartmental IFN-gamma responses during viral infection. J Immunol (2000) 1.63
Nationwide epidemiological survey of chronic pancreatitis in Japan. J Gastroenterol (2000) 1.62
Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex. Proc Natl Acad Sci U S A (2000) 1.62
Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation. Cell Death Differ (2005) 1.62
Sensing of cadmium and copper ions by externally exposed ADL, ASE, and ASH neurons elicits avoidance response in Caenorhabditis elegans. Neuroreport (1999) 1.60
A high-density transcript linkage map of barley derived from a single population. Heredity (Edinb) (2009) 1.59
Ectopic expression of MITF, a gene for Waardenburg syndrome type 2, converts fibroblasts to cells with melanocyte characteristics. Nat Genet (1996) 1.58
Culm Brittleness of Barley (Hordeum vulgare L.) Mutants Is Caused by Smaller Number of Cellulose Molecules in Cell Wall. Plant Physiol (1991) 1.57
The interface between innate and acquired immunity: glycolipid antigen presentation by CD1d-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes. Int Immunol (2000) 1.57
Expression and function of TNF-related apoptosis-inducing ligand on murine activated NK cells. J Immunol (1999) 1.57
Critical contribution of IFN-gamma and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of alpha-galactosylceramide. Eur J Immunol (2001) 1.56
Epistatic relationship between Waardenburg syndrome genes MITF and PAX3. Nat Genet (1998) 1.56
The late, but not early, asthmatic response is dependent on IL-5 and correlates with eosinophil infiltration. J Clin Invest (1999) 1.56
The hypoxic ventilatory response and TRPA1 antagonism in conscious mice. Acta Physiol (Oxf) (2013) 1.55
Transcatheter arterial embolization of ruptured pseudoaneurysms with coils and n-butyl cyanoacrylate. J Vasc Interv Radiol (2000) 1.54
Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function. J Immunol (2000) 1.52
Evaluation of a rapid immunochromatographic test for detection of antibodies to human immunodeficiency virus. J Clin Microbiol (1999) 1.51
Protein transduction domain of HIV-1 Tat protein promotes efficient delivery of DNA into mammalian cells. J Biol Chem (2001) 1.51
Identity of differentiation inducing factor and tumour necrosis factor. Nature (1986) 1.50
Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres. Genes Cells (1998) 1.50
Clock gene dysfunction in patients with obstructive sleep apnoea syndrome. Eur Respir J (2008) 1.49
Downregulation of estrogen and progesterone receptors in the abnormal smooth muscle cells in pulmonary lymphangioleiomyomatosis following therapy. An immunohistochemical study. Am J Respir Crit Care Med (2000) 1.49
Phosphoesterases of Bacillus subtilis. II. Crystallization and properties of alkaline phosphatase. J Biochem (1967) 1.48
Requirement for natural killer T (NKT) cells in the induction of allograft tolerance. Proc Natl Acad Sci U S A (2001) 1.48
A novel mutation causing complete deficiency of thyroxine binding globulin. Clin Endocrinol (Oxf) (1997) 1.48