Overlapping functions of the MAP4K family kinases Hppy and Msn in Hippo signaling.

Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network. Trends Cell Biol (2016) 0.88

The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts. PLoS Genet (2016) 0.75

Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell (2007) 13.04

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell (2005) 10.61

The hippo signaling pathway in development and cancer. Dev Cell (2010) 10.54

hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell (2003) 7.43

Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell (2009) 7.39

salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell (2002) 7.15

Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell (2012) 6.80

The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell (2003) 6.48

The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway. Dev Cell (2008) 5.58

Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat Cell Biol (2003) 5.50

The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes Dev (1995) 5.27

Hippo signaling: growth control and beyond. Development (2011) 5.25

Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development (1995) 5.18

The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. Dev Cell (2008) 4.90

The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila. Nat Cell Biol (2003) 4.84

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A (2010) 4.17

The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes Dev (2003) 3.53

In vivo regulation of Yorkie phosphorylation and localization. Development (2008) 3.51

Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis. Genes Dev (2012) 3.48

SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila. Curr Biol (2008) 3.39

Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. Dev Cell (2010) 2.96

Modulating F-actin organization induces organ growth by affecting the Hippo pathway. EMBO J (2011) 2.75

Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus. Dev Cell (2005) 2.50

Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1. Nat Cell Biol (2002) 2.42

Happyhour, a Ste20 family kinase, implicates EGFR signaling in ethanol-induced behaviors. Cell (2009) 2.22

Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2. Cell (2013) 2.16

The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling. Dev Biol (2006) 1.85

Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms. Dev Biol (2009) 1.54

Hippo signaling pathway and organ size control. Fly (Austin) (2009) 1.21

The cell adhesion molecule echinoid functions as a tumor suppressor and upstream regulator of the Hippo signaling pathway. Dev Cell (2012) 1.16

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Nat Commun (2015) 1.11

The conserved misshapen-warts-Yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila. Dev Cell (2014) 0.98

Identification of Happyhour/MAP4K as Alternative Hpo/Mst-like Kinases in the Hippo Kinase Cascade. Dev Cell (2015) 0.89

Drosophila happyhour modulates JNK-dependent apoptosis. Cell Death Dis (2010) 0.81