Published in Mol Cell on March 13, 2009
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol (2010) 11.85
PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell (2011) 5.98
Genetic animal models of Parkinson's disease. Neuron (2010) 3.86
Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy. Hum Mol Genet (2010) 3.77
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease. Neuron (2015) 2.82
Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. J Biol Chem (2009) 2.64
The role of mitochondria in the pathogenesis of type 2 diabetes. Endocr Rev (2010) 2.59
NCLX is an essential component of mitochondrial Na+/Ca2+ exchange. Proc Natl Acad Sci U S A (2009) 2.36
Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences. EMBO J (2012) 2.36
PINK1 cleavage at position A103 by the mitochondrial protease PARL. Hum Mol Genet (2010) 2.30
Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update. Hum Mutat (2010) 2.29
Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1. PLoS One (2009) 2.23
Maintaining the brain: insight into human neurodegeneration from Drosophila melanogaster mutants. Nat Rev Genet (2009) 1.84
Mechanism of oxidative stress in neurodegeneration. Oxid Med Cell Longev (2012) 1.76
SR/ER-mitochondrial local communication: calcium and ROS. Biochim Biophys Acta (2009) 1.73
The PINK1/Parkin pathway: a mitochondrial quality control system? J Bioenerg Biomembr (2009) 1.72
Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration. PLoS One (2009) 1.71
Molecular and clinical prodrome of Parkinson disease: implications for treatment. Nat Rev Neurol (2010) 1.57
TRPV4 mutations and cytotoxic hypercalcemia in axonal Charcot-Marie-Tooth neuropathies. Neurology (2011) 1.56
Progressive degeneration of dopaminergic neurons through TRP channel-induced cell death. J Neurosci (2014) 1.43
A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease. Hum Mol Genet (2010) 1.41
The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila. PLoS Genet (2010) 1.41
PINK1 expression increases during brain development and stem cell differentiation, and affects the development of GFAP-positive astrocytes. Mol Brain (2016) 1.39
Mitophagy and Parkinson's disease: the PINK1-parkin link. Biochim Biophys Acta (2010) 1.34
Integrating pathways of Parkinson's disease in a molecular interaction map. Mol Neurobiol (2013) 1.34
Mitochondria and quality control defects in a mouse model of Gaucher disease--links to Parkinson's disease. Cell Metab (2013) 1.32
The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology. Physiol Rev (2015) 1.31
Signal transduction to the permeability transition pore. FEBS Lett (2010) 1.30
Mitochondrial biology and Parkinson's disease. Cold Spring Harb Perspect Med (2012) 1.30
Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations. Brain (2010) 1.27
Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer. Am J Pathol (2009) 1.26
Calcium-dependent mitochondrial function and dysfunction in neurons. FEBS J (2010) 1.25
Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease. Redox Biol (2013) 1.24
Role of oxidative stress in Parkinson's disease. Exp Neurobiol (2013) 1.23
Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage. Neurochem Int (2012) 1.23
Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration. Biol Open (2013) 1.20
Parkinson's disease: animal models and dopaminergic cell vulnerability. Front Neuroanat (2014) 1.18
Parkin- and PINK1-Dependent Mitophagy in Neurons: Will the Real Pathway Please Stand Up? Front Neurol (2013) 1.17
Control of tumor bioenergetics and survival stress signaling by mitochondrial HSP90s. Cancer Cell (2012) 1.17
Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through protein kinase A. J Neurochem (2013) 1.16
Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase. J Biol Chem (2014) 1.16
Mitochondria, calcium-dependent neuronal death and neurodegenerative disease. Pflugers Arch (2012) 1.16
Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease. Nat Cell Biol (2014) 1.15
Targeting microglia-mediated neurotoxicity: the potential of NOX2 inhibitors. Cell Mol Life Sci (2012) 1.14
Gene-environment interactions: key to unraveling the mystery of Parkinson's disease. Prog Neurobiol (2011) 1.14
Mutant Parkin impairs mitochondrial function and morphology in human fibroblasts. PLoS One (2010) 1.14
PINK1 function in health and disease. EMBO Mol Med (2009) 1.14
Basic mechanisms of neurodegeneration: a critical update. J Cell Mol Med (2010) 1.13
Cell metabolism affects selective vulnerability in PINK1-associated Parkinson's disease. J Cell Sci (2012) 1.11
Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons. J Neurosci (2014) 1.11
Mitochondrial contribution to Parkinson's disease pathogenesis. Parkinsons Dis (2011) 1.10
Tickled PINK1: mitochondrial homeostasis and autophagy in recessive Parkinsonism. Biochim Biophys Acta (2009) 1.09
Nrf2 regulates ROS production by mitochondria and NADPH oxidase. Biochim Biophys Acta (2014) 1.08
Neuronal calcium signaling: function and dysfunction. Cell Mol Life Sci (2014) 1.07
Measuring mitochondrial function in intact cardiac myocytes. J Mol Cell Cardiol (2011) 1.07
Signalling properties of inorganic polyphosphate in the mammalian brain. Nat Commun (2013) 1.05
Mitochondrial permeability transition pore is a potential drug target for neurodegeneration. Biochim Biophys Acta (2013) 1.05
PINK1 protects against cell death induced by mitochondrial depolarization, by phosphorylating Bcl-xL and impairing its pro-apoptotic cleavage. Cell Death Differ (2013) 1.04
Bioenergetic consequences of PINK1 mutations in Parkinson disease. PLoS One (2011) 1.04
Programmed cell death in Parkinson's disease. Cold Spring Harb Perspect Med (2012) 1.04
Unravelling mitochondrial pathways to Parkinson's disease. Br J Pharmacol (2014) 1.03
Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice. PLoS One (2011) 1.03
Loss of DJ-1 does not affect mitochondrial respiration but increases ROS production and mitochondrial permeability transition pore opening. PLoS One (2012) 1.02
Identifying consensus disease pathways in Parkinson's disease using an integrative systems biology approach. PLoS One (2011) 1.02
Nrf2 affects the efficiency of mitochondrial fatty acid oxidation. Biochem J (2014) 1.01
Role of β-hydroxybutyrate, its polymer poly-β-hydroxybutyrate and inorganic polyphosphate in mammalian health and disease. Front Physiol (2014) 1.01
Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection. Front Neurol (2013) 0.99
PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila. PLoS Genet (2014) 0.99
Mitochondrial quality control and Parkinson's disease: a pathway unfolds. Mol Neurobiol (2010) 0.98
Oxidative stress in genetic mouse models of Parkinson's disease. Oxid Med Cell Longev (2012) 0.98
Energy failure: does it contribute to neurodegeneration? Ann Neurol (2013) 0.98
Mitochondrial Ca(2+) and neurodegeneration. Cell Calcium (2012) 0.97
Protective Action of Neurotrophic Factors and Estrogen against Oxidative Stress-Mediated Neurodegeneration. J Toxicol (2011) 0.96
Loss of PINK1 increases the heart's vulnerability to ischemia-reperfusion injury. PLoS One (2013) 0.95
Human neuronal coenzyme Q10 deficiency results in global loss of mitochondrial respiratory chain activity, increased mitochondrial oxidative stress and reversal of ATP synthase activity: implications for pathogenesis and treatment. J Inherit Metab Dis (2012) 0.94
PINK1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease. FEBS J (2014) 0.94
Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1. EMBO J (2015) 0.94
Mitochondrial medicine for neurodegenerative diseases. Int J Biochem Cell Biol (2010) 0.93
Mitochondrial dysfunction in Parkinson's disease. Parkinsons Dis (2011) 0.93
Oxidative stress modulates mitochondrial failure and cyclophilin D function in X-linked adrenoleukodystrophy. Brain (2012) 0.92
Mitochondrial quality control and dynamics in Parkinson's disease. Antioxid Redox Signal (2011) 0.92
Antioxidant gene therapy against neuronal cell death. Pharmacol Ther (2013) 0.92
Comparative impact of voltage-gated calcium channels and NMDA receptors on mitochondria-mediated neuronal injury. J Neurosci (2012) 0.91
The impact of genetic research on our understanding of Parkinson's disease. Prog Brain Res (2010) 0.90
Quality control gone wrong: mitochondria, lysosomal storage disorders and neurodegeneration. Br J Pharmacol (2014) 0.90
Regulation of mitochondrial permeability transition pore by PINK1. Mol Neurodegener (2012) 0.90
Mitochondrial dysfunction in genetic animal models of Parkinson's disease. Antioxid Redox Signal (2011) 0.90
Hyperexcitable substantia nigra dopamine neurons in PINK1- and HtrA2/Omi-deficient mice. J Neurophysiol (2010) 0.90
Functional Oxygen Sensitivity of Astrocytes. J Neurosci (2015) 0.88
Aetiopathogenesis of Parkinson's disease. J Neurol (2011) 0.88
Parkin and PINK1 parkinsonism may represent nigral mitochondrial cytopathies distinct from Lewy body Parkinson's disease. Parkinsonism Relat Disord (2009) 0.87
Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants. EMBO J (2014) 0.87
To eat or not to eat: neuronal metabolism, mitophagy, and Parkinson's disease. Antioxid Redox Signal (2011) 0.87
GPA protects the nigrostriatal dopamine system by enhancing mitochondrial function. Neurobiol Dis (2011) 0.87
The parkin mutant phenotype in the fly is largely rescued by metal-responsive transcription factor (MTF-1). Mol Cell Biol (2011) 0.87
Calcium homeostasis in aging neurons. Front Genet (2012) 0.86
TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency. Ann Neurol (2013) 0.85
Polyhydroxybutyrate targets mammalian mitochondria and increases permeability of plasmalemmal and mitochondrial membranes. PLoS One (2013) 0.85
NCLX protein, but not LETM1, mediates mitochondrial Ca2+ extrusion, thereby limiting Ca2+-induced NAD(P)H production and modulating matrix redox state. J Biol Chem (2014) 0.85
Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging (2002) 22.40
Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science (2004) 15.91
Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat Neurosci (2000) 10.62
The mitochondrial permeability transition pore and its role in cell death. Biochem J (1999) 7.72
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc Natl Acad Sci U S A (2006) 5.78
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J Neurosci (2007) 5.68
'Rejuvenation' protects neurons in mouse models of Parkinson's disease. Nature (2007) 5.03
Oxidative stress in neurodegeneration: cause or consequence? Nat Med (2004) 4.72
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Nat Cell Biol (2007) 4.60
The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease. Brain (1999) 4.25
Mitochondrial complex I deficiency in Parkinson's disease. J Neurochem (1990) 4.03
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. PLoS Biol (2007) 3.86
Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism. Hum Mol Genet (2005) 3.76
Mitochondria and neuronal survival. Physiol Rev (2000) 3.56
Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. Proc Natl Acad Sci U S A (2007) 3.50
Calcium and neurodegeneration. Aging Cell (2007) 2.90
Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart. J Biol Chem (2000) 2.89
Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP. Proc Natl Acad Sci U S A (2008) 2.64
The interrelations between the transport of sodium and calcium in mitochondria of various mammalian tissues. Eur J Biochem (1978) 2.58
Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria. Proc Natl Acad Sci U S A (1996) 2.50
PINK1 protein in normal human brain and Parkinson's disease. Brain (2006) 2.49
PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. PLoS One (2008) 2.33
Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. J Neurosci (2004) 2.24
Regulation of mitochondrial structure and function by the F1Fo-ATPase inhibitor protein, IF1. Cell Metab (2008) 2.22
The release of calcium from heart mitochondria by sodium. J Mol Cell Cardiol (1974) 2.02
The calcium-induced and sodium-induced effluxes of calcium from heart mitochondria. Evidence for a sodium-calcium carrier. Eur J Biochem (1977) 1.95
Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress. J Neurochem (2006) 1.91
Imaging mitochondrial function in intact cells. Methods Enzymol (2003) 1.85
Expression and modulation of an NADPH oxidase in mammalian astrocytes. J Neurosci (2005) 1.71
Opening of the mitochondrial permeability transition pore induces reactive oxygen species production at the level of the respiratory chain complex I. J Biol Chem (2004) 1.67
A ubiquinone-binding site regulates the mitochondrial permeability transition pore. J Biol Chem (1998) 1.59
Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity. J Neurosci (2003) 1.58
Mitochondrial dynamics and Ca2+ signaling. Biochim Biophys Acta (2006) 1.57
Locus ceruleus lesions and eosinophilic inclusions in MPTP-treated monkeys. Ann Neurol (1986) 1.56
Targeted polyphosphatase expression alters mitochondrial metabolism and inhibits calcium-dependent cell death. Proc Natl Acad Sci U S A (2007) 1.38
Midbrain dopaminergic neurons in the mouse that contain calbindin-D28k exhibit reduced vulnerability to MPTP-induced neurodegeneration. Neurodegeneration (1996) 1.27
Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells. Neurotoxicology (2007) 1.20
Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration? FASEB J (2007) 1.19
Excitotoxic mitochondrial depolarisation requires both calcium and nitric oxide in rat hippocampal neurons. J Physiol (1999) 1.10
Actions of ionomycin, 4-BrA23187 and a novel electrogenic Ca2+ ionophore on mitochondria in intact cells. Cell Calcium (2003) 1.01
Reconstitution, identification, purification, and immunological characterization of the 110-kDa Na+/Ca2+ antiporter from beef heart mitochondria. J Biol Chem (1992) 1.00
Reactive oxygen metabolites increase mitochondrial calcium in endothelial cells: implication of the Ca2+/Na+ exchanger. J Cell Sci (1999) 0.92
Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science (2004) 15.91
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet (2011) 9.10
Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet (2013) 7.44
Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study. Lancet Neurol (2008) 6.76
Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice. Cell (2007) 6.44
Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat Methods (2006) 5.96
A common LRRK2 mutation in idiopathic Parkinson's disease. Lancet (2005) 5.81
Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis. Mol Cell (2003) 5.66
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet (2011) 5.56
Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways. J Cell Biol (2002) 5.07
Huntington's disease: from molecular pathogenesis to clinical treatment. Lancet Neurol (2011) 4.98
Expanding insights of mitochondrial dysfunction in Parkinson's disease. Nat Rev Neurosci (2006) 4.87
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Nat Cell Biol (2007) 4.60
Selection and evaluation of tagging SNPs in the neuronal-sodium-channel gene SCN1A: implications for linkage-disequilibrium gene mapping. Am J Hum Genet (2003) 4.58
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet (2010) 4.42
Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease. Brain (2009) 4.01
Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs. Cancer Cell (2007) 3.89
Chromosomal instability confers intrinsic multidrug resistance. Cancer Res (2011) 3.70
Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis. Nat Cell Biol (2003) 3.56
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nat Genet (2012) 3.40
Direct observation of the interconversion of normal and toxic forms of α-synuclein. Cell (2012) 3.39
Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. N Engl J Med (2003) 3.37
Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21. Hum Mol Genet (2010) 3.34
Effects of raf kinase inhibitor protein expression on suppression of prostate cancer metastasis. J Natl Cancer Inst (2003) 3.19
The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer. Cell (2012) 3.10
A robust model for read count data in exome sequencing experiments and implications for copy number variant calling. Bioinformatics (2012) 3.10
Mitochondria: the hub of cellular Ca2+ signaling. Physiology (Bethesda) (2008) 2.93
Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study. Lancet Neurol (2007) 2.88
The role of pathogenic DJ-1 mutations in Parkinson's disease. Ann Neurol (2003) 2.80
A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease. J Exp Med (2008) 2.78
PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene (2005) 2.77
Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation. J Neurosci (2007) 2.69
Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes. Am J Hum Genet (2010) 2.61
The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif. J Biol Chem (2001) 2.47
A single-nucleotide polymorphism tagging set for human drug metabolism and transport. Nat Genet (2004) 2.44
Parkin disease: a phenotypic study of a large case series. Brain (2003) 2.41
Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin. Proc Natl Acad Sci U S A (2005) 2.39
Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts. Ann Neurol (2008) 2.34
PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. PLoS One (2008) 2.33
PINK1 cleavage at position A103 by the mitochondrial protease PARL. Hum Mol Genet (2010) 2.30
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease. Hum Mol Genet (2005) 2.28
Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo. PLoS Biol (2007) 2.28
Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia-reperfusion injury. Cardiovasc Res (2003) 2.25
Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. J Neurosci (2004) 2.24
Regulation of mitochondrial structure and function by the F1Fo-ATPase inhibitor protein, IF1. Cell Metab (2008) 2.22
Flirting in little space: the ER/mitochondria Ca2+ liaison. Sci STKE (2004) 2.22
Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains. Ann Neurol (2012) 2.20
The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease. Brain (2003) 2.17
Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice. Mol Cell Biol (2004) 2.15
Chromosomal instability determines taxane response. Proc Natl Acad Sci U S A (2009) 2.12
RAS Interaction with PI3K: More Than Just Another Effector Pathway. Genes Cancer (2011) 2.12
Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling. Nat Genet (2013) 2.11
Endothelial mitochondria: contributing to vascular function and disease. Circ Res (2007) 2.11
Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis. Mol Cell Biol (2002) 2.10
Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK population. Am J Hum Genet (2013) 2.09
The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel. Cancer Cell (2007) 2.05
Nova2 interacts with a cis-acting polymorphism to influence the proportions of drug-responsive splice variants of SCN1A. Am J Hum Genet (2007) 2.04
Disease-associated prion protein oligomers inhibit the 26S proteasome. Mol Cell (2007) 2.01
Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis. Clin Cancer Res (2005) 1.99
Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression. Mol Cell Biol (2007) 1.96
Requirement for interaction of PI3-kinase p110α with RAS in lung tumor maintenance. Cancer Cell (2013) 1.95
Genetic risk factors for variant Creutzfeldt-Jakob disease: a genome-wide association study. Lancet Neurol (2009) 1.94
Coordinate direct input of both KRAS and IGF1 receptor to activation of PI3 kinase in KRAS-mutant lung cancer. Cancer Discov (2013) 1.93
Microglial activation in presymptomatic Huntington's disease gene carriers. Brain (2007) 1.93
Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress. J Neurochem (2006) 1.91
Mutations in the autoregulatory domain of β-tubulin 4a cause hereditary dystonia. Ann Neurol (2013) 1.90
Monocyte chemotactic protein-1 (MCP-1) acts as a paracrine and autocrine factor for prostate cancer growth and invasion. Prostate (2006) 1.90
Monitoring conformational changes of proteins in cells by fluorescence lifetime imaging microscopy. Biochem J (2003) 1.89
Retracted The large-conductance Ca2+-activated K+ channel is essential for innate immunity. Nature (2004) 1.85
Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury. J Mol Cell Cardiol (2006) 1.83
Multiphoton imaging reveals differences in mitochondrial function between nephron segments. J Am Soc Nephrol (2009) 1.83
Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes. PLoS One (2010) 1.83
STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis. J Biol Chem (2003) 1.79
Monocyte chemotactic protein-1 mediates prostate cancer-induced bone resorption. Cancer Res (2007) 1.79
Mutations in ANO3 cause dominant craniocervical dystonia: ion channel implicated in pathogenesis. Am J Hum Genet (2012) 1.78