Published in Development on June 01, 2005
The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell (2009) 4.47
Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx. Dev Cell (2011) 2.49
Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression. J Clin Invest (2007) 2.46
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas. EMBO J (2006) 2.02
The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells. Genes Dev (2006) 1.81
Production of functional glucagon-secreting α-cells from human embryonic stem cells. Diabetes (2010) 1.73
Identification of Arx transcriptional targets in the developing basal forebrain. Hum Mol Genet (2008) 1.58
Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming. Genes Dev (2011) 1.48
A triplet repeat expansion genetic mouse model of infantile spasms syndrome, Arx(GCG)10+7, with interneuronopathy, spasms in infancy, persistent seizures, and adult cognitive and behavioral impairment. J Neurosci (2009) 1.48
Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitors. Mol Cell Biol (2008) 1.46
Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity. PLoS Genet (2013) 1.37
Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas. Diabetes (2009) 1.33
Historical perspective: beginnings of the beta-cell: current perspectives in beta-cell development. Diabetes (2011) 1.30
The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells. PLoS Genet (2013) 1.28
Endocrine cell clustering during human pancreas development. J Histochem Cytochem (2009) 1.26
Gene regulatory networks governing pancreas development. Dev Cell (2013) 1.25
Plasticity and dedifferentiation within the pancreas: development, homeostasis, and disease. Cell Stem Cell (2014) 1.21
Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech Dev (2007) 1.20
Glucagon deficiency reduces hepatic glucose production and improves glucose tolerance in adult mice. Mol Endocrinol (2010) 1.19
Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression. Dev Biol (2011) 1.10
Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. J Biol Chem (2009) 1.09
Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice. Dev Biol (2007) 1.07
Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells. Dev Biol (2007) 1.06
Pancreatic α-cell specific deletion of mouse Arx leads to α-cell identity loss. PLoS One (2013) 1.05
Caenorhabditis elegans aristaless/Arx gene alr-1 restricts variable gene expression. Proc Natl Acad Sci U S A (2011) 1.04
Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development. BMC Dev Biol (2009) 1.02
Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas. Mech Dev (2009) 1.00
Expression of Groucho/TLE proteins during pancreas development. BMC Dev Biol (2008) 1.00
Arx is required for normal enteroendocrine cell development in mice and humans. Dev Biol (2012) 0.98
Islet-1 regulates Arx transcription during pancreatic islet alpha-cell development. J Biol Chem (2011) 0.98
Regulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreas. PLoS Genet (2013) 0.96
Islet α-, β-, and δ-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor. Diabetes (2012) 0.95
Promoting ectopic pancreatic fates: pancreas development and future diabetes therapies. Clin Genet (2008) 0.95
Lineage determinants in early endocrine development. Semin Cell Dev Biol (2012) 0.92
Pancreas cell fate. Birth Defects Res C Embryo Today (2009) 0.91
New opportunities: harnessing induced pluripotency for discovery in diabetes and metabolism. Cell Metab (2013) 0.90
The homeodomain-containing transcription factors Arx and Pax4 control enteroendocrine subtype specification in mice. PLoS One (2012) 0.90
The roles of multiple importins for nuclear import of murine aristaless-related homeobox protein. J Biol Chem (2009) 0.90
Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage. BMC Dev Biol (2011) 0.89
The transcriptional activity of Neurog3 affects migration and differentiation of ectopic endocrine cells in chicken endoderm. Dev Dyn (2010) 0.86
Streptozotocin-induced expression of Ngn3 and Pax4 in neonatal rat pancreatic α-cells. World J Gastroenterol (2011) 0.86
Endocrine pancreatic development: impact of obesity and diet. Front Physiol (2013) 0.85
Pax4 is not essential for beta-cell differentiation in zebrafish embryos but modulates alpha-cell generation by repressing arx gene expression. BMC Dev Biol (2012) 0.85
Retinoblastoma tumor suppressor protein in pancreatic progenitors controls α- and β-cell fate. Proc Natl Acad Sci U S A (2013) 0.83
Overexpression of PAX4 reduces glucagon expression in differentiating hESCs. Islets (2014) 0.81
Inactivating the permanent neonatal diabetes gene Mnx1 switches insulin-producing β-cells to a δ-like fate and reveals a facultative proliferative capacity in aged β-cells. Development (2015) 0.81
PAX4 Gene Transfer Induces α-to-β Cell Phenotypic Conversion and Confers Therapeutic Benefits for Diabetes Treatment. Mol Ther (2015) 0.81
Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3. Development (2014) 0.80
The Role of ARX in Human Pancreatic Endocrine Specification. PLoS One (2015) 0.79
Epigenetic regulation of pancreas development and function. Semin Cell Dev Biol (2012) 0.79
Development and regeneration in the endocrine pancreas. ISRN Endocrinol (2012) 0.79
Reprogramming into pancreatic endocrine cells based on developmental cues. Mol Cell Endocrinol (2009) 0.79
The Endocrine Pancreas: insights into development, differentiation and diabetes. Wiley Interdiscip Rev Membr Transp Signal (2012) 0.78
Role of transcription factors in the transdifferentiation of pancreatic islet cells. J Mol Endocrinol (2015) 0.78
Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes. Endocr Rev (2016) 0.78
Generation of animals allowing the conditional inactivation of the Pax4 gene. Transgenic Res (2012) 0.77
A novel dual-color reporter for identifying insulin-producing beta-cells and classifying heterogeneity of insulinoma cell lines. PLoS One (2012) 0.77
Pancreatic regeneration: basic research and gene regulation. Surg Today (2015) 0.77
Impaired enteroendocrine development in intestinal-specific Islet1 mouse mutants causes impaired glucose homeostasis. Am J Physiol Gastrointest Liver Physiol (2014) 0.76
Redifferentiation of expanded human islet β cells by inhibition of ARX. Sci Rep (2016) 0.76
Stem Cells in the Treatment of Insulin-Dependent Diabetes Mellitus. Acta Naturae (2016) 0.75
Transcription factor regulation of pancreatic organogenesis, differentiation and maturation. Islets (2015) 0.75
The Diabetes-Linked Transcription Factor PAX4: From Gene to Functional Consequences. Genes (Basel) (2017) 0.75
Transdifferentiation of pancreatic α-cells into insulin-secreting cells: From experimental models to underlying mechanisms. World J Diabetes (2014) 0.75
Optical projection tomography as a tool for 3D microscopy and gene expression studies. Science (2002) 10.46
Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors. Proc Natl Acad Sci U S A (2003) 7.60
Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci U S A (2008) 7.52
Ambra1 regulates autophagy and development of the nervous system. Nature (2007) 6.94
Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature (2011) 6.21
A Pax3/Pax7-dependent population of skeletal muscle progenitor cells. Nature (2005) 5.31
The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell (2009) 4.47
Opposing actions of Arx and Pax4 in endocrine pancreas development. Genes Dev (2003) 4.00
Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells. J Cell Biol (2005) 3.96
Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex. Neuron (2008) 2.86
An illustrated review of early pancreas development in the mouse. Endocr Rev (2007) 2.68
FOXG1 is responsible for the congenital variant of Rett syndrome. Am J Hum Genet (2008) 2.65
The meso-angioblast: a multipotent, self-renewing cell that originates from the dorsal aorta and differentiates into most mesodermal tissues. Development (2002) 2.50
Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression. J Clin Invest (2007) 2.46
Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Dev Biol (2003) 2.41
Site-specific integration and tailoring of cassette design for sustainable gene transfer. Nat Methods (2011) 2.30
Axonal degeneration in paraplegin-deficient mice is associated with abnormal mitochondria and impairment of axonal transport. J Clin Invest (2004) 2.30
Generating neuronal diversity in the retina: one for nearly all. Trends Neurosci (2002) 2.12
Divergent functions of murine Pax3 and Pax7 in limb muscle development. Genes Dev (2004) 2.12
Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc Natl Acad Sci U S A (2009) 2.09
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas. EMBO J (2006) 2.02
A mouse model demonstrates a multigenic origin of congenital hypothyroidism. Endocrinology (2005) 1.89
Specifying pancreatic endocrine cell fates. Mech Dev (2006) 1.84
Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. J Cell Biol (2002) 1.79
Conditional inactivation of Pax6 in the pancreas causes early onset of diabetes. Dev Biol (2004) 1.78
Transplantation of genetically corrected human iPSC-derived progenitors in mice with limb-girdle muscular dystrophy. Sci Transl Med (2012) 1.78
Novel transcription factor Satb2 interacts with matrix attachment region DNA elements in a tissue-specific manner and demonstrates cell-type-dependent expression in the developing mouse CNS. Eur J Neurosci (2005) 1.75
CDKL5 belongs to the same molecular pathway of MeCP2 and it is responsible for the early-onset seizure variant of Rett syndrome. Hum Mol Genet (2005) 1.72
Direct and concentration-dependent regulation of the proneural gene Neurogenin2 by Pax6. Development (2003) 1.64
Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation. Dev Dyn (2002) 1.61
The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss. J Clin Invest (2014) 1.61
To be or not to be a flatworm: the acoel controversy. PLoS One (2009) 1.59
Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation. Dev Biol (2008) 1.55
An integrated regulatory network controlling survival and migration in thyroid organogenesis. Dev Biol (2004) 1.55
Genetic determinants of pancreatic epsilon-cell development. Dev Biol (2005) 1.54
Permanent Neonatal Diabetes and Enteric Anendocrinosis Associated With Biallelic Mutations in NEUROG3. Diabetes (2011) 1.47
Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes. Dev Cell (2013) 1.46
Emx2 and Pax6 control regionalization of the pre-neuronogenic cortical primordium. Cereb Cortex (2002) 1.45
Arx is a direct target of Dlx2 and thereby contributes to the tangential migration of GABAergic interneurons. J Neurosci (2008) 1.41
Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J Biol Chem (2011) 1.40
Vax2 inactivation in mouse determines alteration of the eye dorsal-ventral axis, misrouting of the optic fibres and eye coloboma. Development (2002) 1.39
Pax6 is required for the normal development of the forebrain axonal connections. Development (2002) 1.39
Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model. Hum Mol Genet (2011) 1.39
Mutations in a novel gene, NHS, cause the pleiotropic effects of Nance-Horan syndrome, including severe congenital cataract, dental anomalies, and mental retardation. Am J Hum Genet (2003) 1.37
Genetic interplay between the transcription factors Sp8 and Emx2 in the patterning of the forebrain. Neural Dev (2007) 1.36
Congenital hypothyroid Pax8(-/-) mutant mice can be rescued by inactivating the TRalpha gene. Mol Endocrinol (2002) 1.36
CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons. Nat Cell Biol (2012) 1.34
Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration. Proc Natl Acad Sci U S A (2008) 1.33
Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6. Development (2003) 1.32
The splanchnic mesodermal plate directs spleen and pancreatic laterality, and is regulated by Bapx1/Nkx3.2. Development (2004) 1.30
The tumorigenicity of mouse embryonic stem cells and in vitro differentiated neuronal cells is controlled by the recipients' immune response. PLoS One (2008) 1.29
The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells. PLoS Genet (2013) 1.28
An improved method for three-dimensional reconstruction of protein expression patterns in intact mouse and chicken embryos and organs. J Histochem Cytochem (2007) 1.28
Hypogonadotropic hypogonadism and peripheral neuropathy in Ebf2-null mice. Development (2003) 1.27
Small-molecule inducers of insulin expression in pancreatic alpha-cells. Proc Natl Acad Sci U S A (2010) 1.26
Genome-wide sequencing data reveals virulence factors implicated in banana Xanthomonas wilt. FEMS Microbiol Lett (2010) 1.25
Emx2 regulates the proliferation of stem cells of the adult mammalian central nervous system. Development (2002) 1.24
Remote control of induced dopaminergic neurons in parkinsonian rats. J Clin Invest (2014) 1.23
Pax6 is required for establishing naso-temporal and dorsal characteristics of the optic vesicle. Development (2002) 1.23
CDKL5 expression is modulated during neuronal development and its subcellular distribution is tightly regulated by the C-terminal tail. J Biol Chem (2008) 1.22
The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron (2010) 1.22
Artifactual insulin release from differentiated embryonic stem cells. Diabetes (2004) 1.22
Lhx1 and Lhx5 maintain the inhibitory-neurotransmitter status of interneurons in the dorsal spinal cord. Development (2006) 1.22
Mouse orthologue of ARX, a gene mutated in several X-linked forms of mental retardation and epilepsy, is a marker of adult neural stem cells and forebrain GABAergic neurons. Dev Dyn (2004) 1.20
The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice. J Mol Endocrinol (2006) 1.20
Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain. Mech Dev (2002) 1.20
Adult human Müller glia cells are a highly efficient source of rod photoreceptors. Stem Cells (2011) 1.20
Conversion of cerebral cortex into basal ganglia in Emx2(-/-) Pax6(Sey/Sey) double-mutant mice. Nat Neurosci (2002) 1.19
The vertebrate ortholog of Aristaless is regulated by Dlx genes in the developing forebrain. J Comp Neurol (2005) 1.19
A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells. Dev Biol (2009) 1.16
Toward improved statistical reporting in the journal of consulting and clinical psychology. J Consult Clin Psychol (2005) 1.15
Endodermal expression of Nkx6 genes depends differentially on Pdx1. Dev Biol (2005) 1.14
The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity. Dev Biol (2004) 1.14
Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype. Proc Natl Acad Sci U S A (2002) 1.11
The guanine nucleotide exchange factor C3G is necessary for the formation of focal adhesions and vascular maturation. Development (2003) 1.11
Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the midbrain-hindbrain organizer. J Neurosci (2003) 1.10
Mutant neurogenin-3 in congenital malabsorptive diarrhea. N Engl J Med (2007) 1.10
Cancer predisposition in mice deficient for the metastasis-associated Mts1(S100A4) gene. Oncogene (2004) 1.09
Preservation of proliferating pancreatic progenitor cells by Delta-Notch signaling in the embryonic chicken pancreas. BMC Dev Biol (2007) 1.08
Necdin mediates skeletal muscle regeneration by promoting myoblast survival and differentiation. J Cell Biol (2007) 1.08
mBtd is required to maintain signaling during murine limb development. Genes Dev (2003) 1.08