Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand.

PubWeight™: 1.93‹?› | Rank: Top 3%

🔗 View Article (PMC 1636616)

Published in EMBO J on October 26, 2006

Authors

Takehiro Yasukawa1, Aurelio Reyes, Tricia J Cluett, Ming-Yao Yang, Mark Bowmaker, Howard T Jacobs, Ian J Holt

Author Affiliations

1: MRC-Dunn Human Nutrition Unit, Cambridge, UK.

Articles citing this

Oxidative stress, mitochondrial dysfunction, and aging. J Signal Transduct (2011) 1.94

PrimPol, an archaic primase/polymerase operating in human cells. Mol Cell (2013) 1.72

Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes. Nucleic Acids Res (2007) 1.69

Mitochondrial DNA mutations in disease and aging. J Cell Biol (2011) 1.67

Mitochondrial DNA replication and disease: insights from DNA polymerase γ mutations. Cell Mol Life Sci (2010) 1.58

Human mitochondrial RNA polymerase primes lagging-strand DNA synthesis in vitro. Proc Natl Acad Sci U S A (2008) 1.52

Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis. Nucleic Acids Res (2012) 1.51

Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid. J Mol Biol (2010) 1.50

Nature of mitochondrial DNA deletions in substantia nigra neurons. Am J Hum Genet (2008) 1.48

Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer. Elife (2014) 1.39

The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA. Nucleic Acids Res (2007) 1.38

Minimizing the damage: repair pathways keep mitochondrial DNA intact. Nat Rev Mol Cell Biol (2012) 1.30

Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA. Nucleic Acids Res (2009) 1.19

Cytosolic RNA:DNA hybrids activate the cGAS-STING axis. EMBO J (2014) 1.16

The mtDNA mutation spectrum of the progeroid Polg mutator mouse includes abundant control region multimers. Cell Metab (2010) 1.16

The accessory subunit of mitochondrial DNA polymerase gamma determines the DNA content of mitochondrial nucleoids in human cultured cells. Nucleic Acids Res (2009) 1.16

TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication. Hum Mol Genet (2013) 1.16

Human mitochondrial DNA replication. Cold Spring Harb Perspect Biol (2012) 1.15

Native R-loops persist throughout the mouse mitochondrial DNA genome. J Biol Chem (2008) 1.14

Mitochondrial DNA replication proceeds via a 'bootlace' mechanism involving the incorporation of processed transcripts. Nucleic Acids Res (2013) 1.10

Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks. J Biol Chem (2009) 1.09

An upstream open reading frame and the context of the two AUG codons affect the abundance of mitochondrial and nuclear RNase H1. Mol Cell Biol (2010) 1.07

Replicating animal mitochondrial DNA. Genet Mol Biol (2013) 0.99

Sequence homology at the breakpoint and clinical phenotype of mitochondrial DNA deletion syndromes. PLoS One (2010) 0.97

Two-dimensional intact mitochondrial DNA agarose electrophoresis reveals the structural complexity of the mammalian mitochondrial genome. Nucleic Acids Res (2012) 0.96

Mitochondrial disease in childhood: mtDNA encoded. Neurotherapeutics (2013) 0.93

Animal models of mitochondrial DNA transactions in disease and ageing. Exp Gerontol (2010) 0.93

Primer retention owing to the absence of RNase H1 is catastrophic for mitochondrial DNA replication. Proc Natl Acad Sci U S A (2015) 0.91

Association of mitochondrial DNA variations with lung cancer risk in a Han Chinese population from southwestern China. PLoS One (2012) 0.91

RNASEH1 Mutations Impair mtDNA Replication and Cause Adult-Onset Mitochondrial Encephalomyopathy. Am J Hum Genet (2015) 0.90

Involvement of DNA ligase III and ribonuclease H1 in mitochondrial DNA replication in cultured human cells. Biochim Biophys Acta (2011) 0.89

Mitochondrial targeting of recombinant RNAs modulates the level of a heteroplasmic mutation in human mitochondrial DNA associated with Kearns Sayre Syndrome. Nucleic Acids Res (2012) 0.89

The interface of transcription and DNA replication in the mitochondria. Biochim Biophys Acta (2011) 0.88

A mechanistic view of human mitochondrial DNA polymerase gamma: providing insight into drug toxicity and mitochondrial disease. Biochim Biophys Acta (2010) 0.88

Linear mtDNA fragments and unusual mtDNA rearrangements associated with pathological deficiency of MGME1 exonuclease. Hum Mol Genet (2014) 0.88

Developmental and pathological changes in the human cardiac muscle mitochondrial DNA organization, replication and copy number. PLoS One (2010) 0.88

Mitochondrial DNA: A disposable genome? Biochim Biophys Acta (2015) 0.85

Maintaining ancient organelles: mitochondrial biogenesis and maturation. Circ Res (2015) 0.85

Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria. Proc Natl Acad Sci U S A (2016) 0.84

Animal Mitochondrial DNA Replication. Enzymes (2016) 0.84

Replication intermediates of the linear mitochondrial DNA of Candida parapsilosis suggest a common recombination based mechanism for yeast mitochondria. J Biol Chem (2014) 0.84

A cryptic targeting signal creates a mitochondrial FEN1 isoform with tailed R-Loop binding properties. PLoS One (2013) 0.84

Enzyme kinetics of the mitochondrial deoxyribonucleoside salvage pathway are not sufficient to support rapid mtDNA replication. PLoS Comput Biol (2011) 0.84

Regulation of DNA replication at the end of the mitochondrial D-loop involves the helicase TWINKLE and a conserved sequence element. Nucleic Acids Res (2015) 0.84

Enlightenment of yeast mitochondrial homoplasmy: diversified roles of gene conversion. Genes (Basel) (2011) 0.84

The association of the mitochondrial DNA OriB variant (16184-16193 polycytosine tract) with type 2 diabetes in Europid populations. Diabetologia (2013) 0.83

Effects on mitochondrial transcription of manipulating mTERF protein levels in cultured human HEK293 cells. BMC Mol Biol (2010) 0.83

Identification of a novel human mitochondrial endo-/exonuclease Ddk1/c20orf72 necessary for maintenance of proper 7S DNA levels. Nucleic Acids Res (2013) 0.83

HMGA1 levels influence mitochondrial function and mitochondrial DNA repair efficiency. Mol Cell Biol (2009) 0.82

Mitochondrial transcription terminator family members mTTF and mTerf5 have opposing roles in coordination of mtDNA synthesis. PLoS Genet (2013) 0.82

Tandem Duplication and Random Loss for mitogenome rearrangement in Symphurus (Teleost: Pleuronectiformes). BMC Genomics (2015) 0.81

Analysis of replication intermediates indicates that Drosophila melanogaster mitochondrial DNA replicates by a strand-coupled theta mechanism. PLoS One (2013) 0.81

A rolling circle replication mechanism produces multimeric lariats of mitochondrial DNA in Caenorhabditis elegans. PLoS Genet (2015) 0.81

The inversion of the Control Region in three mitogenomes provides further evidence for an asymmetric model of vertebrate mtDNA replication. PLoS One (2014) 0.81

Transfection of plant mitochondria and in organello gene integration. Nucleic Acids Res (2011) 0.81

MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria. PLoS Genet (2016) 0.79

Evolution of the metazoan mitochondrial replicase. Genome Biol Evol (2015) 0.79

Analysis of enzyme kinetic data for mtDNA replication. Methods (2010) 0.77

Exploring our origins--the importance of OriL in mtDNA maintenance and replication. EMBO Rep (2012) 0.76

Length heterogeneity at conserved sequence block 2 in human mitochondrial DNA acts as a rheostat for RNA polymerase POLRMT activity. Nucleic Acids Res (2016) 0.76

Low doses of ultraviolet radiation and oxidative damage induce dramatic accumulation of mitochondrial DNA replication intermediates, fork regression, and replication initiation shift. Mol Biol Cell (2015) 0.76

Mitochondrial DNA replication: a PrimPol perspective. Biochem Soc Trans (2017) 0.75

Nucleotide pools dictate the identity and frequency of ribonucleotide incorporation in mitochondrial DNA. PLoS Genet (2017) 0.75

Mitochondrial transcription termination factor 1 directs polar replication fork pausing. Nucleic Acids Res (2016) 0.75

The human mitochondrial transcription factor A is a versatile G-quadruplex binding protein. Sci Rep (2017) 0.75

Non-Canonical Replication Initiation: You're Fired! Genes (Basel) (2017) 0.75

Experimental mitochondria-targeted DNA methylation identifies GpC methylation, not CpG methylation, as potential regulator of mitochondrial gene expression. Sci Rep (2017) 0.75

Engineering human PrimPol into an efficient RNA-dependent-DNA primase/polymerase. Nucleic Acids Res (2017) 0.75

Articles cited by this

Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. Nature (1953) 47.27

The localization of replication origins on ARS plasmids in S. cerevisiae. Cell (1987) 13.29

In vivo footprinting of a muscle specific enhancer by ligation mediated PCR. Science (1989) 10.87

Sequence and gene organization of the chicken mitochondrial genome. A novel gene order in higher vertebrates. J Mol Biol (1990) 5.71

A novel closed-circular mitochondrial DNA with properties of a replicating intermediate. Proc Natl Acad Sci U S A (1971) 5.33

R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells. Nat Immunol (2003) 4.81

Replication of mitochondrial DNA. Circular replicative intermediates in mouse L cells. Proc Natl Acad Sci U S A (1972) 4.38

Analysis of replication intermediates by two-dimensional agarose gel electrophoresis. Methods Enzymol (1995) 3.32

Coupled leading- and lagging-strand synthesis of mammalian mitochondrial DNA. Cell (2000) 2.67

Failure to produce mitochondrial DNA results in embryonic lethality in Rnaseh1 null mice. Mol Cell (2003) 2.60

Biased incorporation of ribonucleotides on the mitochondrial L-strand accounts for apparent strand-asymmetric DNA replication. Cell (2002) 2.32

Unidirectionality of replication in mouse mitochondrial DNA. Nat New Biol (1973) 2.31

Nucleotide sequence of a region of human mitochondrial DNA containing the precisely identified origin of replication. Nature (1979) 2.19

Replication initiates at multiple locations on an autonomously replicating plasmid in human cells. Mol Cell Biol (1991) 2.13

Replication of mitochondrial DNA occurs by strand displacement with alternative light-strand origins, not via a strand-coupled mechanism. Genes Dev (2005) 1.94

Recombination associated with replication of malarial mitochondrial DNA. EMBO J (1996) 1.84

Mammalian mitochondrial DNA replicates bidirectionally from an initiation zone. J Biol Chem (2003) 1.83

A bidirectional origin of replication maps to the major noncoding region of human mitochondrial DNA. Mol Cell (2005) 1.79

The presence of DNA molecules with a displacement loop in standard mitochondrial DNA preparations. Biochim Biophys Acta (1971) 1.73

Revisiting the mouse mitochondrial DNA sequence. Nucleic Acids Res (2003) 1.70

DNA primase of human mitochondria is associated with structural RNA that is essential for enzymatic activity. Cell (1986) 1.54

In vivo determination of replication origins of human mitochondrial DNA by ligation-mediated polymerase chain reaction. J Biol Chem (1997) 1.37

Topoisomerase II can unlink replicating DNA by precatenane removal. EMBO J (2001) 1.30

Initiation of DNA replication in ColE1 plasmids containing multiple potential origins of replication. J Biol Chem (1992) 1.28

Bidirectional replication initiates at sites throughout the mitochondrial genome of birds. J Biol Chem (2004) 1.23

Precise nucleotide location of the 5' ends of RNA-primed nascent light strands of mouse mitochondrial DNA. J Mol Biol (1982) 1.16

Topological complexity of different populations of pBR322 as visualized by two-dimensional agarose gel electrophoresis. Nucleic Acids Res (1998) 1.15

Eukaryotic RNases H1 act processively by interactions through the duplex RNA-binding domain. Nucleic Acids Res (2005) 1.15

Two-dimensional gel analysis of rolling circle replication in the presence and absence of bacteriophage T4 primase. Nucleic Acids Res (1996) 1.11

Composite patterns in neutral/neutral two-dimensional gels demonstrate inefficient replication origin usage. Mol Cell Biol (1996) 1.01

Characterization of novel reverse transcriptase and other RNA-associated catalytic activities by human DNA polymerase gamma: importance in mitochondrial DNA replication. J Biol Chem (2003) 1.00

Biochemical and electron microscopic characterization of DNA-RNA complexes from HeLa cell mitochondria. Biochemistry (1978) 1.00

The migration behaviour of DNA replicative intermediates containing an internal bubble analyzed by two-dimensional agarose gel electrophoresis. Nucleic Acids Res (1993) 0.96

Formation and processing of stalled replication forks--utility of two-dimensional agarose gels. Methods Enzymol (2006) 0.87

Transcription arrest caused by long nascent RNA chains. Biochim Biophys Acta (2004) 0.86

Characterization of a DNA primase from rat liver mitochondria. J Biol Chem (1986) 0.83

Wheat DNA Primase (RNA Primer Synthesis in Vitro, Structural Studies by Photochemical Cross-Linking, and Modulation of Primase Activity by DNA Polymerases). Plant Physiol (1994) 0.83

Articles by these authors

Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature (2004) 11.59

Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production. Proc Natl Acad Sci U S A (2005) 3.42

Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development. Cell (2012) 2.62

Blue Native electrophoresis to study mitochondrial and other protein complexes. Methods (2002) 2.61

Biased incorporation of ribonucleotides on the mitochondrial L-strand accounts for apparent strand-asymmetric DNA replication. Cell (2002) 2.32

Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number. Hum Mol Genet (2004) 2.00

Mammalian mitochondrial DNA replicates bidirectionally from an initiation zone. J Biol Chem (2003) 1.83

No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects. PLoS Genet (2007) 1.82

Response: The mitochondrial DNA replication bubble has not burst. Trends Biochem Sci (2003) 1.80

A bidirectional origin of replication maps to the major noncoding region of human mitochondrial DNA. Mol Cell (2005) 1.79

PrimPol, an archaic primase/polymerase operating in human cells. Mol Cell (2013) 1.72

Mitochondrial medicine: a metabolic perspective on the pathology of oxidative phosphorylation disorders. Cell Metab (2006) 1.62

Mitochondrial RNA polymerase is needed for activation of the origin of light-strand DNA replication. Mol Cell (2010) 1.53

The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization. J Cell Biol (2007) 1.53

Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells. Nucleic Acids Res (2006) 1.51

Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter. Nat Struct Mol Biol (2011) 1.51

Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid. J Mol Biol (2010) 1.50

Mammalian mitochondrial nucleoids: organizing an independently minded genome. Mitochondrion (2007) 1.49

Delaying BCG vaccination from birth to 10 weeks of age may result in an enhanced memory CD4 T cell response. Vaccine (2009) 1.45

The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA. Nucleic Acids Res (2007) 1.38

TEFM (c17orf42) is necessary for transcription of human mtDNA. Nucleic Acids Res (2011) 1.38

Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction. Proc Natl Acad Sci U S A (2010) 1.37

Stabilization of hypoxia-inducible factor-1alpha protein in hypoxia occurs independently of mitochondrial reactive oxygen species production. J Biol Chem (2010) 1.33

Minimizing the damage: repair pathways keep mitochondrial DNA intact. Nat Rev Mol Cell Biol (2012) 1.30

Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation. Cell Metab (2009) 1.29

Bidirectional replication initiates at sites throughout the mitochondrial genome of birds. J Biol Chem (2004) 1.23

Inhibition of mitochondrial fission favours mutant over wild-type mitochondrial DNA. Hum Mol Genet (2009) 1.21

Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. Nucleic Acids Res (2011) 1.21

Mitochondrial DNA in metazoa: degree of freedom in a frozen event. Gene (2002) 1.19

Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA. Nucleic Acids Res (2009) 1.19

Mitochondrial ROS production correlates with, but does not directly regulate lifespan in Drosophila. Aging (Albany NY) (2010) 1.19

Mutations in FBXL4, encoding a mitochondrial protein, cause early-onset mitochondrial encephalomyopathy. Am J Hum Genet (2013) 1.18

Gene expression in a Drosophila model of mitochondrial disease. PLoS One (2010) 1.16

Human mitochondrial DNA replication. Cold Spring Harb Perspect Biol (2012) 1.15

Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat. Nat Struct Mol Biol (2010) 1.12

Mitochondrial DNA replication proceeds via a 'bootlace' mechanism involving the incorporation of processed transcripts. Nucleic Acids Res (2013) 1.10

Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks. J Biol Chem (2009) 1.09

Transmission of mitochondrial DNA diseases and ways to prevent them. PLoS Genet (2010) 1.08

An upstream open reading frame and the context of the two AUG codons affect the abundance of mitochondrial and nuclear RNase H1. Mol Cell Biol (2010) 1.07

Allotopic expression of a mitochondrial alternative oxidase confers cyanide resistance to human cell respiration. EMBO Rep (2005) 1.06

Expression of the alternative oxidase complements cytochrome c oxidase deficiency in human cells. EMBO Mol Med (2009) 1.05

Phylogenetic analyses of complete mitochondrial genome sequences suggest a basal divergence of the enigmatic rodent Anomalurus. BMC Evol Biol (2007) 1.01

Systematic segregation to mutant mitochondrial DNA and accompanying loss of mitochondrial DNA in human NT2 teratocarcinoma Cybrids. Genetics (2005) 1.00

The 7472insC mitochondrial DNA mutation impairs the synthesis and extent of aminoacylation of tRNASer(UCN) but not its structure or rate of turnover. J Biol Chem (2002) 1.00

A mitochondrial ribosomal and RNA decay pathway blocks cell proliferation. Curr Biol (2013) 0.99

Wobble modification deficiency in mutant tRNAs in patients with mitochondrial diseases. FEBS Lett (2005) 0.95

Transcriptional profiling of mycobacterial antigen-induced responses in infants vaccinated with BCG at birth. BMC Med Genomics (2009) 0.95

Respiratory chain alternative enzymes as tools to better understand and counteract respiratory chain deficiencies in human cells and animals. Physiol Plant (2009) 0.94

The dominant cold-sensitive Out-cold mutants of Drosophila melanogaster have novel missense mutations in the voltage-gated sodium channel gene paralytic. Genetics (2008) 0.92

Overexpression of MTERFD1 or MTERFD3 impairs the completion of mitochondrial DNA replication. Mol Biol Rep (2010) 0.92

The isolated carboxy-terminal domain of human mitochondrial leucyl-tRNA synthetase rescues the pathological phenotype of mitochondrial tRNA mutations in human cells. EMBO Mol Med (2014) 0.91

Alternative oxidase expression in the mouse enables bypassing cytochrome c oxidase blockade and limits mitochondrial ROS overproduction. PLoS Genet (2013) 0.91

Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency. Hum Mol Genet (2013) 0.91

A prevalent POLG CAG microsatellite length allele in humans and African great apes. Mamm Genome (2004) 0.89

Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in Drosophila. Hum Mol Genet (2012) 0.89

Alternative translation initiation augments the human mitochondrial proteome. Nucleic Acids Res (2012) 0.89

A cytoplasmic suppressor of a nuclear mutation affecting mitochondrial functions in Drosophila. Genetics (2012) 0.89

Expression of algal nuclear ATP synthase subunit 6 in human cells results in protein targeting to mitochondria but no assembly into ATP synthase. Rejuvenation Res (2006) 0.88

Developmental and pathological changes in the human cardiac muscle mitochondrial DNA organization, replication and copy number. PLoS One (2010) 0.88

163rd ENMC International Workshop: nucleoid and nucleotide biology in syndromes of mitochondrial DNA depletion myopathy 12-14 December 2008, Naarden, The Netherlands. Neuromuscul Disord (2009) 0.87

The bidirectional promoter of two genes for the mitochondrial translational apparatus in mouse is regulated by an array of CCAAT boxes interacting with the transcription factor NF-Y. Nucleic Acids Res (2006) 0.87

Prenatal sonographic diagnosis of fetal right ventricular diverticulum. J Ultrasound Med (2007) 0.86

Glucose modulates respiratory complex I activity in response to acute mitochondrial dysfunction. J Biol Chem (2012) 0.86

The relationship between somatic mtDNA rearrangements, human heart disease and aging. Hum Mol Genet (2002) 0.85

Engineering the alternative oxidase gene to better understand and counteract mitochondrial defects: state of the art and perspectives. Br J Pharmacol (2014) 0.85

DNA conformation-dependent activities of human mitochondrial RNA polymerase. Genes Cells (2009) 0.85

Phenotypic suppression of the Drosophila mitochondrial disease-like mutant tko(25t) by duplication of the mutant gene in its natural chromosomal context. Mitochondrion (2009) 0.85

Novel repetitive structures, deviant protein-encoding sequences and unidentified ORFs in the mitochondrial genome of the brachiopod Lingula anatina. J Mol Evol (2005) 0.84

A novel lipoxygenase in pea roots. Its function in wounding and biotic stress. Plant Physiol (2006) 0.84

A cryptic targeting signal creates a mitochondrial FEN1 isoform with tailed R-Loop binding properties. PLoS One (2013) 0.84