Published in Am J Physiol Endocrinol Metab on June 02, 2009
Mechanisms for insulin resistance: common threads and missing links. Cell (2012) 6.85
The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase. Cell Metab (2010) 3.61
Lipolysis - a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores. Prog Lipid Res (2010) 2.60
Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling. J Biol Chem (2009) 1.63
Differential control of ATGL-mediated lipid droplet degradation by CGI-58 and G0S2. Cell Cycle (2010) 1.43
Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance. J Biol Chem (2011) 1.42
Adipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acids. J Lipid Res (2009) 1.36
Intramuscular triacylglycerol and insulin resistance: guilty as charged or wrongly accused? Biochim Biophys Acta (2009) 1.34
Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity. J Biol Chem (2010) 1.30
Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signaling. Chem Rev (2011) 1.28
Lipid oversupply, selective insulin resistance, and lipotoxicity: molecular mechanisms. Biochim Biophys Acta (2009) 1.28
Pigment epithelium-derived factor regulates lipid metabolism via adipose triglyceride lipase. Diabetes (2011) 1.25
Exercise- and training-induced upregulation of skeletal muscle fatty acid oxidation are not solely dependent on mitochondrial machinery and biogenesis. J Physiol (2012) 1.14
Circadian regulation of lipid mobilization in white adipose tissues. Diabetes (2013) 1.09
Skeletal muscle triacylglycerol hydrolysis does not influence metabolic complications of obesity. Diabetes (2013) 1.06
Measurement of lipolysis. Methods Enzymol (2014) 1.02
Neural innervation of white adipose tissue and the control of lipolysis. Front Neuroendocrinol (2014) 1.02
Contribution of novel ATGL missense mutations to the clinical phenotype of NLSD-M: a strikingly low amount of lipase activity may preserve cardiac function. Hum Mol Genet (2012) 0.99
In vivo, fatty acid translocase (CD36) critically regulates skeletal muscle fuel selection, exercise performance, and training-induced adaptation of fatty acid oxidation. J Biol Chem (2012) 0.98
Conditional knock-out reveals a requirement for O-linked N-Acetylglucosaminase (O-GlcNAcase) in metabolic homeostasis. J Biol Chem (2015) 0.97
Adipose triglyceride lipase expression in human adipose tissue and muscle. Role in insulin resistance and response to training and pioglitazone. Metabolism (2010) 0.96
Contraction-induced lipolysis is not impaired by inhibition of hormone-sensitive lipase in skeletal muscle. J Physiol (2013) 0.95
Investigation and functional characterization of rare genetic variants in the adipose triglyceride lipase in a large healthy working population. PLoS Genet (2010) 0.94
Exercise training protects against an acute inflammatory insult in mouse epididymal adipose tissue. J Appl Physiol (1985) (2014) 0.92
Skeletal muscle lipid flux: running water carries no poison. Am J Physiol Endocrinol Metab (2011) 0.91
A novel non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand UHC1 blocks PPARγ phosphorylation by cyclin-dependent kinase 5 (CDK5) and improves insulin sensitivity. J Biol Chem (2014) 0.91
Defective adipose lipolysis and altered global energy metabolism in mice with adipose overexpression of the lipolytic inhibitor G0/G1 switch gene 2 (G0S2). J Biol Chem (2013) 0.91
PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle. Mol Metab (2014) 0.91
The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis. Nutrients (2015) 0.87
Exercise training enhances white adipose tissue metabolism in rats selectively bred for low- or high-endurance running capacity. Am J Physiol Endocrinol Metab (2013) 0.84
Delineating the role of alterations in lipid metabolism to the pathogenesis of inherited skeletal and cardiac muscle disorders: Thematic Review Series: Genetics of Human Lipid Diseases. J Lipid Res (2011) 0.84
Pleiotropic regulation of mitochondrial function by adipose triglyceride lipase-mediated lipolysis. Biochimie (2013) 0.83
miR-155 Deletion in Female Mice Prevents Diet-Induced Obesity. Sci Rep (2016) 0.82
Higher levels of ATGL are associated with exercise-induced enhancement of lipolysis in rat epididymal adipocytes. PLoS One (2012) 0.81
Lipolytic signaling in response to acute exercise is altered in female mice following ovariectomy. J Cell Biochem (2011) 0.80
Differential regulation of PGC-1alpha expression in rat liver and skeletal muscle in response to voluntary running. Nutr Metab (Lond) (2010) 0.79
Effect and the probable mechanisms of silibinin in regulating insulin resistance in the liver of rats with non-alcoholic fatty liver. Braz J Med Biol Res (2013) 0.79
Adipose Tissue Lipolysis Promotes Exercise-induced Cardiac Hypertrophy Involving the Lipokine C16:1n7-Palmitoleate. J Biol Chem (2015) 0.78
The crucial role of ATGL for energy supply of muscles. J Lipid Res (2009) 0.77
Thyroid-stimulating hormone inhibits adipose triglyceride lipase in 3T3-L1 adipocytes through the PKA pathway. PLoS One (2015) 0.77
Intracellular lipid accumulation and shift during diabetes progression. Wien Med Wochenschr (2014) 0.77
Cellular localization and associations of the major lipolytic proteins in human skeletal muscle at rest and during exercise. PLoS One (2014) 0.76
Adipose triglyceride lipase deletion from adipocytes, but not skeletal myocytes, impairs acute exercise performance in mice. Am J Physiol Endocrinol Metab (2015) 0.76
Impaired glucose metabolism and exercise capacity with muscle-specific glycogen synthase 1 (gys1) deletion in adult mice. Mol Metab (2016) 0.75
Obesity does not promote tumorigenesis of localized patient-derived prostate cancer xenografts. Oncotarget (2016) 0.75
HSL and ATGL: the movers and shakers of muscle lipolysis. J Physiol (2013) 0.75
IL-6 and epinephrine have divergent fiber type effects on intramuscular lipolysis. J Appl Physiol (1985) (2013) 0.75
The Molecular Mechanism Underlying Continuous Exercise Training-Induced Adaptive Changes of Lipolysis in White Adipose Cells. J Obes (2015) 0.75
The Physiological Regulation of Skeletal Muscle Fatty Acid Supply and Oxidation During Moderate-Intensity Exercise. Sports Med (2015) 0.75
Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science (2004) 8.58
Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science (2006) 7.35
Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome. Cell Metab (2006) 6.25
Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest (2007) 4.86
Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. J Clin Invest (2010) 4.56
Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab (2007) 4.51
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1. Nat Med (2011) 3.96
Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism. J Biol Chem (2006) 3.74
Adipose triglyceride lipase contributes to cancer-associated cachexia. Science (2011) 3.70
Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis. J Biol Chem (2001) 3.10
Lipoprotein lipase: the regulation of tissue specific expression and its role in lipid and energy metabolism. Curr Opin Lipidol (2002) 2.85
Cellular fatty acid metabolism and cancer. Cell Metab (2013) 2.82
Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes (2006) 2.80
Reactive oxygen species enhance insulin sensitivity. Cell Metab (2009) 2.77
Lipolysis - a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores. Prog Lipid Res (2010) 2.60
HSP72 protects against obesity-induced insulin resistance. Proc Natl Acad Sci U S A (2008) 2.52
Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metab (2006) 2.43
Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice. Hepatology (2011) 2.33
Towards developing standard operating procedures for pre-clinical testing in the mdx mouse model of Duchenne muscular dystrophy. Neurobiol Dis (2008) 2.20
Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5. Am J Physiol Endocrinol Metab (2009) 2.19
Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance. Diabetes (2008) 2.14
Obese yeast: triglyceride lipolysis is functionally conserved from mammals to yeast. J Biol Chem (2005) 2.11
Hsp72 preserves muscle function and slows progression of severe muscular dystrophy. Nature (2012) 2.04
Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions. J Lipid Res (2008) 1.95
Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis. J Biol Chem (2008) 1.94
Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites. J Appl Physiol (1985) (2005) 1.88
The C-terminal region of human adipose triglyceride lipase affects enzyme activity and lipid droplet binding. J Biol Chem (2008) 1.80
Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome. J Lipid Res (2010) 1.75
Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58). J Biol Chem (2009) 1.72
Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase. Cell Metab (2012) 1.71
Species-specific identification of campylobacters by partial 16S rRNA gene sequencing. J Clin Microbiol (2003) 1.70
Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERalpha-deficient mice. Am J Physiol Endocrinol Metab (2009) 1.69
Adipocyte triglyceride lipase expression in human obesity. Am J Physiol Endocrinol Metab (2007) 1.69
Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness. Biogerontology (2008) 1.67
Pigment epithelium-derived factor contributes to insulin resistance in obesity. Cell Metab (2009) 1.66
The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance. Cell Metab (2012) 1.66
Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase. Proc Natl Acad Sci U S A (2003) 1.65
Fate of fat: the role of adipose triglyceride lipase in lipolysis. Biochim Biophys Acta (2008) 1.64
Brain insulin controls adipose tissue lipolysis and lipogenesis. Cell Metab (2011) 1.64
Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling. J Biol Chem (2009) 1.63
PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humans. Nat Genet (2012) 1.55
Mutations in the fatty acid transport protein 4 gene cause the ichthyosis prematurity syndrome. Am J Hum Genet (2009) 1.53
DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes. J Lipid Res (2011) 1.50
AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance. J Biol Chem (2009) 1.49
Biochemistry and pathophysiology of intravascular and intracellular lipolysis. Genes Dev (2013) 1.49
Improved contractile function of the mdx dystrophic mouse diaphragm muscle after insulin-like growth factor-I administration. Am J Pathol (2002) 1.48
Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice. Endocrinology (2003) 1.47
Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice. FASEB J (2008) 1.46
Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77. Diabetes (2009) 1.46
Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance. J Biol Chem (2011) 1.42
Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Mamm Genome (2010) 1.40
Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance. Am J Physiol Endocrinol Metab (2006) 1.39
Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance. Diabetes (2012) 1.38
The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle. Endocrinology (2008) 1.38
Adipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acids. J Lipid Res (2009) 1.36
Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae. Mol Syst Biol (2014) 1.35
Cardiac-specific knock-out of lipoprotein lipase alters plasma lipoprotein triglyceride metabolism and cardiac gene expression. J Biol Chem (2004) 1.34
Adipose triglyceride lipase in human skeletal muscle is upregulated by exercise training. Am J Physiol Endocrinol Metab (2008) 1.33
G0/G1 switch gene-2 regulates human adipocyte lipolysis by affecting activity and localization of adipose triglyceride lipase. J Lipid Res (2012) 1.32
Adipose triglyceride lipase-null mice are resistant to high-fat diet-induced insulin resistance despite reduced energy expenditure and ectopic lipid accumulation. Endocrinology (2010) 1.32
Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases. J Biol Chem (2012) 1.32
The N-terminal region of comparative gene identification-58 (CGI-58) is important for lipid droplet binding and activation of adipose triglyceride lipase. J Biol Chem (2010) 1.30
Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity. J Biol Chem (2010) 1.30
Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle. Am J Physiol Endocrinol Metab (2007) 1.30
Efficient phagocytosis requires triacylglycerol hydrolysis by adipose triglyceride lipase. J Biol Chem (2010) 1.29
Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion. J Biol Chem (2009) 1.27
Beta 2-agonist administration reverses muscle wasting and improves muscle function in aged rats. J Physiol (2003) 1.25
Pigment epithelium-derived factor regulates lipid metabolism via adipose triglyceride lipase. Diabetes (2011) 1.25
AMPK-independent pathways regulate skeletal muscle fatty acid oxidation. J Physiol (2008) 1.23
Hormone-sensitive lipase deficiency in mice changes the plasma lipid profile by affecting the tissue-specific expression pattern of lipoprotein lipase in adipose tissue and muscle. J Biol Chem (2002) 1.22
The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes. Diabetes (2006) 1.22
The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle. Endocrinology (2006) 1.21
Evaluating an internet weight loss program for diabetes prevention. Health Promot Int (2005) 1.21
Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity. Diabetes (2012) 1.20
Decreased fatty acid esterification compensates for the reduced lipolytic activity in hormone-sensitive lipase-deficient white adipose tissue. J Lipid Res (2003) 1.20
Cholesteryl ester hydrolase activity is abolished in HSL-/- macrophages but unchanged in macrophages lacking KIAA1363. J Lipid Res (2010) 1.20
Antibody-directed myostatin inhibition in 21-mo-old mice reveals novel roles for myostatin signaling in skeletal muscle structure and function. FASEB J (2010) 1.19
Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation. Am J Physiol Endocrinol Metab (2009) 1.19
Systemic administration of beta2-adrenoceptor agonists, formoterol and salmeterol, elicit skeletal muscle hypertrophy in rats at micromolar doses. Br J Pharmacol (2006) 1.17
Retracted PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle. FASEB J (2005) 1.17
Attenuation of myocardial ischemia/reperfusion injury in mice with myocyte-specific overexpression of endothelial nitric oxide synthase. Cardiovasc Res (2003) 1.17
Low dose formoterol administration improves muscle function in dystrophic mdx mice without increasing fatigue. Neuromuscul Disord (2006) 1.16
Skeletal muscle glucose uptake during contraction is regulated by nitric oxide and ROS independently of AMPK. Am J Physiol Endocrinol Metab (2009) 1.16
A genomic island defines subspecies-specific virulence features of the host-adapted pathogen Campylobacter fetus subsp. venerealis. J Bacteriol (2009) 1.14