The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links.

PubWeight™: 1.30‹?› | Rank: Top 10%

🔗 View Article (PMC 2770670)

Published in Nucleic Acids Res on August 27, 2009

Authors

Ali Z Al-Minawi1, Yin-Fai Lee, Daniel Håkansson, Fredrik Johansson, Cecilia Lundin, Nasrollah Saleh-Gohari, Niklas Schultz, Dag Jenssen, Helen E Bryant, Mark Meuth, John M Hinz, Thomas Helleday

Author Affiliations

1: The Institute for Cancer Studies, University of Sheffield, Medical School, Sheffield S10 2RX, UK.

Articles citing this

DNA interstrand crosslink repair and cancer. Nat Rev Cancer (2011) 4.29

Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4. Blood (2012) 2.48

The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance. Nat Rev Cancer (2012) 2.20

Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway. Proc Natl Acad Sci U S A (2011) 1.86

BRCA1 is required for postreplication repair after UV-induced DNA damage. Mol Cell (2011) 1.48

Advances in understanding the complex mechanisms of DNA interstrand cross-link repair. Cold Spring Harb Perspect Biol (2013) 1.45

Downregulation of XPF-ERCC1 enhances cisplatin efficacy in cancer cells. DNA Repair (Amst) (2010) 1.30

PARP inhibition selectively increases sensitivity to cisplatin in ERCC1-low non-small cell lung cancer cells. Carcinogenesis (2012) 1.11

Initiation of DNA interstrand cross-link repair in mammalian cells. Environ Mol Mutagen (2010) 1.09

Homologous recombination repair is essential for repair of vosaroxin-induced DNA double-strand breaks. Oncotarget (2010) 1.06

Novel role of base excision repair in mediating cisplatin cytotoxicity. J Biol Chem (2011) 1.04

Basic mechanisms of therapeutic resistance to radiation and chemotherapy in lung cancer. Cancer J (2013) 1.00

Repair of DNA interstrand cross-links during S phase of the mammalian cell cycle. Environ Mol Mutagen (2010) 0.99

Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity. Exp Cell Res (2012) 0.94

The ERCC1 and ERCC4 (XPF) genes and gene products. Gene (2015) 0.91

Formaldehyde-induced genome instability is suppressed by an XPF-dependent pathway. DNA Repair (Amst) (2011) 0.91

Mitomycin C reduces abundance of replication forks but not rates of fork progression in primary and transformed human cells. Oncoscience (2014) 0.91

Detection of impaired homologous recombination repair in NSCLC cells and tissues. J Thorac Oncol (2013) 0.89

Reduced proficiency in homologous recombination underlies the high sensitivity of embryonal carcinoma testicular germ cell tumors to Cisplatin and poly (adp-ribose) polymerase inhibition. PLoS One (2012) 0.89

Chemotherapy and signaling: How can targeted therapies supercharge cytotoxic agents? Cancer Biol Ther (2010) 0.89

Role of endonucleases XPF and XPG in nucleotide excision repair of platinated DNA and cisplatin/oxaliplatin cytotoxicity. Chembiochem (2011) 0.88

CtIP is required to initiate replication-dependent interstrand crosslink repair. PLoS Genet (2012) 0.86

EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity. Cancer Res (2013) 0.85

The Fanconi anemia protein, FANCG, binds to the ERCC1-XPF endonuclease via its tetratricopeptide repeats and the central domain of ERCC1. Biochemistry (2010) 0.85

A PCNA-derived cell permeable peptide selectively inhibits neuroblastoma cell growth. PLoS One (2014) 0.83

ERCC1 function in nuclear excision and interstrand crosslink repair pathways is mediated exclusively by the ERCC1-202 isoform. Cell Cycle (2013) 0.83

Non-erythroid alpha spectrin prevents telomere dysfunction after DNA interstrand cross-link damage. Nucleic Acids Res (2013) 0.80

Evidence for base excision repair processing of DNA interstrand crosslinks. Mutat Res (2012) 0.80

The SMX DNA Repair Tri-nuclease. Mol Cell (2017) 0.79

Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks. Chin J Cancer (2012) 0.79

Aberrant DNA damage response pathways may predict the outcome of platinum chemotherapy in ovarian cancer. PLoS One (2015) 0.78

Mycobacterium tuberculosis Ku can bind to nuclear DNA damage and sensitize mammalian cells to bleomycin sulfate. Mutagenesis (2011) 0.77

Chemical inhibitor targeting the replication protein A-DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer. Biochem Pharmacol (2014) 0.76

The Cerebro-oculo-facio-skeletal Syndrome Point Mutation F231L in the ERCC1 DNA Repair Protein Causes Dissociation of the ERCC1-XPF Complex. J Biol Chem (2015) 0.76

CITED2 silencing sensitizes cancer cells to cisplatin by inhibiting p53 trans-activation and chromatin relaxation on the ERCC1 DNA repair gene. Nucleic Acids Res (2015) 0.75

Articles cited by this

Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-alpha. Nature (1978) 5.91

Sequential assembly of the nucleotide excision repair factors in vivo. Mol Cell (2001) 5.38

Molecular mechanism of nucleotide excision repair. Genes Dev (1999) 5.27

Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes. Proc Natl Acad Sci U S A (1995) 4.60

Mechanism of replication-coupled DNA interstrand crosslink repair. Cell (2008) 4.53

Chromosome instability and defective recombinational repair in knockout mutants of the five Rad51 paralogs. Mol Cell Biol (2001) 4.19

BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo. Cancer Res (1999) 4.16

The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks. Mol Cell Biol (2004) 3.94

Repair of DNA interstrand cross-links. Mutat Res (2001) 3.92

DNA double-strand break repair: from mechanistic understanding to cancer treatment. DNA Repair (Amst) (2007) 3.69

Defining the roles of nucleotide excision repair and recombination in the repair of DNA interstrand cross-links in mammalian cells. Mol Cell Biol (2000) 3.57

Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation. Cell (2008) 3.42

DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells. J Mol Biol (2001) 3.39

Translesion synthesis: Y-family polymerases and the polymerase switch. DNA Repair (Amst) (2007) 3.27

Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination. Nature (1999) 3.24

Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks. Mol Cell Biol (2005) 3.10

Observations on the chromosomes of Chinese hamster cells in tissue culture. J Natl Cancer Inst (1958) 3.01

Action of DNA repair endonuclease ERCC1/XPF in living cells. Science (1999) 3.00

Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance. Lancet Oncol (2001) 2.98

The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks. EMBO J (2006) 2.89

Repair of an interstrand DNA cross-link initiated by ERCC1-XPF repair/recombination nuclease. J Biol Chem (2000) 2.60

Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene. Proc Natl Acad Sci U S A (1995) 2.48

Evidence for a repair enzyme complex involving ERCC1 and complementing activities of ERCC4, ERCC11 and xeroderma pigmentosum group F. EMBO J (1993) 2.45

Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff. Mol Cell Biol (2000) 2.41

DNA replication is required To elicit cellular responses to psoralen-induced DNA interstrand cross-links. Mol Cell Biol (2000) 2.33

Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions. Mol Cell Biol (2002) 2.14

DNA structural elements required for ERCC1-XPF endonuclease activity. J Biol Chem (1998) 2.12

Transcription-coupled nucleotide excision repair as a determinant of cisplatin sensitivity of human cells. Cancer Res (2002) 2.09

The structure-specific endonuclease Ercc1-Xpf is required for targeted gene replacement in embryonic stem cells. EMBO J (2001) 2.07

Co-correction of the ERCC1, ERCC4 and xeroderma pigmentosum group F DNA repair defects in vitro. EMBO J (1993) 2.04

Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cells. Nucleic Acids Res (2004) 2.02

Formation of a ternary complex by human XPA, ERCC1, and ERCC4(XPF) excision repair proteins. Proc Natl Acad Sci U S A (1994) 2.00

Isolation and cross-sensitivity of X-ray-sensitive mutants of V79-4 hamster cells. Mutat Res (1987) 1.99

Correction of a nucleotide-excision-repair mutation by human chromosome 19 in hamster-human hybrid cells. Somat Cell Mol Genet (1985) 1.91

ERCC1-XPF endonuclease facilitates DNA double-strand break repair. Mol Cell Biol (2008) 1.88

Role of ERCC1 in removal of long non-homologous tails during targeted homologous recombination. EMBO J (2000) 1.76

Involvement of nucleotide excision repair in a recombination-independent and error-prone pathway of DNA interstrand cross-link repair. Mol Cell Biol (2001) 1.76

Nucleotide excision repair- and polymerase eta-mediated error-prone removal of mitomycin C interstrand cross-links. Mol Cell Biol (2003) 1.76

DNA adducts from chemotherapeutic agents. Mutat Res (1996) 1.73

Reconstitution of human excision nuclease with recombinant XPF-ERCC1 complex. J Biol Chem (1997) 1.64

Cross-sensitivity of gamma-ray-sensitive hamster mutants to cross-linking agents. Mutat Res (1991) 1.62

REV3 and REV1 play major roles in recombination-independent repair of DNA interstrand cross-links mediated by monoubiquitinated proliferating cell nuclear antigen (PCNA). J Biol Chem (2006) 1.61

Interstrand crosslink repair: can XPF-ERCC1 be let off the hook? Trends Genet (2008) 1.61

Single-strand breaks in DNA during repair of UV-induced damage in normal human and xeroderma pigmentosum cells as determined by alkaline DNA unwinding and hydroxylapatite chromatography: effects of hydroxyurea, 5-fluorodeoxyuridine and 1-beta-D-arabinofuranosylcytosine on the kinetics of repair. Mutat Res (1979) 1.59

Defects in interstrand cross-link uncoupling do not account for the extreme sensitivity of ERCC1 and XPF cells to cisplatin. Nucleic Acids Res (2002) 1.51

Role of the nucleotide excision repair gene ERCC1 in formation of recombination-dependent rearrangements in mammalian cells. Nucleic Acids Res (2000) 1.48

The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells. Nucleic Acids Res (2007) 1.45

Relative toxicities of DNA cross-links and monoadducts: new insights from studies of decarbamoyl mitomycin C and mitomycin C. Chem Res Toxicol (2002) 1.27

Repression of mutagenesis by Rad51D-mediated homologous recombination. Nucleic Acids Res (2006) 1.27

Double-strand breaks induce homologous recombinational repair of interstrand cross-links via cooperation of MSH2, ERCC1-XPF, REV3, and the Fanconi anemia pathway. DNA Repair (Amst) (2007) 1.26

Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links. Oncogene (2008) 1.20

Evidence for the formation of hybrid DNA during mitotic recombination in Chinese hamster cells. Cell (1976) 1.19

Direct interaction of the Fanconi anaemia protein FANCG with BRCA2/FANCD1. Hum Mol Genet (2003) 1.19

A method to monitor replication fork progression in mammalian cells: nucleotide excision repair enhances and homologous recombination delays elongation along damaged DNA. Nucleic Acids Res (2004) 1.14

The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks in mammalian cells produced by the pyrrolo[2,1-c][1,4]benzodiazepine dimer SJG-136. Nucleic Acids Res (2005) 1.02

XPA versus ERCC1 as chemosensitising agents to cisplatin and mitomycin C in prostate cancer cells: role of ERCC1 in homologous recombination repair. Biochem Pharmacol (2006) 0.97

Differential processing of UV mimetic and interstrand crosslink damage by XPF cell extracts. Nucleic Acids Res (2000) 0.86

Chemotherapy of advanced testicular cancer. Semin Urol (1984) 0.81

Screening for genotoxicity using the DRAG assay: investigation of halogenated environmental contaminants. Mutat Res (2004) 0.81

Articles by these authors

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature (2005) 19.13

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature (2006) 11.76

DNA repair pathways as targets for cancer therapy. Nat Rev Cancer (2008) 6.69

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nat Cell Biol (2005) 4.62

Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair. Mol Cell (2010) 4.57

Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Mol Cell Biol (2005) 4.54

Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2. Cell (2010) 3.43

miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. Mol Cell (2010) 3.27

Pathways of mammalian replication fork restart. Nat Rev Mol Cell Biol (2010) 3.26

Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks. Mol Cell Biol (2005) 3.10

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination. EMBO J (2009) 2.99

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1. Nature (2005) 2.98

The histone methyltransferase SET8 is required for S-phase progression. J Cell Biol (2007) 2.74

Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells. Mol Cell Biol (2002) 2.73

Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment. Cancer Res (2010) 2.68

Association of a common variant of the CASP8 gene with reduced risk of breast cancer. J Natl Cancer Inst (2004) 2.66

FGFR3 mutations indicate better survival in invasive upper urinary tract and bladder tumours. Eur Urol (2008) 2.65

Distinct microRNA alterations characterize high- and low-grade bladder cancer. Cancer Res (2009) 2.58

Promoter hypermethylation is associated with tumor location, stage, and subsequent progression in transitional cell carcinoma. J Clin Oncol (2005) 2.45

Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks. Nucleic Acids Res (2005) 2.44

Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase. J Cell Biol (2010) 2.43

Do glucose and lipids exert independent effects on atherosclerotic lesion initiation or progression to advanced plaques? Circ Res (2007) 2.06

PCNA on the crossroad of cancer. Biochem Soc Trans (2009) 2.03

Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cells. Nucleic Acids Res (2004) 2.02

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Res (2013) 1.92

Break-induced replication repair of damaged forks induces genomic duplications in human cells. Science (2013) 1.90

Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair. Nucleic Acids Res (2006) 1.88

Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination. Nucleic Acids Res (2003) 1.86

Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights. Mutat Res (2009) 1.80

Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control. Proc Natl Acad Sci U S A (2008) 1.74

Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions. J Clin Invest (2004) 1.73

Chk1 promotes replication fork progression by controlling replication initiation. Proc Natl Acad Sci U S A (2010) 1.71

Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1. Cancer Res (2012) 1.65

A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown. Cancer Res (2010) 1.65

Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells. Cancer Res (2010) 1.64

Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress. Mol Biol Cell (2005) 1.60

Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate. Nucleic Acids Res (2010) 1.57

Multifocal urothelial cancers with the mutator phenotype are of monoclonal origin and require panurothelial treatment for tumor clearance. J Urol (2006) 1.54

How Fanconi anemia proteins promote the four Rs: replication, recombination, repair, and recovery. Environ Mol Mutagen (2005) 1.51

UV stalled replication forks restart by re-priming in human fibroblasts. Nucleic Acids Res (2011) 1.51

Overexpression of POLQ confers a poor prognosis in early breast cancer patients. Oncotarget (2010) 1.49

Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy. Cell Cycle (2005) 1.48

ATM is required for the cellular response to thymidine induced replication fork stress. Hum Mol Genet (2004) 1.46

PTEN deletion in prostate cancer cells does not associate with loss of RAD51 function: implications for radiotherapy and chemotherapy. Clin Cancer Res (2011) 1.46

Transcription-associated recombination is dependent on replication in Mammalian cells. Mol Cell Biol (2007) 1.45

The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells. Nucleic Acids Res (2007) 1.45

Distinct patterns of microsatellite instability are seen in tumours of the urinary tract. Oncogene (2003) 1.43

ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress. PLoS Genet (2009) 1.43

RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair. Mol Cell Biol (2007) 1.41

A potential role for the XRCC2 R188H polymorphic site in DNA-damage repair and breast cancer. Hum Mol Genet (2002) 1.40

Claspin promotes normal replication fork rates in human cells. Mol Biol Cell (2008) 1.38

RAD51 is involved in repair of damage associated with DNA replication in mammalian cells. J Mol Biol (2003) 1.36

Enhanced H2AX phosphorylation, DNA replication fork arrest, and cell death in the absence of Chk1. Mol Biol Cell (2010) 1.34

A mutant allele of MRE11 found in mismatch repair-deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner. Mol Biol Cell (2008) 1.34

PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA. J Biol Chem (2010) 1.32

Promoter hypermethylation identifies progression risk in bladder cancer. Clin Cancer Res (2007) 1.32

Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3. J Med Chem (2009) 1.31

Transcription-associated recombination in eukaryotes: link between transcription, replication and recombination. Mutagenesis (2009) 1.31

6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance. Cancer Res (2010) 1.29

Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells. Mol Cell Biol (2009) 1.29

Molecular detection of localized prostate cancer using quantitative methylation-specific PCR on urinary cells obtained following prostate massage. Clin Cancer Res (2007) 1.23

Identification of the MMS22L-TONSL complex that promotes homologous recombination. Mol Cell (2010) 1.21

Defects in homologous recombination repair in mismatch-repair-deficient tumour cell lines. Hum Mol Genet (2002) 1.19

Methylated DNA causes a physical block to replication forks independently of damage signalling, O(6)-methylguanine or DNA single-strand breaks and results in DNA damage. J Mol Biol (2010) 1.16

Ligand-induced dimerization of Drosophila peptidoglycan recognition proteins in vitro. Proc Natl Acad Sci U S A (2005) 1.16

Reduced expression of miRNA-27a modulates cisplatin resistance in bladder cancer by targeting the cystine/glutamate exchanger SLC7A11. Clin Cancer Res (2014) 1.16