Published in J Cell Sci on June 09, 2009
Rare copy number variations in congenital heart disease patients identify unique genes in left-right patterning. Proc Natl Acad Sci U S A (2011) 1.71
Post-translational regulation of TGF-β receptor and Smad signaling. FEBS Lett (2012) 1.21
The Rho kinase Rock2b establishes anteroposterior asymmetry of the ciliated Kupffer's vesicle in zebrafish. Development (2010) 1.06
Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model. J Neurosci (2013) 0.96
Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism. Blood (2016) 0.96
Interruption of cenph causes mitotic failure and embryonic death, and its haploinsufficiency suppresses cancer in zebrafish. J Biol Chem (2010) 0.90
Angiomotin-like2 gene (amotl2) is required for migration and proliferation of endothelial cells during angiogenesis. J Biol Chem (2011) 0.88
The Amotl2 gene inhibits Wnt/β-catenin signaling and regulates embryonic development in zebrafish. J Biol Chem (2012) 0.87
Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm development by directly phosphorylating the Smad2 linker region. Nat Commun (2013) 0.86
Eph/ephrin signaling maintains the boundary of dorsal forerunner cell cluster during morphogenesis of the zebrafish embryonic left-right organizer. Development (2016) 0.85
Loss of zygotic NUP107 protein causes missing of pharyngeal skeleton and other tissue defects with impaired nuclear pore function in zebrafish embryos. J Biol Chem (2012) 0.80
Non-muscle myosin II in disease: mechanisms and therapeutic opportunities. Dis Model Mech (2015) 0.76
Fscn1 is required for the trafficking of TGF-β family type I receptors during endoderm formation. Nat Commun (2016) 0.75
A high-content small molecule screen identifies novel inducers of definitive endoderm. Mol Metab (2017) 0.75
Alkbh4 and Atrn Act Maternally to Regulate Zebrafish Epiboly. Int J Biol Sci (2017) 0.75
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science (2009) 9.29
Involvement of microRNA in AU-rich element-mediated mRNA instability. Cell (2005) 9.01
Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proc Natl Acad Sci U S A (2007) 7.96
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling. Cell (2006) 5.28
Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat Genet (2003) 3.71
Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation. Science (2012) 2.50
Endothelial Smad4 maintains cerebrovascular integrity by activating N-cadherin through cooperation with Notch. Dev Cell (2011) 2.17
Structure-based modeling of the functional HIV-1 intasome and its inhibition. Proc Natl Acad Sci U S A (2010) 2.16
Organization of the core structure of the postsynaptic density. Proc Natl Acad Sci U S A (2008) 2.06
The requirement for cellular transportin 3 (TNPO3 or TRN-SR2) during infection maps to human immunodeficiency virus type 1 capsid and not integrase. J Virol (2009) 1.99
Development of genome-wide DNA polymorphism database for map-based cloning of rice genes. Plant Physiol (2004) 1.98
GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. Science (2012) 1.84
Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO J (2004) 1.79
Genomic evidence for ameiotic evolution in the bdelloid rotifer Adineta vaga. Nature (2013) 1.76
Decreased NKX3.1 protein expression in focal prostatic atrophy, prostatic intraepithelial neoplasia, and adenocarcinoma: association with gleason score and chromosome 8p deletion. Cancer Res (2006) 1.76
The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nat Chem Biol (2012) 1.75
How human location-specific contact patterns impact spatial transmission between populations? Sci Rep (2013) 1.74
Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals. Mol Cell (2008) 1.71
Light-induced rescue of breathing after spinal cord injury. J Neurosci (2008) 1.68
Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation. Mol Cell Biol (2007) 1.68
KNN/BNT composite lead-free films for high-frequency ultrasonic transducer applications. IEEE Trans Ultrason Ferroelectr Freq Control (2011) 1.65
Evolution of scaling emergence in large-scale spatial epidemic spreading. PLoS One (2011) 1.64
Prevalence of and racial differences in pterygium: a multiethnic population study in Asians. Ophthalmology (2012) 1.63
Protein kinase A type I and type II define distinct intracellular signaling compartments. Circ Res (2008) 1.62
NOD2 promotes renal injury by exacerbating inflammation and podocyte insulin resistance in diabetic nephropathy. Kidney Int (2013) 1.61
Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nat Cell Biol (2011) 1.59
Congenital lethal motor neuron disease with a novel defect in ribosome biogenesis. Neurology (2014) 1.59
Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nat Chem Biol (2008) 1.58
Development of integrated preamplifier for high-frequency ultrasonic transducers and low-power handheld receiver. IEEE Trans Ultrason Ferroelectr Freq Control (2011) 1.58
Three common TP53 polymorphisms in susceptibility to breast cancer, evidence from meta-analysis. Breast Cancer Res Treat (2009) 1.56
Serum protein S100A9, SOD3, and MMP9 as new diagnostic biomarkers for pulmonary tuberculosis by iTRAQ-coupled two-dimensional LC-MS/MS. Proteomics (2014) 1.55
Ceramide-enriched membrane domains--structure and function. Biochim Biophys Acta (2008) 1.49
Integrated intravascular optical coherence tomography ultrasound imaging system. J Biomed Opt (2010) 1.47
Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J (2006) 1.47
Intron 3 16 bp duplication polymorphism of TP53 contributes to cancer susceptibility: a meta-analysis. Carcinogenesis (2010) 1.47
Subcellular organelle lipidomics in TLR-4-activated macrophages. J Lipid Res (2010) 1.46
Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5. Biochem J (2006) 1.46
Axin: a master scaffold for multiple signaling pathways. Neurosignals (2004) 1.45
Photocatalytic oxidation of arsenite over TiO2: is superoxide the main oxidant in normal air-saturated aqueous solutions? Environ Sci Technol (2011) 1.42
Identification of a hybrid PKS/NRPS required for pseurotin A biosynthesis in the human pathogen Aspergillus fumigatus. Chembiochem (2007) 1.42
Patient-specific dose estimation for pediatric chest CT. Med Phys (2008) 1.41
Rapid detection of the ACMG/ACOG-recommended 23 CFTR disease-causing mutations using ion torrent semiconductor sequencing. J Biomol Tech (2012) 1.40
MicroRNAome of porcine pre- and postnatal development. PLoS One (2010) 1.40
Role of Wnt/beta-catenin signaling pathway in epithelial-mesenchymal transition of human prostate cancer induced by hypoxia-inducible factor-1alpha. Int J Urol (2007) 1.36
Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity. PLoS Pathog (2013) 1.36
Integrated optical coherence tomography, ultrasound and photoacoustic imaging for ovarian tissue characterization. Biomed Opt Express (2011) 1.35
The Fused/Smurf complex controls the fate of Drosophila germline stem cells by generating a gradient BMP response. Cell (2010) 1.34
Reduction of false positives by internal features for polyp detection in CT-based virtual colonoscopy. Med Phys (2005) 1.34
PSD-95 is required to sustain the molecular organization of the postsynaptic density. J Neurosci (2011) 1.33
Nitrogen-doped porous carbon nanofiber webs as anodes for lithium ion batteries with a superhigh capacity and rate capability. Adv Mater (2012) 1.33
High-resolution coregistered intravascular imaging with integrated ultrasound and optical coherence tomography probe. Appl Phys Lett (2010) 1.32
Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors. Science (2004) 1.31
Gold biomineralization by a metallophore from a gold-associated microbe. Nat Chem Biol (2013) 1.31
Sp1-like transcription factors are regulators of embryonic development in vertebrates. Dev Growth Differ (2005) 1.31
Activation of Nod-like receptor protein 3 inflammasomes turns on podocyte injury and glomerular sclerosis in hyperhomocysteinemia. Hypertension (2012) 1.31
Isolation and characterization of a new ginsenoside from the fresh root of Panax Ginseng. Molecules (2010) 1.30
miR-148b functions as a tumor suppressor in pancreatic cancer by targeting AMPKα1. Mol Cancer Ther (2012) 1.29
An improved electronic colon cleansing method for detection of colonic polyps by virtual colonoscopy. IEEE Trans Biomed Eng (2006) 1.28
Roles of mixing patterns in cooperation on a scale-free networked game. Phys Rev E Stat Nonlin Soft Matter Phys (2007) 1.27
Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity. J Virol (2008) 1.27
Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus. J Biol Chem (2008) 1.26
Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORgamma t. Eur J Immunol (2008) 1.26
NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter. Cancer Res (2002) 1.25
Arabidopsis CSN5B interacts with VTC1 and modulates ascorbic acid synthesis. Plant Cell (2013) 1.25
Novel combined miniature optical coherence tomography ultrasound probe for in vivo intravascular imaging. J Biomed Opt (2011) 1.25
miRNA-141, downregulated in pancreatic cancer, inhibits cell proliferation and invasion by directly targeting MAP4K4. Mol Cancer Ther (2013) 1.23
MiR-130b is a prognostic marker and inhibits cell proliferation and invasion in pancreatic cancer through targeting STAT3. PLoS One (2013) 1.23
Integrated ultrasound and photoacoustic probe for co-registered intravascular imaging. J Biomed Opt (2011) 1.20
SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling. J Biol Chem (2002) 1.20
Mortality and morbidity associated with simultaneous bilateral or staged bilateral total knee arthroplasty: a meta-analysis. Arch Orthop Trauma Surg (2011) 1.19
Six cytotoxic annonaceous acetogenins from Annona squamosa seeds. Food Chem (2012) 1.19
Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity. Dev Cell (2006) 1.19
HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor. Nucleic Acids Res (2012) 1.18
Pim kinase substrate identification and specificity. J Biochem (2007) 1.17
ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers. OMICS (2010) 1.17
Tob genes in development and homeostasis. Dev Dyn (2007) 1.17
The core protein of glypican Dally-like determines its biphasic activity in wingless morphogen signaling. Dev Cell (2009) 1.17
Alterations in ceramide concentration and pH determine the release of reactive oxygen species by Cftr-deficient macrophages on infection. J Immunol (2010) 1.17
A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Dev Cell (2007) 1.16
Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions. J Biol Chem (2004) 1.16
Repression of seed maturation genes by a trihelix transcriptional repressor in Arabidopsis seedlings. Plant Cell (2009) 1.15
Antidiabetic effects of malonyl ginsenosides from Panax ginseng on type 2 diabetic rats induced by high-fat diet and streptozotocin. J Ethnopharmacol (2012) 1.15
Prioritizing candidate disease miRNAs by topological features in the miRNA target-dysregulated network: case study of prostate cancer. Mol Cancer Ther (2011) 1.14
Cardiotonic pills, a compound Chinese medicine, protects ischemia-reperfusion-induced microcirculatory disturbance and myocardial damage in rats. Am J Physiol Heart Circ Physiol (2010) 1.13
Axin determines cell fate by controlling the p53 activation threshold after DNA damage. Nat Cell Biol (2009) 1.13
Transcriptional modulation of ethylene response factor protein JERF3 in the oxidative stress response enhances tolerance of tobacco seedlings to salt, drought, and freezing. Plant Physiol (2008) 1.13
The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory. Nat Neurosci (2011) 1.13
Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1. J Biol Chem (2007) 1.13
Tumorspheres derived from prostate cancer cells possess chemoresistant and cancer stem cell properties. J Cancer Res Clin Oncol (2012) 1.12
Pediatric chest and abdominopelvic CT: organ dose estimation based on 42 patient models. Radiology (2013) 1.12
The evolutionally conserved activity of Dapper2 in antagonizing TGF-beta signaling. FASEB J (2006) 1.11
Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays. Biochem J (2007) 1.10
EUS elastography for the differentiation of benign and malignant lymph nodes: a meta-analysis. Gastrointest Endosc (2011) 1.10
Transcriptional regulation of the ethylene response factor LeERF2 in the expression of ethylene biosynthesis genes controls ethylene production in tomato and tobacco. Plant Physiol (2009) 1.10
Visual impairment, age-related eye diseases, and cognitive function: the Singapore Malay Eye study. Arch Ophthalmol (2012) 1.10