PubRank

Ian J Holt

Author PubWeight™ 49.98‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development. Cell 2012 2.62
2 Blue Native electrophoresis to study mitochondrial and other protein complexes. Methods 2002 2.61
3 Biased incorporation of ribonucleotides on the mitochondrial L-strand accounts for apparent strand-asymmetric DNA replication. Cell 2002 2.32
4 Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number. Hum Mol Genet 2004 2.00
5 Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand. EMBO J 2006 1.93
6 Mammalian mitochondrial DNA replicates bidirectionally from an initiation zone. J Biol Chem 2003 1.83
7 Response: The mitochondrial DNA replication bubble has not burst. Trends Biochem Sci 2003 1.80
8 A bidirectional origin of replication maps to the major noncoding region of human mitochondrial DNA. Mol Cell 2005 1.79
9 PrimPol, an archaic primase/polymerase operating in human cells. Mol Cell 2013 1.72
10 Mitochondrial RNA polymerase is needed for activation of the origin of light-strand DNA replication. Mol Cell 2010 1.53
11 The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization. J Cell Biol 2007 1.53
12 Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells. Nucleic Acids Res 2006 1.51
13 Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid. J Mol Biol 2010 1.50
14 The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA. Nucleic Acids Res 2007 1.38
15 TEFM (c17orf42) is necessary for transcription of human mtDNA. Nucleic Acids Res 2011 1.38
16 Minimizing the damage: repair pathways keep mitochondrial DNA intact. Nat Rev Mol Cell Biol 2012 1.30
17 Bidirectional replication initiates at sites throughout the mitochondrial genome of birds. J Biol Chem 2004 1.23
18 Inhibition of mitochondrial fission favours mutant over wild-type mitochondrial DNA. Hum Mol Genet 2009 1.21
19 Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. Nucleic Acids Res 2011 1.21
20 Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA. Nucleic Acids Res 2009 1.19
21 Mitochondrial DNA replication proceeds via a 'bootlace' mechanism involving the incorporation of processed transcripts. Nucleic Acids Res 2013 1.10
22 Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks. J Biol Chem 2009 1.09
23 Transmission of mitochondrial DNA diseases and ways to prevent them. PLoS Genet 2010 1.08
24 An upstream open reading frame and the context of the two AUG codons affect the abundance of mitochondrial and nuclear RNase H1. Mol Cell Biol 2010 1.07
25 Systematic segregation to mutant mitochondrial DNA and accompanying loss of mitochondrial DNA in human NT2 teratocarcinoma Cybrids. Genetics 2005 1.00
26 Wobble modification deficiency in mutant tRNAs in patients with mitochondrial diseases. FEBS Lett 2005 0.95
27 Overexpression of MTERFD1 or MTERFD3 impairs the completion of mitochondrial DNA replication. Mol Biol Rep 2010 0.92
28 Alternative translation initiation augments the human mitochondrial proteome. Nucleic Acids Res 2012 0.89
29 Expression of algal nuclear ATP synthase subunit 6 in human cells results in protein targeting to mitochondria but no assembly into ATP synthase. Rejuvenation Res 2006 0.88
30 163rd ENMC International Workshop: nucleoid and nucleotide biology in syndromes of mitochondrial DNA depletion myopathy 12-14 December 2008, Naarden, The Netherlands. Neuromuscul Disord 2009 0.87
31 Analysis of replicating mitochondrial DNA by two-dimensional agarose gel electrophoresis. Methods Mol Biol 2007 0.84
32 A cryptic targeting signal creates a mitochondrial FEN1 isoform with tailed R-Loop binding properties. PLoS One 2013 0.84
33 Analysis of mitochondrial DNA by two-dimensional agarose gel electrophoresis. Methods Mol Biol 2009 0.84
34 Acquisition of the wobble modification in mitochondrial tRNALeu(CUN) bearing the G12300A mutation suppresses the MELAS molecular defect. Hum Mol Genet 2006 0.83
35 Mitochondrial transcription terminator family members mTTF and mTerf5 have opposing roles in coordination of mtDNA synthesis. PLoS Genet 2013 0.82
36 Cultured muscle cells display defects of mitochondrial myopathy ameliorated by anti-oxidants. Brain 2007 0.81
37 Clinical and molecular aspects of diseases of mitochondrial DNA instability. Chang Gung Med J 2009 0.81
38 The yeast Holliday junction resolvase, CCE1, can restore wild-type mitochondrial DNA to human cells carrying rearranged mitochondrial DNA. Hum Mol Genet 2007 0.80
39 The conserved translocase Tim17 prevents mitochondrial DNA loss. Hum Mol Genet 2008 0.80
40 Corrigendum: Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure. Sci Rep 2015 0.75