Published in Cell on May 29, 2009
SF1 and SF2 helicases: family matters. Curr Opin Struct Biol (2010) 3.79
Running in reverse: the structural basis for translocation polarity in hexameric helicases. Cell (2009) 3.38
The hexameric helicase DnaB adopts a nonplanar conformation during translocation. Cell (2012) 2.37
Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism. Proc Natl Acad Sci U S A (2009) 1.94
Hepatitis C virus non-structural protein 3 (HCV NS3): a multifunctional antiviral target. J Biol Chem (2010) 1.58
The T4 phage SF1B helicase Dda is structurally optimized to perform DNA strand separation. Structure (2012) 1.52
Visualizing ATP-dependent RNA translocation by the NS3 helicase from HCV. J Mol Biol (2010) 1.38
Bacterial DNA repair: recent insights into the mechanism of RecBCD, AddAB and AdnAB. Nat Rev Microbiol (2012) 1.37
Functional and structural studies of the nucleotide excision repair helicase XPD suggest a polarity for DNA translocation. EMBO J (2011) 1.28
Characterization of the mycobacterial AdnAB DNA motor provides insights into the evolution of bacterial motor-nuclease machines. J Biol Chem (2009) 1.13
Sequence-specific assembly of FtsK hexamers establishes directional translocation on DNA. Proc Natl Acad Sci U S A (2010) 1.13
Processive translocation mechanism of the human Bloom's syndrome helicase along single-stranded DNA. Nucleic Acids Res (2010) 1.08
Ensemble methods for monitoring enzyme translocation along single stranded nucleic acids. Methods (2010) 1.07
Regulation of translocation polarity by helicase domain 1 in SF2B helicases. EMBO J (2011) 1.04
Fitting CRISPR-associated Cas3 into the helicase family tree. Curr Opin Struct Biol (2014) 1.04
The AddAB helicase-nuclease catalyses rapid and processive DNA unwinding using a single Superfamily 1A motor domain. Nucleic Acids Res (2010) 1.02
Fork sensing and strand switching control antagonistic activities of RecQ helicases. Nat Commun (2013) 0.97
Yeast Pif1 helicase exhibits a one-base-pair stepping mechanism for unwinding duplex DNA. J Biol Chem (2013) 0.96
Lessons learned from UvrD helicase: mechanism for directional movement. Annu Rev Biophys (2010) 0.96
Structural insights into the unique single-stranded DNA-binding mode of Helicobacter pylori DprA. Nucleic Acids Res (2013) 0.95
Single-stranded DNA translocation of E. coli UvrD monomer is tightly coupled to ATP hydrolysis. J Mol Biol (2012) 0.90
Fluorescence methods to study DNA translocation and unwinding kinetics by nucleic acid motors. Methods Mol Biol (2012) 0.89
Single-stranded DNA binding by F TraI relaxase and helicase domains is coordinately regulated. J Bacteriol (2010) 0.89
Complex activities of the human Bloom's syndrome helicase are encoded in a core region comprising the RecA and Zn-binding domains. Nucleic Acids Res (2012) 0.89
Superfamily 2 helicases. Front Biosci (Landmark Ed) (2012) 0.89
Translocation, switching and gating: potential roles for ATP in long-range communication on DNA by Type III restriction endonucleases. Biochem Soc Trans (2011) 0.89
Crystal structure of the superfamily 1 helicase from Tomato mosaic virus. J Virol (2012) 0.87
BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner. PLoS One (2012) 0.87
Grip it and rip it: structural mechanisms of DNA helicase substrate binding and unwinding. Protein Sci (2014) 0.86
Structure and Mechanisms of SF1 DNA Helicases. Adv Exp Med Biol (2013) 0.86
The Ighmbp2 helicase structure reveals the molecular basis for disease-causing mutations in DMSA1. Nucleic Acids Res (2012) 0.84
Dna2 nuclease-helicase structure, mechanism and regulation by Rpa. Elife (2015) 0.84
Interdomain Communication of the Chd1 Chromatin Remodeler across the DNA Gyres of the Nucleosome. Mol Cell (2017) 0.82
Functional characterization of the multidomain F plasmid TraI relaxase-helicase. J Biol Chem (2011) 0.82
ATPase mechanism of the 5'-3' DNA helicase, RecD2: evidence for a pre-hydrolysis conformation change. J Biol Chem (2013) 0.81
RecD2 helicase limits replication fork stress in Bacillus subtilis. J Bacteriol (2014) 0.80
Translocation-coupled DNA cleavage by the Type ISP restriction-modification enzymes. Nat Chem Biol (2015) 0.80
Kinetics of DNA unwinding by the RecD2 helicase from Deinococcus radiodurans. J Biol Chem (2010) 0.79
Simultaneous binding to the tracking strand, displaced strand and the duplex of a DNA fork enhances unwinding by Dda helicase. Nucleic Acids Res (2014) 0.79
Molecular mechanics of RNA translocases. Methods Enzymol (2012) 0.78
Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase. Nucleic Acids Res (2013) 0.78
Sequence-dependent nanometer-scale conformational dynamics of individual RecBCD-DNA complexes. Nucleic Acids Res (2016) 0.77
Molecular and Functional Characterization of RecD, a Novel Member of the SF1 Family of Helicases, from Mycobacterium tuberculosis. J Biol Chem (2015) 0.77
Mechanism for nuclease regulation in RecBCD. Elife (2016) 0.77
Crystal structures of the BsPif1 helicase reveal that a major movement of the 2B SH3 domain is required for DNA unwinding. Nucleic Acids Res (2016) 0.76
The Q Motif Is Involved in DNA Binding but Not ATP Binding in ChlR1 Helicase. PLoS One (2015) 0.76
Functional link between DEAH/RHA helicase Prp43 activation and ATP base binding. Nucleic Acids Res (2017) 0.75
A Decade of Biochemical and Structural Studies of the DNA Repair Machinery of Deinococcus radiodurans: Major Findings, Functional and Mechanistic Insight and Challenges. Comput Struct Biotechnol J (2016) 0.75
Unique helicase determinants in the essential conjugative TraI factor from Salmonella enterica serovar Typhimurium plasmid pCU1. J Bacteriol (2014) 0.75
Chemical modifications of DNA for study of helicase mechanisms. Bioorg Med Chem (2014) 0.75
Modulation of Escherichia coli UvrD Single-Stranded DNA Translocation by DNA Base Composition. Biophys J (2017) 0.75
Structure and mechanism of helicases and nucleic acid translocases. Annu Rev Biochem (2007) 7.83
Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks. Nature (2004) 4.35
Pumps, paradoxes and ploughshares: mechanism of the MCM2-7 DNA helicase. Trends Biochem Sci (2005) 2.53
Structure of the single-strand annealing domain of human RAD52 protein. Proc Natl Acad Sci U S A (2002) 2.24
Modularity and specialization in superfamily 1 and 2 helicases. J Bacteriol (2002) 2.14
Structural basis of DNA replication origin recognition by an ORC protein. Science (2007) 2.00
Direct measurement of single-stranded DNA translocation by PcrA helicase using the fluorescent base analogue 2-aminopurine. Biochemistry (2002) 1.76
Direct observation of the mechanochemical coupling in myosin Va during processive movement. Nature (2008) 1.51
CeBRC-2 stimulates D-loop formation by RAD-51 and promotes DNA single-strand annealing. J Mol Biol (2006) 1.42
The 'glutamate switch' provides a link between ATPase activity and ligand binding in AAA+ proteins. Nat Struct Mol Biol (2008) 1.38
DNA binding to RecD: role of the 1B domain in SF1B helicase activity. EMBO J (2008) 1.32
Conformational changes induced by nucleotide binding in Cdc6/ORC from Aeropyrum pernix. J Mol Biol (2004) 1.30
Kinetics of ADP dissociation from the trail and lead heads of actomyosin V following the power stroke. J Biol Chem (2007) 1.28
Insights into Chi recognition from the structure of an AddAB-type helicase-nuclease complex. EMBO J (2012) 1.21
Smooth muscle myosin: regulation and properties. Philos Trans R Soc Lond B Biol Sci (2004) 1.20
PcrA helicase tightly couples ATP hydrolysis to unwinding double-stranded DNA, modulated by the initiator protein for plasmid replication, RepD. Biochemistry (2009) 1.17
Biochemical analysis of a DNA replication origin in the archaeon Aeropyrum pernix. J Mol Biol (2006) 1.16
Biochemical analysis of components of the pre-replication complex of Archaeoglobus fulgidus. Nucleic Acids Res (2003) 1.16
Bipolar DNA translocation contributes to highly processive DNA unwinding by RecBCD enzyme. J Biol Chem (2005) 1.15
Restart of DNA replication in Gram-positive bacteria: functional characterisation of the Bacillus subtilis PriA initiator. Nucleic Acids Res (2002) 1.11
Fluorescent single-stranded DNA binding protein as a probe for sensitive, real-time assays of helicase activity. Biophys J (2008) 1.11
Distinct roles for ATP binding and hydrolysis at individual subunits of an archaeal clamp loader. EMBO J (2004) 1.07
Detecting intramolecular conformational dynamics of single molecules in short distance range with subnanometer sensitivity. Nano Lett (2011) 1.07
Kinetic mechanism of myosinV-S1 using a new fluorescent ATP analogue. Biochemistry (2006) 1.06
Molecular determinants responsible for recognition of the single-stranded DNA regulatory sequence, χ, by RecBCD enzyme. Proc Natl Acad Sci U S A (2012) 1.04
Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent. Proc Natl Acad Sci U S A (2008) 1.03
Mechanism of translocation and kinetics of DNA unwinding by the helicase RecG. Biochemistry (2005) 1.03
Communication between subunits within an archaeal clamp-loader complex. EMBO J (2006) 1.03
The AddAB helicase-nuclease catalyses rapid and processive DNA unwinding using a single Superfamily 1A motor domain. Nucleic Acids Res (2010) 1.02
Switch 1 mutation S217A converts myosin V into a low duty ratio motor. J Biol Chem (2008) 1.01
Mechanism of interaction between single-stranded DNA binding protein and DNA. Biochemistry (2010) 1.01
The ATPase cycle of PcrA helicase and its coupling to translocation on DNA. J Mol Biol (2009) 1.01
A biosensor for inorganic phosphate using a rhodamine-labeled phosphate binding protein. Biochemistry (2006) 0.99
Biochemical characterisation of the clamp/clamp loader proteins from the euryarchaeon Archaeoglobus fulgidus. Nucleic Acids Res (2002) 0.98
A biosensor for fluorescent determination of ADP with high time resolution. J Biol Chem (2009) 0.98
Structural basis for nuclear import of splicing factors by human Transportin 3. Proc Natl Acad Sci U S A (2014) 0.98
The mechanism of Ras GTPase activation by neurofibromin. Biochemistry (2003) 0.97
Myosin regulatory light chain phosphorylation and strain modulate adenosine diphosphate release from smooth muscle Myosin. Biophys J (2004) 0.95
Interactions between the nucleosome histone core and Arp8 in the INO80 chromatin remodeling complex. Proc Natl Acad Sci U S A (2012) 0.94
Alteration of χ recognition by RecBCD reveals a regulated molecular latch and suggests a channel-bypass mechanism for biological control. Proc Natl Acad Sci U S A (2012) 0.94
Visualizing helicases unwinding DNA at the single molecule level. Nucleic Acids Res (2010) 0.93
Millisecond-scale biochemical response to change in strain. Biophys J (2011) 0.93
Evidence that phosphate release is the rate-limiting step on the overall ATPase of psoas myofibrils prevented from shortening by chemical cross-linking. Biochemistry (2002) 0.89
Evidence for a novel, strongly bound acto-S1 complex carrying ADP and phosphate stabilized in the G680V mutant of Dictyostelium myosin II. Biochemistry (2002) 0.88
A fluorescent, reagentless biosensor for ADP based on tetramethylrhodamine-labeled ParM. ACS Chem Biol (2010) 0.88
Time course and strain dependence of ADP release during contraction of permeabilized skeletal muscle fibers. Biophys J (2009) 0.88
Fluorescence tools to measure helicase activity in real time. Methods (2010) 0.86
Probing nucleotide dissociation from myosin in vitro using microgram quantities of myosin. J Muscle Res Cell Motil (2003) 0.86
Monomeric PcrA helicase processively unwinds plasmid lengths of DNA in the presence of the initiator protein RepD. Nucleic Acids Res (2013) 0.83
The mechanism of smooth muscle caldesmon-tropomyosin inhibition of the elementary steps of the actomyosin ATPase. J Biol Chem (2006) 0.83
Multiple roles for ATP hydrolysis in nucleic acid modifying enzymes. EMBO J (2003) 0.82
ATPase cycle and DNA unwinding kinetics of RecG helicase. PLoS One (2012) 0.82
Mycobacterial ABC transport system: structure of the primary phosphate receptor. Structure (2003) 0.82
Structural features of Chi recognition in AddAB with implications for RecBCD. Cell Cycle (2014) 0.81
ATPase mechanism of the 5'-3' DNA helicase, RecD2: evidence for a pre-hydrolysis conformation change. J Biol Chem (2013) 0.81
A single-molecule approach to visualize the unwinding activity of DNA helicases. Methods Mol Biol (2011) 0.80
Fluorescence detection of GDP in real time with the reagentless biosensor rhodamine-ParM. Biochem J (2011) 0.80
Role of magnesium in nucleotide exchange on the small G protein rac investigated using novel fluorescent Guanine nucleotide analogues. Biochemistry (2002) 0.80
Fluorescent nucleoside triphosphates for single-molecule enzymology. Methods Mol Biol (2011) 0.79
A tale of the unexpected. Structure (2006) 0.79
Structural prediction of a rhodamine-based biosensor and comparison with biophysical data. Phys Chem Chem Phys (2012) 0.79
Fluorescent biosensors: design and application to motor proteins. EXS (2014) 0.79
The RecB nuclease domain binds to RecA-DNA filaments: implications for filament loading. J Mol Biol (2009) 0.78
Transient kinetics of aminoglycoside phosphotransferase(3')-IIIa reveals a potential drug target in the antibiotic resistance mechanism. FEBS Lett (2012) 0.78
Kinetic mechanism of initiation by RepD as a part of asymmetric, rolling circle plasmid unwinding. Biochemistry (2012) 0.77
Fluorescence lifetime imaging reveals that the environment of the ATP binding site of myosin in muscle senses force. Biophys J (2010) 0.77
Ligand-dependent dynamics of the active-site lid in bacterial dimethylarginine dimethylaminohydrolase. Biochemistry (2014) 0.76
Helicase unwinding: active or merely perfect? J Mol Biol (2012) 0.75
Fluorescent SSB as a reagentless biosensor for single-stranded DNA. Methods Mol Biol (2012) 0.75
Promotion of acellular dermal matrix resolution in vitro by matrix metalloproteinase-2. Arch Facial Plast Surg (2006) 0.75