Published in Science on April 12, 2013
Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature (2015) 7.49
Regulation of type I interferon responses. Nat Rev Immunol (2014) 3.60
Molecular and cellular insights into T cell exhaustion. Nat Rev Immunol (2015) 2.74
Type I interferons in infectious disease. Nat Rev Immunol (2015) 2.37
Aging. Aging-induced type I interferon response at the choroid plexus negatively affects brain function. Science (2014) 2.22
Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression. Nature (2014) 2.20
Overcoming T cell exhaustion in infection and cancer. Trends Immunol (2015) 1.72
Immunologic strategies for HIV-1 remission and eradication. Science (2014) 1.70
Tolerance and exhaustion: defining mechanisms of T cell dysfunction. Trends Immunol (2013) 1.70
Molecular and transcriptional basis of CD4⁺ T cell dysfunction during chronic infection. Immunity (2014) 1.68
Successful Interferon-Free Therapy of Chronic Hepatitis C Virus Infection Normalizes Natural Killer Cell Function. Gastroenterology (2015) 1.65
Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade. Cell (2016) 1.57
Relative resistance of HIV-1 founder viruses to control by interferon-alpha. Retrovirology (2013) 1.55
Immune responses to HCV and other hepatitis viruses. Immunity (2014) 1.52
The multifaceted biology of plasmacytoid dendritic cells. Nat Rev Immunol (2015) 1.52
Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice. Cell Host Microbe (2016) 1.51
NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses. Cell Host Microbe (2016) 1.48
NK cells inhibit humoral immunity by reducing the abundance of CD4+ T follicular helper cells during a chronic virus infection. J Leukoc Biol (2015) 1.46
Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection. J Exp Med (2014) 1.40
Type I Interferon Receptor Deficiency in Dendritic Cells Facilitates Systemic Murine Norovirus Persistence Despite Enhanced Adaptive Immunity. PLoS Pathog (2016) 1.40
Regulatory T-cell homeostasis: steady-state maintenance and modulation during inflammation. Immunol Rev (2014) 1.38
A helicopter perspective on TB biomarkers: pathway and process based analysis of gene expression data provides new insight into TB pathogenesis. PLoS One (2013) 1.31
Targeting the tumor microenvironment with interferon-β bridges innate and adaptive immune responses. Cancer Cell (2014) 1.31
Type I interferon in the pathogenesis of lupus. J Immunol (2014) 1.29
Current concepts on the pathogenesis of type 1 diabetes--considerations for attempts to prevent and reverse the disease. Diabetes Care (2015) 1.25
Suppression of Fcγ-receptor-mediated antibody effector function during persistent viral infection. Immunity (2015) 1.23
The Z proteins of pathogenic but not nonpathogenic arenaviruses inhibit RIG-I-like receptor-dependent interferon production. J Virol (2014) 1.22
Interferon-dependent IL-10 production by Tregs limits tumor Th17 inflammation. J Clin Invest (2013) 1.21
Immunological aspects of antiviral therapy of chronic hepatitis B virus and hepatitis C virus infections. Hepatology (2015) 1.19
Pathogenic potential of interferon αβ in acute influenza infection. Nat Commun (2014) 1.19
Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection. J Exp Med (2014) 1.17
Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis. Proc Natl Acad Sci U S A (2015) 1.17
STING-dependent type I IFN production inhibits cell-mediated immunity to Listeria monocytogenes. PLoS Pathog (2014) 1.14
Guarding the frontiers: the biology of type III interferons. Nat Immunol (2015) 1.12
Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus. Proc Natl Acad Sci U S A (2015) 1.10
Resolution of acute inflammation bridges the gap between innate and adaptive immunity. Blood (2014) 1.09
T-cell exhaustion: understanding the interface of chronic viral and autoinflammatory diseases. Immunol Cell Biol (2016) 1.08
Bystander chronic infection negatively impacts development of CD8(+) T cell memory. Immunity (2014) 1.07
Sex-based differences in HIV type 1 pathogenesis. J Infect Dis (2014) 1.05
Multifaceted activities of type I interferon are revealed by a receptor antagonist. Sci Signal (2014) 1.04
Type I interferon upregulates Bak and contributes to T cell loss during human immunodeficiency virus (HIV) infection. PLoS Pathog (2013) 1.04
Type I IFN induces binding of STAT1 to Bcl6: divergent roles of STAT family transcription factors in the T follicular helper cell genetic program. J Immunol (2014) 1.03
Plasmacytoid dendritic cells suppress HIV-1 replication but contribute to HIV-1 induced immunopathogenesis in humanized mice. PLoS Pathog (2014) 1.03
Networking at the level of host immunity: immune cell interactions during persistent viral infections. Cell Host Microbe (2013) 1.03
Resolution of inflammation: a new therapeutic frontier. Nat Rev Drug Discov (2016) 1.02
Blockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infection. Cell Host Microbe (2015) 1.01
T cell exhaustion during persistent viral infections. Virology (2015) 1.00
Type I interferon suppresses de novo virus-specific CD4 Th1 immunity during an established persistent viral infection. Proc Natl Acad Sci U S A (2014) 0.99
Immunology. An interferon paradox. Science (2013) 0.99
Macrophage and T cell produced IL-10 promotes viral chronicity. PLoS Pathog (2013) 0.98
Innate immune response to arenaviral infection: a focus on the highly pathogenic New World hemorrhagic arenaviruses. J Mol Biol (2013) 0.98
Therapeutic depletion of natural killer cells controls persistent infection. J Virol (2013) 0.97
Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection. Front Cell Infect Microbiol (2013) 0.96
In vitro and in vivo characterizations of pichinde viral nucleoprotein exoribonuclease functions. J Virol (2015) 0.96
Type I IFN signaling in CD8- DCs impairs Th1-dependent malaria immunity. J Clin Invest (2014) 0.96
Transcriptional analysis of murine macrophages infected with different Toxoplasma strains identifies novel regulation of host signaling pathways. PLoS Pathog (2013) 0.94
Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity. Am J Respir Crit Care Med (2014) 0.93
Confounding roles for type I interferons during bacterial and viral pathogenesis. Int Immunol (2013) 0.93
Advances in understanding the role of type I interferons in systemic lupus erythematosus. Curr Opin Rheumatol (2014) 0.93
Targeting of type I interferon in systemic autoimmune diseases. Transl Res (2014) 0.92
Selection on a variant associated with improved viral clearance drives local, adaptive pseudogenization of interferon lambda 4 (IFNL4). PLoS Genet (2014) 0.92
Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality. Proc Natl Acad Sci U S A (2014) 0.91
Type I interferons in bacterial infections: taming of myeloid cells and possible implications for autoimmunity. Front Immunol (2014) 0.91
Disease-promoting effects of type I interferons in viral, bacterial, and coinfections. J Interferon Cytokine Res (2015) 0.90
Decoding the complexity of type I interferon to treat persistent viral infections. Trends Microbiol (2013) 0.90
Innate and Adaptive Immune Regulation During Chronic Viral Infections. Annu Rev Virol (2015) 0.89
Effects of alpha interferon treatment on intrinsic anti-HIV-1 immunity in vivo. J Virol (2013) 0.89
The role of type I interferons in intestinal infection, homeostasis, and inflammation. Immunol Rev (2014) 0.89
Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease. Immunity (2016) 0.88
IFN-α/β receptor signaling promotes regulatory T cell development and function under stress conditions. J Immunol (2015) 0.88
Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS. Proc Natl Acad Sci U S A (2016) 0.87
Type I interferon is a therapeutic target for virus-induced lethal vascular damage. Proc Natl Acad Sci U S A (2014) 0.86
Enhanced innate antiviral gene expression, IFN-α, and cytolytic responses are predictive of mucosal immune recovery during simian immunodeficiency virus infection. J Immunol (2014) 0.86
Immune responses and immunopathology in acute and chronic viral hepatitis. Nat Rev Immunol (2016) 0.86
Absence of Siglec-H in MCMV infection elevates interferon alpha production but does not enhance viral clearance. PLoS Pathog (2013) 0.85
Epigenetic manipulation restores functions of defective CD8⁺ T cells from chronic viral infection. Mol Ther (2014) 0.85
Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell Types. Front Immunol (2014) 0.85
T-cell immunity and hepatitis C virus reinfection after cure of chronic hepatitis C with an interferon-free antiviral regimen in a chimpanzee. Hepatology (2014) 0.85
Sendai virus pathogenesis in mice is prevented by Ifit2 and exacerbated by interferon. J Virol (2014) 0.85
Mucosal polyinosinic-polycytidylic acid improves protection elicited by replicating influenza vaccines via enhanced dendritic cell function and T cell immunity. J Immunol (2014) 0.85
IRF3 helps control acute TMEV infection through IL-6 expression but contributes to acute hippocampus damage following TMEV infection. Virus Res (2013) 0.84
The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness. Sci Immunol (2016) 0.84
Dendritic cells in progression and pathology of HIV infection. Trends Immunol (2013) 0.84
Out-of-Sequence Signal 3 Paralyzes Primary CD4(+) T-Cell-Dependent Immunity. Immunity (2015) 0.84
Interferons and the Immunogenic Effects of Cancer Therapy. Trends Immunol (2015) 0.84
The Dual Role of Exosomes in Hepatitis A and C Virus Transmission and Viral Immune Activation. Viruses (2015) 0.83
Interactions between Type 1 Interferons and the Th17 Response in Tuberculosis: Lessons Learned from Autoimmune Diseases. Front Immunol (2017) 0.83
HIV and innate immunity - a genomics perspective. F1000Prime Rep (2013) 0.83
Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection. Nat Immunol (2016) 0.83
Differential Inhibition of Macrophage Activation by Lymphocytic Choriomeningitis Virus and Pichinde Virus Is Mediated by the Z Protein N-Terminal Domain. J Virol (2015) 0.83
Clash of the Cytokine Titans: counter-regulation of interleukin-1 and type I interferon-mediated inflammatory responses. Cell Mol Immunol (2016) 0.83
Early virus-host interactions dictate the course of a persistent infection. PLoS Pathog (2015) 0.82
Plasmacytoid dendritic cells promote HIV-1-induced group 3 innate lymphoid cell depletion. J Clin Invest (2015) 0.82
Interferon-γ facilitates hepatic antiviral T cell retention for the maintenance of liver-induced systemic tolerance. J Exp Med (2016) 0.82
Macrophage Polarization in Virus-Host Interactions. J Clin Cell Immunol (2015) 0.82
Increased antigen presentation but impaired T cells priming after upregulation of interferon-beta induced by lipopolysaccharides is mediated by upregulation of B7H1 and GITRL. PLoS One (2014) 0.81
Sex differences in HIV-1-mediated immunopathology. Curr Opin HIV AIDS (2016) 0.81
IFN-α inhibits telomerase in human CD8⁺ T cells by both hTERT downregulation and induction of p38 MAPK signaling. J Immunol (2013) 0.81
Regulatory T Cells in Autoimmune and Viral Chronic Hepatitis. J Immunol Res (2015) 0.81
New insights into type I interferon and the immunopathogenesis of persistent viral infections. Curr Opin Immunol (2015) 0.81
Restoring function in exhausted CD8 T cells during chronic viral infection. Nature (2005) 28.04
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature (2006) 20.00
Functional role of type I and type II interferons in antiviral defense. Science (1994) 18.92
Interferon signaling and treatment outcome in chronic hepatitis C. Proc Natl Acad Sci U S A (2008) 8.56
Interleukin-10 determines viral clearance or persistence in vivo. Nat Med (2006) 8.01
Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C viral infection. Gastroenterology (2005) 5.33
Resolution of a chronic viral infection after interleukin-10 receptor blockade. J Exp Med (2006) 4.97
Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity (2011) 3.97
Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response. J Clin Invest (2009) 3.89
Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes. Proc Natl Acad Sci U S A (1995) 3.62
Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys. J Clin Invest (2009) 3.55
IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells. Blood (2009) 3.14
Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus. J Clin Invest (1994) 3.12
Critical role for alpha/beta and gamma interferons in persistence of lymphocytic choriomeningitis virus by clonal exhaustion of cytotoxic T cells. J Virol (2001) 2.69
Visualizing antigen-specific and infected cells in situ predicts outcomes in early viral infection. Science (2009) 2.64
An essential role for type 1 interferon-gamma in terminating persistent viral infection. Virology (1995) 2.60
Nonredundant roles for B cell-derived IL-10 in immune counter-regulation. J Immunol (2009) 2.48
Pathogenic mechanisms of HIV disease. Annu Rev Pathol (2011) 2.36
Constitutive type I interferon modulates homeostatic balance through tonic signaling. Immunity (2012) 2.23
Blocking of interleukin-10 receptor--a novel approach to stimulate T-helper cell type 1 responses to hepatitis C virus. Clin Immunol (2005) 1.60
Virus-induced immunosuppression. 1. Age at infection relates to a selective or generalized defect. Virology (1993) 1.50
In vitro restoration of T cell immune function in human immunodeficiency virus-positive persons: effects of interleukin (IL)-12 and anti-IL-10. J Infect Dis (1996) 1.41
Early IL-10 predominant responses are associated with progression to chronic hepatitis C virus infection in injecting drug users. J Viral Hepat (2010) 1.23
Emergence of distinct multiarmed immunoregulatory antigen-presenting cells during persistent viral infection. Cell Host Microbe (2012) 1.22
Role of an intact splenic microarchitecture in early lymphocytic choriomeningitis virus production. J Virol (2002) 1.14
The blood transcriptional signature of chronic hepatitis C virus is consistent with an ongoing interferon-mediated antiviral response. J Interferon Cytokine Res (2012) 1.12
Low-affinity cytotoxic T-lymphocytes require IFN-gamma to clear an acute viral infection. Virology (1997) 1.12
Translating insights from persistent LCMV infection into anti-HIV immunity. Immunol Res (2010) 1.00
Design and implementation of microarray gene expression markup language (MAGE-ML). Genome Biol (2002) 16.75
Induction of colonic regulatory T cells by indigenous Clostridium species. Science (2010) 16.71
MicroRNA-155 is induced during the macrophage inflammatory response. Proc Natl Acad Sci U S A (2007) 11.42
ToppGene Suite for gene list enrichment analysis and candidate gene prioritization. Nucleic Acids Res (2009) 7.34
IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity (2002) 6.85
Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature (2005) 5.56
Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. J Clin Invest (2006) 5.48
Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature (2008) 4.85
IL-21 is required to control chronic viral infection. Science (2009) 4.80
Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nat Immunol (2009) 4.76
Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circ Res (2007) 4.53
An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets. Genome Biol (2003) 4.49
Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability. Circ Res (2006) 4.41
Type I interferon production enhances susceptibility to Listeria monocytogenes infection. J Exp Med (2004) 4.34
MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus. Immunity (2006) 4.28
Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10. Nat Med (2009) 4.22
ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo. Neuron (2004) 4.21
LXR-dependent gene expression is important for macrophage survival and the innate immune response. Cell (2004) 4.20
Pattern of sequence variation across 213 environmental response genes. Genome Res (2004) 3.93
Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat Immunol (2008) 3.91
The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor. Cell (2012) 3.91
DUBA: a deubiquitinase that regulates type I interferon production. Science (2007) 3.88
IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest (2010) 3.40
Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome. Physiol Genomics (2007) 3.37
Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers. EMBO J (2004) 3.32
Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages. Sci Transl Med (2011) 3.27
Cutting edge: TLR4 activation mediates liver ischemia/reperfusion inflammatory response via IFN regulatory factor 3-dependent MyD88-independent pathway. J Immunol (2004) 3.27
Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif. EMBO J (2006) 3.13
Disease candidate gene identification and prioritization using protein interaction networks. BMC Bioinformatics (2009) 3.03
DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells. Immunity (2011) 3.01
Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism. Mol Cell (2003) 2.99
Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice. J Clin Invest (2009) 2.96
Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105. Nat Immunol (2005) 2.85
Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection. J Exp Med (2004) 2.80
Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biol (2007) 2.70
The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J Clin Invest (2008) 2.66
The signaling adaptors and pathways activated by TNF superfamily. Cytokine Growth Factor Rev (2003) 2.66
Effects of prostratin on T-cell activation and human immunodeficiency virus latency. J Virol (2002) 2.63
Detection and visualization of compositionally similar cis-regulatory element clusters in orthologous and coordinately controlled genes. Genome Res (2002) 2.60
Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature (2002) 2.60
Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2002) 2.58
Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock. Mol Med (2007) 2.58
Improved human disease candidate gene prioritization using mouse phenotype. BMC Bioinformatics (2007) 2.56
Toll-like receptors induce a phagocytic gene program through p38. J Exp Med (2003) 2.49
Nonredundant roles for B cell-derived IL-10 in immune counter-regulation. J Immunol (2009) 2.48
Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells. J Exp Med (2011) 2.48
Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding. Immunity (2012) 2.47
GUDMAP: the genitourinary developmental molecular anatomy project. J Am Soc Nephrol (2008) 2.45
ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury. Hepatology (2013) 2.45
Atlas of gene expression in the developing kidney at microanatomic resolution. Dev Cell (2008) 2.44
Genetic induction of proinflammatory immunity in children with biliary atresia. Lancet (2002) 2.44
Outer membrane vesicles of a human commensal mediate immune regulation and disease protection. Cell Host Microbe (2012) 2.41
A role for immune complexes in enhanced respiratory syncytial virus disease. J Exp Med (2002) 2.34
Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses. Science (2013) 2.34
Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo. J Immunol (2007) 2.32
Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M. J Clin Invest (2006) 2.29
Closed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithm. Proc Natl Acad Sci U S A (2008) 2.22
IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection. J Exp Med (2008) 2.20
The GUDMAP database--an online resource for genitourinary research. Development (2011) 2.20
Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays. Mol Cell Biol (2004) 2.19
Systematic identification of type I and type II interferon-induced antiviral factors. Proc Natl Acad Sci U S A (2012) 2.18
The retinoblastoma tumor suppressor modifies the therapeutic response of breast cancer. J Clin Invest (2006) 2.18
Systemic but not local infections elicit immunosuppressive IL-10 production by natural killer cells. Cell Host Microbe (2009) 2.17
Rescue of TRAF3-null mice by p100 NF-kappa B deficiency. J Exp Med (2006) 2.17
The FaceBase Consortium: a comprehensive program to facilitate craniofacial research. Dev Biol (2011) 2.16
Altered gene expression profiles in nasal respiratory epithelium reflect stable versus acute childhood asthma. J Allergy Clin Immunol (2005) 2.16
NF-kappaB inhibits gammaherpesvirus lytic replication. J Virol (2003) 2.15
Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses. PLoS One (2009) 2.14
Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol. Immunity (2012) 2.13
The host type I interferon response to viral and bacterial infections. Cell Res (2005) 2.12
Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. J Clin Invest (2007) 2.12
The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nat Immunol (2012) 2.11
Cardiolipin provides an essential activating platform for caspase-8 on mitochondria. J Cell Biol (2008) 2.06
Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy. Nat Med (2002) 2.05
Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease. Nature (2009) 2.05
Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation. Sci Signal (2010) 2.05
Control of canonical NF-kappaB activation through the NIK-IKK complex pathway. Proc Natl Acad Sci U S A (2008) 2.05
Independent and overlapping transcriptional activation during liver development and regeneration in mice. Hepatology (2002) 2.02
MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity. J Immunol (2011) 2.00
Interleukin-7 induces expression of latent human immunodeficiency virus type 1 with minimal effects on T-cell phenotype. J Virol (2002) 1.93
Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice. J Biol Chem (2006) 1.92
Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK. J Biol Chem (2007) 1.89
Decreased serum ferritin is associated with alopecia in women. J Invest Dermatol (2003) 1.87
Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 production. J Immunol (2007) 1.87
Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection. J Infect Dis (2011) 1.86
Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis. Proc Natl Acad Sci U S A (2007) 1.86
IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection. Proc Natl Acad Sci U S A (2008) 1.84
A catalogue of gene expression in the developing kidney. Kidney Int (2003) 1.83
MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors. J Clin Invest (2012) 1.83
Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Dev Biol (2009) 1.83
Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues. Cancer Res (2006) 1.80
MicroRNA signature in patients with eosinophilic esophagitis, reversibility with glucocorticoids, and assessment as disease biomarkers. J Allergy Clin Immunol (2012) 1.79
The TLR4 antagonist Eritoran protects mice from lethal influenza infection. Nature (2013) 1.78
Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4. J Immunol (2003) 1.76
ToppCluster: a multiple gene list feature analyzer for comparative enrichment clustering and network-based dissection of biological systems. Nucleic Acids Res (2010) 1.75
Specificity of TRAF3 in its negative regulation of the noncanonical NF-kappa B pathway. J Biol Chem (2006) 1.75