Published in Epidemiology on July 01, 2009
Antidepressant use in pregnancy and the risk of cardiac defects. N Engl J Med (2014) 4.99
Higher potency statins and the risk of new diabetes: multicentre, observational study of administrative databases. BMJ (2014) 4.34
A combined comorbidity score predicted mortality in elderly patients better than existing scores. J Clin Epidemiol (2011) 3.98
Differential risk of death in older residents in nursing homes prescribed specific antipsychotic drugs: population based cohort study. BMJ (2012) 3.44
Antidepressant use late in pregnancy and risk of persistent pulmonary hypertension of the newborn. JAMA (2015) 3.20
Cardiovascular outcomes and mortality in patients using clopidogrel with proton pump inhibitors after percutaneous coronary intervention or acute coronary syndrome. Circulation (2009) 3.09
Confounding control in healthcare database research: challenges and potential approaches. Med Care (2010) 3.01
Comparative safety and effectiveness of sitagliptin in patients with type 2 diabetes: retrospective population based cohort study. BMJ (2013) 2.92
Pharmacovigilance using clinical notes. Clin Pharmacol Ther (2013) 2.63
Novel data-mining methodologies for adverse drug event discovery and analysis. Clin Pharmacol Ther (2012) 2.56
Pioglitazone use and risk of bladder cancer: population based cohort study. BMJ (2016) 2.37
Association between the Part D coverage gap and adverse health outcomes. J Am Geriatr Soc (2012) 1.99
A basic study design for expedited safety signal evaluation based on electronic healthcare data. Pharmacoepidemiol Drug Saf (2010) 1.95
Confounding adjustment via a semi-automated high-dimensional propensity score algorithm: an application to electronic medical records. Pharmacoepidemiol Drug Saf (2011) 1.85
Annotation Analysis for Testing Drug Safety Signals using Unstructured Clinical Notes. J Biomed Semantics (2012) 1.83
Evaluating the impact of database heterogeneity on observational study results. Am J Epidemiol (2013) 1.83
Effects of adjusting for instrumental variables on bias and precision of effect estimates. Am J Epidemiol (2011) 1.77
Statins and congenital malformations: cohort study. BMJ (2015) 1.75
Healthy user and related biases in observational studies of preventive interventions: a primer for physicians. J Gen Intern Med (2011) 1.74
Covariate selection in high-dimensional propensity score analyses of treatment effects in small samples. Am J Epidemiol (2011) 1.72
Do observational studies using propensity score methods agree with randomized trials? A systematic comparison of studies on acute coronary syndromes. Eur Heart J (2012) 1.64
Propensity score methods for confounding control in nonexperimental research. Circ Cardiovasc Qual Outcomes (2013) 1.62
A Method to Combine Signals from Spontaneous Reporting Systems and Observational Healthcare Data to Detect Adverse Drug Reactions. Drug Saf (2015) 1.54
Clostridium difficile infection in hospitalized children in the United States. Arch Pediatr Adolesc Med (2011) 1.48
Metformin and low levels of thyroid-stimulating hormone in patients with type 2 diabetes mellitus. CMAJ (2014) 1.44
Variation in the risk of suicide attempts and completed suicides by antidepressant agent in adults: a propensity score-adjusted analysis of 9 years' data. Arch Gen Psychiatry (2010) 1.43
Effects of xanthine oxidase inhibitors on cardiovascular disease in patients with gout: a cohort study. Am J Med (2015) 1.42
Comparative safety of antidepressant agents for children and adolescents regarding suicidal acts. Pediatrics (2010) 1.40
Comparative Effectiveness of Statin Therapy in Chronic Kidney Disease and Acute Myocardial Infarction: A Retrospective Cohort Study. Am J Med (2015) 1.38
Role of disease risk scores in comparative effectiveness research with emerging therapies. Pharmacoepidemiol Drug Saf (2012) 1.32
Study design for a comprehensive assessment of biologic safety using multiple healthcare data systems. Pharmacoepidemiol Drug Saf (2011) 1.30
Using Big Data to Emulate a Target Trial When a Randomized Trial Is Not Available. Am J Epidemiol (2016) 1.29
Using temporal patterns in medical records to discern adverse drug events from indications. AMIA Jt Summits Transl Sci Proc (2012) 1.29
Squeezing the balloon: propensity scores and unmeasured covariate balance. Health Serv Res (2012) 1.29
Incretin based drugs and risk of acute pancreatitis in patients with type 2 diabetes: cohort study. BMJ (2014) 1.27
Risk of death and hospital admission for major medical events after initiation of psychotropic medications in older adults admitted to nursing homes. CMAJ (2011) 1.26
Proton pump inhibitors and the risk of hospitalisation for community-acquired pneumonia: replicated cohort studies with meta-analysis. Gut (2013) 1.26
Incentive-Based Primary Care: Cost and Utilization Analysis. Perm J (2015) 1.26
Privacy-maintaining propensity score-based pooling of multiple databases applied to a study of biologics. Med Care (2010) 1.25
Model feedback in Bayesian propensity score estimation. Biometrics (2013) 1.23
Active safety monitoring of newly marketed medications in a distributed data network: application of a semi-automated monitoring system. Clin Pharmacol Ther (2012) 1.20
Mining high-dimensional administrative claims data to predict early hospital readmissions. J Am Med Inform Assoc (2013) 1.19
Building the graph of medicine from millions of clinical narratives. Sci Data (2014) 1.14
Antipsychotic drug use in pregnancy: high dimensional, propensity matched, population based cohort study. BMJ (2015) 1.10
Multivariate-adjusted pharmacoepidemiologic analyses of confidential information pooled from multiple health care utilization databases. Pharmacoepidemiol Drug Saf (2010) 1.10
Analyzing patterns of drug use in clinical notes for patient safety. AMIA Jt Summits Transl Sci Proc (2012) 1.10
High-dimensional versus conventional propensity scores in a comparative effectiveness study of coxibs and reduced upper gastrointestinal complications. Eur J Clin Pharmacol (2012) 1.09
Prognostic score-based balance measures can be a useful diagnostic for propensity score methods in comparative effectiveness research. J Clin Epidemiol (2013) 1.09
Matched designs and causal diagrams. Int J Epidemiol (2013) 1.08
Propensity scores for confounder adjustment when assessing the effects of medical interventions using nonexperimental study designs. J Intern Med (2014) 1.06
On weighting approaches for missing data. Stat Methods Med Res (2011) 1.05
Maximum likelihood, profile likelihood, and penalized likelihood: a primer. Am J Epidemiol (2013) 1.04
Death, debility, and destitution following hip fracture. J Gerontol A Biol Sci Med Sci (2013) 1.03
Applying propensity scores estimated in a full cohort to adjust for confounding in subgroup analyses. Pharmacoepidemiol Drug Saf (2011) 1.00
Signal detection and monitoring based on longitudinal healthcare data. Pharmaceutics (2012) 1.00
On the joint use of propensity and prognostic scores in estimation of the average treatment effect on the treated: a simulation study. Stat Med (2013) 0.99
Comparison of different approaches to confounding adjustment in a study on the association of antipsychotic medication with mortality in older nursing home patients. Am J Epidemiol (2011) 0.98
A method for controlling complex confounding effects in the detection of adverse drug reactions using electronic health records. J Am Med Inform Assoc (2013) 0.95
A review of covariate selection for non-experimental comparative effectiveness research. Pharmacoepidemiol Drug Saf (2013) 0.95
Digoxin and risk of death in adults with atrial fibrillation: the ATRIA-CVRN study. Circ Arrhythm Electrophysiol (2014) 0.94
Comparative safety of antipsychotic medications in nursing home residents. J Am Geriatr Soc (2012) 0.93
Association of early post-discharge follow-up by a primary care physician and 30-day rehospitalization among older adults. J Gen Intern Med (2014) 0.91
Active safety monitoring of new medical products using electronic healthcare data: selecting alerting rules. Epidemiology (2012) 0.91
Measuring frailty using claims data for pharmacoepidemiologic studies of mortality in older adults: evidence and recommendations. Pharmacoepidemiol Drug Saf (2014) 0.91
Does design matter? Systematic evaluation of the impact of analytical choices on effect estimates in observational studies. Ther Adv Drug Saf (2013) 0.90
Improving propensity score estimators' robustness to model misspecification using super learner. Am J Epidemiol (2014) 0.90
Antipsychotic Use in Pregnancy and the Risk for Congenital Malformations. JAMA Psychiatry (2016) 0.90
Comparative effectiveness of dabigatran and rivaroxaban versus warfarin for the treatment of non-valvular atrial fibrillation. J Cardiol (2016) 0.89
Massive parallelization of serial inference algorithms for a complex generalized linear model. ACM Trans Model Comput Simul (2013) 0.88
Hospital variation in nitric oxide use for premature infants. Pediatrics (2012) 0.88
Hospital level under-utilization of minimally invasive surgery in the United States: retrospective review. BMJ (2014) 0.88
Comparative effectiveness research in heart failure therapies: women, elderly patients, and patients with kidney disease. Heart Fail Clin (2012) 0.87
Severe hypoglycemia in users of sulfonylurea antidiabetic agents and antihyperlipidemics. Clin Pharmacol Ther (2016) 0.87
Exhaustion, automation, theory, and confounding. Epidemiology (2009) 0.87
Confronting "confounding by health system use" in Medicare Part D: comparative effectiveness of propensity score approaches to confounding adjustment. Pharmacoepidemiol Drug Saf (2012) 0.86
Clopidogrel and proton pump inhibitors--where do we stand in 2012? World J Gastroenterol (2012) 0.85
Uncertainty in Propensity Score Estimation: Bayesian Methods for Variable Selection and Model Averaged Causal Effects. J Am Stat Assoc (2014) 0.85
Analyzing search behavior of healthcare professionals for drug safety surveillance. Pac Symp Biocomput (2015) 0.85
Beneficiaries with cardiovascular disease and thePart D coverage gap. Circ Cardiovasc Qual Outcomes (2012) 0.85
Observing versus Predicting: Initial Patterns of Filling Predict Long-Term Adherence More Accurately Than High-Dimensional Modeling Techniques. Health Serv Res (2015) 0.85
Super learning to hedge against incorrect inference from arbitrary parametric assumptions in marginal structural modeling. J Clin Epidemiol (2013) 0.84
Propensity score methods and unobserved covariate imbalance: comments on "squeezing the balloon". Health Serv Res (2014) 0.83
Effects of aggregation of drug and diagnostic codes on the performance of the high-dimensional propensity score algorithm: an empirical example. BMC Med Res Methodol (2013) 0.83
Consistent causal effect estimation under dual misspecification and implications for confounder selection procedures. Stat Methods Med Res (2012) 0.83
Outcome modelling strategies in epidemiology: traditional methods and basic alternatives. Int J Epidemiol (2016) 0.82
Methodological considerations in assessing the effectiveness of antidepressant medication continuation during pregnancy using administrative data. Pharmacoepidemiol Drug Saf (2015) 0.81
Field-wide meta-analyses of observational associations can map selective availability of risk factors and the impact of model specifications. J Clin Epidemiol (2015) 0.81
Sparse conditional logistic regression for analyzing large-scale matched data from epidemiological studies: a simple algorithm. BMC Bioinformatics (2015) 0.81
A comparison of confounding adjustment methods for assessment of asthma controller medication effectiveness. Am J Epidemiol (2014) 0.81
Association between anti-TNF-α therapy and interstitial lung disease. Pharmacoepidemiol Drug Saf (2013) 0.81
Discussion: An estimate of the science-wise false discovery rate and application to the top medical literature. Biostatistics (2013) 0.80
Risk of ischemic stroke associated with the use of antipsychotic drugs in elderly patients: a retrospective cohort study in Korea. PLoS One (2015) 0.80
Estimating causal effects in observational studies using Electronic Health Data: Challenges and (some) solutions. EGEMS (Wash DC) (2013) 0.80
Risk of neonatal drug withdrawal after intrauterine co-exposure to opioids and psychotropic medications: cohort study. BMJ (2017) 0.80
The challenges of comparing results between placebo controlled randomized trials and non-experimental new user, active comparator cohort studies: the example of olmesartan. Pharmacoepidemiol Drug Saf (2014) 0.79
A modular, prospective, semi-automated drug safety monitoring system for use in a distributed data environment. Pharmacoepidemiol Drug Saf (2014) 0.79
Head to head comparison of the propensity score and the high-dimensional propensity score matching methods. BMC Med Res Methodol (2016) 0.79
"Weekend effect" on stroke mortality revisited: Application of a claims-based stroke severity index in a population-based cohort study. Medicine (Baltimore) (2016) 0.79
Revisiting the behavioral model and access to medical care: does it matter? J Health Soc Behav (1995) 38.24
Evaluating medication effects outside of clinical trials: new-user designs. Am J Epidemiol (2003) 11.24
Variable selection for propensity score models. Am J Epidemiol (2006) 10.68
A review of uses of health care utilization databases for epidemiologic research on therapeutics. J Clin Epidemiol (2005) 8.77
Bootstrap confidence intervals: when, which, what? A practical guide for medical statisticians. Stat Med (2000) 7.79
A review of the application of propensity score methods yielded increasing use, advantages in specific settings, but not substantially different estimates compared with conventional multivariable methods. J Clin Epidemiol (2005) 7.31
Quantifying biases in causal models: classical confounding vs collider-stratification bias. Epidemiology (2003) 6.35
The effect of misclassification in the presence of covariates. Am J Epidemiol (1980) 5.66
Confounding by indication. Epidemiology (1996) 5.01
Estimating exposure effects by modelling the expectation of exposure conditional on confounders. Biometrics (1992) 3.99
Recall accuracy for prescription medications: self-report compared with database information. Am J Epidemiol (1995) 3.33
Relationship between selective cyclooxygenase-2 inhibitors and acute myocardial infarction in older adults. Circulation (2004) 2.98
Selective prescribing led to overestimation of the benefits of lipid-lowering drugs. J Clin Epidemiol (2006) 2.81
Effect of increased cost-sharing on oral hypoglycemic use in five managed care organizations: how much is too much? Med Care (2005) 2.33
Increasing levels of restriction in pharmacoepidemiologic database studies of elderly and comparison with randomized trial results. Med Care (2007) 2.31
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An application of propensity score matching using claims data. Pharmacoepidemiol Drug Saf (2005) 2.15
Invited commentary: variable selection versus shrinkage in the control of multiple confounders. Am J Epidemiol (2008) 2.02
Efficacy and safety of statin monotherapy in older adults: a meta-analysis. J Gerontol A Biol Sci Med Sci (2007) 1.97
Positive predictive value of ICD-9 codes in the identification of cases of complicated peptic ulcer disease in the Saskatchewan hospital automated database. Epidemiology (1996) 1.87
A Medicare database review found that physician preferences increasingly outweighed patient characteristics as determinants of first-time prescriptions for COX-2 inhibitors. J Clin Epidemiol (2005) 1.83
Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial reports. Arthritis Res Ther (2005) 1.63
Simultaneous assessment of short-term gastrointestinal benefits and cardiovascular risks of selective cyclooxygenase 2 inhibitors and nonselective nonsteroidal antiinflammatory drugs: an instrumental variable analysis. Arthritis Rheum (2006) 1.60
Spurious effects from an extraneous variable. J Chronic Dis (1966) 1.56
The validity of medicaid pharmacy claims for estimating drug use among elderly nursing home residents: The Oregon experience. J Clin Epidemiol (2000) 1.47
Use of propensity score technique to account for exposure-related covariates: an example and lesson. Med Care (2007) 1.44
Understanding secondary databases: a commentary on "Sources of bias for health state characteristics in secondary databases". J Clin Epidemiol (2007) 1.37
Impact of mis-specification of the treatment model on estimates from a marginal structural model. Stat Med (2008) 1.27
Gastrointestinal tolerability of the selective cyclooxygenase-2 (COX-2) inhibitor rofecoxib compared with nonselective COX-1 and COX-2 inhibitors in osteoarthritis. Arch Intern Med (2000) 1.27
Variable selection and raking in propensity scoring. Stat Med (2007) 1.25
Use of automated databases for pharmacoepidemiology research. Epidemiol Rev (1990) 1.24
The comparative safety of rosuvastatin: a retrospective matched cohort study in over 48,000 initiators of statin therapy. Pharmacoepidemiol Drug Saf (2006) 1.20
Meta-analysis: upper gastrointestinal tolerability of valdecoxib, a cyclooxygenase-2-specific inhibitor, compared with nonspecific nonsteroidal anti-inflammatory drugs among patients with osteoarthritis and rheumatoid arthritis. Aliment Pharmacol Ther (2005) 0.99
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med (2008) 43.36
Variable selection for propensity score models. Am J Epidemiol (2006) 10.68
Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial. Lancet (2009) 10.52
A review of uses of health care utilization databases for epidemiologic research on therapeutics. J Clin Epidemiol (2005) 8.77
Long-term, low-intensity warfarin therapy for the prevention of recurrent venous thromboembolism. N Engl J Med (2003) 8.65
Risk of death in elderly users of conventional vs. atypical antipsychotic medications. N Engl J Med (2005) 8.44
Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA (2008) 8.32
A review of the application of propensity score methods yielded increasing use, advantages in specific settings, but not substantially different estimates compared with conventional multivariable methods. J Clin Epidemiol (2005) 7.31
Long-term persistence in use of statin therapy in elderly patients. JAMA (2002) 7.19
Clinical equivalence of generic and brand-name drugs used in cardiovascular disease: a systematic review and meta-analysis. JAMA (2008) 6.63
Accuracy of Medicare claims-based diagnosis of acute myocardial infarction: estimating positive predictive value on the basis of review of hospital records. Am Heart J (2004) 6.57
Results of multivariable logistic regression, propensity matching, propensity adjustment, and propensity-based weighting under conditions of nonuniform effect. Am J Epidemiol (2005) 6.20
A randomized study of how physicians interpret research funding disclosures. N Engl J Med (2012) 5.47
Multivitamins in the prevention of cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA (2012) 5.25
Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA (2008) 5.13
Antidepressant use in pregnancy and the risk of cardiac defects. N Engl J Med (2014) 4.99
Nonadherence to adjuvant tamoxifen therapy in women with primary breast cancer. J Clin Oncol (2003) 4.95
Risk of death and cardiovascular events in initially healthy women with new-onset atrial fibrillation. JAMA (2011) 4.73
Self-management education programs in chronic disease: a systematic review and methodological critique of the literature. Arch Intern Med (2004) 4.68
Full coverage for preventive medications after myocardial infarction. N Engl J Med (2011) 4.51
The comparative safety of analgesics in older adults with arthritis. Arch Intern Med (2010) 4.47
Cardiovascular benefits and diabetes risks of statin therapy in primary prevention: an analysis from the JUPITER trial. Lancet (2012) 4.46
Multivitamins in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA (2012) 4.40
New FDA breakthrough-drug category--implications for patients. N Engl J Med (2014) 4.30
Adherence to therapy with oral antineoplastic agents. J Natl Cancer Inst (2002) 4.16
HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trial. Lancet (2010) 4.07
Outcomes of reference pricing for angiotensin-converting-enzyme inhibitors. N Engl J Med (2002) 4.07
Depression and risk of sudden cardiac death and coronary heart disease in women: results from the Nurses' Health Study. J Am Coll Cardiol (2009) 3.99
A combined comorbidity score predicted mortality in elderly patients better than existing scores. J Clin Epidemiol (2011) 3.98
Use of antidepressants near delivery and risk of postpartum hemorrhage: cohort study of low income women in the United States. BMJ (2013) 3.88
Anticonvulsant medications and the risk of suicide, attempted suicide, or violent death. JAMA (2010) 3.85
Adherence to lipid-lowering therapy and the use of preventive health services: an investigation of the healthy user effect. Am J Epidemiol (2007) 3.82
The epidemiology of prescriptions abandoned at the pharmacy. Ann Intern Med (2010) 3.78
Primary prevention of cardiovascular diseases with statin therapy: a meta-analysis of randomized controlled trials. Arch Intern Med (2006) 3.75
The implications of choice: prescribing generic or preferred pharmaceuticals improves medication adherence for chronic conditions. Arch Intern Med (2006) 3.64
Burden of changes in pill appearance for patients receiving generic cardiovascular medications after myocardial infarction: cohort and nested case-control studies. Ann Intern Med (2014) 3.62
Altitude and all-cause mortality in incident dialysis patients. JAMA (2009) 3.62
Primary medication non-adherence: analysis of 195,930 electronic prescriptions. J Gen Intern Med (2010) 3.57
Effect of smoking on comparative efficacy of antiplatelet agents: systematic review, meta-analysis, and indirect comparison. BMJ (2013) 3.43
The quality of pharmacologic care for vulnerable older patients. Ann Intern Med (2004) 3.34
Analytic strategies to adjust confounding using exposure propensity scores and disease risk scores: nonsteroidal antiinflammatory drugs and short-term mortality in the elderly. Am J Epidemiol (2005) 3.33
The implications of therapeutic complexity on adherence to cardiovascular medications. Arch Intern Med (2011) 3.27
Rethinking the use of physicians as hired expert lecturers. Ann Intern Med (2014) 3.22
Blood pressure and risk of developing type 2 diabetes mellitus: the Women's Health Study. Eur Heart J (2007) 3.21
Drug-review deadlines and safety problems. N Engl J Med (2008) 3.16
Variations in pill appearance of antiepileptic drugs and the risk of nonadherence. JAMA Intern Med (2013) 3.13
Cardiovascular outcomes and mortality in patients using clopidogrel with proton pump inhibitors after percutaneous coronary intervention or acute coronary syndrome. Circulation (2009) 3.09
Balancing innovation, access, and profits--market exclusivity for biologics. N Engl J Med (2009) 3.08
Tumor necrosis factor alpha antagonist use and cancer in patients with rheumatoid arthritis. Arthritis Rheum (2006) 3.04
High-density lipoprotein cholesterol, size, particle number, and residual vascular risk after potent statin therapy. Circulation (2013) 3.03
Confounding control in healthcare database research: challenges and potential approaches. Med Care (2010) 3.01
Relationship between selective cyclooxygenase-2 inhibitors and acute myocardial infarction in older adults. Circulation (2004) 2.98
University-based science and biotechnology products: defining the boundaries of intellectual property. JAMA (2005) 2.95
Compliance with osteoporosis medications. Arch Intern Med (2005) 2.91
Noncompliance with antihypertensive medications: the impact of depressive symptoms and psychosocial factors. J Gen Intern Med (2002) 2.85
Nonsteroidal anti-inflammatory drug use and acute myocardial infarction. Arch Intern Med (2002) 2.82
Selective prescribing led to overestimation of the benefits of lipid-lowering drugs. J Clin Epidemiol (2006) 2.81
The comparative short-term effectiveness of iron dosing and formulations in US hemodialysis patients. Am J Med (2013) 2.77
Internet marketing of herbal products. JAMA (2003) 2.77
Economic implications of evidence-based prescribing for hypertension: can better care cost less? JAMA (2004) 2.77
Treatment effects in the presence of unmeasured confounding: dealing with observations in the tails of the propensity score distribution--a simulation study. Am J Epidemiol (2010) 2.74
Inhibition of clinical benefits of aspirin on first myocardial infarction by nonsteroidal antiinflammatory drugs. Circulation (2003) 2.73
The comparative safety of opioids for nonmalignant pain in older adults. Arch Intern Med (2010) 2.71
Comparative mortality risk of anemia management practices in incident hemodialysis patients. JAMA (2010) 2.71
Sending pharma better signals. Science (2005) 2.69
Identification of individuals with CKD from Medicare claims data: a validation study. Am J Kidney Dis (2005) 2.65
Improved comorbidity adjustment for predicting mortality in Medicare populations. Health Serv Res (2003) 2.65
The increasing prevalence of atrial fibrillation among hemodialysis patients. J Am Soc Nephrol (2011) 2.61
Characteristics of clinical trials to support approval of orphan vs nonorphan drugs for cancer. JAMA (2011) 2.60
Improvements in long-term mortality after myocardial infarction and increased use of cardiovascular drugs after discharge: a 10-year trend analysis. J Am Coll Cardiol (2008) 2.58