Published in EMBO J on September 01, 1999
What does Stat3 do? J Clin Invest (2002) 4.83
Cytokine signaling modules in inflammatory responses. Immunity (2008) 4.09
Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis. J Clin Invest (2004) 3.70
Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?. Ann N Y Acad Sci (2009) 3.27
ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles. J Cell Biol (2005) 2.50
Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liver. Mol Cell Biol (2001) 2.44
Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth. Proc Natl Acad Sci U S A (2003) 2.35
First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy. Cancer Discov (2012) 2.31
Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin. J Cell Biol (2006) 2.21
Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth. Neoplasia (2005) 2.18
Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte migration in cutaneous wound healing. J Cell Biol (2000) 2.14
STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils. Blood (2006) 2.12
c-Met is essential for wound healing in the skin. J Cell Biol (2007) 1.98
Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation. Mol Cell Biol (2004) 1.76
Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial-mesenchymal transition in ovarian carcinomas. Br J Cancer (2008) 1.75
Essential role of STAT3 in body weight and glucose homeostasis. Mol Cell Biol (2004) 1.74
Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition. J Biol Chem (2011) 1.70
Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells. Blood (2005) 1.60
Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation. J Exp Med (2001) 1.55
IL-6 signaling via the STAT3/SOCS3 pathway: functional analysis of the conserved STAT3 N-domain. Mol Cell Biochem (2006) 1.54
Stat-3 is required for pulmonary homeostasis during hyperoxia. J Clin Invest (2004) 1.51
Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction. Neoplasia (2007) 1.49
Endothelial cells require STAT3 for protection against endotoxin-induced inflammation. J Exp Med (2003) 1.49
Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation. J Cell Biol (2008) 1.48
Toll-like receptor 9 activation of signal transducer and activator of transcription 3 constrains its agonist-based immunotherapy. Cancer Res (2009) 1.46
Leptin enhances wound re-epithelialization and constitutes a direct function of leptin in skin repair. J Clin Invest (2000) 1.45
Tissue-specific autoregulation of the stat3 gene and its role in interleukin-6-induced survival signals in T cells. Mol Cell Biol (2001) 1.38
Clinical manifestations, etiology, and pathogenesis of the hyper-IgE syndromes. Pediatr Res (2009) 1.36
Signaling by STATs. Arthritis Res Ther (2004) 1.35
GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium. Am J Pathol (2008) 1.34
Therapeutic modulators of STAT signalling for human diseases. Nat Rev Drug Discov (2013) 1.33
New insights into the roles of Stat5a/b and Stat3 in T cell development and differentiation. Semin Cell Dev Biol (2008) 1.31
Signal transducers and activators of transcription as regulators of growth, apoptosis and breast development. Breast Cancer Res (2000) 1.30
Biology and significance of the JAK/STAT signalling pathways. Growth Factors (2012) 1.29
Role of STAT3 in cancer metastasis and translational advances. Biomed Res Int (2013) 1.29
A Stat3-interacting protein (StIP1) regulates cytokine signal transduction. Proc Natl Acad Sci U S A (2000) 1.28
Stage-specific disruption of Stat3 demonstrates a direct requirement during both the initiation and promotion stages of mouse skin tumorigenesis. Carcinogenesis (2008) 1.26
Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function. J Clin Invest (2003) 1.26
Stat3 is required for the development of skin cancer. J Clin Invest (2004) 1.26
Defining a tissue stem cell-driven Runx1/Stat3 signalling axis in epithelial cancer. EMBO J (2012) 1.25
Runx1 directly promotes proliferation of hair follicle stem cells and epithelial tumor formation in mouse skin. Mol Cell Biol (2010) 1.23
ephrinB1 signals from the cell surface to the nucleus by recruitment of STAT3. Proc Natl Acad Sci U S A (2007) 1.21
Helicobacter pylori CagA phosphorylation status determines the gp130-activated SHP2/ERK and JAK/STAT signal transduction pathways in gastric epithelial cells. J Biol Chem (2010) 1.18
A discoidin domain receptor 1/SHP-2 signaling complex inhibits alpha2beta1-integrin-mediated signal transducers and activators of transcription 1/3 activation and cell migration. Mol Biol Cell (2006) 1.16
STAT-3 overexpression and p21 up-regulation accompany impaired regeneration of fatty livers. Am J Pathol (2002) 1.16
Wound healing in mice with high-fat diet- or ob gene-induced diabetes-obesity syndromes: a comparative study. Exp Diabetes Res (2011) 1.15
STAT3-stathmin interactions control microtubule dynamics in migrating T-cells. J Biol Chem (2009) 1.13
Growth factor signaling pathways as targets for prevention of epithelial carcinogenesis. Mol Carcinog (2010) 1.12
Neural stem cells: involvement in adult neurogenesis and CNS repair. Philos Trans R Soc Lond B Biol Sci (2008) 1.12
Grb2 regulates Stat3 activation negatively in epidermal growth factor signalling. Biochem J (2003) 1.08
IL-27 inhibits epithelial-mesenchymal transition and angiogenic factor production in a STAT1-dominant pathway in human non-small cell lung cancer. J Exp Clin Cancer Res (2013) 1.07
The stat3/socs3a pathway is a key regulator of hair cell regeneration in zebrafish. [corrected]. J Neurosci (2012) 1.06
Role of STAT3 in inflammatory bowel disease. World J Gastroenterol (2008) 1.05
Constitutive activation and targeted disruption of signal transducer and activator of transcription 3 (Stat3) in mouse epidermis reveal its critical role in UVB-induced skin carcinogenesis. Oncogene (2009) 1.05
Targeted disruption of stat3 reveals a major role for follicular stem cells in skin tumor initiation. Cancer Res (2009) 1.04
Stat3 mediates expression of autotaxin in breast cancer. PLoS One (2011) 1.03
Protein tyrosine phosphatases, TC-PTP, SHP1, and SHP2, cooperate in rapid dephosphorylation of Stat3 in keratinocytes following UVB irradiation. PLoS One (2010) 1.03
The Grainyhead transcription factor Grhl3/Get1 suppresses miR-21 expression and tumorigenesis in skin: modulation of the miR-21 target MSH2 by RNA-binding protein DND1. Oncogene (2012) 1.03
STAT3 positively regulates an early step in B-cell development. Blood (2006) 1.03
Cytokine signaling through Stat3 activates integrins, promotes adhesion, and induces growth arrest in the myeloid cell line 32D. J Biol Chem (2000) 1.01
Dermatitis due to epiregulin deficiency and a critical role of epiregulin in immune-related responses of keratinocyte and macrophage. Proc Natl Acad Sci U S A (2004) 1.00
Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments. J Cell Biol (2011) 0.99
Critical analysis of the potential for targeting STAT3 in human malignancy. Onco Targets Ther (2013) 0.99
Tcf3 promotes cell migration and wound repair through regulation of lipocalin 2. Nat Commun (2014) 0.98
Stat3 promotes the development of erythroleukemia by inducing Pu.1 expression and inhibiting erythroid differentiation. Oncogene (2009) 0.97
IKKα represses a network of inflammation and proliferation pathways and elevates c-Myc antagonists and differentiation in a dose-dependent manner in the skin. Cell Death Differ (2011) 0.96
A role for transcription factor STAT3 signaling in oncogene smoothened-driven carcinogenesis. J Biol Chem (2012) 0.96
Cooperation between Stat3 and Akt signaling leads to prostate tumor development in transgenic mice. Neoplasia (2011) 0.95
Stat3 inhibition augments the immunogenicity of B-cell lymphoma cells, leading to effective antitumor immunity. Cancer Res (2012) 0.94
How much do we really know about our favorite cosmeceutical ingredients? J Clin Aesthet Dermatol (2010) 0.93
Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis. J Allergy Clin Immunol (2016) 0.93
STAT3 in Cancer-Friend or Foe? Cancers (Basel) (2014) 0.93
A novel Stat3 binding motif in Gab2 mediates transformation of primary hematopoietic cells by the Stk/Ron receptor tyrosine kinase in response to Friend virus infection. Mol Cell Biol (2007) 0.92
A small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells. Int J Cancer (2011) 0.90
Two distinct signaling pathways in hair cycle induction: Stat3-dependent and -independent pathways. Proc Natl Acad Sci U S A (2000) 0.90
Regulation and function of trefoil factor family 3 expression in the biliary tree. Am J Pathol (2004) 0.90
Wound healing and cancer stem cells: inflammation as a driver of treatment resistance in breast cancer. Cancer Growth Metastasis (2015) 0.90
Early gene expression in wounded human keratinocytes revealed by DNA microarray analysis. Comp Funct Genomics (2003) 0.89
Pharmacologic inhibition of JAK-STAT signaling promotes hair growth. Sci Adv (2015) 0.89
PTTG acts as a STAT3 target gene for colorectal cancer cell growth and motility. Oncogene (2013) 0.88
Lasp1 gene disruption is linked to enhanced cell migration and tumor formation. Physiol Genomics (2009) 0.88
Immunologic consequences of signal transducers and activators of transcription 3 activation in human squamous cell carcinoma. Cancer Res (2010) 0.87
STAT3: A Novel Molecular Mediator of Resistance to Chemoradiotherapy. Cancers (Basel) (2014) 0.87
Imaging of STAT3 signaling pathway during mouse embryonic stem cell differentiation. Stem Cells Dev (2009) 0.87
Targeting apoptosis pathways in cancer with alantolactone and isoalantolactone. ScientificWorldJournal (2013) 0.87
Role of stat3 in skin carcinogenesis: insights gained from relevant mouse models. J Skin Cancer (2013) 0.86
Interleukin-22 Promotes Wound Repair in Diabetes by Improving Keratinocyte Pro-Healing Functions. J Invest Dermatol (2015) 0.85
Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation. Genes Dev (2014) 0.85
Epidermal hyperproliferation in mice lacking fatty acid transport protein 4 (FATP4) involves ectopic EGF receptor and STAT3 signaling. Dev Biol (2010) 0.85
STAT3 Inhibition by Microtubule-Targeted Drugs: Dual Molecular Effects of Chemotherapeutic Agents. Mol Cell Pharmacol (2011) 0.84
Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populations. Mol Carcinog (2013) 0.84
Mouse models for human hair loss disorders. J Anat (2003) 0.83
Inducible costimulator (ICOS) and ICOS ligand signaling has pivotal roles in skin wound healing via cytokine production. Am J Pathol (2011) 0.83
Genomic and computational approaches to dissect the mechanisms of STAT3's universal and cell type-specific functions. JAKSTAT (2013) 0.82
Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells. Oncotarget (2016) 0.79
Relevance and therapeutic possibility of PTEN-long in renal cell carcinoma. PLoS One (2015) 0.79
SPRR2A expression in cholangiocarcinoma increases local tumor invasiveness but prevents metastasis. Clin Exp Metastasis (2013) 0.79
A New STAT3-binding Partner, ARL3, Enhances the Phosphorylation and Nuclear Accumulation of STAT3. J Biol Chem (2016) 0.79
Epidermal stem cells undergo age-associated changes. Aging (Albany NY) (2013) 0.78
A Toll-like receptor recognizes bacterial DNA. Nature (2000) 26.34
Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol (2001) 18.80
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity (1998) 18.12
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity (1999) 17.40
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol (1999) 16.86
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature (2001) 14.24
Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity (1999) 11.64
Establishment and characterization of a human acute monocytic leukemia cell line (THP-1). Int J Cancer (1980) 10.11
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J (1998) 9.36
TLR signaling. Cell Death Differ (2006) 9.24
The Banff 97 working classification of renal allograft pathology. Kidney Int (1999) 9.02
Glucose tolerance, insulin secretion, and insulin sensitivity in nonobese and obese Japanese subjects. Diabetes Care (1997) 8.52
Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity (1999) 7.90
Toll-like receptors control activation of adaptive immune responses. Nat Immunol (2001) 7.54
Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med (1997) 7.12
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci U S A (1997) 7.08
DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs. Genes Dev (1998) 6.96
Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J Immunol (2000) 6.61
Essential role of Stat6 in IL-4 signalling. Nature (1996) 6.56
Structure and function of a new STAT-induced STAT inhibitor. Nature (1997) 6.02
Determination of 16S rRNA sequences of Streptococcus mitis and Streptococcus gordonii and phylogenetic relationships among members of the genus Streptococcus. Int J Syst Bacteriol (1995) 5.91
Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int Immunol (2001) 5.36
Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3) Nature (1996) 5.32
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep (2001) 5.32
Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol (2001) 5.27
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Cytokine signal transduction. Cell (1994) 5.14
Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci U S A (2001) 5.02
Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J Immunol (1998) 4.74
Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity (1998) 4.70
Interleukin-6 family of cytokines and gp130. Blood (1995) 4.52
Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene. EMBO J (1997) 4.51
Induction of direct antimicrobial activity through mammalian toll-like receptors. Science (2001) 4.46
Proteoglycans as modulators of growth factor activities. Cell (1991) 4.45
Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science (1999) 4.43
Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J Biol Chem (1999) 4.38
Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell (1995) 4.34
Endovascular stent-graft placement for the treatment of acute aortic dissection. N Engl J Med (1999) 4.33
Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc Natl Acad Sci U S A (1993) 4.23
Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J Immunol (2000) 4.10
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A novel reporter mouse strain that expresses enhanced green fluorescent protein upon Cre-mediated recombination. FEBS Lett (2000) 4.03
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Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus. N Engl J Med (1993) 3.96
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Pig cloning by microinjection of fetal fibroblast nuclei. Science (2000) 3.51
Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway. Proc Natl Acad Sci U S A (2001) 3.49
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Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages. J Immunol (2000) 3.10
CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med (2001) 3.05
Evolutionary motif and its biological and structural significance. J Mol Evol (1997) 3.03
Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Genes Dev (1999) 2.91
Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus. Nature (1992) 2.86
A highly purified RNA polymerase II elongation control system. J Biol Chem (2001) 2.84
IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases. Int Immunol (1999) 2.84
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The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis. Science (1993) 2.77
Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. Cancer Res (1999) 2.74
STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. Proc Natl Acad Sci U S A (1996) 2.64
Univalent reduction of molecular oxygen by spinach chloroplasts on illumination. J Biol Chem (1974) 2.63
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A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6. Proc Natl Acad Sci U S A (1992) 2.55
Molecular cloning and expression of a member of the aquaporin family with permeability to glycerol and urea in addition to water expressed at the basolateral membrane of kidney collecting duct cells. Proc Natl Acad Sci U S A (1994) 2.54
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EphB/syndecan-2 signaling in dendritic spine morphogenesis. Neuron (2001) 2.53
Efficient chromosomal transposition of a Tc1/mariner- like transposon Sleeping Beauty in mice. Proc Natl Acad Sci U S A (2001) 2.51
Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation. J Biol Chem (2000) 2.50