Subtype-specific peripheral blood gene expression profiles in recent-onset juvenile idiopathic arthritis.

PubWeight™: 1.56‹?› | Rank: Top 4%

🔗 View Article (PMC 2782469)

Published in Arthritis Rheum on July 01, 2009

Authors

Michael G Barnes1, Alexei A Grom, Susan D Thompson, Thomas A Griffin, Paul Pavlidis, Lukasz Itert, Ndate Fall, Dawn Paxson Sowders, Claas H Hinze, Bruce J Aronow, Lorie K Luyrink, Shweta Srivastava, Norman T Ilowite, Beth S Gottlieb, Judyann C Olson, David D Sherry, David N Glass, Robert A Colbert

Author Affiliations

1: Division of Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA. michael.barnes@cchmc.org

Articles citing this

A genomic approach to human autoimmune diseases. Annu Rev Immunol (2010) 2.10

Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. Nat Immunol (2010) 2.07

Assessing the human immune system through blood transcriptomics. BMC Biol (2010) 1.86

Pathogenesis of systemic juvenile idiopathic arthritis: some answers, more questions. Nat Rev Rheumatol (2011) 1.67

Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) is a disorder of innate immunity and Th1 activation responsive to IL-1 blockade. Proc Natl Acad Sci U S A (2011) 1.33

Role of IL-1 beta in the development of human T(H)17 cells: lesson from NLPR3 mutated patients. PLoS One (2011) 1.17

Systemic JIA: new developments in the understanding of the pathophysiology and therapy. Best Pract Res Clin Rheumatol (2009) 1.05

Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13. Arthritis Rheum (2012) 1.03

Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis: implications for pathogenesis. Arthritis Res Ther (2010) 1.01

Biologic similarities based on age at onset in oligoarticular and polyarticular subtypes of juvenile idiopathic arthritis. Arthritis Rheum (2010) 0.97

Generation of novel pharmacogenomic candidates in response to methotrexate in juvenile idiopathic arthritis: correlation between gene expression and genotype. Pharmacogenet Genomics (2010) 0.97

Update on the pathogenesis and treatment of systemic idiopathic arthritis. Curr Opin Pediatr (2011) 0.95

From bench to bedside and back again: translational research in autoinflammation. Nat Rev Rheumatol (2015) 0.87

Multiple juvenile idiopathic arthritis subtypes demonstrate proinflammatory IgG glycosylation. Arthritis Rheum (2012) 0.85

Association of the IL-10 gene family locus on chromosome 1 with juvenile idiopathic arthritis (JIA). PLoS One (2012) 0.84

Premature cell senescence and T cell receptor-independent activation of CD8+ T cells in juvenile idiopathic arthritis. Arthritis Rheum (2013) 0.84

Comparison of biomarkers for systemic juvenile idiopathic arthritis. Pediatr Res (2015) 0.83

Alternative activation in systemic juvenile idiopathic arthritis monocytes. Clin Immunol (2011) 0.83

Developmental pharmacogenetics in pediatric rheumatology: utilizing a new paradigm to effectively treat patients with juvenile idiopathic arthritis with methotrexate. Hum Genomics Proteomics (2010) 0.81

Development of biomarkers to optimize pediatric patient management: what makes children different? Biomark Med (2011) 0.81

An overview of genetics of paediatric rheumatic diseases. Best Pract Res Clin Rheumatol (2009) 0.80

Periodic fever syndrome and autoinflammatory diseases. F1000 Med Rep (2010) 0.80

Aberrant expression of shared master-key genes contributes to the immunopathogenesis in patients with juvenile spondyloarthritis. PLoS One (2014) 0.79

Correlation analyses of clinical and molecular findings identify candidate biological pathways in systemic juvenile idiopathic arthritis. BMC Med (2012) 0.78

Development of positive antinuclear antibodies and rheumatoid factor in systemic juvenile idiopathic arthritis points toward an autoimmune phenotype later in the disease course. Pediatr Rheumatol Online J (2014) 0.77

Biomarkers in systemic juvenile idiopathic arthritis: a comparison with biomarkers in cryopyrin-associated periodic syndromes. Curr Opin Rheumatol (2014) 0.77

Pediatric rheumatic disease: can molecular profiling predict the future in JIA? Nat Rev Rheumatol (2009) 0.77

Elevated IgG autoantibody production in oligoarticular juvenile idiopathic arthritis may predict a refractory course. Clin Exp Rheumatol (2011) 0.77

[Genetic background of juvenile idiopathic arthritis]. Z Rheumatol (2010) 0.76

Up regulated complement and fc receptors in juvenile idiopathic arthritis and correlation with disease phenotype. J Clin Immunol (2012) 0.76

Inverted expression profiles of sex-biased genes in response to toxicant perturbations and diseases. PLoS One (2013) 0.76

The biologic basis of clinical heterogeneity in juvenile idiopathic arthritis. Arthritis Rheumatol (2014) 0.76

Intermediate monocytes are increased in enthesitis-related arthritis, a category of juvenile idiopathic arthritis. Clin Exp Immunol (2016) 0.76

Autoinflammatory gene polymorphisms and susceptibility to UK juvenile idiopathic arthritis. Pediatr Rheumatol Online J (2013) 0.75

Network analysis and juvenile idiopathic arthritis (JIA): a new horizon for the understanding of disease pathogenesis and therapeutic target identification. Pediatr Rheumatol Online J (2016) 0.75

Altered signaling in systemic juvenile idiopathic arthritis monocytes. Clin Immunol (2015) 0.75

A Putative Blood-Based Biomarker for Autism Spectrum Disorder-Associated Ileocolitis. Sci Rep (2016) 0.75

Mitochondrial and oxidative stress genes are differentially expressed in neutrophils of sJIA patients treated with tocilizumab: a pilot microarray study. Pediatr Rheumatol Online J (2016) 0.75

Primary complement and antibody deficiencies in autoimmune rheumatologic diseases with juvenile onset: a prospective study at two centers. Pediatr Rheumatol Online J (2015) 0.75

Redox Regulation of Pro-IL-1β Processing May Contribute to the Increased Severity of Serum-Induced Arthritis in NOX2-Deficient Mice. Antioxid Redox Signal (2015) 0.75

Divergent gene activation in peripheral blood and tissues of patients with rheumatoid arthritis, psoriatic arthritis and psoriasis following infliximab therapy. PLoS One (2014) 0.75

Identification of potential peripheral blood diagnostic biomarkers for patients with juvenile idiopathic arthritis by bioinformatics analysis. Rheumatol Int (2016) 0.75

The profile of polyunsaturated fatty acids in juvenile idiopathic arthritis and association with disease activity. Clin Rheumatol (2017) 0.75

The frontline of immune response in peripheral blood. PLoS One (2017) 0.75

Articles cited by this

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res (2002) 76.95

The KEGG databases at GenomeNet. Nucleic Acids Res (2002) 33.68

International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol (2004) 14.06

The molecular portraits of breast tumors are conserved across microarray platforms. BMC Genomics (2006) 12.45

Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J Exp Med (2003) 11.23

Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol (2007) 10.49

Revision of the proposed classification criteria for juvenile idiopathic arthritis: Durban, 1997. J Rheumatol (1998) 5.69

Adjustment of systematic microarray data biases. Bioinformatics (2004) 5.22

Human C'3: evidence for the liver as the primary site of synthesis. Science (1969) 4.17

Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade. J Exp Med (2007) 3.51

A gene expression signature predicts survival of patients with stage I non-small cell lung cancer. PLoS Med (2006) 3.37

Whole blood and leukocyte RNA isolation for gene expression analyses. Physiol Genomics (2004) 3.22

Use of immunohistologic and in situ hybridization techniques in the examination of sacroiliac joint biopsy specimens from patients with ankylosing spondylitis. Arthritis Rheum (1995) 3.10

Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock. Mol Med (2007) 2.58

The pattern of response to anti-interleukin-1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis. Arthritis Rheum (2008) 2.08

Gene expression profiling of peripheral blood from patients with untreated new-onset systemic juvenile idiopathic arthritis reveals molecular heterogeneity that may predict macrophage activation syndrome. Arthritis Rheum (2007) 2.00

Molecular classification of Crohn's disease and ulcerative colitis patients using transcriptional profiles in peripheral blood mononuclear cells. J Mol Diagn (2006) 1.89

Biosynthesis of the first component of complement by human and guinea pig peritoneal macrophages: evidence for an independent production of the C1 subunits. J Immunol (1978) 1.79

Expression levels for many genes in human peripheral blood cells are highly sensitive to ex vivo incubation. Genes Immun (2004) 1.77

Specific gene expression profiles in systemic juvenile idiopathic arthritis. Arthritis Rheum (2007) 1.54

Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis. Arthritis Res Ther (2004) 1.33

A comprehensive review of the genetics of juvenile idiopathic arthritis. Pediatr Rheumatol Online J (2008) 1.27

Maturation of dendritic cells abrogates C1q production in vivo and in vitro. Blood (2004) 1.20

Gene expression in juvenile arthritis and spondyloarthropathy: pro-angiogenic ELR+ chemokine genes relate to course of arthritis. Rheumatology (Oxford) (2004) 1.18

A genome-wide scan for juvenile rheumatoid arthritis in affected sibpair families provides evidence of linkage. Arthritis Rheum (2004) 1.09

Metabolic persistence of fetal hemoglobin. Blood (1995) 1.01

Dendritic cells in the arterial wall express C1q: potential significance in atherogenesis. Cardiovasc Res (2003) 0.97

Hematology and biochemistry of ankylosing spondylitis. Br Med J (1973) 0.94

The regulatory roles of C1q. Immunobiology (2006) 0.87

Sequential and concerted gene expression changes in a chronic in vitro model of parkinsonism. Neuroscience (2008) 0.87

Juvenile chronic arthritis--a time for change? Eur J Immunogenet (1996) 0.87

Fetal hemoglobin synthesis in vivo: direct evidence for control at the level of erythroid progenitors. Proc Natl Acad Sci U S A (1988) 0.85

Synthesis and regulation of complement components by human monocytes/macrophages and by acute monocytic leukemia. DNA Cell Biol (1993) 0.83

Fibrin D-dimer as a marker of disease activity in systemic onset juvenile rheumatoid arthritis. J Rheumatol (1998) 0.82

Synthesis of complement components C2 and C4 by human monocyte-derived macrophages during in vitro differentiation in serum-free culture conditions. Pathobiology (1991) 0.79

Activation of the haemostatic system in children with juvenile rheumatoid arthritis correlates with disease activity. Thromb Res (1998) 0.79

Articles by these authors

Design and implementation of microarray gene expression markup language (MAGE-ML). Genome Biol (2002) 16.75

International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol (2004) 14.06

Coexpression analysis of human genes across many microarray data sets. Genome Res (2004) 9.38

ToppGene Suite for gene list enrichment analysis and candidate gene prioritization. Nucleic Acids Res (2009) 7.34

Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. J Clin Invest (2006) 5.48

ErmineJ: tool for functional analysis of gene expression data sets. BMC Bioinformatics (2005) 4.98

Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circ Res (2007) 4.53

An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets. Genome Biol (2003) 4.49

Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability. Circ Res (2006) 4.41

Experimental comparison and cross-validation of the Affymetrix and Illumina gene expression analysis platforms. Nucleic Acids Res (2005) 4.41

ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo. Neuron (2004) 4.21

Blockade of chronic type I interferon signaling to control persistent LCMV infection. Science (2013) 4.14

Pattern of sequence variation across 213 environmental response genes. Genome Res (2004) 3.93

The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor. Cell (2012) 3.91

Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat Genet (2008) 3.76

Zac1 regulates an imprinted gene network critically involved in the control of embryonic growth. Dev Cell (2006) 3.67

2011 American College of Rheumatology recommendations for the treatment of juvenile idiopathic arthritis: initiation and safety monitoring of therapeutic agents for the treatment of arthritis and systemic features. Arthritis Care Res (Hoboken) (2011) 3.66

Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome. Physiol Genomics (2007) 3.37

Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers. EMBO J (2004) 3.32

Disease candidate gene identification and prioritization using protein interaction networks. BMC Bioinformatics (2009) 3.03

Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biol (2007) 2.70

Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. Nat Genet (2013) 2.60

Detection and visualization of compositionally similar cis-regulatory element clusters in orthologous and coordinately controlled genes. Genome Res (2002) 2.60

Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2002) 2.58

Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock. Mol Med (2007) 2.58

Safety and efficacy of up to eight years of continuous etanercept therapy in patients with juvenile rheumatoid arthritis. Arthritis Rheum (2008) 2.56

The diagnostic significance of soluble CD163 and soluble interleukin-2 receptor alpha-chain in macrophage activation syndrome and untreated new-onset systemic juvenile idiopathic arthritis. Arthritis Rheum (2007) 2.56

Improved human disease candidate gene prioritization using mouse phenotype. BMC Bioinformatics (2007) 2.56

GUDMAP: the genitourinary developmental molecular anatomy project. J Am Soc Nephrol (2008) 2.45

Atlas of gene expression in the developing kidney at microanatomic resolution. Dev Cell (2008) 2.44

Genetic induction of proinflammatory immunity in children with biliary atresia. Lancet (2002) 2.44

Hierarchical model of gene regulation by transforming growth factor beta. Proc Natl Acad Sci U S A (2003) 2.37

Consensus treatment plans for new-onset systemic juvenile idiopathic arthritis. Arthritis Care Res (Hoboken) (2012) 2.21

The GUDMAP database--an online resource for genitourinary research. Development (2011) 2.20

Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays. Mol Cell Biol (2004) 2.19

Classification of clear-cell sarcoma as a subtype of melanoma by genomic profiling. J Clin Oncol (2003) 2.18

The retinoblastoma tumor suppressor modifies the therapeutic response of breast cancer. J Clin Invest (2006) 2.18

The FaceBase Consortium: a comprehensive program to facilitate craniofacial research. Dev Biol (2011) 2.16

Altered gene expression profiles in nasal respiratory epithelium reflect stable versus acute childhood asthma. J Allergy Clin Immunol (2005) 2.16

The concept of axial spondyloarthritis: joint statement of the spondyloarthritis research and treatment network and the Assessment of SpondyloArthritis international Society in response to the US Food and Drug Administration's comments and concerns. Arthritis Rheumatol (2014) 2.14

Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. J Clin Invest (2007) 2.12

Gene Ontology term overlap as a measure of gene functional similarity. BMC Bioinformatics (2008) 2.10

Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cells. Cell Stem Cell (2009) 2.09

Molecular aging in human prefrontal cortex is selective and continuous throughout adult life. Biol Psychiatry (2005) 2.06

Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy. Nat Med (2002) 2.05

Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease. Nature (2009) 2.05

Independent and overlapping transcriptional activation during liver development and regeneration in mice. Hepatology (2002) 2.02

Gene expression profiling of peripheral blood from patients with untreated new-onset systemic juvenile idiopathic arthritis reveals molecular heterogeneity that may predict macrophage activation syndrome. Arthritis Rheum (2007) 2.00

MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity. J Immunol (2011) 2.00

Juvenile idiopathic arthritis and HLA class I and class II interactions and age-at-onset effects. Arthritis Rheum (2010) 1.99

Classification and subtype prediction of adult soft tissue sarcoma by functional genomics. Am J Pathol (2003) 1.94

Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice. J Biol Chem (2006) 1.92

Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice. Nat Neurosci (2005) 1.91

HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats. Arthritis Rheum (2009) 1.87

Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy. J Clin Invest (2007) 1.87

Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis. Proc Natl Acad Sci U S A (2007) 1.86

Development of consensus treatment plans for juvenile localized scleroderma: a roadmap toward comparative effectiveness studies in juvenile localized scleroderma. Arthritis Care Res (Hoboken) (2012) 1.84

A catalogue of gene expression in the developing kidney. Kidney Int (2003) 1.83

MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors. J Clin Invest (2012) 1.83

Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Dev Biol (2009) 1.83

Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues. Cancer Res (2006) 1.80

Inducible enhancement of memory storage and synaptic plasticity in transgenic mice expressing an inhibitor of ATF4 (CREB-2) and C/EBP proteins. Neuron (2003) 1.80

Measuring process of arthritis care: a proposed set of quality measures for the process of care in juvenile idiopathic arthritis. Arthritis Care Res (Hoboken) (2011) 1.79

MicroRNA signature in patients with eosinophilic esophagitis, reversibility with glucocorticoids, and assessment as disease biomarkers. J Allergy Clin Immunol (2012) 1.79

Anakinra as first-line disease-modifying therapy in systemic juvenile idiopathic arthritis: report of forty-six patients from an international multicenter series. Arthritis Rheum (2011) 1.79

ToppCluster: a multiple gene list feature analyzer for comparative enrichment clustering and network-based dissection of biological systems. Nucleic Acids Res (2010) 1.75

Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box binding protein 1. Eur J Immunol (2008) 1.71

The impact of multifunctional genes on "guilt by association" analysis. PLoS One (2011) 1.69

Hypoxia induces chondrocyte-specific gene expression in mesenchymal cells in association with transcriptional activation of Sox9. Bone (2005) 1.68

Wnt/beta-catenin signaling is required for development of the exocrine pancreas. BMC Dev Biol (2007) 1.68

Pathogenesis of systemic juvenile idiopathic arthritis: some answers, more questions. Nat Rev Rheumatol (2011) 1.67

American College of Rheumatology provisional criteria for defining clinical inactive disease in select categories of juvenile idiopathic arthritis. Arthritis Care Res (Hoboken) (2011) 1.65

Clonality analysis after retroviral-mediated gene transfer to CD34+ cells from the cord blood of ADA-deficient SCID neonates. Nat Med (2003) 1.65

New population-based reference values for spinal mobility measures based on the 2009-2010 National Health and Nutrition Examination Survey. Arthritis Rheumatol (2014) 1.64

HLA-B27 misfolding in transgenic rats is associated with activation of the unfolded protein response. J Immunol (2005) 1.63

MiR-223 deficiency increases eosinophil progenitor proliferation. J Immunol (2013) 1.60

Transcriptional profiles of intestinal tumors in Apc(Min) mice are unique from those of embryonic intestine and identify novel gene targets dysregulated in human colorectal tumors. Cancer Res (2005) 1.58

PolyDoms: a whole genome database for the identification of non-synonymous coding SNPs with the potential to impact disease. Nucleic Acids Res (2006) 1.58

Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism. Proc Natl Acad Sci U S A (2009) 1.58

ImmunoChip study implicates antigen presentation to T cells in narcolepsy. PLoS Genet (2013) 1.55

Unbiased analysis of RB-mediated transcriptional repression identifies novel targets and distinctions from E2F action. Cancer Res (2002) 1.55

Transcript signatures in experimental asthma: identification of STAT6-dependent and -independent pathways. J Immunol (2004) 1.54

Ethical and practical issues associated with aggregating databases. PLoS Med (2008) 1.53

Genes that confer the identity of the renin cell. J Am Soc Nephrol (2011) 1.52

Randomized, double-blind, placebo-controlled trial of the efficacy and safety of rilonacept in the treatment of systemic juvenile idiopathic arthritis. Arthritis Rheumatol (2014) 1.51

Trial of early aggressive therapy in polyarticular juvenile idiopathic arthritis. Arthritis Rheum (2011) 1.51

Prolonged exposure to reduced levels of androgen accelerates prostate cancer progression in Nkx3.1; Pten mutant mice. Cancer Res (2007) 1.51

Sharing and reusing gene expression profiling data in neuroscience. Neuroinformatics (2007) 1.50