Published in Cell on May 21, 2009
Genetic manipulation of genes and cells in the nervous system of the fruit fly. Neuron (2011) 2.54
EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila. Cell Stem Cell (2010) 2.34
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. Proc Natl Acad Sci U S A (2011) 2.01
The peripheral nervous system supports blood cell homing and survival in the Drosophila larva. Development (2011) 1.40
Drosophila melanogaster as a model to study drug addiction. Hum Genet (2012) 1.39
Preferential ethanol consumption in Drosophila models features of addiction. Curr Biol (2009) 1.39
Signaling pathways mediating alcohol effects. Curr Top Behav Neurosci (2013) 1.20
Altered glutamatergic neurotransmission in the striatum regulates ethanol sensitivity and intake in mice lacking ENT1. Behav Brain Res (2010) 1.15
An evolutionary conserved role for anaplastic lymphoma kinase in behavioral responses to ethanol. PLoS One (2011) 1.10
Chloride intracellular channels modulate acute ethanol behaviors in Drosophila, Caenorhabditis elegans and mice. Genes Brain Behav (2012) 1.03
A differential role for neuropeptides in acute and chronic adaptive responses to alcohol: behavioural and genetic analysis in Caenorhabditis elegans. PLoS One (2010) 1.02
The genetics of behavioral alcohol responses in Drosophila. Int Rev Neurobiol (2010) 0.99
Rsu1 regulates ethanol consumption in Drosophila and humans. Proc Natl Acad Sci U S A (2015) 0.98
Lmo genes regulate behavioral responses to ethanol in Drosophila melanogaster and the mouse. Alcohol Clin Exp Res (2011) 0.94
The genetic relationships between ethanol preference, acute ethanol sensitivity, and ethanol tolerance in Drosophila melanogaster. Fly (Austin) (2011) 0.94
JNK pathway activation is controlled by Tao/TAOK3 to modulate ethanol sensitivity. PLoS One (2012) 0.92
A Drosophila model for fetal alcohol syndrome disorders: role for the insulin pathway. Dis Model Mech (2011) 0.90
Acute ethanol responses in Drosophila are sexually dimorphic. Proc Natl Acad Sci U S A (2012) 0.89
Identification of Happyhour/MAP4K as Alternative Hpo/Mst-like Kinases in the Hippo Kinase Cascade. Dev Cell (2015) 0.89
EGFR may couple moderate alcohol consumption to increased breast cancer risk. Breast Cancer (Dove Med Press) (2009) 0.85
Genetic research: who is at risk for alcoholism. Alcohol Res Health (2010) 0.85
Addiction-like behavior in Drosophila. Commun Integr Biol (2010) 0.85
C. elegans STK39/SPAK ortholog-mediated inhibition of ClC anion channel activity is regulated by WNK-independent ERK kinase signaling. Am J Physiol Cell Physiol (2010) 0.85
Ethanol preference in Drosophila melanogaster is driven by its caloric value. Alcohol Clin Exp Res (2012) 0.85
A role for dynamin in triggering ethanol tolerance. Alcohol Clin Exp Res (2011) 0.85
A small group of neurosecretory cells expressing the transcriptional regulator apontic and the neuropeptide corazonin mediate ethanol sedation in Drosophila. J Neurosci (2013) 0.85
Genetics and genomics of alcohol sensitivity. Mol Genet Genomics (2014) 0.83
MAP4K3 is a component of the TORC1 signalling complex that modulates cell growth and viability in Drosophila melanogaster. PLoS One (2011) 0.83
Taok2 controls behavioral response to ethanol in mice. Genes Brain Behav (2012) 0.82
Unraveling the complexities of circadian and sleep interactions with memory formation through invertebrate research. Front Syst Neurosci (2014) 0.82
The germinal center kinase GCK-1 is a negative regulator of MAP kinase activation and apoptosis in the C. elegans germline. PLoS One (2009) 0.82
Drosophila happyhour modulates JNK-dependent apoptosis. Cell Death Dis (2010) 0.81
Polymorphisms in early neurodevelopmental genes affect natural variation in alcohol sensitivity in adult drosophila. BMC Genomics (2015) 0.80
EGFR and FGFR pathways have distinct roles in Drosophila mushroom body development and ethanol-induced behavior. PLoS One (2014) 0.80
Melatonin Attenuates Her-2, p38 MAPK, p-AKT, and mTOR Levels in Ovarian Carcinoma of Ethanol-Preferring Rats. J Cancer (2014) 0.80
I Believe I Can Fly!: Use of Drosophila as a Model Organism in Neuropsychopharmacology Research. Neuropsychopharmacology (2015) 0.79
The novel gene tank, a tumor suppressor homolog, regulates ethanol sensitivity in Drosophila. J Neurosci (2013) 0.79
Genetic aspects of behavioral neurotoxicology. Neurotoxicology (2009) 0.79
Dual-trait selection for ethanol consumption and withdrawal: genetic and transcriptional network effects. Alcohol Clin Exp Res (2014) 0.78
Contrasting influences of Drosophila white/mini-white on ethanol sensitivity in two different behavioral assays. Alcohol Clin Exp Res (2014) 0.78
Developmental ethanol exposure leads to dysregulation of lipid metabolism and oxidative stress in Drosophila. G3 (Bethesda) (2014) 0.78
The role of the actin cytoskeleton in regulating Drosophila behavior. Rev Neurosci (2013) 0.78
Congenital brain serotonin deficiency leads to reduced ethanol sensitivity and increased ethanol consumption in mice. Neuropharmacology (2013) 0.78
DlgS97/SAP97, a neuronal isoform of discs large, regulates ethanol tolerance. PLoS One (2012) 0.77
Overlapping functions of the MAP4K family kinases Hppy and Msn in Hippo signaling. Cell Discov (2015) 0.77
Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder. Alcohol Clin Exp Res (2015) 0.77
Protein kinase C deficiency-induced alcohol insensitivity and underlying cellular targets in Drosophila. Neuroscience (2009) 0.76
EGFR signaling modulates synaptic connectivity via Gurken. Dev Neurobiol (2012) 0.76
With Happyhour, everyone's under the table. Cell (2009) 0.75
Is alcoholism learned? Insights from the fruit fly. Curr Opin Neurobiol (2013) 0.75
The Unique Dopamine/Ecdysteroid Receptor Modulates Ethanol-Induced Sedation in Drosophila. J Neurosci (2016) 0.75
An inexpensive, scalable behavioral assay for measuring ethanol sedation sensitivity and rapid tolerance in Drosophila. J Vis Exp (2015) 0.75
Commentary: Methamphetamine mediates immune dysregulation in a murine model of chronic viral infection. Front Microbiol (2015) 0.75
Genetics and genomics of alcohol responses in Drosophila. Neuropharmacology (2017) 0.75
Guidelines on nicotine dose selection for in vivo research. Psychopharmacology (Berl) (2006) 3.68
Intermittent access to 20% ethanol induces high ethanol consumption in Long-Evans and Wistar rats. Alcohol Clin Exp Res (2008) 2.98
Opioid receptors. Annu Rev Biochem (2004) 2.71
Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking. Proc Natl Acad Sci U S A (2007) 2.68
High-resolution analysis of ethanol-induced locomotor stimulation in Drosophila. J Neurosci (2002) 2.58
Rapid and chronic: two distinct forms of ethanol tolerance in Drosophila. Alcohol Clin Exp Res (2004) 2.48
Sensory neurons in the Drosophila genital tract regulate female reproductive behavior. Neuron (2009) 2.21
Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts. Genes Dev (2006) 2.06
Distinct behavioral responses to ethanol are regulated by alternate RhoGAP18B isoforms. Cell (2006) 2.05
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. Proc Natl Acad Sci U S A (2011) 2.01
Partial agonists of the α3β4* neuronal nicotinic acetylcholine receptor reduce ethanol consumption and seeking in rats. Neuropsychopharmacology (2010) 1.99
Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics. Cell (2006) 1.92
Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats. Psychopharmacology (Berl) (2008) 1.89
Chlorzoxazone, an SK-type potassium channel activator used in humans, reduces excessive alcohol intake in rats. Biol Psychiatry (2010) 1.74
A Drosophila model for alcohol reward. Nat Neurosci (2011) 1.72
GPCR signaling is required for blood-brain barrier formation in drosophila. Cell (2005) 1.70
moody encodes two GPCRs that regulate cocaine behaviors and blood-brain barrier permeability in Drosophila. Cell (2005) 1.69
A pair of dopamine neurons target the D1-like dopamine receptor DopR in the central complex to promote ethanol-stimulated locomotion in Drosophila. PLoS One (2010) 1.68
Mechanism of hedgehog signaling during Drosophila eye development. Development (2003) 1.64
Oviposition preference for and positional avoidance of acetic acid provide a model for competing behavioral drives in Drosophila. Proc Natl Acad Sci U S A (2009) 1.62
Invertebrate models of drug abuse. J Neurobiol (2003) 1.51
Drosophila melanogaster, a genetic model system for alcohol research. Int Rev Neurobiol (2003) 1.49
Varenicline decreases alcohol consumption in heavy-drinking smokers. Psychopharmacology (Berl) (2012) 1.41
Drosophila melanogaster as a model to study drug addiction. Hum Genet (2012) 1.39
Preferential ethanol consumption in Drosophila models features of addiction. Curr Biol (2009) 1.39
Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster. Nat Neurosci (2004) 1.38
Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nat Neurosci (2013) 1.35
Functional dissection of neuroanatomical loci regulating ethanol sensitivity in Drosophila. J Neurosci (2002) 1.32
The hangover gene defines a stress pathway required for ethanol tolerance development. Nature (2005) 1.31
Ethanol-regulated genes that contribute to ethanol sensitivity and rapid tolerance in Drosophila. Alcohol Clin Exp Res (2009) 1.27
Drugs, flies, and videotape: the effects of ethanol and cocaine on Drosophila locomotion. Curr Opin Neurobiol (2002) 1.22
Varenicline, a partial agonist at neuronal nicotinic acetylcholine receptors, reduces nicotine-induced increases in 20% ethanol operant self-administration in Sprague-Dawley rats. Addict Biol (2011) 1.21
Lmo mutants reveal a novel role for circadian pacemaker neurons in cocaine-induced behaviors. PLoS Biol (2004) 1.15
Tre1, a G protein-coupled receptor, directs transepithelial migration of Drosophila germ cells. PLoS Biol (2003) 1.13
An evolutionary conserved role for anaplastic lymphoma kinase in behavioral responses to ethanol. PLoS One (2011) 1.10
Long-Evans rats acquire operant self-administration of 20% ethanol without sucrose fading. Neuropsychopharmacology (2010) 1.10
Ethanol sensitivity and tolerance in long-term memory mutants of Drosophila melanogaster. Alcohol Clin Exp Res (2008) 1.08
Drosophila tao controls mushroom body development and ethanol-stimulated behavior through par-1. J Neurosci (2011) 1.08
arouser reveals a role for synapse number in the regulation of ethanol sensitivity. Neuron (2011) 1.07
Tissue-specific activation of a single gustatory receptor produces opposing behavioral responses in Drosophila. Genetics (2012) 1.06
Competing dopamine neurons drive oviposition choice for ethanol in Drosophila. Proc Natl Acad Sci U S A (2013) 1.05
Neuronal nicotinic acetylcholine receptors: neuroplastic changes underlying alcohol and nicotine addictions. Front Mol Neurosci (2012) 1.04
A novel delta opioid receptor antagonist, SoRI-9409, produces a selective and long-lasting decrease in ethanol consumption in heavy-drinking rats. Biol Psychiatry (2008) 1.03
Genetic dissociation of ethanol sensitivity and memory formation in Drosophila melanogaster. Genetics (2008) 1.02
Glycogen synthase kinase-3/Shaggy mediates ethanol-induced excitotoxic cell death of Drosophila olfactory neurons. Proc Natl Acad Sci U S A (2009) 1.01
BIG news in alcohol addiction: new findings on growth factor pathways BDNF, insulin, and GDNF. Alcohol Clin Exp Res (2006) 0.99
The ghrelin signalling system is involved in the consumption of sweets. PLoS One (2011) 0.98
The neurokinin 1 receptor antagonist, ezlopitant, reduces appetitive responding for sucrose and ethanol. PLoS One (2010) 0.96
Ghrelin receptor (GHS-R1A) antagonism suppresses both operant alcohol self-administration and high alcohol consumption in rats. Addict Biol (2011) 0.95
Lmo genes regulate behavioral responses to ethanol in Drosophila melanogaster and the mouse. Alcohol Clin Exp Res (2011) 0.94
The genetic relationships between ethanol preference, acute ethanol sensitivity, and ethanol tolerance in Drosophila melanogaster. Fly (Austin) (2011) 0.94
Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12,566 individuals. Hum Mol Genet (2010) 0.93
JNK pathway activation is controlled by Tao/TAOK3 to modulate ethanol sensitivity. PLoS One (2012) 0.92
Mifepristone in the central nucleus of the amygdala reduces yohimbine stress-induced reinstatement of ethanol-seeking. Neuropsychopharmacology (2011) 0.92
Pharmacological consequence of the A118G μ opioid receptor polymorphism on morphine- and fentanyl-mediated modulation of Ca²⁺ channels in humanized mouse sensory neurons. Anesthesiology (2011) 0.92
Orexin/hypocretin role in reward: implications for opioid and other addictions. Br J Pharmacol (2014) 0.92
Protein Phosphatase 2a and glycogen synthase kinase 3 signaling modulate prepulse inhibition of the acoustic startle response by altering cortical M-Type potassium channel activity. J Neurosci (2010) 0.91
An analytical tool that quantifies cellular morphology changes from three-dimensional fluorescence images. J Vis Exp (2012) 0.91
Cabergoline decreases alcohol drinking and seeking behaviors via glial cell line-derived neurotrophic factor. Biol Psychiatry (2009) 0.90
δ-opioid receptor function in the dorsal striatum plays a role in high levels of ethanol consumption in rats. J Neurosci (2012) 0.90
A Drosophila model for fetal alcohol syndrome disorders: role for the insulin pathway. Dis Model Mech (2011) 0.90
GSK-3/Shaggy regulates olfactory habituation in Drosophila. Proc Natl Acad Sci U S A (2007) 0.90
Alk is a transcriptional target of LMO4 and ERα that promotes cocaine sensitization and reward. J Neurosci (2011) 0.90
Acute ethanol responses in Drosophila are sexually dimorphic. Proc Natl Acad Sci U S A (2012) 0.89
The evolution of Drosophila melanogaster as a model for alcohol research. Annu Rev Neurosci (2013) 0.89
Intermittent access ethanol consumption dysregulates CRF function in the hypothalamus and is attenuated by the CRF-R1 antagonist, CP-376395. Addict Biol (2013) 0.88
The dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administration. PLoS One (2012) 0.87
The α5 subunit regulates the expression and function of α4*-containing neuronal nicotinic acetylcholine receptors in the ventral-tegmental area. PLoS One (2013) 0.86
Induction of multiple reinstatements of ethanol- and sucrose-seeking behavior in Long-Evans rats by the α-2 adrenoreceptor antagonist yohimbine. Psychopharmacology (Berl) (2011) 0.86
Addiction-like behavior in Drosophila. Commun Integr Biol (2010) 0.85
The α5 neuronal nicotinic acetylcholine receptor subunit plays an important role in the sedative effects of ethanol but does not modulate consumption in mice. Alcohol Clin Exp Res (2012) 0.85
A small group of neurosecretory cells expressing the transcriptional regulator apontic and the neuropeptide corazonin mediate ethanol sedation in Drosophila. J Neurosci (2013) 0.85
Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: involvement of adenosine and dopamine receptors. Pharmacol Biochem Behav (2012) 0.84
Lmo4 in the basolateral complex of the amygdala modulates fear learning. PLoS One (2012) 0.84
Stress and addiction: contribution of the corticotropin releasing factor (CRF) system in neuroplasticity. Front Mol Neurosci (2012) 0.83
The delta opioid receptor antagonist, SoRI-9409, decreases yohimbine stress-induced reinstatement of ethanol-seeking. Addict Biol (2011) 0.83
The role of the glucocorticoids in developing resilience to stress and addiction. Front Psychiatry (2013) 0.82
Conditioned cues and yohimbine induce reinstatement of beer and near-beer seeking in Long-Evans rats. Addict Biol (2008) 0.81
Rough eye is a gain-of-function allele of amos that disrupts regulation of the proneural gene atonal during Drosophila retinal differentiation. Genetics (2002) 0.81
Tao kinases as coordinators of actin and microtubule dynamics in developing neurons. Commun Integr Biol (2011) 0.80
The role of δ-opioid receptors in learning and memory underlying the development of addiction. Br J Pharmacol (2014) 0.79
The novel gene tank, a tumor suppressor homolog, regulates ethanol sensitivity in Drosophila. J Neurosci (2013) 0.79