Published in Hum Mol Genet on June 27, 2009
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase. Nature (2011) 4.32
Mitochondrial DNA stress primes the antiviral innate immune response. Nature (2015) 3.82
Mitochondrial DNA genetics and the heteroplasmy conundrum in evolution and disease. Cold Spring Harb Perspect Biol (2013) 2.06
The interplay between mitochondrial dynamics and mitophagy. Antioxid Redox Signal (2011) 2.05
New insights into the role of mitochondria in aging: mitochondrial dynamics and more. J Cell Sci (2010) 2.03
Abnormal mitochondrial dynamics and neurodegenerative diseases. Biochim Biophys Acta (2009) 1.49
Is Placental Mitochondrial Function a Regulator that Matches Fetal and Placental Growth to Maternal Nutrient Intake in the Mouse? PLoS One (2015) 1.40
Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress. J Cell Sci (2012) 1.30
Mechanisms of mitochondria and autophagy crosstalk. Cell Cycle (2011) 1.01
Mitochondrial dysregulation in the pathogenesis of diabetes: potential for mitochondrial biogenesis-mediated interventions. Exp Diabetes Res (2011) 0.98
Mitochondrial network morphology: building an integrative, geometrical view. BMC Biol (2013) 0.92
Abnormal mitochondrial dynamics--a novel therapeutic target for Alzheimer's disease? Mol Neurobiol (2010) 0.92
The role of dynamin-related protein 1 in cancer growth: a promising therapeutic target? Expert Opin Ther Targets (2013) 0.90
Quality matters: how does mitochondrial network dynamics and quality control impact on mtDNA integrity? Philos Trans R Soc Lond B Biol Sci (2014) 0.82
Context-Dependent Role of Mitochondrial Fusion-Fission in Clonal Expansion of mtDNA Mutations. PLoS Comput Biol (2015) 0.82
Non-random mtDNA segregation patterns indicate a metastable heteroplasmic segregation unit in m.3243A>G cybrid cells. PLoS One (2012) 0.80
The road to rack and ruin: selecting deleterious mitochondrial DNA variants. Philos Trans R Soc Lond B Biol Sci (2014) 0.79
Mathematical modeling of the role of mitochondrial fusion and fission in mitochondrial DNA maintenance. PLoS One (2013) 0.79
HIV-1 infection and first line ART induced differential responses in mitochondria from blood lymphocytes and monocytes: the ANRS EP45 "Aging" study. PLoS One (2012) 0.78
Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases. Ageing Res Rev (2016) 0.78
Increased mitophagy in the skeletal muscle of spinal and bulbar muscular atrophy patients. Hum Mol Genet (2017) 0.77
Mitochondrial Quality Control and Disease: Insights into Ischemia-Reperfusion Injury. Mol Neurobiol (2017) 0.76
Mitochondrial quality control: Cell-type-dependent responses to pathological mutant mitochondrial DNA. Autophagy (2016) 0.75
Modulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy children. Biochem Soc Trans (2016) 0.75
Mitochondrial Dynamics in Mitochondrial Diseases. Diseases (2016) 0.75
Autophagy is required to maintain muscle mass. Cell Metab (2009) 4.46
Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development. Cell (2012) 2.62
Blue Native electrophoresis to study mitochondrial and other protein complexes. Methods (2002) 2.61
Biased incorporation of ribonucleotides on the mitochondrial L-strand accounts for apparent strand-asymmetric DNA replication. Cell (2002) 2.32
Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number. Hum Mol Genet (2004) 2.00
Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand. EMBO J (2006) 1.93
Mammalian mitochondrial DNA replicates bidirectionally from an initiation zone. J Biol Chem (2003) 1.83
Response: The mitochondrial DNA replication bubble has not burst. Trends Biochem Sci (2003) 1.80
A bidirectional origin of replication maps to the major noncoding region of human mitochondrial DNA. Mol Cell (2005) 1.79
PrimPol, an archaic primase/polymerase operating in human cells. Mol Cell (2013) 1.72
ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice. J Clin Invest (2012) 1.62
The mitochondrial fission protein hFis1 requires the endoplasmic reticulum gateway to induce apoptosis. Mol Biol Cell (2006) 1.58
Mitochondrial RNA polymerase is needed for activation of the origin of light-strand DNA replication. Mol Cell (2010) 1.53
The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization. J Cell Biol (2007) 1.53
Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells. Nucleic Acids Res (2006) 1.51
Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid. J Mol Biol (2010) 1.50
The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA. Nucleic Acids Res (2007) 1.38
TEFM (c17orf42) is necessary for transcription of human mtDNA. Nucleic Acids Res (2011) 1.38
Human skeletal muscle atrophy in amyotrophic lateral sclerosis reveals a reduction in Akt and an increase in atrogin-1. FASEB J (2006) 1.31
Minimizing the damage: repair pathways keep mitochondrial DNA intact. Nat Rev Mol Cell Biol (2012) 1.30
Bidirectional replication initiates at sites throughout the mitochondrial genome of birds. J Biol Chem (2004) 1.23
Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. Nucleic Acids Res (2011) 1.21
A novel deletion in the GTPase domain of OPA1 causes defects in mitochondrial morphology and distribution, but not in function. Hum Mol Genet (2008) 1.20
Spinal and bulbar muscular atrophy: skeletal muscle pathology in male patients and heterozygous females. J Neurol Sci (2007) 1.20
Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA. Nucleic Acids Res (2009) 1.19
Overexpression of microRNA-206 in the skeletal muscle from myotonic dystrophy type 1 patients. J Transl Med (2010) 1.13
Mitochondrial DNA replication proceeds via a 'bootlace' mechanism involving the incorporation of processed transcripts. Nucleic Acids Res (2013) 1.10
Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks. J Biol Chem (2009) 1.09
Examining the role of cyclin D1 in breast cancer. Future Oncol (2011) 1.08
Transmission of mitochondrial DNA diseases and ways to prevent them. PLoS Genet (2010) 1.08
An upstream open reading frame and the context of the two AUG codons affect the abundance of mitochondrial and nuclear RNase H1. Mol Cell Biol (2010) 1.07
Systematic segregation to mutant mitochondrial DNA and accompanying loss of mitochondrial DNA in human NT2 teratocarcinoma Cybrids. Genetics (2005) 1.00
Wobble modification deficiency in mutant tRNAs in patients with mitochondrial diseases. FEBS Lett (2005) 0.95
Respiratory function in cybrid cell lines carrying European mtDNA haplogroups: implications for Leber's hereditary optic neuropathy. Biochim Biophys Acta (2002) 0.93
Overexpression of MTERFD1 or MTERFD3 impairs the completion of mitochondrial DNA replication. Mol Biol Rep (2010) 0.92
Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer. Nat Commun (2013) 0.91
Cyclins and cell cycle control in cancer and disease. Genes Cancer (2012) 0.90
Alternative translation initiation augments the human mitochondrial proteome. Nucleic Acids Res (2012) 0.89
Androgen-dependent impairment of myogenesis in spinal and bulbar muscular atrophy. Acta Neuropathol (2013) 0.89
Expression of algal nuclear ATP synthase subunit 6 in human cells results in protein targeting to mitochondria but no assembly into ATP synthase. Rejuvenation Res (2006) 0.88
163rd ENMC International Workshop: nucleoid and nucleotide biology in syndromes of mitochondrial DNA depletion myopathy 12-14 December 2008, Naarden, The Netherlands. Neuromuscul Disord (2009) 0.87
Biosynthesis of flavin cofactors in man: implications in health and disease. Curr Pharm Des (2013) 0.87
Analysis of replicating mitochondrial DNA by two-dimensional agarose gel electrophoresis. Methods Mol Biol (2007) 0.84
A cryptic targeting signal creates a mitochondrial FEN1 isoform with tailed R-Loop binding properties. PLoS One (2013) 0.84
Analysis of mitochondrial DNA by two-dimensional agarose gel electrophoresis. Methods Mol Biol (2009) 0.84
Acquisition of the wobble modification in mitochondrial tRNALeu(CUN) bearing the G12300A mutation suppresses the MELAS molecular defect. Hum Mol Genet (2006) 0.83
Mitochondrial transcription terminator family members mTTF and mTerf5 have opposing roles in coordination of mtDNA synthesis. PLoS Genet (2013) 0.82
Clinical and molecular aspects of diseases of mitochondrial DNA instability. Chang Gung Med J (2009) 0.81
Cultured muscle cells display defects of mitochondrial myopathy ameliorated by anti-oxidants. Brain (2007) 0.81
A pilot trial with clenbuterol in amyotrophic lateral sclerosis. Amyotroph Lateral Scler (2006) 0.81
Coordinated and reversible reduction of enzymes involved in terminal oxidative metabolism in skeletal muscle mitochondria from a riboflavin-responsive, multiple acyl-CoA dehydrogenase deficiency patient. Electrophoresis (2006) 0.80
The conserved translocase Tim17 prevents mitochondrial DNA loss. Hum Mol Genet (2008) 0.80
The yeast Holliday junction resolvase, CCE1, can restore wild-type mitochondrial DNA to human cells carrying rearranged mitochondrial DNA. Hum Mol Genet (2007) 0.80
Decreased fatty acid beta-oxidation in riboflavin-responsive, multiple acylcoenzyme A dehydrogenase-deficient patients is associated with an increase in uncoupling protein-3. J Clin Endocrinol Metab (2003) 0.78
Energy matters: mitochondrial proteomics for biomedicine. Proteomics (2011) 0.76
Development and characterization of polyspecific anti-mitochondrion antibodies for proteomics studies on in toto tissue homogenates. Electrophoresis (2009) 0.76
IPG with electrodic plateaus (and other unusual procedures for 2-DE). Electrophoresis (2007) 0.75
Corrigendum: Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure. Sci Rep (2015) 0.75