Published in Am J Physiol Cell Physiol on February 26, 2014
Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol (2014) 0.87
Inhibition of Excessive Cell Proliferation by Calcilytics in Idiopathic Pulmonary Arterial Hypertension. PLoS One (2015) 0.86
Notch Activation of Ca(2+) Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension. Am J Respir Cell Mol Biol (2015) 0.82
Calcium entry via connexin hemichannels in lens epithelium. Exp Eye Res (2015) 0.80
Inactivated Pseudomonas aeruginosa inhibits hypoxia-induced pulmonary hypertension by preventing TGF-β1/Smad signaling. Braz J Med Biol Res (2016) 0.77
Gamma-secretase Inhibitor Prevents Proliferation and Migration of Ductus Arteriosus Smooth Muscle Cells through the Notch3-HES1/2/5 Pathway. Int J Biol Sci (2016) 0.75
A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self-renewal. Mol Syst Biol (2017) 0.75
Notch activation of Ca(2+)-sensing receptor mediates hypoxia-induced pulmonary hypertension. Hypertens Res (2016) 0.75
The canonical Notch signaling pathway: unfolding the activation mechanism. Cell (2009) 14.72
Notch signaling is essential for vascular morphogenesis in mice. Genes Dev (2000) 6.88
Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Nat Genet (1997) 6.66
Clinical classification of pulmonary hypertension. J Am Coll Cardiol (2004) 5.87
Mutations in the human Jagged1 gene are responsible for Alagille syndrome. Nat Genet (1997) 5.58
Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1. Hum Mol Genet (1999) 4.55
Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev (2004) 4.14
Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc Natl Acad Sci U S A (2004) 4.06
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev (2004) 3.95
PIP2 is a necessary cofactor for ion channel function: how and why? Annu Rev Biophys (2008) 3.89
Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development (1996) 3.84
Inflammation, growth factors, and pulmonary vascular remodeling. J Am Coll Cardiol (2009) 3.75
Cellular and molecular basis of pulmonary arterial hypertension. J Am Coll Cardiol (2009) 3.69
Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity. Nature (2005) 3.67
Regulation of vascular morphogenesis by Notch signaling. Genes Dev (2007) 3.10
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2. EMBO Rep (2008) 3.03
Notch3 is required for arterial identity and maturation of vascular smooth muscle cells. Genes Dev (2004) 3.00
A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency. Development (2002) 2.88
Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels. Mech Dev (2001) 2.69
Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. Cell Death Differ (2002) 2.60
Upregulated TRP and enhanced capacitative Ca(2+) entry in human pulmonary artery myocytes during proliferation. Am J Physiol Heart Circ Physiol (2001) 2.35
Notch signaling in vascular development. Arterioscler Thromb Vasc Biol (2003) 2.31
Chronic hypoxia-induced upregulation of store-operated and receptor-operated Ca2+ channels in pulmonary arterial smooth muscle cells: a novel mechanism of hypoxic pulmonary hypertension. Circ Res (2004) 2.13
Inhibition of endogenous TRP1 decreases capacitative Ca2+ entry and attenuates pulmonary artery smooth muscle cell proliferation. Am J Physiol Lung Cell Mol Physiol (2002) 2.13
Pulmonary hypertension surveillance--United States, 1980-2002. MMWR Surveill Summ (2005) 1.91
PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression. Am J Physiol Cell Physiol (2003) 1.91
Transient receptor potential channels meet phosphoinositides. EMBO J (2008) 1.89
Notch3 signaling promotes the development of pulmonary arterial hypertension. Nat Med (2009) 1.77
Notch signaling in the vasculature. Curr Top Dev Biol (2010) 1.62
Determinants of Notch-3 receptor expression and signaling in vascular smooth muscle cells: implications in cell-cycle regulation. Circ Res (2002) 1.55
Notch and vascular smooth muscle cell phenotype. Circ Res (2008) 1.48
Notch-mediated CBF-1/RBP-J{kappa}-dependent regulation of human vascular smooth muscle cell phenotype in vitro. Am J Physiol Cell Physiol (2005) 1.44
JAGGED1 gene expression during human embryogenesis elucidates the wide phenotypic spectrum of Alagille syndrome. Hepatology (2000) 1.34
Characterization of Notch receptor expression in the developing mammalian heart and liver. Am J Med Genet (2002) 1.32
The expression of Jagged1 in the developing mammalian heart correlates with cardiovascular disease in Alagille syndrome. Hum Mol Genet (1999) 1.27
TRP channels in hypertension. Biochim Biophys Acta (2007) 1.25
Stim, ORAI and TRPC channels in the control of calcium entry signals in smooth muscle. Clin Exp Pharmacol Physiol (2008) 1.25
New mechanisms of pulmonary arterial hypertension: role of Ca²⁺ signaling. Am J Physiol Heart Circ Physiol (2012) 1.24
Receptor channel TRPC6 is a key mediator of Notch-driven glioblastoma growth and invasiveness. Cancer Res (2009) 1.18
The notch target gene HES1 regulates cell cycle inhibitor expression in the developing pituitary. Endocrinology (2009) 1.17
Role of Na+/Ca2+ exchange in regulating cytosolic Ca2+ in cultured human pulmonary artery smooth muscle cells. Am J Physiol Cell Physiol (2004) 1.17
An overview of Notch3 function in vascular smooth muscle cells. Prog Biophys Mol Biol (2007) 1.14
STIM2 Contributes to Enhanced Store-operated Ca Entry in Pulmonary Artery Smooth Muscle Cells from Patients with Idiopathic Pulmonary Arterial Hypertension. Pulm Circ (2011) 1.03
Notch signaling regulates the differentiation of bone marrow-derived cells into smooth muscle-like cells during arterial lesion formation. Biochem Biophys Res Commun (2009) 1.03
Notch-Hes1 pathway contributes to the cochlear prosensory formation potentially through the transcriptional down-regulation of p27Kip1. J Neurosci Res (2009) 1.03
Notch signalling and voltage-gated Na+ channel activity in human prostate cancer cells: independent modulation of in vitro motility. Prostate Cancer Prostatic Dis (2006) 0.98
JAGGED1 expression in human embryos: correlation with the Alagille syndrome phenotype. J Med Genet (2000) 0.96
Complex roles of PIP2 in the regulation of ion channels and transporters. Am J Physiol Renal Physiol (2007) 0.95
Activity of Ca -activated Cl channels contributes to regulating receptor- and store-operated Ca entry in human pulmonary artery smooth muscle cells. Pulm Circ (2011) 0.94
Physiological functions of transient receptor potential channels in pulmonary arterial smooth muscle cells. Adv Exp Med Biol (2010) 0.89
Functional characterization of voltage-gated K+ channels in mouse pulmonary artery smooth muscle cells. Am J Physiol Cell Physiol (2007) 0.87
Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel. J Biol Chem (2009) 0.86
Expression and role of Notch signalling in the regeneration of rat tracheal epithelium. Cell Prolif (2009) 0.85
Notch signaling in pulmonary hypertension. Adv Exp Med Biol (2010) 0.81
Genome-wide atlas of gene expression in the adult mouse brain. Nature (2006) 28.02
Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature (2005) 9.44
Inflammation, growth factors, and pulmonary vascular remodeling. J Am Coll Cardiol (2009) 3.75
Cellular and molecular basis of pulmonary arterial hypertension. J Am Coll Cardiol (2009) 3.69
Dexmedetomidine and cardiac arrest. Anesthesiology (2004) 3.49
Pulmonary endarterectomy: experience and lessons learned in 1,500 cases. Ann Thorac Surg (2003) 3.04
Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. Proc Natl Acad Sci U S A (2004) 2.79
Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell (2008) 2.54
Signaling molecules in nonfamilial pulmonary hypertension. N Engl J Med (2003) 2.36
Intravascular ultrasound parameters associated with stent thrombosis after drug-eluting stent deployment. Am J Cardiol (2007) 2.32
Large-scale cellular-resolution gene profiling in human neocortex reveals species-specific molecular signatures. Cell (2012) 2.29
A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension. Circulation (2009) 2.17
Inhibition of endogenous TRP1 decreases capacitative Ca2+ entry and attenuates pulmonary artery smooth muscle cell proliferation. Am J Physiol Lung Cell Mol Physiol (2002) 2.13
Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension. Am J Respir Crit Care Med (2010) 2.09
Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration. J Clin Invest (2009) 2.02
Juvenile exposure to anthracyclines impairs cardiac progenitor cell function and vascularization resulting in greater susceptibility to stress-induced myocardial injury in adult mice. Circulation (2010) 1.97
PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression. Am J Physiol Cell Physiol (2003) 1.91
Development and pathology of pulmonary hypertension. J Am Coll Cardiol (2009) 1.88
Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse. J Am Coll Cardiol (2005) 1.85
Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases. PLoS One (2008) 1.84
A reduction in clot formation rate and strength assessed by thrombelastography is indicative of transfusion requirements in patients with penetrating injuries. J Trauma (2008) 1.79
Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2003) 1.77
Notch3 signaling promotes the development of pulmonary arterial hypertension. Nat Med (2009) 1.77
Cellular and molecular mechanisms of pulmonary vascular remodeling: role in the development of pulmonary hypertension. Microvasc Res (2004) 1.65
A novel molecular signature for elevated tricuspid regurgitation velocity in sickle cell disease. Am J Respir Crit Care Med (2012) 1.63
Hyperexpression of cyclooxygenase 2 in the lupus immune system and effect of cyclooxygenase 2 inhibitor diet therapy in a murine model of systemic lupus erythematosus. Arthritis Rheum (2007) 1.60
Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling. Circulation (2007) 1.53
Activation of K+ channels: an essential pathway in programmed cell death. Am J Physiol Lung Cell Mol Physiol (2004) 1.51
Endothelial expression of bone morphogenetic protein receptor type 1a is required for atrioventricular valve formation. Ann Thorac Surg (2008) 1.51
Lung cancer and radiofrequency ablation. J Vasc Interv Radiol (2006) 1.51
Persistence of the lactate paradox over 8 weeks at 3,800 m. High Alt Med Biol (2003) 1.49
Angiotensin-(1-7) binds to specific receptors on cardiac fibroblasts to initiate antifibrotic and antitrophic effects. Am J Physiol Heart Circ Physiol (2005) 1.49
Function of Kv1.5 channels and genetic variations of KCNA5 in patients with idiopathic pulmonary arterial hypertension. Am J Physiol Cell Physiol (2007) 1.47
Angiotensin receptor blocker added to previous antihypertensive agents on arteries of diabetic hypertensive patients. Hypertension (2006) 1.40
Adaptation to altitude as a vehicle for experiential learning of physiology by university undergraduates. Adv Physiol Educ (2007) 1.40
Five-year outcomes of moderate or ambiguous left main coronary artery disease and the intravascular ultrasound predictors of events. J Invasive Cardiol (2008) 1.39
Dynamics of alpha-synuclein aggregation and inhibition of pore-like oligomer development by beta-synuclein. FEBS J (2007) 1.35
Hypoxia increases AP-1 binding activity by enhancing capacitative Ca2+ entry in human pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol (2003) 1.35
Role of capacitative Ca2+ entry in bronchial contraction and remodeling. J Appl Physiol (1985) (2002) 1.34
Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension. FASEB J (2007) 1.33
Risk factors and basic mechanisms of chronic thromboembolic pulmonary hypertension: a current understanding. Eur Respir J (2012) 1.31
Pathogenesis of pulmonary arterial hypertension: the need for multiple hits. Circulation (2005) 1.29
Outcomes of coronary artery bypass grafting versus percutaneous coronary intervention with drug-eluting stents for patients with multivessel coronary artery disease. Circulation (2007) 1.27
TRP channels in hypertension. Biochim Biophys Acta (2007) 1.25
New mechanisms of pulmonary arterial hypertension: role of Ca²⁺ signaling. Am J Physiol Heart Circ Physiol (2012) 1.24
Calcium and TRP channels in pulmonary vascular smooth muscle cell proliferation. News Physiol Sci (2004) 1.21
Concept analysis of cognitive artifacts. ANS Adv Nurs Sci (2010) 1.20
Downregulation of connexin40 is associated with coronary endothelial cell dysfunction in streptozotocin-induced diabetic mice. Am J Physiol Cell Physiol (2008) 1.19
Overexpression of TRPC1 enhances pulmonary vasoconstriction induced by capacitative Ca2+ entry. Am J Physiol Lung Cell Mol Physiol (2004) 1.18
TRPC1 functions as a store-operated Ca2+ channel in intestinal epithelial cells and regulates early mucosal restitution after wounding. Am J Physiol Gastrointest Liver Physiol (2005) 1.18
Induction of pulmonary hypertension by an angiopoietin 1/TIE2/serotonin pathway. Proc Natl Acad Sci U S A (2003) 1.17
Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1. Am J Physiol Lung Cell Mol Physiol (2006) 1.17
Role of Na+/Ca2+ exchange in regulating cytosolic Ca2+ in cultured human pulmonary artery smooth muscle cells. Am J Physiol Cell Physiol (2004) 1.17
Hypoxia divergently regulates production of reactive oxygen species in human pulmonary and coronary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2007) 1.16
Identification of putative endothelial progenitor cells (CD34+CD133+Flk-1+) in endarterectomized tissue of patients with chronic thromboembolic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol (2009) 1.14
p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response. J Biol Chem (2007) 1.13
Activation of K(+) channels and increased migration of differentiated intestinal epithelial cells after wounding. Am J Physiol Cell Physiol (2002) 1.13
Molecular and anatomical signatures of sleep deprivation in the mouse brain. Front Neurosci (2010) 1.12
Functional and physical interaction between the selenium-binding protein 1 (SBP1) and the glutathione peroxidase 1 selenoprotein. Carcinogenesis (2010) 1.11
PDGF enhances store-operated Ca2+ entry by upregulating STIM1/Orai1 via activation of Akt/mTOR in human pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol (2011) 1.10
Decorin-mediated inhibition of colorectal cancer growth and migration is associated with E-cadherin in vitro and in mice. Carcinogenesis (2011) 1.10
Idiopathic pulmonary arterial hypertension. Dis Model Mech (2010) 1.09
Upregulation of Na+/Ca2+ exchanger contributes to the enhanced Ca2+ entry in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension. Am J Physiol Cell Physiol (2006) 1.09
Differential myocardial gene delivery by recombinant serotype-specific adeno-associated viral vectors. Mol Ther (2004) 1.09
ATP-induced mitogenesis is mediated by cyclic AMP response element-binding protein-enhanced TRPC4 expression and activity in human pulmonary artery smooth muscle cells. Am J Physiol Cell Physiol (2004) 1.09
Donor transfer of pulmonary coccidioidomycosis in lung transplantation. Ann Thorac Surg (2002) 1.08
Hypoxic pulmonary vasoconstriction: role of ion channels. J Appl Physiol (1985) (2005) 1.08
Pulmonary artery smooth muscle cells from normal subjects and IPAH patients show divergent cAMP-mediated effects on TRPC expression and capacitative Ca2+ entry. Am J Physiol Lung Cell Mol Physiol (2006) 1.07
Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca2+ channel activity in pulmonary artery by upregulating Cav1.2 and Cav3.2. Am J Physiol Lung Cell Mol Physiol (2013) 1.07
The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension. Am J Respir Crit Care Med (2014) 1.04
STIM2 Contributes to Enhanced Store-operated Ca Entry in Pulmonary Artery Smooth Muscle Cells from Patients with Idiopathic Pulmonary Arterial Hypertension. Pulm Circ (2011) 1.03
Direct comparison of efficiency and stability of gene transfer into the mammalian heart using adeno-associated virus versus adenovirus vectors. J Thorac Cardiovasc Surg (2003) 1.03
Expression profiling of ion channel genes predicts clinical outcome in breast cancer. Mol Cancer (2013) 1.03
Overexpression of human KCNA5 increases IK V and enhances apoptosis. Am J Physiol Cell Physiol (2004) 1.02
Acute hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells. Am J Physiol Cell Physiol (2005) 1.01
Diversity of voltage-dependent K+ channels in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2004) 1.01
Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2006) 1.01
Rac1 promotes intestinal epithelial restitution by increasing Ca2+ influx through interaction with phospholipase C-(gamma)1 after wounding. Am J Physiol Cell Physiol (2008) 1.00
Cytochrome c activates K+ channels before inducing apoptosis. Am J Physiol Cell Physiol (2002) 0.99
Introduction to TRP channels: structure, function, and regulation. Adv Exp Med Biol (2010) 0.99
Inhibition of mTOR attenuates store-operated Ca2+ entry in cells from endarterectomized tissues of patients with chronic thromboembolic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol (2009) 0.99
Bosentan inhibits transient receptor potential channel expression in pulmonary vascular myocytes. Am J Respir Crit Care Med (2004) 0.99