Published in Cell Metab on October 01, 2009
Signal transduction by reactive oxygen species. J Cell Biol (2011) 5.21
Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance. Cell Metab (2010) 3.07
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab (2012) 2.59
Cellular metabolic stress: considering how cells respond to nutrient excess. Mol Cell (2010) 2.50
Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. Cell Metab (2012) 2.43
Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proc Natl Acad Sci U S A (2011) 2.41
Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging? Free Radic Biol Med (2009) 2.00
Insulin signaling meets mitochondria in metabolism. Trends Endocrinol Metab (2010) 1.77
Role of metabolic H2O2 generation: redox signaling and oxidative stress. J Biol Chem (2014) 1.70
RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition. PLoS Genet (2010) 1.66
Linking mitochondrial bioenergetics to insulin resistance via redox biology. Trends Endocrinol Metab (2012) 1.64
Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal (2011) 1.57
Electron transport chain-dependent and -independent mechanisms of mitochondrial H2O2 emission during long-chain fatty acid oxidation. J Biol Chem (2009) 1.52
S-glutathionylation: from molecular mechanisms to health outcomes. Antioxid Redox Signal (2011) 1.49
TAp73 depletion accelerates aging through metabolic dysregulation. Genes Dev (2012) 1.45
Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models? Free Radic Biol Med (2011) 1.35
Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity. PLoS Genet (2011) 1.35
Redox regulation of mitochondrial function. Antioxid Redox Signal (2012) 1.34
Selenoproteins: molecular pathways and physiological roles. Physiol Rev (2014) 1.34
Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans. J Clin Invest (2010) 1.33
Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals. Cell Res (2011) 1.32
Redox regulation of mitochondrial function with emphasis on cysteine oxidation reactions. Redox Biol (2013) 1.28
Mitochondrial dysfunction in white adipose tissue. Trends Endocrinol Metab (2012) 1.22
Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage. Free Radic Biol Med (2011) 1.21
Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance. Cell Metab (2011) 1.21
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease. Free Radic Biol Med (2015) 1.17
Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances. Front Endocrinol (Lausanne) (2012) 1.17
Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training. Compr Physiol (2013) 1.17
Aging, atherosclerosis, and IGF-1. J Gerontol A Biol Sci Med Sci (2012) 1.16
Redox signaling in cardiovascular health and disease. Free Radic Biol Med (2013) 1.16
Oxidative stress and metabolic pathologies: from an adipocentric point of view. Oxid Med Cell Longev (2014) 1.16
Differentiation of human adipose-derived stem cells into fat involves reactive oxygen species and Forkhead box O1 mediated upregulation of antioxidant enzymes. Stem Cells Dev (2012) 1.12
Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis. PLoS One (2012) 1.12
Leptin and insulin act on POMC neurons to promote the browning of white fat. Cell (2015) 1.11
Neuroinflammatory basis of metabolic syndrome. Mol Metab (2013) 1.10
Reactive oxygen species and redox compartmentalization. Front Physiol (2014) 1.07
From form to function: the role of Nox4 in the cardiovascular system. Front Physiol (2012) 1.07
Reduction in reactive oxygen species production by mitochondria from elderly subjects with normal and impaired glucose tolerance. Diabetes (2011) 1.07
12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases. Proc Natl Acad Sci U S A (2010) 1.06
Oxidative stress accumulates in adipose tissue during aging and inhibits adipogenesis. PLoS One (2011) 1.05
Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice. Antioxid Redox Signal (2011) 1.04
Thioredoxin/Txnip: redoxisome, as a redox switch for the pathogenesis of diseases. Front Immunol (2014) 1.04
T-cell protein tyrosine phosphatase attenuates STAT3 and insulin signaling in the liver to regulate gluconeogenesis. Diabetes (2010) 1.03
Mechanisms of increased in vivo insulin sensitivity by dietary methionine restriction in mice. Diabetes (2014) 1.03
The role of oxidative stress in the pathogenesis of type 2 diabetes: from molecular mechanism to clinical implication. Am J Transl Res (2010) 1.03
High selenium intake and increased diabetes risk: experimental evidence for interplay between selenium and carbohydrate metabolism. J Clin Biochem Nutr (2010) 1.03
Regulation of redox signaling by selenoproteins. Biol Trace Elem Res (2010) 1.01
IGF-1, oxidative stress and atheroprotection. Trends Endocrinol Metab (2010) 0.99
The mitochondrial paradigm for cardiovascular disease susceptibility and cellular function: a complementary concept to Mendelian genetics. Lab Invest (2011) 0.99
Glutathione defense mechanism in liver injury: insights from animal models. Food Chem Toxicol (2013) 0.98
Concentration-dependent dual effects of hydrogen peroxide on insulin signal transduction in H4IIEC hepatocytes. PLoS One (2011) 0.97
FFA-induced hepatic insulin resistance in vivo is mediated by PKCδ, NADPH oxidase, and oxidative stress. Am J Physiol Endocrinol Metab (2014) 0.97
A metabolomics-driven elucidation of the anti-obesity mechanisms of xanthohumol. J Biol Chem (2013) 0.97
Overexpression of manganese superoxide dismutase ameliorates high-fat diet-induced insulin resistance in rat skeletal muscle. Am J Physiol Endocrinol Metab (2012) 0.96
RNase L controls terminal adipocyte differentiation, lipids storage and insulin sensitivity via CHOP10 mRNA regulation. Cell Death Differ (2012) 0.95
Energy metabolism and inflammation in brain aging and Alzheimer's disease. Free Radic Biol Med (2016) 0.95
Metabolic regulation by protein tyrosine phosphatases. J Biomed Res (2014) 0.95
Two tales of antioxidant enzymes on β cells and diabetes. Antioxid Redox Signal (2010) 0.95
Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice. Cell Death Dis (2015) 0.94
Mutations in CYC1, encoding cytochrome c1 subunit of respiratory chain complex III, cause insulin-responsive hyperglycemia. Am J Hum Genet (2013) 0.94
Overfeeding reduces insulin sensitivity and increases oxidative stress, without altering markers of mitochondrial content and function in humans. PLoS One (2012) 0.93
Emodin regulates glucose utilization by activating AMP-activated protein kinase. J Biol Chem (2013) 0.93
Mitochondrial reactive oxygen species and adipose tissue thermogenesis: bridging physiology and mechanisms. J Biol Chem (2017) 0.93
Mice deficient in the respiratory chain gene Cox6a2 are protected against high-fat diet-induced obesity and insulin resistance. PLoS One (2013) 0.93
Nonalcoholic Fatty liver disease: pathogenesis and therapeutics from a mitochondria-centric perspective. Oxid Med Cell Longev (2014) 0.92
A high-selenium diet induces insulin resistance in gestating rats and their offspring. Free Radic Biol Med (2012) 0.92
Inducible liver-specific knockdown of protein tyrosine phosphatase 1B improves glucose and lipid homeostasis in adult mice. Diabetologia (2013) 0.91
Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling. Proc Natl Acad Sci U S A (2013) 0.91
Intrinsic aerobic capacity correlates with greater inherent mitochondrial oxidative and H2O2 emission capacities without major shifts in myosin heavy chain isoform. J Appl Physiol (1985) (2012) 0.91
H2O2 Signalling Pathway: A Possible Bridge between Insulin Receptor and Mitochondria. Curr Neuropharmacol (2012) 0.91
Role of reactive oxygen species in injury-induced insulin resistance. Mol Endocrinol (2011) 0.90
Mitochondrial dysfunction has divergent, cell type-dependent effects on insulin action. Mol Metab (2014) 0.90
Selenium and diabetes--evidence from animal studies. Free Radic Biol Med (2013) 0.89
Production and detection of reactive oxygen species (ROS) in cancers. J Vis Exp (2011) 0.89
Prolonged dietary selenium deficiency or excess does not globally affect selenoprotein gene expression and/or protein production in various tissues of pigs. J Nutr (2012) 0.89
Treatment with a SOD mimetic reduces visceral adiposity, adipocyte death, and adipose tissue inflammation in high fat-fed mice. Obesity (Silver Spring) (2013) 0.88
Mitochondrial fatty acid oxidation in obesity. Antioxid Redox Signal (2012) 0.88
NOX4 pathway as a source of selective insulin resistance and responsiveness. Arterioscler Thromb Vasc Biol (2012) 0.88
Walking the oxidative stress tightrope: a perspective from the naked mole-rat, the longest-living rodent. Curr Pharm Des (2011) 0.88
Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training? J Physiol (2016) 0.88
Hypothalamic microinflammation: a common basis of metabolic syndrome and aging. Trends Neurosci (2014) 0.88
Selenium supranutrition: are the potential benefits of chemoprevention outweighed by the promotion of diabetes and insulin resistance? Nutrients (2013) 0.88
Metabolic crosstalk between choline/1-carbon metabolism and energy homeostasis. Clin Chem Lab Med (2013) 0.87
Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men. J Physiol (2014) 0.87
Revisiting an age-old question regarding oxidative stress. Free Radic Biol Med (2014) 0.86
Biotin starvation causes mitochondrial protein hyperacetylation and partial rescue by the SIRT3-like deacetylase Hst4p. Nat Commun (2015) 0.86
Deletion of selenoprotein M leads to obesity without cognitive deficits. J Biol Chem (2013) 0.84
Hepatic gene expression profiling reveals key pathways involved in leptin-mediated weight loss in ob/ob mice. PLoS One (2010) 0.84
Hepatic oxidative stress promotes insulin-STAT-5 signaling and obesity by inactivating protein tyrosine phosphatase N2. Cell Metab (2014) 0.83
The neurodegenerative effects of selenium are inhibited by FOXO and PINK1/PTEN regulation of insulin/insulin-like growth factor signaling in Caenorhabditis elegans. Neurotoxicology (2014) 0.82
Physical exercise regulates p53 activity targeting SCO2 and increases mitochondrial COX biogenesis in cardiac muscle with age. PLoS One (2011) 0.82
Measurement of DCF fluorescence as a measure of reactive oxygen species in murine islets of Langerhans. Anal Methods (2014) 0.82
Redox homeostasis in pancreatic β cells. Oxid Med Cell Longev (2012) 0.82
DJ-1 links muscle ROS production with metabolic reprogramming and systemic energy homeostasis in mice. Nat Commun (2015) 0.82
Selenium and Metabolic Disorders: An Emphasis on Type 2 Diabetes Risk. Nutrients (2016) 0.82
T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice. Diabetologia (2011) 0.82
Interaction between insulin-like growth factor-1 and atherosclerosis and vascular aging. Front Horm Res (2014) 0.81
Increased Energy Expenditure, Ucp1 Expression, and Resistance to Diet-induced Obesity in Mice Lacking Nuclear Factor-Erythroid-2-related Transcription Factor-2 (Nrf2). J Biol Chem (2016) 0.81
Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA (2007) 11.87
Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature (2006) 10.07
Protein tyrosine phosphatases: from genes, to function, to disease. Nat Rev Mol Cell Biol (2006) 7.93
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science (1999) 7.84
Cell signaling. H2O2, a necessary evil for cell signaling. Science (2006) 7.53
Hydrogen peroxide sensing and signaling. Mol Cell (2007) 6.24
Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation. J Biol Chem (2003) 5.86
Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. J Clin Invest (2009) 5.66
Antioxidants prevent health-promoting effects of physical exercise in humans. Proc Natl Acad Sci U S A (2009) 5.19
Reversible inactivation of the tumor suppressor PTEN by H2O2. J Biol Chem (2002) 5.08
Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors. Proc Natl Acad Sci U S A (2004) 3.49
Role of mitochondrial dysfunction in insulin resistance. Circ Res (2008) 3.45
Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways. J Clin Invest (2001) 3.41
The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction. Mol Cell Biol (2004) 3.35
Regulation of ROS signal transduction by NADPH oxidase 4 localization. J Cell Biol (2008) 3.13
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK. Nat Med (2006) 3.11
Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking. J Biol Chem (2005) 3.04
Localizing NADPH oxidase-derived ROS. Sci STKE (2006) 2.91
Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia. J Biol Chem (1997) 2.35
Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase. Proc Natl Acad Sci U S A (2004) 2.27
Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity. J Physiol (2007) 2.13
The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease. Biochem J (2009) 1.97
Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase. Mol Cell Biol (1998) 1.94
Muscle-specific Pten deletion protects against insulin resistance and diabetes. Mol Cell Biol (2005) 1.93
Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B. J Biol Chem (2004) 1.81
Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide. J Biol Chem (1998) 1.73
A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia. Diabetes (2000) 1.73
Sac phosphatase domain proteins. Biochem J (2000) 1.69
Role of reactive oxygen species in contraction-mediated glucose transport in mouse skeletal muscle. J Physiol (2006) 1.55
The major target of the endogenously generated reactive oxygen species in response to insulin stimulation is phosphatase and tensin homolog and not phosphoinositide-3 kinase (PI-3 kinase) in the PI-3 kinase/Akt pathway. Mol Biol Cell (2004) 1.52
Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice. J Clin Invest (1999) 1.50
The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis. Nat Med (2006) 1.42
Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP. Mol Cell Biol (2005) 1.41
Hydrogen peroxide as an endogenous mediator and exogenous tool in cardiovascular research: issues and considerations. Curr Opin Pharmacol (2008) 1.41
A modified cysteinyl-labeling assay reveals reversible oxidation of protein tyrosine phosphatases in angiomyolipoma cells. Proc Natl Acad Sci U S A (2008) 1.33
Insulin regulation of skeletal muscle PDK4 mRNA expression is impaired in acute insulin-resistant states. Diabetes (2006) 1.32
Cloning and characterization of a 72-kDa inositol-polyphosphate 5-phosphatase localized to the Golgi network. J Biol Chem (2000) 1.31
Molecular mechanisms for hyperinsulinaemia induced by overproduction of selenium-dependent glutathione peroxidase-1 in mice. Diabetologia (2008) 1.27
Lipid phosphatases as drug discovery targets for type 2 diabetes. Nat Rev Drug Discov (2006) 1.26
N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: possible role of oxidative stress. Am J Physiol Endocrinol Metab (2003) 1.25
Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury. J Neurochem (2001) 1.23
Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling. Cell Metab (2006) 1.15
DNA replication stalling attenuates tyrosine kinase signaling to suppress S phase progression. Cancer Cell (2008) 1.07
Insulin suppresses PDK-4 expression in skeletal muscle independently of plasma FFA. Am J Physiol Endocrinol Metab (2004) 0.96
Lack of the antioxidant glutathione peroxidase-1 does not increase atherosclerosis in C57BL/J6 mice fed a high-fat diet. J Lipid Res (2006) 0.95
Insulin signalling: effects of prior exercise. Acta Physiol Scand (2003) 0.89
Treadmill running increases phosphatidylinostol 3-kinase activity in rat skeletal muscle. Biochem Biophys Res Commun (1997) 0.85
Point: Interleukin-6 does have a beneficial role in insulin sensitivity and glucose homeostasis. J Appl Physiol (1985) (2006) 7.97
Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo. Mol Cell (2002) 5.41
Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol Rev (2008) 4.87
Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol (2012) 4.87
Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest (2007) 4.86
Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate. Nature (2003) 4.60
Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab (2007) 4.51
Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation. Nat Immunol (2006) 3.94
FHL3 binds MyoD and negatively regulates myotube formation. J Cell Sci (2007) 3.34
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK. Nat Med (2006) 3.11
Binge drinking induces whole-body insulin resistance by impairing hypothalamic insulin action. Sci Transl Med (2013) 3.07
Interleukin-6 stimulates lipolysis and fat oxidation in humans. J Clin Endocrinol Metab (2003) 2.90
Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes. Nature (2012) 2.83
Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes (2006) 2.80
H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response. Sci Signal (2011) 2.70
Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers. Proc Natl Acad Sci U S A (2010) 2.67
Exosome-dependent trafficking of HSP70: a novel secretory pathway for cellular stress proteins. J Biol Chem (2005) 2.64
HSP72 protects against obesity-induced insulin resistance. Proc Natl Acad Sci U S A (2008) 2.52
The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells. Nat Immunol (2013) 2.48
Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metab (2006) 2.43
Sec15 is an effector for the Rab11 GTPase in mammalian cells. J Biol Chem (2004) 2.24
Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance. Diabetes (2008) 2.14
Hsp72 preserves muscle function and slows progression of severe muscular dystrophy. Nature (2012) 2.04
Ciliary neurotrophic factor prevents acute lipid-induced insulin resistance by attenuating ceramide accumulation and phosphorylation of c-Jun N-terminal kinase in peripheral tissues. Endocrinology (2006) 2.01
High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus. Circulation (2009) 2.00
The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease. Biochem J (2009) 1.97
Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin. Nat Med (2013) 1.91
Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites. J Appl Physiol (1985) (2005) 1.88
A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage. FASEB J (2004) 1.88
Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells. Cell Microbiol (2009) 1.87
Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B. J Biol Chem (2004) 1.81
Transcript profiling of an Arabidopsis PSEUDO RESPONSE REGULATOR arrhythmic triple mutant reveals a role for the circadian clock in cold stress response. Plant Cell Physiol (2009) 1.70
Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERalpha-deficient mice. Am J Physiol Endocrinol Metab (2009) 1.69
Adipocyte triglyceride lipase expression in human obesity. Am J Physiol Endocrinol Metab (2007) 1.69
Pigment epithelium-derived factor contributes to insulin resistance in obesity. Cell Metab (2009) 1.66
Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat. Cell (2012) 1.65
Targeted reduction of advanced glycation improves renal function in obesity. Kidney Int (2011) 1.63
Adipose triacylglycerol lipase deletion alters whole body energy metabolism and impairs exercise performance in mice. Am J Physiol Endocrinol Metab (2009) 1.62
Glycogen availability does not affect the TCA cycle or TAN pools during prolonged, fatiguing exercise. J Appl Physiol (1985) (2002) 1.60
Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling. Proc Natl Acad Sci U S A (2008) 1.58
Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1. J Biol Chem (2002) 1.57
Myeloid-specific estrogen receptor alpha deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development. Proc Natl Acad Sci U S A (2011) 1.52
Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly. J Biol Chem (2006) 1.50
Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid. Diabetes (2003) 1.49
The structure of the cell cycle protein Cdc14 reveals a proline-directed protein phosphatase. EMBO J (2003) 1.49
Four and a half LIM protein 1: a partner for KCNA5 in human atrium. Cardiovasc Res (2008) 1.49
AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance. J Biol Chem (2009) 1.49
Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase. Nat Immunol (2005) 1.49
Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue. Am J Physiol Endocrinol Metab (2005) 1.48
Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy. J Clin Invest (2008) 1.46
Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77. Diabetes (2009) 1.46
Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP. Mol Cell Biol (2003) 1.44
IL-6 and TNF-alpha expression in, and release from, contracting human skeletal muscle. Am J Physiol Endocrinol Metab (2002) 1.43
Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation. FEBS Lett (2004) 1.42
Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP. Mol Cell Biol (2005) 1.41
Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor. Immunity (2009) 1.40
Redox regulation of the protein tyrosine phosphatase PTP1B in cancer cells. FEBS J (2007) 1.39
Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance. Am J Physiol Endocrinol Metab (2006) 1.39
Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance. Diabetes (2012) 1.38
Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent. J Biol Chem (2009) 1.38
The structural basis for autonomous dimerization of the pre-T-cell antigen receptor. Nature (2010) 1.35
Physiological roles of the beta-substituted alanine synthase gene family in Arabidopsis. Plant Physiol (2007) 1.35
Conformation-sensing antibodies stabilize the oxidized form of PTP1B and inhibit its phosphatase activity. Cell (2011) 1.34
A modified cysteinyl-labeling assay reveals reversible oxidation of protein tyrosine phosphatases in angiomyolipoma cells. Proc Natl Acad Sci U S A (2008) 1.33
Adipose triglyceride lipase-null mice are resistant to high-fat diet-induced insulin resistance despite reduced energy expenditure and ectopic lipid accumulation. Endocrinology (2010) 1.32
PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling. Blood (2008) 1.32
Tissue-specific effects of rosiglitazone and exercise in the treatment of lipid-induced insulin resistance. Diabetes (2007) 1.32
Modulation of neuro-inflammation and vascular response by oxidative stress following cerebral ischemia-reperfusion injury. Curr Med Chem (2008) 1.31
Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle. Am J Physiol Endocrinol Metab (2007) 1.30
Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity. J Biol Chem (2010) 1.30
Consolidating metabolite identifiers to enable contextual and multi-platform metabolomics data analysis. BMC Bioinformatics (2010) 1.30
Skeletal myocytes are a source of interleukin-6 mRNA expression and protein release during contraction: evidence of fiber type specificity. FASEB J (2004) 1.29
Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes. PLoS One (2012) 1.28
The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane. Mol Biol Cell (2005) 1.26
Reduced plasma FFA availability increases net triacylglycerol degradation, but not GPAT or HSL activity, in human skeletal muscle. Am J Physiol Endocrinol Metab (2004) 1.25
Unbiased characterization of genotype-dependent metabolic regulations by metabolomic approach in Arabidopsis thaliana. BMC Syst Biol (2007) 1.25
Pigment epithelium-derived factor regulates lipid metabolism via adipose triglyceride lipase. Diabetes (2011) 1.25
Compensation for systematic cross-contribution improves normalization of mass spectrometry based metabolomics data. Anal Chem (2009) 1.25