Published in Science on May 28, 2009
Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis. Nat Neurosci (2013) 2.37
The role of early life stress as a predictor for alcohol and drug dependence. Psychopharmacology (Berl) (2010) 2.04
Elevated BDNF after cocaine withdrawal facilitates LTP in medial prefrontal cortex by suppressing GABA inhibition. Neuron (2010) 1.90
Brain-derived neurotrophic factor and cocaine addiction. Brain Res (2009) 1.76
Opioid activation of toll-like receptor 4 contributes to drug reinforcement. J Neurosci (2012) 1.55
Developmental changes in dopamine neurotransmission in adolescence: behavioral implications and issues in assessment. Brain Cogn (2009) 1.44
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BDNF is a negative modulator of morphine action. Science (2012) 1.41
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BDNF signaling in the VTA links the drug-dependent state to drug withdrawal aversions. J Neurosci (2014) 0.88
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Prefrontal/accumbal catecholamine system processes high motivational salience. Front Behav Neurosci (2012) 0.85
Regulation of BDNF expression by cocaine. Yale J Biol Med (2012) 0.84
Persistent pain maintains morphine-seeking behavior after morphine withdrawal through reduced MeCP2 repression of GluA1 in rat central amygdala. J Neurosci (2015) 0.84
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Glutamate mechanisms underlying opiate memories. Cold Spring Harb Perspect Med (2012) 0.80
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Ventral tegmental area GABA neurons and opiate motivation. Psychopharmacology (Berl) (2013) 0.79
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Knockdown of ventral tegmental area mu-opioid receptors in rats prevents effects of social defeat stress: implications for amphetamine cross-sensitization, social avoidance, weight regulation and expression of brain-derived neurotrophic factor. Neuropharmacology (2015) 0.77
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Normalization of ventral tegmental area structure following acupuncture in a rat model of heroin relapse. Neural Regen Res (2014) 0.76
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Neurotrophins in the ventral tegmental area: Role in social stress, mood disorders and drug abuse. Neuroscience (2014) 0.76
Expression of BDNF and TrkB Phosphorylation in the Rat Frontal Cortex During Morphine Withdrawal are NO Dependent. Cell Mol Neurobiol (2015) 0.75
Altered Acoustic Startle Reflex, Pre-pulse Inhibition, and Peripheral Brain-derived Neurotrophic Factor in Morphine Self-administered Rats. Int J Neuropsychopharmacol (2016) 0.75
Changes in Expression of Dopamine, Its Receptor, and Transporter in Nucleus Accumbens of Heroin-Addicted Rats with Brain-Derived Neurotrophic Factor (BDNF) Overexpression. Med Sci Monit (2017) 0.75
Dopamine D1 receptors are not critical for opiate reward but can mediate opiate memory retrieval in a state-dependent manner. Behav Brain Res (2013) 0.75
Higher reward value of starvation imagery in anorexia nervosa and association with the Val66Met BDNF polymorphism. Transl Psychiatry (2016) 0.75
Cerebrolysin Attenuates Heat Shock Protein (HSP 72 KD) Expression in the Rat Spinal Cord Following Morphine Dependence and Withdrawal: Possible New Therapy for Pain Management. Curr Neuropharmacol (2011) 0.75
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MicroRNA expression signature of methamphetamine use and addiction in the rat nucleus accumbens. Metab Brain Dis (2017) 0.75
Neural mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci (2006) 12.37
BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature (2005) 7.07
Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving. J Neurosci (2003) 3.30
A single infusion of brain-derived neurotrophic factor into the ventral tegmental area induces long-lasting potentiation of cocaine seeking after withdrawal. J Neurosci (2004) 2.47
BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion. J Cell Biol (2002) 2.40
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Early changes in KCC2 phosphorylation in response to neuronal stress result in functional downregulation. J Neurosci (2007) 1.72
Neurotrophic mechanisms in drug addiction. Neuromolecular Med (2004) 1.54
Opiate state controls bi-directional reward signaling via GABAA receptors in the ventral tegmental area. Nat Neurosci (2004) 1.43
GABA(A) receptors in the ventral tegmental area control bidirectional reward signalling between dopaminergic and non-dopaminergic neural motivational systems. Eur J Neurosci (2001) 1.35
Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon. J Neurosci (1994) 1.28
Implication of brain-derived neurotrophic factor in the release of dopamine and dopamine-related behaviors induced by methamphetamine. Neuroscience (2003) 1.18
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Motivational state determines the functional role of the mesolimbic dopamine system in the mediation of opiate reward processes. Behav Brain Res (2002) 1.09
Responses of ventral tegmental area GABA neurons to brain stimulation reward. Brain Res (2001) 1.07
Excitotoxic lesions of the tegmental pedunculopontine nucleus impair copulation in naive male rats and block the rewarding effects of copulation in experienced male rats. Eur J Neurosci (2003) 0.91
GABAA receptors signal bidirectional reward transmission from the ventral tegmental area to the tegmental pedunculopontine nucleus as a function of opiate state. Eur J Neurosci (2004) 0.91
A test of the opponent-process theory of motivation using lesions that selectively block morphine reward. Eur J Neurosci (2007) 0.90
A single brain stem substrate mediates the motivational effects of both opiates and food in nondeprived rats but not in deprived rats. Behav Neurosci (1992) 0.90
Increased central brain-derived neurotrophic factor activity could be a risk factor for substance abuse: Implications for treatment. Med Hypotheses (2006) 0.89
Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40
Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21
The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics. PLoS Biol (2003) 13.32
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Genome analysis of the platypus reveals unique signatures of evolution. Nature (2008) 5.74
The functional spectrum of low-frequency coding variation. Genome Biol (2011) 4.42
Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterations. Nat Med (2002) 3.94
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells. Genes Dev (2002) 3.55
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Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages. Nat Biotechnol (2004) 3.36
p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity. Genes Dev (2005) 3.08
Global survey of genomic imprinting by transcriptome sequencing. Curr Biol (2008) 2.80
Critical evaluation of imprinted gene expression by RNA-Seq: a new perspective. PLoS Genet (2012) 2.57
The neurobiology of nicotine addiction: bridging the gap from molecules to behaviour. Nat Rev Neurosci (2004) 2.53
Adult rodent neurogenic regions: the ventricular subependyma contains neural stem cells, but the dentate gyrus contains restricted progenitors. J Neurosci (2002) 2.43
The adult mouse and human pancreas contain rare multipotent stem cells that express insulin. Cell Stem Cell (2011) 2.31
Facile isolation and the characterization of human retinal stem cells. Proc Natl Acad Sci U S A (2004) 2.18
The germline stem cells of Drosophila melanogaster partition DNA non-randomly. Eur J Cell Biol (2009) 2.17
Support for the immortal strand hypothesis: neural stem cells partition DNA asymmetrically in vitro. J Cell Biol (2005) 2.08
Regulation of vertebrate nervous system alternative splicing and development by an SR-related protein. Cell (2009) 1.98
Stem and progenitor cells: the premature desertion of rigorous definitions. Trends Neurosci (2003) 1.86
Functional coordination of alternative splicing in the mammalian central nervous system. Genome Biol (2007) 1.80
Dopamine modulates the plasticity of mechanosensory responses in Caenorhabditis elegans. EMBO J (2004) 1.79
A progressive and cell non-autonomous increase in striatal neural stem cells in the Huntington's disease R6/2 mouse. J Neurosci (2006) 1.64
DREAM is a critical transcriptional repressor for pain modulation. Cell (2002) 1.63
Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling. Genes Dev (2004) 1.63
In vivo infusions of exogenous growth factors into the fourth ventricle of the adult mouse brain increase the proliferation of neural progenitors around the fourth ventricle and the central canal of the spinal cord. Eur J Neurosci (2002) 1.56
Conserved site for neurosteroid modulation of GABA A receptors. Neuropharmacology (2008) 1.56
Embryonic stem cells assume a primitive neural stem cell fate in the absence of extrinsic influences. J Cell Biol (2006) 1.54
Opiate state controls bi-directional reward signaling via GABAA receptors in the ventral tegmental area. Nat Neurosci (2004) 1.43
High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model. Cancer Res (2006) 1.42
Coordinated international action to accelerate genome-to-phenome with FAANG, the Functional Annotation of Animal Genomes project. Genome Biol (2015) 1.40
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Targeted disruption of RC3 reveals a calmodulin-based mechanism for regulating metaplasticity in the hippocampus. J Neurosci (2002) 1.33
Don't look: growing clonal versus nonclonal neural stem cell colonies. Stem Cells (2008) 1.33
Notch signaling is required to maintain all neural stem cell populations--irrespective of spatial or temporal niche. Dev Neurosci (2006) 1.32
Dopamine specifically inhibits forebrain neural stem cell proliferation, suggesting a novel effect of antipsychotic drugs. J Neurosci (2005) 1.29
Ethanol suppression of ventral tegmental area GABA neuron electrical transmission involves N-methyl-D-aspartate receptors. J Pharmacol Exp Ther (2004) 1.26
Vascular endothelial growth factor directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival. J Neurosci (2006) 1.24
Low oxygen enhances primitive and definitive neural stem cell colony formation by inhibiting distinct cell death pathways. Stem Cells (2009) 1.23
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E-Cadherin regulates neural stem cell self-renewal. J Neurosci (2009) 1.21
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Suppression of Oct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage. J Neurosci (2009) 1.13
Lesions of the tegmental pedunculopontine nucleus block the rewarding effects and reveal the aversive effects of nicotine in the ventral tegmental area. J Neurosci (2002) 1.13
Motivational state determines the functional role of the mesolimbic dopamine system in the mediation of opiate reward processes. Behav Brain Res (2002) 1.09
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Maximizing functional photoreceptor differentiation from adult human retinal stem cells. Stem Cells (2010) 1.07
BH3 mimetic ABT-737 and a proteasome inhibitor synergistically kill melanomas through Noxa-dependent apoptosis. J Invest Dermatol (2008) 1.07
Barriers to HPV immunization for African American adolescent females. Vaccine (2012) 1.05
Cocaine disinhibits dopamine neurons in the ventral tegmental area via use-dependent blockade of GABA neuron voltage-sensitive sodium channels. Eur J Neurosci (2008) 1.04
Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells. J Cell Biol (2006) 1.04
Dopaminergic signaling mediates the motivational response underlying the opponent process to chronic but not acute nicotine. Neuropsychopharmacology (2009) 1.03
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Brain stimulation reward is integrated by a network of electrically coupled GABA neurons. Brain Res (2007) 1.02
Connexin-36 gap junctions mediate electrical coupling between ventral tegmental area GABA neurons. Synapse (2006) 1.01
Clonal neural stem cells from human embryonic stem cell colonies. J Neurosci (2012) 1.00
The motivational valence of nicotine in the rat ventral tegmental area is switched from rewarding to aversive following blockade of the alpha7-subunit-containing nicotinic acetylcholine receptor. Psychopharmacology (Berl) (2003) 1.00
The asymmetric segregation of damaged proteins is stem cell-type dependent. J Cell Biol (2013) 0.99
The proliferation and expansion of retinal stem cells require functional Pax6. Dev Biol (2007) 0.98
Loss of retinal progenitor cells leads to an increase in the retinal stem cell population in vivo. Eur J Neurosci (2006) 0.98
A hydrogel-based stem cell delivery system to treat retinal degenerative diseases. Biomaterials (2010) 0.97
Neurologic phenotype of Schimke immuno-osseous dysplasia and neurodevelopmental expression of SMARCAL1. J Neuropathol Exp Neurol (2008) 0.96
Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal. Proc Natl Acad Sci U S A (2012) 0.94
Different neural systems mediate morphine reward and its spontaneous withdrawal aversion. Eur J Neurosci (2009) 0.93
Genetic deletion of regulator of G-protein signaling 4 (RGS4) rescues a subset of fragile X related phenotypes in the FMR1 knockout mouse. Mol Cell Neurosci (2011) 0.93
Insulin signaling plays a dual role in Caenorhabditis elegans memory acquisition and memory retrieval. J Neurosci (2010) 0.92
'Sensing' autoimmunity in type 1 diabetes. Trends Mol Med (2007) 0.92
The role of connexin-36 gap junctions in alcohol intoxication and consumption. Synapse (2010) 0.92
Fetal alcohol exposure leads to abnormal olfactory bulb development and impaired odor discrimination in adult mice. Mol Brain (2011) 0.92
Contingent and non-contingent effects of low-dose ethanol on GABA neuron activity in the ventral tegmental area. Pharmacol Biochem Behav (2008) 0.92
Acupuncture inhibits GABA neuron activity in the ventral tegmental area and reduces ethanol self-administration. Alcohol Clin Exp Res (2010) 0.91
Excitotoxic lesions of the tegmental pedunculopontine nucleus impair copulation in naive male rats and block the rewarding effects of copulation in experienced male rats. Eur J Neurosci (2003) 0.91
GABAA receptors signal bidirectional reward transmission from the ventral tegmental area to the tegmental pedunculopontine nucleus as a function of opiate state. Eur J Neurosci (2004) 0.91
A test of the opponent-process theory of motivation using lesions that selectively block morphine reward. Eur J Neurosci (2007) 0.90
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The generation of definitive neural stem cells from PiggyBac transposon-induced pluripotent stem cells can be enhanced by induction of the NOTCH signaling pathway. Stem Cells Dev (2012) 0.90
Mefloquine effects on ventral tegmental area dopamine and GABA neuron inhibition: a physiologic role for connexin-36 GAP junctions. Synapse (2011) 0.89
Oct4 is required ~E7.5 for proliferation in the primitive streak. PLoS Genet (2013) 0.89
The adult mouse dentate gyrus contains populations of committed progenitor cells that are distinct from subependymal zone neural stem cells. Stem Cells (2011) 0.88
Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye. EMBO Mol Med (2014) 0.87
The adult retinal stem cell is a rare cell in the ciliary epithelium whose progeny can differentiate into photoreceptors. Biol Open (2012) 0.87
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Two forms of learning following training to a single odorant in Caenorhabditis elegans AWC neurons. J Neurosci (2012) 0.85
Cortex- and striatum- derived neural stem cells produce distinct progeny in the olfactory bulb and striatum. Eur J Neurosci (2008) 0.84
Adhesion is prerequisite, but alone insufficient, to elicit stem cell pluripotency. J Neurosci (2007) 0.84
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Acute and chronic ethanol modulate dopamine D2-subtype receptor responses in ventral tegmental area GABA neurons. Alcohol Clin Exp Res (2009) 0.82