Published in Cell on February 08, 2008
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol (2009) 9.43
The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors. Br J Pharmacol (2013) 5.74
Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis. J Lipid Res (2008) 4.09
Ghrelin octanoylation mediated by an orphan lipid transferase. Proc Natl Acad Sci U S A (2008) 3.41
GOAT links dietary lipids with the endocrine control of energy balance. Nat Med (2009) 2.42
A link between FTO, ghrelin, and impaired brain food-cue responsivity. J Clin Invest (2013) 2.23
Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor. Science (2010) 2.12
Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice. Proc Natl Acad Sci U S A (2010) 2.06
Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men. J Clin Endocrinol Metab (2008) 1.96
Acyl-coenzyme A:cholesterol acyltransferases. Am J Physiol Endocrinol Metab (2009) 1.85
Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog. J Biol Chem (2008) 1.75
Induced ablation of ghrelin cells in adult mice does not decrease food intake, body weight, or response to high-fat diet. Cell Metab (2014) 1.63
Ghrelin increases intake of rewarding food in rodents. Addict Biol (2010) 1.61
2-Bromopalmitate and 2-(2-hydroxy-5-nitro-benzylidene)-benzo[b]thiophen-3-one inhibit DHHC-mediated palmitoylation in vitro. J Lipid Res (2008) 1.58
Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides. Proc Natl Acad Sci U S A (2008) 1.36
The pharmacokinetics of acyl, des-acyl, and total ghrelin in healthy human subjects. Eur J Endocrinol (2013) 1.36
Prebiotic fibres dose-dependently increase satiety hormones and alter Bacteroidetes and Firmicutes in lean and obese JCR:LA-cp rats. Br J Nutr (2011) 1.36
Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome. Proc Natl Acad Sci U S A (2011) 1.35
Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine. J Biol Chem (2012) 1.33
Ghrelin. Mol Metab (2015) 1.29
Bioorthogonal chemical reporters for analyzing protein lipidation and lipid trafficking. Acc Chem Res (2011) 1.28
Bowels control brain: gut hormones and obesity. Nat Rev Endocrinol (2010) 1.23
Colocalization of ghrelin O-acyltransferase and ghrelin in gastric mucosal cells. Am J Physiol Endocrinol Metab (2009) 1.21
The traditional Japanese medicine Rikkunshito increases the plasma level of ghrelin in humans and mice. J Gastroenterol (2009) 1.20
Ghrelin secretion stimulated by {beta}1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice. Proc Natl Acad Sci U S A (2010) 1.20
Ghrelin, des-acyl ghrelin and nesfatin-1 in gastric X/A-like cells: role as regulators of food intake and body weight. Peptides (2009) 1.19
Diet and gastrointestinal bypass-induced weight loss: the roles of ghrelin and peptide YY. Diabetes (2011) 1.19
Ghrelin in central neurons. Curr Neuropharmacol (2009) 1.17
Effect of des-acyl ghrelin on adiposity and glucose metabolism. Endocrinology (2008) 1.15
Lipoexpediency: de novo lipogenesis as a metabolic signal transmitter. Trends Endocrinol Metab (2011) 1.14
Ghrelin induces abdominal obesity via GHS-R-dependent lipid retention. Mol Endocrinol (2009) 1.14
GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis. J Lipid Res (2010) 1.14
Metabolic regulation of ghrelin O-acyl transferase (GOAT) expression in the mouse hypothalamus, pituitary, and stomach. Mol Cell Endocrinol (2009) 1.14
Identification of conserved regions and residues within Hedgehog acyltransferase critical for palmitoylation of Sonic Hedgehog. PLoS One (2010) 1.11
Gastric mammalian target of rapamycin signaling regulates ghrelin production and food intake. Endocrinology (2009) 1.10
Characterization of a novel ghrelin cell reporter mouse. Regul Pept (2009) 1.08
Physiologic concentrations of exogenously infused ghrelin reduces insulin secretion without affecting insulin sensitivity in healthy humans. J Clin Endocrinol Metab (2013) 1.08
Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease. World J Gastroenterol (2014) 1.07
Actions and therapeutic pathways of ghrelin for gastrointestinal disorders. Nat Rev Gastroenterol Hepatol (2009) 1.06
Acyl-CoA:lysophosphatidylcholine acyltransferase I (Lpcat1) catalyzes histone protein O-palmitoylation to regulate mRNA synthesis. J Biol Chem (2011) 1.06
Structure and physiological actions of ghrelin. Scientifica (Cairo) (2013) 1.06
Neuroanatomical characterization of a growth hormone secretagogue receptor-green fluorescent protein reporter mouse. J Comp Neurol (2014) 1.05
The physiology of protein S-acylation. Physiol Rev (2015) 1.03
Identification of key residues and regions important for porcupine-mediated Wnt acylation. J Biol Chem (2014) 1.02
Precise regulation of porcupine activity is required for physiological Wnt signaling. J Biol Chem (2012) 1.02
Feedback inactivation of D-serine synthesis by NMDA receptor-elicited translocation of serine racemase to the membrane. Proc Natl Acad Sci U S A (2009) 1.02
Modification of ghrelin receptor signaling by somatostatin receptor-5 regulates insulin release. Proc Natl Acad Sci U S A (2012) 1.02
Ghrelin is produced in taste cells and ghrelin receptor null mice show reduced taste responsivity to salty (NaCl) and sour (citric acid) tastants. PLoS One (2010) 1.01
A novel human ghrelin variant (In1-ghrelin) and ghrelin-O-acyltransferase are overexpressed in breast cancer: potential pathophysiological relevance. PLoS One (2011) 1.01
The GOAT-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction. PLoS One (2012) 1.01
Estrogen elevates the peak overnight production rate of acylated ghrelin. J Clin Endocrinol Metab (2008) 1.00
Postprandial inhibition of gastric ghrelin secretion by long-chain fatty acid through GPR120 in isolated gastric ghrelin cells and mice. Am J Physiol Gastrointest Liver Physiol (2012) 0.99
Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice. J Clin Invest (2013) 0.99
Comparison of competitive radioimmunoassays and two-site sandwich assays for the measurement and interpretation of plasma ghrelin levels. J Clin Endocrinol Metab (2010) 0.98
Mice with hyperghrelinemia are hyperphagic and glucose intolerant and have reduced leptin sensitivity. Diabetes (2009) 0.98
Interrelationships between ghrelin, insulin and glucose homeostasis: Physiological relevance. World J Diabetes (2014) 0.98
Lipopolysaccharide differentially decreases plasma acyl and desacyl ghrelin levels in rats: potential role of the circulating ghrelin-acylating enzyme GOAT. Peptides (2010) 0.98
The development of highly potent inhibitors for porcupine. J Med Chem (2013) 0.97
Drugging the cancer stem cell compartment: lessons learned from the hedgehog and Wnt signal transduction pathways. Annu Rev Pharmacol Toxicol (2011) 0.97
Palmitoylation of amyloid precursor protein regulates amyloidogenic processing in lipid rafts. J Neurosci (2013) 0.97
Unacylated ghrelin rapidly modulates lipogenic and insulin signaling pathway gene expression in metabolically active tissues of GHSR deleted mice. PLoS One (2010) 0.97
Modulation of ghrelin O-acyltransferase expression in pancreatic islets. Cell Physiol Biochem (2010) 0.97
Structural architecture and functional evolution of Wnts. Dev Cell (2012) 0.97
Drosophila lysophospholipid acyltransferases are specifically required for germ cell development. Mol Biol Cell (2009) 0.96
Topology of 1-acyl-sn-glycerol-3-phosphate acyltransferases SLC1 and ALE1 and related membrane-bound O-acyltransferases (MBOATs) of Saccharomyces cerevisiae. J Biol Chem (2011) 0.95
Ghrelin attenuates cAMP-PKA signaling to evoke insulinostatic cascade in islet β-cells. Diabetes (2011) 0.94
Proteomic analysis of fatty-acylated proteins. Curr Opin Chem Biol (2015) 0.94
Identification of N-terminal residues of Sonic Hedgehog important for palmitoylation by Hedgehog acyltransferase. J Biol Chem (2012) 0.94
Differential palmit(e)oylation of Wnt1 on C93 and S224 residues has overlapping and distinct consequences. PLoS One (2011) 0.94
Ghrelin's second life: from appetite stimulator to glucose regulator. World J Gastroenterol (2012) 0.93
Differential distribution of ghrelin-O-acyltransferase (GOAT) immunoreactive cells in the mouse and rat gastric oxyntic mucosa. Biochem Biophys Res Commun (2010) 0.93
Ghrelin and cardiovascular diseases. Curr Cardiol Rev (2010) 0.93
Lipid-modified morphogens: functions of fats. Curr Opin Genet Dev (2009) 0.93
Ghrelin is neuroprotective in Parkinson's disease: molecular mechanisms of metabolic neuroprotection. Ther Adv Endocrinol Metab (2013) 0.92
Deorphanization of novel peptides and their receptors. AAPS J (2010) 0.92
Role of ghrelin in the pathophysiology of gastrointestinal disease. Gut Liver (2013) 0.91
Investigating endogenous peptides and peptidases using peptidomics. Biochemistry (2011) 0.91
Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein. PLoS One (2012) 0.91
Architectural organization of the metabolic regulatory enzyme ghrelin O-acyltransferase. J Biol Chem (2013) 0.91
Stress-related alterations of acyl and desacyl ghrelin circulating levels: mechanisms and functional implications. Peptides (2011) 0.90
Ghrelin: central and peripheral implications in anorexia nervosa. Front Endocrinol (Lausanne) (2013) 0.90
Ghrelin attenuates the osteoblastic differentiation of vascular smooth muscle cells through the ERK pathway. PLoS One (2012) 0.90
Hindbrain ghrelin receptor signaling is sufficient to maintain fasting glucose. PLoS One (2012) 0.90
Metabolic and cardiovascular effects of ghrelin. Int J Pept (2010) 0.89
The β-cell GHSR and downstream cAMP/TRPM2 signaling account for insulinostatic and glycemic effects of ghrelin. Sci Rep (2015) 0.89
Acylation type determines ghrelin's effects on energy homeostasis in rodents. Endocrinology (2012) 0.88
GOAT induced ghrelin acylation regulates hedonic feeding. Horm Behav (2012) 0.88
Acylated ghrelin concentrations are markedly decreased during pregnancy in mothers with and without gestational diabetes: relationship with cholinesterase. Am J Physiol Endocrinol Metab (2009) 0.88
cat-ELCCA: a robust method to monitor the fatty acid acyltransferase activity of ghrelin O-acyltransferase (GOAT). Angew Chem Int Ed Engl (2010) 0.88
Effect of ghrelin on glucose-insulin homeostasis: therapeutic implications. Int J Pept (2010) 0.88
Integrating GHS into the Ghrelin System. Int J Pept (2010) 0.88
Ghrelin - a pleiotropic hormone secreted from endocrine x/a-like cells of the stomach. Front Neurosci (2012) 0.87
The central nervous system sites mediating the orexigenic actions of ghrelin. Annu Rev Physiol (2013) 0.87
Abdominal surgery inhibits circulating acyl ghrelin and ghrelin-O-acyltransferase levels in rats: role of the somatostatin receptor subtype 2. Am J Physiol Gastrointest Liver Physiol (2011) 0.87
Fatty acylation of Wnt proteins. Nat Chem Biol (2016) 0.87
Blunted suppression of acyl-ghrelin in response to fructose ingestion in obese adolescents: the role of insulin resistance. Obesity (Silver Spring) (2015) 0.87
Ghrelin and NUCB2/nesfatin-1 are expressed in the same gastric cell and differentially correlated with body mass index in obese subjects. Histochem Cell Biol (2013) 0.87
Ghrelin in diabetes and metabolic syndrome. Int J Pept (2010) 0.87
Use of ghrelin as a treatment for inflammatory bowel disease: mechanistic considerations. Int J Pept (2011) 0.86
Ghrelin and eating behavior: evidence and insights from genetically-modified mouse models. Front Neurosci (2013) 0.86
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest (2002) 21.08
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol Cell (2006) 11.38
A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action. Biol Direct (2006) 11.31
Protein sensors for membrane sterols. Cell (2006) 8.62
Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc Natl Acad Sci U S A (2003) 8.20
PROMALS3D: a tool for multiple protein sequence and structure alignments. Nucleic Acids Res (2008) 7.16
Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell (2012) 6.83
Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c. J Biol Chem (2002) 5.89
Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell (2002) 5.70
Selective versus total insulin resistance: a pathogenic paradox. Cell Metab (2008) 5.25
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proc Natl Acad Sci U S A (2010) 4.40
A DNA repair system specific for thermophilic Archaea and bacteria predicted by genomic context analysis. Nucleic Acids Res (2002) 4.39
Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli. Mol Cell Proteomics (2008) 4.36
Structure of the LDL receptor extracellular domain at endosomal pH. Science (2002) 4.06
Structural classification of zinc fingers: survey and summary. Nucleic Acids Res (2003) 3.94
Genome trees and the tree of life. Trends Genet (2002) 3.79
The LDL receptor. Arterioscler Thromb Vasc Biol (2009) 3.78
Identification of a candidate therapeutic autophagy-inducing peptide. Nature (2013) 3.76
Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. Proc Natl Acad Sci U S A (2004) 3.73
Structure prediction for CASP8 with all-atom refinement using Rosetta. Proteins (2009) 3.64
Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity. Proc Natl Acad Sci U S A (2004) 3.63
Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc Natl Acad Sci U S A (2004) 3.54
Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc Natl Acad Sci U S A (2002) 3.51
AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling. Science (2008) 3.44
A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis. J Biol Chem (2009) 3.41
Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation. Proc Natl Acad Sci U S A (2003) 3.38
Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance. Cell Metab (2008) 3.33
Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL. J Lipid Res (2008) 3.31
PROMALS: towards accurate multiple sequence alignments of distantly related proteins. Bioinformatics (2007) 3.26
Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol. Cell (2009) 3.24
PCMA: fast and accurate multiple sequence alignment based on profile consistency. Bioinformatics (2003) 3.23
The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology. Proc Natl Acad Sci U S A (2007) 3.11
Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response. Immunity (2012) 3.07
Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain. Mol Cell (2004) 3.07
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig. Proc Natl Acad Sci U S A (2007) 3.01
Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs. J Biol Chem (2004) 2.82
NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes. Proc Natl Acad Sci U S A (2008) 2.81
Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism. Mol Cell (2002) 2.80
Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication. Mol Cell (2005) 2.78
Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis. J Clin Invest (2004) 2.66
EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance. Cell (2013) 2.63
Atypical angiopoietin-like protein that regulates ANGPTL3. Proc Natl Acad Sci U S A (2012) 2.62
Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis. Arch Biochem Biophys (2002) 2.57
Structural basis for converting a general transcription factor into an operon-specific virulence regulator. Mol Cell (2007) 2.56
History of science. A golden era of Nobel laureates. Science (2012) 2.55
Secreted kinase phosphorylates extracellular proteins that regulate biomineralization. Science (2012) 2.55
Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer. Am J Hum Genet (2008) 2.53
Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis. Proc Natl Acad Sci U S A (2003) 2.49
An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis. Science (2009) 2.49
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins. Proc Natl Acad Sci U S A (2007) 2.46
Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain. Mol Cell (2003) 2.40
Evolution of protein structures and functions. Curr Opin Struct Biol (2002) 2.38
Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop. J Biol Chem (2007) 2.34
Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein. J Biol Chem (2007) 2.29
25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production. Proc Natl Acad Sci U S A (2009) 2.14
Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice. Proc Natl Acad Sci U S A (2010) 2.06
Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol. J Biol Chem (2003) 2.05
C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation. Science (2009) 2.04
Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. J Clin Invest (2005) 2.03
The SREBP pathway in Drosophila: regulation by palmitate, not sterols. Dev Cell (2002) 2.01
The conserved plant sterility gene HAP2 functions after attachment of fusogenic membranes in Chlamydomonas and Plasmodium gametes. Genes Dev (2008) 1.95
Fido, a novel AMPylation domain common to fic, doc, and AvrB. PLoS One (2009) 1.92
Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro. J Biol Chem (2005) 1.91
CASP9 assessment of free modeling target predictions. Proteins (2011) 1.90
Detecting distant homology with Meta-BASIC. Nucleic Acids Res (2004) 1.86
MUMMALS: multiple sequence alignment improved by using hidden Markov models with local structural information. Nucleic Acids Res (2006) 1.85