PubRank

Michael S Brown

Author PubWeight™ 173.42‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 2002 21.08
2 Protein sensors for membrane sterols. Cell 2006 8.62
3 Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc Natl Acad Sci U S A 2003 8.20
4 Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c. J Biol Chem 2002 5.89
5 Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell 2002 5.70
6 Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 2008 5.10
7 Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proc Natl Acad Sci U S A 2010 4.40
8 Structure of the LDL receptor extracellular domain at endosomal pH. Science 2002 4.06
9 The LDL receptor. Arterioscler Thromb Vasc Biol 2009 3.78
10 Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. Proc Natl Acad Sci U S A 2004 3.73
11 Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc Natl Acad Sci U S A 2002 3.51
12 Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation. Proc Natl Acad Sci U S A 2003 3.38
13 Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance. Cell Metab 2008 3.33
14 Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol. Cell 2009 3.24
15 Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain. Mol Cell 2004 3.07
16 Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig. Proc Natl Acad Sci U S A 2007 3.01
17 Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs. J Biol Chem 2004 2.82
18 NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes. Proc Natl Acad Sci U S A 2008 2.81
19 Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism. Mol Cell 2002 2.80
20 Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication. Mol Cell 2005 2.78
21 Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis. J Clin Invest 2004 2.66
22 Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis. Arch Biochem Biophys 2002 2.57
23 History of science. A golden era of Nobel laureates. Science 2012 2.55
24 Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis. Proc Natl Acad Sci U S A 2003 2.49
25 Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins. Proc Natl Acad Sci U S A 2007 2.46
26 Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain. Mol Cell 2003 2.40
27 Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop. J Biol Chem 2007 2.34
28 Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein. J Biol Chem 2007 2.29
29 Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice. Proc Natl Acad Sci U S A 2010 2.06
30 Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol. J Biol Chem 2003 2.05
31 Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. J Clin Invest 2005 2.03
32 The SREBP pathway in Drosophila: regulation by palmitate, not sterols. Dev Cell 2002 2.01
33 Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro. J Biol Chem 2005 1.91
34 The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals. Cell Metab 2012 1.79
35 Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake. Cell Metab 2006 1.74
36 Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells. Proc Natl Acad Sci U S A 2009 1.69
37 Motion regularization for matting motion blurred objects. IEEE Trans Pattern Anal Mach Intell 2011 1.56
38 Identification of surface residues on Niemann-Pick C2 essential for hydrophobic handoff of cholesterol to NPC1 in lysosomes. Cell Metab 2010 1.44
39 Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles. Proc Natl Acad Sci U S A 2003 1.42
40 Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase. Proc Natl Acad Sci U S A 2012 1.37
41 Membrane topology of human insig-1, a protein regulator of lipid synthesis. J Biol Chem 2003 1.36
42 Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides. Proc Natl Acad Sci U S A 2008 1.36
43 Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver. Cell Metab 2005 1.34
44 Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin. J Clin Invest 2006 1.32
45 Characterization of mouse short-chain aldehyde reductase (SCALD), an enzyme regulated by sterol regulatory element-binding proteins. J Biol Chem 2003 1.26
46 Ghrelin secretion stimulated by {beta}1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice. Proc Natl Acad Sci U S A 2010 1.20
47 Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis. J Biol Chem 2011 1.18
48 Profound hypoglycemia in starved, ghrelin-deficient mice is caused by decreased gluconeogenesis and reversed by lactate or fatty acids. J Biol Chem 2012 1.17
49 As-Projective-As-Possible Image Stitching with Moving DLT. IEEE Trans Pattern Anal Mach Intell 2014 1.16
50 From fatty streak to fatty liver: 33 years of joint publications in the JCI. J Clin Invest 2008 1.15
51 Accelerated fatty acid oxidation in muscle averts fasting-induced hepatic steatosis in SJL/J mice. J Biol Chem 2009 1.14
52 LXR-SREBP-1c-phospholipid transfer protein axis controls very low density lipoprotein (VLDL) particle size. J Biol Chem 2009 1.12
53 Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis. Proc Natl Acad Sci U S A 2006 1.11
54 Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs. J Biol Chem 2003 1.10
55 Intramembrane aspartic acid in SCAP protein governs cholesterol-induced conformational change. Proc Natl Acad Sci U S A 2005 1.08
56 Use of mutant 125I-perfringolysin O to probe transport and organization of cholesterol in membranes of animal cells. Proc Natl Acad Sci U S A 2013 1.01
57 Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes. J Biol Chem 2009 0.99
58 Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin. J Invest Dermatol 2010 0.99
59 Illuminant estimation for color constancy: why spatial-domain methods work and the role of the color distribution. J Opt Soc Am A Opt Image Sci Vis 2014 0.99
60 Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice. Proc Natl Acad Sci U S A 2011 0.97
61 Acceptance remarks of Joseph L Goldstein and Michael S. Brown on the occasion of the presentation of the Kober Medal, 2002. J Clin Invest 2002 0.96
62 Correction of spatially varying image and video motion blur using a hybrid camera. IEEE Trans Pattern Anal Mach Intell 2010 0.91
63 Antimicrobial susceptibility of enteric bacteria recovered from feedlot cattle administered chlortetracycline in feed. Am J Vet Res 2008 0.88
64 Point mutation in luminal loop 7 of Scap protein blocks interaction with loop 1 and abolishes movement to Golgi. J Biol Chem 2013 0.85
65 Three-dimensional spatiotemporal features for fast content-based retrieval of focal liver lesions. IEEE Trans Biomed Eng 2014 0.84
66 Cooperia punctata: effect on cattle productivity? Vet Parasitol 2011 0.81
67 High-quality depth map upsampling and completion for RGB-D cameras. IEEE Trans Image Process 2014 0.79
68 Interactive visualization of hyperspectral images of historical documents. IEEE Trans Vis Comput Graph 2010 0.78
69 Globally optimized linear windowed tone mapping. IEEE Trans Vis Comput Graph 2010 0.77
70 Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties. Bioorg Med Chem Lett 2008 0.77
71 Allosteric and orthosteric binding modes of two nonpeptide human gonadotropin-releasing hormone receptor antagonists. Biochemistry 2006 0.76
72 Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholeserolemia heterozygotes. 1983. Atheroscler Suppl 2004 0.76
73 Lowering plasma cholesterol by raising ldl receptors. 1981. Atheroscler Suppl 2004 0.76
74 Visual Interpretation with Three-Dimensional Annotations (VITA): three-dimensional image interpretation tool for radiological reporting. J Digit Imaging 2014 0.75
75 Selection, synthesis, and structure-activity relationship of tetrahydropyrido[4,3-d]pyrimidine-2,4-diones as human GnRH receptor antagonists. Bioorg Med Chem 2007 0.75
76 Nonlinear camera response functions and image deblurring: theoretical analysis and practice. IEEE Trans Pattern Anal Mach Intell 2013 0.75
77 Protocol for the examination of specimens from patients with hematopoietic neoplasms of the ocular adnexa. Arch Pathol Lab Med 2010 0.75
78 Online tracking of deformable objects under occlusion using dominant points. J Opt Soc Am A Opt Image Sci Vis 2013 0.75
79 DEB: definite error bounded tangent estimator for digital curves. IEEE Trans Image Process 2014 0.75
80 Design of macro-filter-lens with simultaneous chromatic and geometric aberration correction. Appl Opt 2014 0.75
81 A new in-camera imaging model for color computer vision and its application. IEEE Trans Pattern Anal Mach Intell 2012 0.75
82 Single Image Rain Streak Separation Using Layer Priors. IEEE Trans Image Process 2017 0.75
83 Combustion exhaust measurements of nitric oxide with an ultraviolet diode-laser-based absorption sensor. Appl Opt 2005 0.75
84 Effect of dietary lipoic acid on metabolic hormones and acute-phase proteins during challenge with infectious bovine rhinotracheitis virus in cattle. Am J Vet Res 2006 0.75
85 Protocol for the examination of specimens from patients with non-Hodgkin lymphoma/lymphoid neoplasms. Arch Pathol Lab Med 2010 0.75
86 User-assisted ink-bleed reduction. IEEE Trans Image Process 2010 0.75
87 Kinetic behavior of polymer-coated long-period-grating fiber-optic sensors. Appl Opt 2005 0.75
88 Richardson-Lucy Deblurring for Scenes under a Projective Motion Path. IEEE Trans Pattern Anal Mach Intell 2010 0.75