Hypermethylation of genomic 3.3-kb repeats is frequent event in HPV-positive cervical cancer.

PubWeight™: 0.85‹?›

🔗 View Article (PMC 2695481)

Published in BMC Med Genomics on May 27, 2009

Authors

Alexey N Katargin1, Larissa S Pavlova, Fjodor L Kisseljov, Natalia P Kisseljova

Author Affiliations

1: Laboratory of Molecular Biology of Viruses, Institute of Carcinogenesis, NN Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia. akatar@yandex.ru

Articles cited by this

The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science (1989) 16.54

Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer (2002) 15.46

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet (2005) 8.45

DNA methylation in cancer: too much, but also too little. Oncogene (2002) 6.96

DNA hypomethylation and human diseases. Biochim Biophys Acta (2006) 4.31

Hypomethylation of D4Z4 in 4q-linked and non-4q-linked facioscapulohumeral muscular dystrophy. Nat Genet (2003) 3.60

Inappropriate gene activation in FSHD: a repressor complex binds a chromosomal repeat deleted in dystrophic muscle. Cell (2002) 3.56

A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity. Cell (2005) 3.35

DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1. Proc Natl Acad Sci U S A (2007) 3.32

Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element. Gene (1999) 3.00

The DUX4 gene at the FSHD1A locus encodes a pro-apoptotic protein. Neuromuscul Disord (2007) 2.85

Analysis of the tandem repeat locus D4Z4 associated with facioscapulohumeral muscular dystrophy. Hum Mol Genet (1994) 2.60

Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation. Hum Mol Genet (2006) 2.51

Facioscapulohumeral muscular dystrophy. Muscle Nerve (2006) 2.40

Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival. Proc Natl Acad Sci U S A (2006) 2.25

Genome-wide hypomethylation in human glioblastomas associated with specific copy number alteration, methylenetetrahydrofolate reductase allele status, and increased proliferation. Cancer Res (2006) 2.18

Testing the position-effect variegation hypothesis for facioscapulohumeral muscular dystrophy by analysis of histone modification and gene expression in subtelomeric 4q. Hum Mol Genet (2003) 2.15

Evolutionary conservation of a coding function for D4Z4, the tandem DNA repeat mutated in facioscapulohumeral muscular dystrophy. Am J Hum Genet (2007) 2.06

The FSHD-associated repeat, D4Z4, is a member of a dispersed family of homeobox-containing repeats, subsets of which are clustered on the short arms of the acrocentric chromosomes. Genomics (1995) 1.77

Genomic analysis of human chromosome 10q and 4q telomeres suggests a common origin. Genomics (2002) 1.75

Whole-genome methylation scan in ICF syndrome: hypomethylation of non-satellite DNA repeats D4Z4 and NBL2. Hum Mol Genet (2000) 1.73

Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis. Proc Natl Acad Sci U S A (2002) 1.73

Role of the DNA methyltransferase variant DNMT3b3 in DNA methylation. Mol Cancer Res (2004) 1.68

The DNA rearrangement associated with facioscapulohumeral muscular dystrophy involves a heterochromatin-associated repetitive element: implications for a role of chromatin structure in the pathogenesis of the disease. Chromosome Res (1994) 1.63

Viral oncoproteins target the DNA methyltransferases. Oncogene (2006) 1.59

Regulation of DNA methyltransferase 1 by the pRb/E2F1 pathway. Cancer Res (2005) 1.53

Identification and characterization of differentially methylated regions of genomic DNA by methylation-sensitive arbitrarily primed PCR. Cancer Res (1997) 1.51

Increased levels of adenine nucleotide translocator 1 protein and response to oxidative stress are early events in facioscapulohumeral muscular dystrophy muscle. J Mol Med (Berl) (2004) 1.39

The retinoblastoma gene product interacts with maintenance human DNA (cytosine-5) methyltransferase and modulates its activity. EMBO J (2002) 1.28

Global DNA hypomethylation increases progressively in cervical dysplasia and carcinoma. Cancer (1994) 1.21

A nuclear matrix attachment site in the 4q35 locus has an enhancer-blocking activity in vivo: implications for the facio-scapulo-humeral dystrophy. Genome Res (2007) 1.17

Transcriptional activation of p53 by Pitx1. Cell Death Differ (2007) 1.15

Epigenetics of a tandem DNA repeat: chromatin DNaseI sensitivity and opposite methylation changes in cancers. Nucleic Acids Res (2008) 1.14

Active genes in junk DNA? Characterization of DUX genes embedded within 3.3 kb repeated elements. Gene (2001) 1.10

A DNA repeat, NBL2, is hypermethylated in some cancers but hypomethylated in others. Cancer Biol Ther (2005) 1.04

Characterization of a double homeodomain protein (DUX1) encoded by a cDNA homologous to 3.3 kb dispersed repeated elements. Hum Mol Genet (1998) 1.04

Sequence homology between 4qter and 10qter loci facilitates the instability of subtelomeric KpnI repeat units implicated in facioscapulohumeral muscular dystrophy. Am J Hum Genet (1998) 1.03

Both hypomethylation and hypermethylation in a 0.2-kb region of a DNA repeat in cancer. Mol Cancer Res (2005) 1.02

A functional role for 4qA/B in the structural rearrangement of the 4q35 region and in the regulation of FRG1 and ANT1 in facioscapulohumeral dystrophy. PLoS One (2008) 1.01

DNA demethylation and carcinogenesis. Biochemistry (Mosc) (2005) 1.00

Line-1 hypomethylation in multistage carcinogenesis of the uterine cervix. Asian Pac J Cancer Prev (2007) 0.99

HPV infection in cervical-cancer cases in Russia. Int J Cancer (1995) 0.96

Intracellular trafficking and dynamics of double homeodomain proteins. Biochemistry (2005) 0.95

Methylation of the FSHD syndrome-linked subtelomeric repeat in normal and FSHD cell cultures and tissues. Mol Genet Metab (2001) 0.93

Up-regulation of expression and lack of 5' CpG island hypermethylation of p16 INK4a in HPV-positive cervical carcinomas. BMC Cancer (2007) 0.91

Demethylation of repetitive DNA sequences in neuroblastoma. Genes Chromosomes Cancer (1996) 0.87