Published in Cell on June 17, 2005
Highly parallel identification of essential genes in cancer cells. Proc Natl Acad Sci U S A (2008) 7.45
Cancer proliferation gene discovery through functional genomics. Science (2008) 5.41
Methylation determines fibroblast activation and fibrogenesis in the kidney. Nat Med (2010) 3.60
DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1. Proc Natl Acad Sci U S A (2007) 3.32
The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis. BMC Med Genomics (2008) 3.11
Making sense of cancer genomic data. Genes Dev (2011) 3.01
Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer. J Hepatol (2010) 2.05
HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype. J Clin Invest (2010) 2.00
Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions. Mol Cell Biol (2006) 1.97
KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Nat Cell Biol (2009) 1.97
Kinase requirements in human cells: I. Comparing kinase requirements across various cell types. Proc Natl Acad Sci U S A (2008) 1.95
Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment. Drug Resist Updat (2008) 1.90
Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer. Nat Genet (2012) 1.85
Identification of RASAL1 as a major tumor suppressor gene in thyroid cancer. J Natl Cancer Inst (2013) 1.78
BRD7 is a candidate tumour suppressor gene required for p53 function. Nat Cell Biol (2010) 1.76
Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1 as critical target genes. J Clin Invest (2006) 1.51
Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers. Proc Natl Acad Sci U S A (2007) 1.43
Using functional genetics to understand breast cancer biology. Cold Spring Harb Perspect Biol (2010) 1.39
p53 induces transcriptional and translational programs to suppress cell proliferation and growth. Genome Biol (2013) 1.33
RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia. Blood (2007) 1.33
GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins. J Biol Chem (2006) 1.22
In vivo selection for metastasis promoting genes in the mouse. Proc Natl Acad Sci U S A (2007) 1.20
Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest. Genome Biol (2008) 1.15
Integration of transcriptomics, proteomics, and microRNA analyses reveals novel microRNA regulation of targets in the mammalian inner ear. PLoS One (2011) 1.15
A microRNA contribution to aberrant Ras activation in gastric cancer. Am J Transl Res (2011) 1.14
Our changing view of the genomic landscape of cancer. J Pathol (2010) 1.13
Kinase requirements in human cells: IV. Differential kinase requirements in cervical and renal human tumor cell lines. Proc Natl Acad Sci U S A (2008) 1.12
Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference. Nucleic Acids Res (2015) 1.10
Loss of desmocollin 1-3 and homeobox genes PITX1 and CDX2 are associated with tumor progression and survival in colorectal carcinoma. Int J Colorectal Dis (2012) 1.10
Maintenance of tumor initiating cells of defined genetic composition by nucleostemin. Proc Natl Acad Sci U S A (2011) 1.09
Differential Regulation of RasGAPs in Cancer. Genes Cancer (2011) 1.07
Fibrosis under arrest. Nat Med (2010) 1.05
Targeted comparative RNA interference analysis reveals differential requirement of genes essential for cell proliferation. Mol Biol Cell (2006) 1.04
Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis. Sci Signal (2013) 1.03
Identification of PITX1 as a TERT suppressor gene located on human chromosome 5. Mol Cell Biol (2011) 1.01
Gene expression signatures differentiate ovarian/peritoneal serous carcinoma from breast carcinoma in effusions. J Cell Mol Med (2011) 0.98
Multiplexing siRNAs to compress RNAi-based screen size in human cells. Nucleic Acids Res (2007) 0.98
Optimized PCR conditions and increased shRNA fold representation improve reproducibility of pooled shRNA screens. PLoS One (2012) 0.97
Functional parsing of driver mutations in the colorectal cancer genome reveals numerous suppressors of anchorage-independent growth. Cancer Res (2011) 0.94
Cytoplasmic ezrin and moesin correlate with poor survival in head and neck squamous cell carcinoma. Head Neck Pathol (2012) 0.91
Conditional over-expression of PITX1 causes skeletal muscle dystrophy in mice. Biol Open (2012) 0.90
A functional genome-wide RNAi screen identifies TAF1 as a regulator for apoptosis in response to genotoxic stress. Nucleic Acids Res (2008) 0.89
Expression of pituitary homeobox 1 gene in human gastric carcinogenesis and its clinicopathological significance. World J Gastroenterol (2008) 0.89
Optimization of a Genome-Wide Disordered Lentivector-Based Short Hairpin RNA Library. Mol Biol (2006) 0.89
Forward RNAi screens in primary human hematopoietic stem/progenitor cells. Blood (2009) 0.87
Identification of GAS1 as an epirubicin resistance-related gene in human gastric cancer cells with a partially randomized small interfering RNA library. J Biol Chem (2009) 0.86
PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia. Cell Cycle (2014) 0.86
Hypermethylation of genomic 3.3-kb repeats is frequent event in HPV-positive cervical cancer. BMC Med Genomics (2009) 0.85
Ras GTPase activating (RasGAP) activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes. Proc Natl Acad Sci U S A (2012) 0.85
RNA interference libraries prove their worth in hunt for tumor suppressor genes. Cell (2005) 0.85
Transcriptome profiling of esophageal squamous cell carcinoma reveals a long noncoding RNA acting as a tumor suppressor. Oncotarget (2015) 0.85
The RNA helicase RHAU (DHX36) suppresses expression of the transcription factor PITX1. Nucleic Acids Res (2013) 0.84
miR-19b regulates hTERT mRNA expression through targeting PITX1 mRNA in melanoma cells. Sci Rep (2015) 0.84
C/EBP-β-activated microRNA-223 promotes tumour growth through targeting RASA1 in human colorectal cancer. Br J Cancer (2015) 0.84
The estrogen-regulated transcription factor PITX1 coordinates gene-specific regulation by estrogen receptor-alpha in breast cancer cells. Mol Endocrinol (2011) 0.82
The Cancer BioChip System: a functional genomic assay for anchorage-independent three-dimensional breast cancer cell growth. Horm Cancer (2012) 0.81
A novel EST-derived RNAi screen reveals a critical role for farnesyl diphosphate synthase in β2-adrenergic receptor internalization and down-regulation. FASEB J (2012) 0.81
Specific and nontoxic silencing in mammalian cells with expressed long dsRNAs. Nucleic Acids Res (2006) 0.81
PITX1 is a reliable biomarker for predicting prognosis in patients with oral epithelial dysplasia. Oncol Lett (2013) 0.81
The role of wild type RAS isoforms in cancer. Semin Cell Dev Biol (2016) 0.81
Noncoding RNAs in cancer medicine. J Biomed Biotechnol (2006) 0.80
Annexin A6 is down-regulated through promoter methylation in gastric cancer. Am J Transl Res (2013) 0.80
Single nucleotide polymorphisms associated with colorectal cancer susceptibility and loss of heterozygosity in a Taiwanese population. PLoS One (2014) 0.79
Rasa3 controls megakaryocyte Rap1 activation, integrin signaling and differentiation into proplatelet. PLoS Genet (2014) 0.79
Integrative genomic approaches to understanding cancer. Biochim Biophys Acta (2009) 0.78
RNA interference-mediated gene silencing in murine T cells: in vitro and in vivo validation of proinflammatory target genes. Cell Commun Signal (2008) 0.78
Identification of a Potential Regulatory Variant for Colorectal Cancer Risk Mapping to Chromosome 5q31.1: A Post-GWAS Study. PLoS One (2015) 0.78
Decoding Ca2+ signals: a question of timing. J Cell Biol (2005) 0.77
PITX1 is a novel predictor of the response to chemotherapy in head and neck squamous cell carcinoma. Mol Clin Oncol (2016) 0.77
The Significance of Ras Activity in Pancreatic Cancer Initiation. Int J Biol Sci (2016) 0.77
The tumor suppressor HHEX inhibits axon growth when prematurely expressed in developing central nervous system neurons. Mol Cell Neurosci (2015) 0.76
miR-135 family members mediate podocyte injury through the activation of Wnt/β-catenin signaling. Int J Mol Med (2015) 0.76
Studies of Tumor Suppressor Genes via Chromosome Engineering. Cancers (Basel) (2015) 0.75
In vivo and in vitro expression of the RASAL1 gene in human gastric adenocarcinoma and its clinicopathological significance. Oncol Lett (2011) 0.75
Protein tyrosine phosphatase 1B targets PITX1/p120RasGAP thus showing therapeutic potential in colorectal carcinoma. Sci Rep (2016) 0.75
RNA-binding protein QKI-5 inhibits the proliferation of clear cell renal cell carcinoma via post-transcriptional stabilization of RASA1 mRNA. Cell Cycle (2016) 0.75
Back to the Future: Mutant Hunts Are Still the Way To Go. Genetics (2016) 0.75
Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation. Elife (2016) 0.75
MiR-30a Inhibits the Epithelial--Mesenchymal Transition of Podocytes through Downregulation of NFATc3. Int J Mol Sci (2015) 0.75
RASAL1 is a potent regulator of hepatic stellate cell activity and liver fibrosis. Oncotarget (2017) 0.75
MicroRNA-135a is involved in podocyte injury in a transient receptor potential channel 1-dependent manner. Int J Mol Med (2017) 0.75
RAS protein activator-like 1 is functionally involved in hypoxia resistance in breast cancer cells by targeting hypoxia inducible factor-1α. Oncol Lett (2017) 0.75
A system for stable expression of short interfering RNAs in mammalian cells. Science (2002) 35.21
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell (2007) 11.21
A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell (2006) 11.01
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature (2012) 9.39
A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature (2004) 8.67
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer Res (2008) 8.12
Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell (2002) 7.88
The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis. Nat Cell Biol (2008) 7.86
RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. Cell (2007) 7.06
Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation. EMBO J (2007) 6.26
Statistical methods for analysis of high-throughput RNA interference screens. Nat Methods (2009) 4.76
miR-148 targets human DNMT3b protein coding region. RNA (2008) 4.56
Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. EMBO Rep (2003) 4.52
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo. Genes Dev (2009) 4.15
MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling. Cell (2012) 4.01
MicroRNA regulation by RNA-binding proteins and its implications for cancer. Nat Rev Cancer (2011) 3.91
Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235. Cancer Res (2008) 3.70
eRNAs are required for p53-dependent enhancer activity and gene transcription. Mol Cell (2012) 3.63
The ubiquitin-specific protease USP28 is required for MYC stability. Nat Cell Biol (2007) 3.63
Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer. Cancer Res (2008) 3.06
ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome. Cancer Cell (2009) 2.93
An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors. Nat Chem Biol (2006) 2.91
Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension. EMBO J (2003) 2.70
A cell proliferation signature is a marker of extremely poor outcome in a subpopulation of breast cancer patients. Cancer Res (2005) 2.65
A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility. Nat Cell Biol (2010) 2.53
Alternative cleavage and polyadenylation: extent, regulation and function. Nat Rev Genet (2013) 2.37
The tumor-suppressive functions of the human INK4A locus. Cancer Cell (2003) 2.31
The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability. Cell (2013) 2.24
TRPM7, a novel regulator of actomyosin contractility and cell adhesion. EMBO J (2006) 2.20
Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1. Nature (2007) 2.19
The poly(A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites. Cell (2012) 2.14
AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation. J Biol Chem (2004) 2.07
MiRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression. Cell Cycle (2011) 2.06
Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia. Circulation (2011) 1.99
Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability. Genes Dev (2005) 1.97
Genomic loss of miR-486 regulates tumor progression and the OLFM4 antiapoptotic factor in gastric cancer. Clin Cancer Res (2011) 1.86
BRD7 is a candidate tumour suppressor gene required for p53 function. Nat Cell Biol (2010) 1.76
Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer. Mol Cancer (2010) 1.69
shRNA libraries and their use in cancer genetics. Nat Methods (2006) 1.66
Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition. Int J Cancer (2013) 1.60
Immunofluorescence-based screening identifies germ cell associated microRNA 302 as an antagonist to p63 expression. Cell Cycle (2009) 1.56
Interplay between microRNAs and RNA-binding proteins determines developmental processes. Cell Cycle (2008) 1.51
Analysis of the MammaPrint breast cancer assay in a predominantly postmenopausal cohort. Clin Cancer Res (2008) 1.48
Major role for mRNA stability in shaping the kinetics of gene induction. BMC Genomics (2010) 1.46
Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake. BMC Neurosci (2002) 1.44
Using functional genetics to understand breast cancer biology. Cold Spring Harb Perspect Biol (2010) 1.39
Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1. EMBO J (2008) 1.36
Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells. Mol Cell (2005) 1.34
p53 induces transcriptional and translational programs to suppress cell proliferation and growth. Genome Biol (2013) 1.33
A large scale shRNA barcode screen identifies the circadian clock component ARNTL as putative regulator of the p53 tumor suppressor pathway. PLoS One (2009) 1.29
The miRNA-192/194 cluster regulates the Period gene family and the circadian clock. FEBS J (2009) 1.27
A diagnostic gene profile for molecular subtyping of breast cancer associated with treatment response. Breast Cancer Res Treat (2011) 1.26
miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1. Autophagy (2012) 1.25
Akt and 14-3-3eta regulate Miz1 to control cell-cycle arrest after DNA damage. Nat Cell Biol (2004) 1.25
E2F mediates enhanced alternative polyadenylation in proliferation. Genome Biol (2012) 1.24
Oncogenic miR-181a/b affect the DNA damage response in aggressive breast cancer. Cell Cycle (2013) 1.23
Tumorigenicity of the miR-17-92 cluster distilled. Genes Dev (2010) 1.22
MicroRNA hsa-miR-135b regulates mineralization in osteogenic differentiation of human unrestricted somatic stem cells. Stem Cells Dev (2010) 1.21
p53-Dependent regulation of Cdc6 protein stability controls cellular proliferation. Mol Cell Biol (2005) 1.21
Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity. Nat Commun (2011) 1.20
Classifying microRNAs in cancer: the good, the bad and the ugly. Biochim Biophys Acta (2006) 1.20
miRNA-based mechanism for the commitment of multipotent progenitors to a single cellular fate. Proc Natl Acad Sci U S A (2010) 1.19
The chemokine receptor CXCR4 and the metalloproteinase MT1-MMP are mutually required during melanoma metastasis to lungs. Am J Pathol (2009) 1.17
Noncoding RNAs and cancer. Cell (2013) 1.16
Inhibition of oncogenic transformation by mammalian Lin-9, a pRB-associated protein. EMBO J (2004) 1.15
A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Adv Exp Med Biol (2007) 1.15
Telomerase-independent regulation of ATR by human telomerase RNA. J Biol Chem (2006) 1.15
Diverse ways to control p27Kip1 function: miRNAs come into play. Cell Cycle (2007) 1.14
A Genome-wide multidimensional RNAi screen reveals pathways controlling MHC class II antigen presentation. Cell (2011) 1.14
Biological functions of the genes in the mammaprint breast cancer profile reflect the hallmarks of cancer. Biomark Insights (2010) 1.11
miR-21 and miR-214 are consistently modulated during renal injury in rodent models. Am J Pathol (2011) 1.10
MIR181A regulates starvation- and rapamycin-induced autophagy through targeting of ATG5. Autophagy (2013) 1.10
MicroRNA-182 and microRNA-200a control G-protein subunit α-13 (GNA13) expression and cell invasion synergistically in prostate cancer cells. J Biol Chem (2013) 1.07
Ribosome profiling reveals features of normal and disease-associated mitochondrial translation. Nat Commun (2013) 1.07
Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility. Breast Cancer Res (2010) 1.05
Alternative cleavage and polyadenylation during colorectal cancer development. Clin Cancer Res (2012) 1.02
A robust genomic signature for the detection of colorectal cancer patients with microsatellite instability phenotype and high mutation frequency. J Pathol (2012) 1.00
p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6. Nucleic Acids Res (2012) 0.99
The histone demethylase Jarid1b (Kdm5b) is a novel component of the Rb pathway and associates with E2f-target genes in MEFs during senescence. PLoS One (2011) 0.98
Immense promises for tiny molecules: uncovering miRNA functions. Cell Cycle (2006) 0.97
A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d. J Exp Med (2007) 0.97
Oncogenic cooperation between SOCS family proteins and EGFR identified using a Drosophila epithelial transformation model. Genes Dev (2012) 0.97
New insights into lineage restriction of mammary gland epithelium using parity-identified mammary epithelial cells. Breast Cancer Res (2014) 0.96
Methylation-mediated transcriptional repression of microRNAs during cervical carcinogenesis. Epigenetics (2013) 0.94
Removal of AU bias from microarray mRNA expression data enhances computational identification of active microRNAs. PLoS Comput Biol (2008) 0.94
BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1. J Clin Invest (2016) 0.94
Ras interference as cancer therapy. Semin Cancer Biol (2003) 0.94
miR-Sens--a retroviral dual-luciferase reporter to detect microRNA activity in primary cells. RNA (2012) 0.93