Published in J Biol Chem on June 03, 2009
Nuclear import by karyopherin-βs: recognition and inhibition. Biochim Biophys Acta (2010) 2.19
Interneuron, interrupted: molecular pathogenesis of ARX mutations and X-linked infantile spasms. Curr Opin Neurobiol (2012) 0.98
Stimulated nuclear import by β-like importins. F1000Prime Rep (2013) 0.85
Karyopherins in nuclear transport of homeodomain proteins during development. Biochim Biophys Acta (2011) 0.83
Mutations in the nuclear localization sequence of the Aristaless related homeobox; sequestration of mutant ARX with IPO13 disrupts normal subcellular distribution of the transcription factor and retards cell division. Pathogenetics (2010) 0.82
Autosomal recessive mutations in nuclear transport factor KPNA7 are associated with infantile spasms and cerebellar malformation. Eur J Hum Genet (2013) 0.80
Distinct DNA binding and transcriptional repression characteristics related to different ARX mutations. Neurogenetics (2012) 0.80
A novel role of proteasomal β1 subunit in tumorigenesis. Biosci Rep (2013) 0.79
Expression and subcellular distribution of imp13 are regulated in brain development. In Vitro Cell Dev Biol Anim (2013) 0.76
Candesartan Mediated Amelioration of Cisplatin-Induced Testicular Damage Is Associated with Alterations in Expression Patterns of Nephrin and Podocin. Biomed Res Int (2015) 0.75
Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci U S A (2002) 25.47
Transport between the cell nucleus and the cytoplasm. Annu Rev Cell Dev Biol (1999) 13.27
Protein aggregation and neurodegenerative disease. Nat Med (2004) 9.51
Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors. J Cell Biol (1990) 8.75
Transport into and out of the nucleus. Microbiol Mol Biol Rev (2001) 6.36
Finding nuclear localization signals. EMBO Rep (2000) 6.15
Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor. EMBO J (1987) 5.76
Kinetic analysis of translocation through nuclear pore complexes. EMBO J (2001) 5.27
Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycle. Cell (2003) 5.05
Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans. Nat Genet (2002) 4.01
Opposing actions of Arx and Pax4 in endocrine pancreas development. Genes Dev (2003) 4.00
Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. EMBO J (1998) 3.86
Crossing the nuclear envelope: hierarchical regulation of nucleocytoplasmic transport. Science (2007) 3.86
Mechanisms of receptor-mediated nuclear import and nuclear export. Traffic (2005) 3.83
Structural biology of nucleocytoplasmic transport. Annu Rev Biochem (2007) 3.66
Importin alpha: a multipurpose nuclear-transport receptor. Trends Cell Biol (2004) 3.64
Karyopherins and nuclear import. Curr Opin Struct Biol (2001) 3.53
Nuclear translocation of extradenticle requires homothorax, which encodes an extradenticle-related homeodomain protein. Cell (1997) 3.49
PAX-6 in development and evolution. Annu Rev Neurosci (1997) 2.68
Nucleocytoplasmic transport of macromolecules. Microbiol Mol Biol Rev (1997) 2.51
Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression. J Clin Invest (2007) 2.46
CRM1-mediated nuclear export: to the pore and beyond. Trends Cell Biol (2007) 2.32
Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Pse1/Kap121. Genes Dev (1998) 2.30
ARX, a novel Prd-class-homeobox gene highly expressed in the telencephalon, is mutated in X-linked mental retardation. Hum Mol Genet (2002) 2.30
Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor. Mol Cell Biol (2005) 2.20
The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas. Development (2005) 1.98
Importin 13: a novel mediator of nuclear import and export. EMBO J (2001) 1.98
Karyopherin flexibility in nucleocytoplasmic transport. Curr Opin Struct Biol (2006) 1.86
Mutations of ARX are associated with striking pleiotropy and consistent genotype-phenotype correlation. Hum Mutat (2004) 1.76
Discrimination between NL1- and NL2-mediated nuclear localization of the glucocorticoid receptor. Mol Cell Biol (1999) 1.66
Nucleocytoplasmic transport: navigating the channel. Traffic (2003) 1.66
Differential modes of nuclear localization signal (NLS) recognition by three distinct classes of NLS receptors. J Biol Chem (1997) 1.60
Importin 7 and importin alpha/importin beta are nuclear import receptors for the glucocorticoid receptor. Mol Biol Cell (2004) 1.59
Infantile spasms, dystonia, and other X-linked phenotypes caused by mutations in Aristaless related homeobox gene, ARX. Brain Dev (2002) 1.56
Genetic determinants of pancreatic epsilon-cell development. Dev Biol (2005) 1.54
Expression of a novel aristaless related homeobox gene 'Arx' in the vertebrate telencephalon, diencephalon and floor plate. Mech Dev (1997) 1.53
ARX: a gene for all seasons. Curr Opin Genet Dev (2006) 1.46
In or out? Regulating nuclear transport. Curr Opin Cell Biol (1999) 1.42
Arx is a direct target of Dlx2 and thereby contributes to the tangential migration of GABAergic interneurons. J Neurosci (2008) 1.41
Arx homeobox gene is essential for development of mouse olfactory system. Development (2005) 1.31
In vivo analysis of importin alpha proteins reveals cellular proliferation inhibition and substrate specificity. Mol Cell Biol (2004) 1.29
Neuroanatomical distribution of ARX in brain and its localisation in GABAergic neurons. Brain Res Mol Brain Res (2004) 1.19
Importin 13 regulates nuclear import of the glucocorticoid receptor in airway epithelial cells. Am J Respir Cell Mol Biol (2006) 1.18
Nuclear import of c-Jun is mediated by multiple transport receptors. J Biol Chem (2007) 1.17
Subunits of the heterotrimeric transcription factor NF-Y are imported into the nucleus by distinct pathways involving importin beta and importin 13. Mol Cell Biol (2005) 1.15
Molecular pathology of expanded polyalanine tract mutations in the Aristaless-related homeobox gene. Genomics (2007) 1.11
A conformational change in PBX1A is necessary for its nuclear localization. Exp Cell Res (2000) 1.07
A polyalanine tract expansion in Arx forms intranuclear inclusions and results in increased cell death. J Cell Biol (2004) 1.05
Expression patterns of Brx1 (Rieg gene), Sonic hedgehog, Nkx2.2, Dlx1 and Arx during zona limitans intrathalamica and embryonic ventral lateral geniculate nuclear formation. Mech Dev (1997) 1.02
Nuclear export is evolutionarily conserved in CVC paired-like homeobox proteins and influences protein stability, transcriptional activation, and extracellular secretion. Mol Cell Biol (2005) 1.02
Regulated nuclear export of the homeodomain transcription factor Prospero. Development (2001) 1.00
Evolutionary and transcriptional analysis of karyopherin beta superfamily proteins. Mol Cell Proteomics (2008) 0.98
Nucleocytoplasmic shuttling of the zinc finger protein EZI Is mediated by importin-7-dependent nuclear import and CRM1-independent export mechanisms. J Biol Chem (2007) 0.96
Paired-type homeodomain transcription factors are imported into the nucleus by karyopherin 13. Mol Cell Biol (2004) 0.94
Severe acute respiratory syndrome coronavirus protein 6 accelerates murine hepatitis virus infections by more than one mechanism. J Virol (2008) 0.94
Hormonal regulation of the nuclear localization signals of the human glucocorticosteroid receptor. Exp Cell Res (1992) 0.94
Balancing import and export in development. Genes Dev (1999) 0.93
BSAP (Pax5)-importin alpha 1 (Rch1) interaction identifies a nuclear localization sequence. J Biol Chem (2000) 0.93
Importin 4 is responsible for ligand-independent nuclear translocation of vitamin D receptor. J Biol Chem (2005) 0.91
Interaction between importin 13 and myopodin suggests a nuclear import pathway for myopodin. Mol Cell Biochem (2007) 0.91
Importin beta1 mediates the glucose-stimulated nuclear import of pancreatic and duodenal homeobox-1 in pancreatic islet beta-cells (MIN6). Biochem J (2004) 0.90
Human ARX gene: genomic characterization and expression. Mol Genet Metab (2002) 0.90
Stage-specific Importin13 activity influences meiosis of germ cells in the mouse. Dev Biol (2006) 0.90
Identification of multiple nuclear localization signals in murine Elf3, an ETS transcription factor. FEBS Lett (2006) 0.89
Nucleocytoplasmic shuttling of lgl2 is developmentally regulated in fetal lung. Am J Respir Cell Mol Biol (2003) 0.89
Reversing neurodegeneration: a promise unfolds. Cell (2000) 0.89
Nuclear relocation of normal huntingtin. Traffic (2001) 0.89
Regulated nuclear trafficking of the homeodomain protein otx1 in cortical neurons. Mol Cell Neurosci (2002) 0.87
The ARX mutations: a frequent cause of X-linked mental retardation. Am J Med Genet A (2006) 0.87
A novel karyopherin-beta homolog is developmentally and hormonally regulated in fetal lung. Am J Respir Cell Mol Biol (2000) 0.85
Importin alpha/beta-mediated nuclear protein import is regulated in a cell cycle-dependent manner. Exp Cell Res (2004) 0.84
The POU protein Oct-6 is a nucleocytoplasmic shuttling protein. Nucleic Acids Res (2005) 0.84
Long persistence of importin-beta explains extended survival of cells and zygotes that lack the encoding gene. Mech Dev (2007) 0.83
The moleskin gene product is essential for Caudal-mediated constitutive antifungal Drosomycin gene expression in Drosophila epithelia. Insect Mol Biol (2004) 0.83
Nuclear transport: randy couples. Curr Biol (1999) 0.82
The carboxy terminus of Prospero regulates its subcellular localization. Mol Cell Biol (2003) 0.80
Review: dynamic stability of the interphase nucleus in health and disease. J Struct Biol (2000) 0.79
Three biomarkers identified from serum proteomic analysis for the detection of early stage ovarian cancer. Cancer Res (2004) 5.68
A genetically defined model for human ovarian cancer. Cancer Res (2004) 3.02
BLAST: a more efficient report with usability improvements. Nucleic Acids Res (2013) 2.77
The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells. J Clin Invest (2008) 2.63
Kindlin-2 is an essential component of intercalated discs and is required for vertebrate cardiac structure and function. Circ Res (2008) 2.48
Potential markers that complement expression of CA125 in epithelial ovarian cancer. Gynecol Oncol (2005) 2.34
Preoperative sensitivity and specificity for early-stage ovarian cancer when combining cancer antigen CA-125II, CA 15-3, CA 72-4, and macrophage colony-stimulating factor using mixtures of multivariate normal distributions. J Clin Oncol (2004) 2.32
Impact of the lung allocation score on lung transplantation for pulmonary arterial hypertension. Am J Respir Crit Care Med (2009) 2.19
Mutations of CASK cause an X-linked brain malformation phenotype with microcephaly and hypoplasia of the brainstem and cerebellum. Nat Genet (2008) 2.16
Independent validation of candidate breast cancer serum biomarkers identified by mass spectrometry. Clin Chem (2005) 2.13
G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer. J Clin Invest (2012) 2.12
Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation. Cancer (2008) 1.69
Correlation between CpG methylation profiles and hormone receptor status in breast cancers. Breast Cancer Res (2007) 1.68
Intrapulmonary pharmacokinetics of linezolid. Antimicrob Agents Chemother (2002) 1.65
Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron. J Biol Chem (2005) 1.61
Identification of Arx transcriptional targets in the developing basal forebrain. Hum Mol Genet (2008) 1.58
Metformin reverses progestin resistance in endometrial cancer cells by downregulating GloI expression. Int J Gynecol Cancer (2011) 1.56
Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human phenotype in heterozygous females. Brain (2009) 1.52
Body composition and mortality after adult lung transplantation in the United States. Am J Respir Crit Care Med (2014) 1.49
Tracheal compression by the stomach following gastric pull-up: diagnosis with CT and treatment with expandable metallic stent placement. Chest (2002) 1.46
Identification of novel tumor markers in prostate, colon and breast cancer by unbiased methylation profiling. PLoS One (2008) 1.46
Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy. J Clin Invest (2008) 1.46
The association study of plasma levels of pigment epithelium-derived factor with acute coronary syndrome in the chinese han population. Cardiology (2013) 1.41
Visual experience regulates transient expression and dendritic localization of fragile X mental retardation protein. J Neurosci (2004) 1.39
Steady-state serum and intrapulmonary pharmacokinetics and pharmacodynamics of tigecycline. Int J Antimicrob Agents (2005) 1.38
Use of mycophenolate mofetil to treat scleroderma-associated interstitial lung disease. Respir Med (2007) 1.37
Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancers. Cancer Res (2003) 1.35
Intrapulmonary pharmacokinetics and pharmacodynamics of posaconazole at steady state in healthy subjects. Antimicrob Agents Chemother (2008) 1.35
Safety and efficacy of subretinal readministration of a viral vector in large animals to treat congenital blindness. Sci Transl Med (2010) 1.35
Gastroesophageal reflux in patients with idiopathic pulmonary fibrosis referred for lung transplantation. J Thorac Cardiovasc Surg (2007) 1.34
A novel variant of Inpp5f is imprinted in brain, and its expression is correlated with differential methylation of an internal CpG island. Mol Cell Biol (2005) 1.32
Does chronic microaspiration cause idiopathic pulmonary fibrosis? Am J Med (2010) 1.30
Snail is critical for tumor growth and metastasis of ovarian carcinoma. Int J Cancer (2010) 1.26
Combined use of fasting plasma glucose and glycated hemoglobin A1c in the screening of diabetes and impaired glucose tolerance. Acta Diabetol (2009) 1.26
Combining multiple serum tumor markers improves detection of stage I epithelial ovarian cancer. Gynecol Oncol (2007) 1.26
PIP5KI gamma is required for cardiovascular and neuronal development. Proc Natl Acad Sci U S A (2007) 1.25
ARHI is a Ras-related small G-protein with a novel N-terminal extension that inhibits growth of ovarian and breast cancers. Oncogene (2003) 1.23
The proapoptotic activities of Bax and Bak limit the size of the neural stem cell pool. J Neurosci (2003) 1.22
Expression of the tumor suppressor gene ARHI in epithelial ovarian cancer is associated with increased expression of p21WAF1/CIP1 and prolonged progression-free survival. Clin Cancer Res (2004) 1.22
Prevention and early detection of ovarian cancer: mission impossible? Recent Results Cancer Res (2007) 1.22
Loss of the expression of the tumor suppressor gene ARHI is associated with progression of breast cancer. Clin Cancer Res (2003) 1.22
Long-term tumor-free survival from treatment with the GFP-TRAIL fusion gene expressed from the hTERT promoter in breast cancer cells. Oncogene (2002) 1.20
Oligodendrocyte maturation is inhibited by bone morphogenetic protein. Mol Cell Neurosci (2004) 1.19
Prenatal MR findings of the middle interhemispheric variant of holoprosencephaly. AJNR Am J Neuroradiol (2004) 1.17
Reactivation of the silenced and imprinted alleles of ARHI is associated with increased histone H3 acetylation and decreased histone H3 lysine 9 methylation. Hum Mol Genet (2003) 1.15
The integrin coactivator kindlin-2 plays a critical role in angiogenesis in mice and zebrafish. Blood (2011) 1.14
Inhibition of survivin reduces cell proliferation and induces apoptosis in human endometrial cancer. Cancer (2006) 1.12
Intrapulmonary pharmacokinetics and pharmacodynamics of itraconazole and 14-hydroxyitraconazole at steady state. Antimicrob Agents Chemother (2004) 1.12
Undifferentiated connective tissue disease-associated interstitial lung disease: changes in lung function. Lung (2010) 1.11
Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression. Dev Biol (2011) 1.10
Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation. Cell (2012) 1.09
Genotypically defined lissencephalies show distinct pathologies. J Neuropathol Exp Neurol (2005) 1.09
Reexpression of the tumor suppressor gene ARHI induces apoptosis in ovarian and breast cancer cells through a caspase-independent calpain-dependent pathway. Cancer Res (2002) 1.08
Lis1 is necessary for normal non-radial migration of inhibitory interneurons. Am J Pathol (2004) 1.08
Education resources of the National Center for Biotechnology Information. Brief Bioinform (2010) 1.08
Loss of murine Na+/myo-inositol cotransporter leads to brain myo-inositol depletion and central apnea. J Biol Chem (2003) 1.08
Correlation of TWIST2 up-regulation and epithelial-mesenchymal transition during tumorigenesis and progression of cervical carcinoma. Gynecol Oncol (2011) 1.07
MiRNA-181b suppresses IGF-1R and functions as a tumor suppressor gene in gliomas. RNA (2013) 1.06
Macrophage activating effects of new alkamides from the roots of Echinacea species. J Nat Prod (2005) 1.06
FACS-array gene expression analysis during early development of mouse telencephalic interneurons. Dev Neurobiol (2008) 1.05
A polyalanine tract expansion in Arx forms intranuclear inclusions and results in increased cell death. J Cell Biol (2004) 1.05
Losses of chromosomes 1p and 19q are rare in pediatric oligodendrogliomas. Acta Neuropathol (2005) 1.04
Effects of gender, AIDS, and acetylator status on intrapulmonary concentrations of isoniazid. Antimicrob Agents Chemother (2002) 1.04
ISS--an electronic syndromic surveillance system for infectious disease in rural China. PLoS One (2013) 1.04
Transcriptional and posttranscriptional down-regulation of the imprinted tumor suppressor gene ARHI (DRAS3) in ovarian cancer. Clin Cancer Res (2006) 1.04
Delayed myelination in an intrauterine growth retardation model is mediated by oxidative stress upregulating bone morphogenetic protein 4. J Neuropathol Exp Neurol (2012) 1.03
Intrapulmonary pharmacokinetics and pharmacodynamics of meropenem. Int J Antimicrob Agents (2005) 1.03
Computational pathology: an emerging definition. Arch Pathol Lab Med (2014) 1.03
Upregulation of miR-196b confers a poor prognosis in glioblastoma patients via inducing a proliferative phenotype. PLoS One (2012) 1.03
Trio is a key guanine nucleotide exchange factor coordinating regulation of the migration and morphogenesis of granule cells in the developing cerebellum. J Biol Chem (2010) 1.02
Differential effects of a polyalanine tract expansion in Arx on neural development and gene expression. Hum Mol Genet (2011) 1.02
FSH inhibits ovarian cancer cell apoptosis by up-regulating survivin and down-regulating PDCD6 and DR5. Endocr Relat Cancer (2010) 1.02
Regioselective nitration of tryptophan by a complex between bacterial nitric-oxide synthase and tryptophanyl-tRNA synthetase. J Biol Chem (2004) 1.01
Analysis of non-radial interneuron migration dynamics and its disruption in Lis1+/- mice. J Comp Neurol (2006) 1.00
GEPS: the Gene Expression Pattern Scanner. Nucleic Acids Res (2006) 1.00
SDF1 regulates leading process branching and speed of migrating interneurons. J Neurosci (2011) 1.00
Re-expression of ARHI (DIRAS3) induces autophagy in breast cancer cells and enhances the inhibitory effect of paclitaxel. BMC Cancer (2011) 0.99
Evolutionary and transcriptional analysis of karyopherin beta superfamily proteins. Mol Cell Proteomics (2008) 0.98
SUMO interaction motifs in Sizn1 are required for promyelocytic leukemia protein nuclear body localization and for transcriptional activation. J Biol Chem (2009) 0.97
Role of myosin light chain kinase in regulation of basal blood pressure and maintenance of salt-induced hypertension. Am J Physiol Heart Circ Physiol (2011) 0.97
Steady-state intrapulmonary pharmacokinetics and pharmacodynamics of posaconazole in lung transplant recipients. Antimicrob Agents Chemother (2010) 0.97
Effect of sex and AIDS status on the plasma and intrapulmonary pharmacokinetics of rifampicin. Clin Pharmacokinet (2004) 0.97
Rice black-streaked dwarf virus P6 self-interacts to form punctate, viroplasm-like structures in the cytoplasm and recruits viroplasm-associated protein P9-1. Virol J (2011) 0.97
Mechanisms by which cytoplasmic calcium wave propagation and alternans are generated in cardiac atrial myocytes lacking T-tubules-insights from a simulation study. Biophys J (2012) 0.97
Tolerogenic dendritic cells generated by RelB silencing using shRNA prevent acute rejection. Cell Immunol (2012) 0.96
Huaier aqueous extract inhibits ovarian cancer cell motility via the AKT/GSK3β/β-catenin pathway. PLoS One (2013) 0.96
Inhibiting the PI3K/Akt pathway reversed progestin resistance in endometrial cancer. Cancer Sci (2011) 0.96
Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancer is associated with clinical characteristics, but only RASSF1A methylation is associated with outcome. BMC Cancer (2012) 0.96
Outcomes of tracheobronchial stent placement for benign disease. Radiology (2006) 0.96
Activation of the PI3K/AKT pathway mediates FSH-stimulated VEGF expression in ovarian serous cystadenocarcinoma. Cell Res (2008) 0.95
Traumatic brain injury in piglets of different ages: techniques for lesion analysis using histology and magnetic resonance imaging. J Neurosci Methods (2003) 0.95
Immobility, inheritance and plasticity of shape of the yeast nucleus. BMC Cell Biol (2007) 0.95
Intrapulmonary pharmacokinetics and pharmacodynamics of high-dose levofloxacin in healthy volunteer subjects. Int J Antimicrob Agents (2006) 0.95
In vivo roles for myosin phosphatase targeting subunit-1 phosphorylation sites T694 and T852 in bladder smooth muscle contraction. J Physiol (2014) 0.95
Intrapulmonary pharmacodynamics of high-dose levofloxacin in subjects with chronic bronchitis or chronic obstructive pulmonary disease. Int J Antimicrob Agents (2007) 0.95
Subunit-subunit interactions in the human 26S proteasome. Proteomics (2008) 0.95