BRCA2-dependent homologous recombination is required for repair of Arsenite-induced replication lesions in mammalian cells.

PubWeight™: 0.92‹?›

🔗 View Article (PMC 2731915)

Published in Nucleic Acids Res on June 23, 2009

Authors

Songmin Ying1, Katie Myers, Sarah Bottomley, Thomas Helleday, Helen E Bryant

Author Affiliations

1: The Institute for Cancer Studies, University of Sheffield, Sheffield S10 2RX, UK.

Articles citing this

Arsenic exposure and the induction of human cancers. J Toxicol (2011) 1.16

Role and mechanism of arsenic in regulating angiogenesis. PLoS One (2011) 0.94

Metals and breast cancer: risk factors or healing agents? J Toxicol (2011) 0.88

Chronic inflammation-related DNA damage response: a driving force of gastric cardia carcinogenesis. Oncotarget (2015) 0.86

Arsenic biotransformation as a cancer promoting factor by inducing DNA damage and disruption of repair mechanisms. Mol Biol Int (2011) 0.84

The 3'-5' DNA exonuclease TREX1 directly interacts with poly(ADP-ribose) polymerase-1 (PARP1) during the DNA damage response. J Biol Chem (2014) 0.82

Photodynamic killing of cancer cells by a Platinum(II) complex with cyclometallating ligand. Sci Rep (2016) 0.81

Arsenite induces premature senescence via p53/p21 pathway as a result of DNA damage in human malignant glioblastoma cells. BMB Rep (2014) 0.80

Antagonism between curcumin and the topoisomerase II inhibitor etoposide: a study of DNA damage, cell cycle regulation and death pathways. Cancer Biol Ther (2012) 0.80

Arsenic is cytotoxic and genotoxic to primary human lung cells. Mutat Res Genet Toxicol Environ Mutagen (2013) 0.80

Oxidative stress and replication-independent DNA breakage induced by arsenic in Saccharomyces cerevisiae. PLoS Genet (2013) 0.79

The mammary gland carcinogens: the role of metal compounds and organic solvents. Int J Breast Cancer (2013) 0.76

Bioaerosols, Noise, and Ultraviolet Radiation Exposures for Municipal Solid Waste Handlers. J Environ Public Health (2017) 0.75

Prolonged particulate chromate exposure does not inhibit homologous recombination repair in North Atlantic right whale (Eubalaena glacialis) lung cells. Toxicol Appl Pharmacol (2017) 0.75

Articles cited by this

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature (2005) 19.13

Chromosomal stability and the DNA double-stranded break connection. Nat Rev Genet (2001) 6.77

Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-alpha. Nature (1978) 5.91

Resistance to therapy caused by intragenic deletion in BRCA2. Nature (2008) 5.85

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell (1995) 5.58

Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro. Cell (1996) 5.29

Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes. Proc Natl Acad Sci U S A (1995) 4.60

Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water. Br J Cancer (1992) 3.46

Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks. Mol Cell Biol (2005) 3.10

A CHO-cell strain having hypersensitivity to mutagens, a defect in DNA strand-break repair, and an extraordinary baseline frequency of sister-chromatid exchange. Mutat Res (1982) 2.92

Incidence of internal cancers and ingested inorganic arsenic: a seven-year follow-up study in Taiwan. Cancer Res (1995) 2.75

Ecological correlation between arsenic level in well water and age-adjusted mortality from malignant neoplasms. Cancer Res (1990) 2.66

Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression. Proc Natl Acad Sci U S A (1997) 2.51

Some drinking-water disinfectants and contaminants, including arsenic. IARC Monogr Eval Carcinog Risks Hum (2004) 2.50

Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene. Proc Natl Acad Sci U S A (1995) 2.48

The role of biomethylation in toxicity and carcinogenicity of arsenic: a research update. Environ Health Perspect (2002) 2.48

Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage. EMBO J (2002) 2.45

Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff. Mol Cell Biol (2000) 2.41

Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions. Mol Cell Biol (2002) 2.14

Camptothecin, a specific inhibitor of type I DNA topoisomerase, induces DNA breakage at replication forks. Mol Cell Biol (1988) 2.05

A Chinese hamster ovary cell line hypersensitive to ionizing radiation and deficient in repair replication. Mutat Res (1988) 2.00

Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation. Nat Cell Biol (2000) 1.89

Interaction between replication forks and topoisomerase I-DNA cleavable complexes: studies in a cell-free SV40 DNA replication system. Cancer Res (1993) 1.88

Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial. Mol Cancer Ther (2007) 1.85

Mortality for certain diseases in areas with high levels of arsenic in drinking water. Arch Environ Health (1999) 1.82

Cellular functions of the BRCA tumour-suppressor proteins. Biochem Soc Trans (2006) 1.82

Comparative activity of melarsoprol and arsenic trioxide in chronic B-cell leukemia lines. Blood (1997) 1.69

Methods for the quantification of DNA double-strand breaks determined from the distribution of DNA fragment sizes measured by pulsed-field gel electrophoresis. Radiat Res (1995) 1.61

Arsenic trioxide: new clinical experience with an old medication in hematologic malignancies. J Clin Oncol (2005) 1.51

Camptothecin cytotoxicity in mammalian cells is associated with the induction of persistent double strand breaks in replicating DNA. Nucleic Acids Res (1991) 1.47

Inhibition of poly(ADP-ribose) polymerase-1 by arsenite interferes with repair of oxidative DNA damage. J Biol Chem (2008) 1.44

Induction of oxidative DNA damage by arsenite and its trivalent and pentavalent methylated metabolites in cultured human cells and isolated DNA. Carcinogenesis (2003) 1.35

Arsenic mediates cell proliferation and gene expression in the bladder epithelium: association with activating protein-1 transactivation. Cancer Res (2000) 1.32

Modulation of DNA repair processes by arsenic and selenium compounds. Toxicology (2003) 1.25

Co-ordination of DNA single strand break repair. DNA Repair (Amst) (2006) 1.25

Arsenic trioxide induces apoptosis in human gastric cancer cells through up-regulation of p53 and activation of caspase-3. Int J Cancer (2001) 1.20

The role of oxidative DNA damage in human arsenic carcinogenesis: detection of 8-hydroxy-2'-deoxyguanosine in arsenic-related Bowen's disease. J Invest Dermatol (1999) 1.20

Inorganic arsenic compounds cause oxidative damage to DNA and protein by inducing ROS and RNS generation in human keratinocytes. Mol Cell Biochem (2005) 1.19

A partial hprt gene duplication generated by non-homologous recombination in V79 Chinese hamster cells is eliminated by homologous recombination. J Mol Biol (1998) 1.16

Association of blood arsenic levels with increased reactive oxidants and decreased antioxidant capacity in a human population of northeastern Taiwan. Environ Health Perspect (2001) 1.15

Arsenic induces oxidative DNA damage in mammalian cells. Mol Cell Biochem (2002) 1.08

Impact of arsenite and its methylated metabolites on PARP-1 activity, PARP-1 gene expression and poly(ADP-ribosyl)ation in cultured human cells. DNA Repair (Amst) (2006) 1.08

Treatment of acute promyelocytic leukemia. Hematology Am Soc Hematol Educ Program (2006) 1.07

Arsenic-induced DNA hypomethylation affects chromosomal instability in mammalian cells. Carcinogenesis (2003) 1.06

Cytogenetic characterization of the ionizing radiation-sensitive Chinese hamster mutant irs1. Mutat Res (1991) 1.05

Arsenic-induced DNA-strand breaks associated with DNA-protein crosslinks in human fetal lung fibroblasts. Mutat Res (1993) 0.99

Oxidative DNA adducts and DNA-protein cross-links are the major DNA lesions induced by arsenite. Environ Health Perspect (2002) 0.97

Low dose exposure to sodium arsenite synergistically interacts with UV radiation to induce mutations and alter DNA repair in human cells. Mutagenesis (2004) 0.96

Chromosomal aberrations and sister chromatid exchanges in individuals exposed to arsenic through drinking water in West Bengal, India. Mutat Res (2003) 0.95

Arsenite induces oxidative DNA adducts and DNA-protein cross-links in mammalian cells. Free Radic Biol Med (2001) 0.94

DNA repair deficiency leads to susceptibility to develop arsenic-induced premalignant skin lesions. Int J Cancer (2008) 0.93

hOGG1(326), XRCC1(399) and XRCC3(241) polymorphisms influence micronucleus frequencies in human lymphocytes in vivo. Mutagenesis (2007) 0.93

Inorganic and dimethylated arsenic species induce cellular p53. Chem Res Toxicol (2003) 0.93

Sister-chromatid exchange (SCE) among individuals chronically exposed to arsenic in drinking water. Mutat Res (1994) 0.93

Pharmacokinetics, metabolism, and carcinogenicity of arsenic. Rev Environ Contam Toxicol (2001) 0.92

Arsenic trioxide: an anti cancer missile with multiple warheads. Hematology (2005) 0.90

Arsenic disrupts cellular levels of p53 and mdm2: a potential mechanism of carcinogenesis. Biochem Biophys Res Commun (1999) 0.88

Attenuation of DNA damage-induced p53 expression by arsenic: a possible mechanism for arsenic co-carcinogenesis. Mol Carcinog (2008) 0.87

DNA damage in blood cells from children exposed to arsenic and lead in a mining area. Environ Res (2003) 0.83

Chromosomal aberrations in arsenic-exposed human populations: a review with special reference to a comprehensive study in West Bengal, India. Cytogenet Genome Res (2004) 0.83

Formamidopyrimidine-DNA glycosylase enhances arsenic-induced DNA strand breaks in PHA-stimulated and unstimulated human lymphocytes. Environ Health Perspect (2001) 0.80

A retrospective lung cancer mortality study of people exposed to insoluble arsenic and radon. Lung Cancer (1996) 0.78

Articles by these authors

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature (2005) 19.13

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature (2006) 11.76

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nat Cell Biol (2005) 4.62

Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair. Mol Cell (2010) 4.57

Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Mol Cell Biol (2005) 4.54

Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2. Cell (2010) 3.43

miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. Mol Cell (2010) 3.27

Pathways of mammalian replication fork restart. Nat Rev Mol Cell Biol (2010) 3.26

Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks. Mol Cell Biol (2005) 3.10

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination. EMBO J (2009) 2.99

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1. Nature (2005) 2.98

The histone methyltransferase SET8 is required for S-phase progression. J Cell Biol (2007) 2.74

Efficacy of cytisine in helping smokers quit: systematic review and meta-analysis. Thorax (2013) 2.74

Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells. Mol Cell Biol (2002) 2.73

Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment. Cancer Res (2010) 2.68

Distinct microRNA alterations characterize high- and low-grade bladder cancer. Cancer Res (2009) 2.58

Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks. Nucleic Acids Res (2005) 2.44

Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase. J Cell Biol (2010) 2.43

PCNA on the crossroad of cancer. Biochem Soc Trans (2009) 2.03

Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cells. Nucleic Acids Res (2004) 2.02

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Res (2013) 1.92

Break-induced replication repair of damaged forks induces genomic duplications in human cells. Science (2013) 1.90

Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair. Nucleic Acids Res (2006) 1.88

Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination. Nucleic Acids Res (2003) 1.86

Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control. Proc Natl Acad Sci U S A (2008) 1.74

Chk1 promotes replication fork progression by controlling replication initiation. Proc Natl Acad Sci U S A (2010) 1.71

Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1. Cancer Res (2012) 1.65

A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown. Cancer Res (2010) 1.65

Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells. Cancer Res (2010) 1.64

Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate. Nucleic Acids Res (2010) 1.57

UV stalled replication forks restart by re-priming in human fibroblasts. Nucleic Acids Res (2011) 1.51

Overexpression of POLQ confers a poor prognosis in early breast cancer patients. Oncotarget (2010) 1.49

Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy. Cell Cycle (2005) 1.48

ATM is required for the cellular response to thymidine induced replication fork stress. Hum Mol Genet (2004) 1.46

PTEN deletion in prostate cancer cells does not associate with loss of RAD51 function: implications for radiotherapy and chemotherapy. Clin Cancer Res (2011) 1.46

Transcription-associated recombination is dependent on replication in Mammalian cells. Mol Cell Biol (2007) 1.45

The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells. Nucleic Acids Res (2007) 1.45

RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair. Mol Cell Biol (2007) 1.41

Claspin promotes normal replication fork rates in human cells. Mol Biol Cell (2008) 1.38

RAD51 is involved in repair of damage associated with DNA replication in mammalian cells. J Mol Biol (2003) 1.36

PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA. J Biol Chem (2010) 1.32

Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3. J Med Chem (2009) 1.31

Transcription-associated recombination in eukaryotes: link between transcription, replication and recombination. Mutagenesis (2009) 1.31

The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links. Nucleic Acids Res (2009) 1.30

6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance. Cancer Res (2010) 1.29

Folate pathway genetic polymorphisms are related to attention disorders in childhood leukemia survivors. J Pediatr (2007) 1.29

Identification of the MMS22L-TONSL complex that promotes homologous recombination. Mol Cell (2010) 1.21

Defects in homologous recombination repair in mismatch-repair-deficient tumour cell lines. Hum Mol Genet (2002) 1.19

Methylated DNA causes a physical block to replication forks independently of damage signalling, O(6)-methylguanine or DNA single-strand breaks and results in DNA damage. J Mol Biol (2010) 1.16

Reduced expression of miRNA-27a modulates cisplatin resistance in bladder cancer by targeting the cystine/glutamate exchanger SLC7A11. Clin Cancer Res (2014) 1.16

ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair. EMBO Rep (2011) 1.12

Homologous recombination repairs secondary replication induced DNA double-strand breaks after ionizing radiation. Nucleic Acids Res (2012) 1.11

Zinc binding catalytic domain of human tankyrase 1. J Mol Biol (2008) 1.09

Crystal structure of human MTH1 and the 8-oxo-dGMP product complex. FEBS Lett (2011) 1.09

RPA mediates recombination repair during replication stress and is displaced from DNA by checkpoint signalling in human cells. J Mol Biol (2007) 1.09

The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer. Int J Cancer (2003) 1.09

Up-regulation of the error-prone DNA polymerase {kappa} promotes pleiotropic genetic alterations and tumorigenesis. Cancer Res (2005) 1.09

Homologous recombination repair is essential for repair of vosaroxin-induced DNA double-strand breaks. Oncotarget (2010) 1.06

Downregulation of SMG-1 in HPV-positive head and neck squamous cell carcinoma due to promoter hypermethylation correlates with improved survival. Clin Cancer Res (2012) 1.05

Targeting homologous recombination repair defects in cancer. Trends Pharmacol Sci (2010) 1.05

p53 protects from replication-associated DNA double-strand breaks in mammalian cells. Oncogene (2004) 1.04

Rapid excess weight loss following laparoscopic gastric bypass leads to increased risk of internal hernia. Surg Endosc (2010) 1.04

WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks. Mol Biol Cell (2008) 1.02

Inhibition of poly(ADP-ribose) glycohydrolase (PARG) specifically kills BRCA2-deficient tumor cells. Cell Cycle (2012) 1.01

Thymidine selectively enhances growth suppressive effects of camptothecin/irinotecan in MSI+ cells and tumors containing a mutation of MRE11. Clin Cancer Res (2008) 1.00

Castration therapy results in decreased Ku70 levels in prostate cancer. Clin Cancer Res (2013) 1.00

Cohesin phosphorylation and mobility of SMC1 at ionizing radiation-induced DNA double-strand breaks in human cells. Exp Cell Res (2010) 0.99

Homologous recombination is involved in repair of chromium-induced DNA damage in mammalian cells. Mutat Res (2006) 0.98

DNA repair rate and etoposide (VP16) resistance of tumor cell subpopulations derived from a single human small cell lung cancer. Lung Cancer (2003) 0.97

Identification of novel regions of amplification and deletion within mantle cell lymphoma DNA by comparative genomic hybridization. Br J Haematol (2002) 0.96

Repair pathways independent of the Fanconi anemia nuclear core complex play a predominant role in mitigating formaldehyde-induced DNA damage. Biochem Biophys Res Commun (2010) 0.95

XRCC1 phosphorylation by CK2 is required for its stability and efficient DNA repair. DNA Repair (Amst) (2010) 0.95

5-Aza-2'-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair. Nucleic Acids Res (2013) 0.95

Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity. Proc Natl Acad Sci U S A (2013) 0.94

Targeting protein for xenopus kinesin-like protein 2 (TPX2) regulates γ-histone 2AX (γ-H2AX) levels upon ionizing radiation. J Biol Chem (2012) 0.93

A tumour-derived mutant allele of XRCC2 preferentially suppresses homologous recombination at DNA replication forks. Hum Mol Genet (2003) 0.92

Reduced apoptotic response to camptothecin in CHO cells deficient in XRCC3. Carcinogenesis (2003) 0.92

Mitotic defects in XRCC3 variants T241M and D213N and their relation to cancer susceptibility. Hum Mol Genet (2006) 0.90

Strand invasion involving short tract gene conversion is specifically suppressed in BRCA2-deficient hamster cells. Oncogene (2004) 0.90

Weight change during and after Ramadan fasting. J Public Health (Oxf) (2011) 0.88

FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ. PLoS One (2011) 0.87

PI3King the lock: targeting the PI3K/Akt/mTOR pathway as a novel therapeutic strategy in neuroblastoma. J Pediatr Hematol Oncol (2015) 0.87

Early replication fragile sites: where replication-transcription collisions cause genetic instability. EMBO J (2013) 0.87

Homologous recombination mediates cellular resistance and fraction size sensitivity to radiation therapy. Radiother Oncol (2013) 0.87

"Sex" in the cancer cell. Oncotarget (2014) 0.86

Breast cancer stem-like cells show dominant homologous recombination due to a larger S-G2 fraction. Cancer Biol Ther (2011) 0.85

Transcription-associated recombination is independent of XRCC2 and mechanistically separate from homology-directed DNA double-strand break repair. Nucleic Acids Res (2008) 0.84

DNA damage response in peritumoral regions of oesophageal cancer microenvironment. Carcinogenesis (2012) 0.84

Thyroid cancer in young adults. Semin Oncol (2009) 0.84

CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair. DNA Repair (Amst) (2011) 0.83

Human RECQL5 overcomes thymidine-induced replication stress. DNA Repair (Amst) (2010) 0.82

The relationship between homologous recombination repair and the sensitivity of human epidermis to the size of daily doses over a 5-week course of breast radiotherapy. Clin Cancer Res (2012) 0.81

Screening for genotoxicity using the DRAG assay: investigation of halogenated environmental contaminants. Mutat Res (2004) 0.81

CHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation. Nucleic Acids Res (2012) 0.81